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MX2019008652A - Metodos mejorados para la acilacion del maitansinol. - Google Patents

Metodos mejorados para la acilacion del maitansinol.

Info

Publication number
MX2019008652A
MX2019008652A MX2019008652A MX2019008652A MX2019008652A MX 2019008652 A MX2019008652 A MX 2019008652A MX 2019008652 A MX2019008652 A MX 2019008652A MX 2019008652 A MX2019008652 A MX 2019008652A MX 2019008652 A MX2019008652 A MX 2019008652A
Authority
MX
Mexico
Prior art keywords
amino acid
maytansinol
maitansinol
acilation
improved methods
Prior art date
Application number
MX2019008652A
Other languages
English (en)
Other versions
MX390615B (es
Inventor
C Widdison Wayne
Yongxin Zhao Robert
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of MX2019008652A publication Critical patent/MX2019008652A/es
Publication of MX390615B publication Critical patent/MX390615B/es

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
    • H01R12/00—Structural associations of a plurality of mutually-insulated electrical connecting elements, specially adapted for printed circuits, e.g. printed circuit boards [PCB], flat or ribbon cables, or like generally planar structures, e.g. terminal strips, terminal blocks; Coupling devices specially adapted for printed circuits, flat or ribbon cables, or like generally planar structures; Terminals specially adapted for contact with, or insertion into, printed circuits, flat or ribbon cables, or like generally planar structures
    • H01R12/50—Fixed connections
    • H01R12/51—Fixed connections for rigid printed circuits or like structures
    • H01R12/55—Fixed connections for rigid printed circuits or like structures characterised by the terminals
    • H01R12/58—Fixed connections for rigid printed circuits or like structures characterised by the terminals terminals for insertion into holes
    • H01R12/585—Terminals having a press fit or a compliant portion and a shank passing through a hole in the printed circuit board
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/0201—Thermal arrangements, e.g. for cooling, heating or preventing overheating
    • H05K1/0203—Cooling of mounted components
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/11—Printed elements for providing electric connections to or between printed circuits
    • H05K1/115—Via connections; Lands around holes or via connections
    • H05K1/116—Lands, clearance holes or other lay-out details concerning the surrounding of a via
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/18—Printed circuits structurally associated with non-printed electric components
    • H05K1/181—Printed circuits structurally associated with non-printed electric components associated with surface mounted components

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se proporciona un método para preparar un éster de aminoácidos de maitansinol representado por la siguiente fórmula al hacer reaccionar maitansinol con un N-carboxianhídrido de un aminoácido (NCA) en presencia de un agente de secado. También se proporciona un método mejorado para preparar un éster de aminoácido de maitansinol en el cual se agrega un nucleófilo a la mezcla de reacción después de completar la reacción entre maitansinol y un N-carboxianhídrido de un aminoácido.
MX2019008652A 2012-09-26 2013-09-26 Metodos mejorados para la acilacion del maitansinol. MX390615B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261705731P 2012-09-26 2012-09-26
PCT/US2013/061839 WO2014052537A1 (en) 2012-09-26 2013-09-26 Improved methods for the acylation of maytansinol

Publications (2)

Publication Number Publication Date
MX2019008652A true MX2019008652A (es) 2019-09-13
MX390615B MX390615B (es) 2025-03-20

Family

ID=49328648

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015003745A MX366701B (es) 2012-09-26 2013-09-26 Métodos mejorados para la acilación del maitansinol.
MX2019008652A MX390615B (es) 2012-09-26 2013-09-26 Metodos mejorados para la acilacion del maitansinol.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015003745A MX366701B (es) 2012-09-26 2013-09-26 Métodos mejorados para la acilación del maitansinol.

Country Status (27)

Country Link
US (9) US9012629B2 (es)
EP (3) EP3904358A1 (es)
JP (7) JP6517693B2 (es)
CN (2) CN108586487B (es)
AU (4) AU2013323572B2 (es)
BR (2) BR122021022582B1 (es)
CA (2) CA2884873C (es)
CY (2) CY1121415T1 (es)
DK (2) DK2900676T3 (es)
ES (2) ES2880754T3 (es)
HR (2) HRP20190473T1 (es)
HU (2) HUE043285T2 (es)
IL (2) IL237899A (es)
LT (2) LT2900676T (es)
MX (2) MX366701B (es)
MY (1) MY169250A (es)
NZ (2) NZ706019A (es)
PL (2) PL3486248T3 (es)
PT (2) PT2900676T (es)
RS (2) RS58493B1 (es)
RU (2) RU2648992C2 (es)
SG (1) SG11201501918UA (es)
SI (2) SI2900676T1 (es)
SM (2) SMT202100390T1 (es)
TR (1) TR201903625T4 (es)
WO (1) WO2014052537A1 (es)
ZA (1) ZA201501898B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108586487B (zh) * 2012-09-26 2021-11-05 伊缪诺金公司 用于美登醇酰化的改进的方法
CN105585579A (zh) * 2014-10-24 2016-05-18 南京联宁生物制药有限公司 一种化合物及其制备方法以及美登素dm1的制备方法
US10526344B2 (en) 2015-03-17 2020-01-07 Regeneron Pharmaceuticals, Inc. Amino acid acylation reagents and methods of using the same
CN118562004A (zh) 2016-12-16 2024-08-30 蓝鳍生物医药公司 抗-含cub结构域蛋白1(cdcp1)抗体、抗体药物缀合物及其使用方法
DK3956332T3 (da) * 2019-04-18 2023-05-01 Indena Spa Diasteroselektiv fremgangsmåde til fremstilling af thiol- eller disulfid-holdige maytansionidestere og mellemprodukter deraf
EP4067497A4 (en) 2019-11-29 2024-03-13 MicroBiopharm Japan Co., Ltd. Method for enzymatically producing maytansinol
WO2024225377A1 (ja) 2023-04-28 2024-10-31 中外製薬株式会社 Ｎ－カルボキシアミノ酸無水物を用いたアミド基含有化合物の製造方法

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JPS6034556B2 (ja) * 1977-03-31 1985-08-09 武田薬品工業株式会社 抗生物質ｃ−１５００３
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US4265814A (en) 1978-03-24 1981-05-05 Takeda Chemical Industries Matansinol 3-n-hexadecanoate
JPS5562090A (en) 1978-10-27 1980-05-10 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164687A (en) 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS5566585A (en) 1978-11-14 1980-05-20 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55162791A (en) 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
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JP2008288289A (ja) 2007-05-16 2008-11-27 Oki Electric Ind Co Ltd 電界効果トランジスタとその製造方法
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CN108586487B (zh) * 2012-09-26 2021-11-05 伊缪诺金公司 用于美登醇酰化的改进的方法

Also Published As

Publication number Publication date
SI2900676T1 (sl) 2019-04-30
RS62075B1 (sr) 2021-07-30
CY1124337T1 (el) 2022-07-22
AU2022201557A1 (en) 2022-03-31
PT2900676T (pt) 2019-03-29
SI3486248T1 (sl) 2021-10-29
LT3486248T (lt) 2021-08-25
US10100062B2 (en) 2018-10-16
RU2018109295A (ru) 2019-02-26
JP2020180150A (ja) 2020-11-05
HUE055443T2 (hu) 2021-11-29
US20150191488A1 (en) 2015-07-09
US20200153130A1 (en) 2020-05-14
US20190013604A1 (en) 2019-01-10
US20250007192A1 (en) 2025-01-02
DK2900676T3 (en) 2019-04-08
IL237899A (en) 2017-08-31
CN104768955B (zh) 2018-04-27
HK1212341A1 (en) 2016-06-10
US9796731B2 (en) 2017-10-24
RU2765072C2 (ru) 2022-01-25
NZ739573A (en) 2019-11-29
CY1121415T1 (el) 2020-05-29
PL3486248T3 (pl) 2021-10-25
PT3486248T (pt) 2021-07-12
US20140142297A1 (en) 2014-05-22
JP2025098242A (ja) 2025-07-01
JP6735000B1 (ja) 2020-08-05
US10944190B2 (en) 2021-03-09
EP2900676B1 (en) 2018-12-19
AU2013323572A1 (en) 2015-04-02
US20240313444A1 (en) 2024-09-19
DK3486248T3 (da) 2021-07-12
IL253988B (en) 2019-02-28
JP2018109044A (ja) 2018-07-12
US9012629B2 (en) 2015-04-21
MX390615B (es) 2025-03-20
EP2900676A1 (en) 2015-08-05
JP2022068367A (ja) 2022-05-09
EP3486248B1 (en) 2021-04-07
HRP20211030T1 (hr) 2021-10-01
JP2020117527A (ja) 2020-08-06
IL253988A0 (en) 2017-10-31
CN104768955A (zh) 2015-07-08
JP2024010055A (ja) 2024-01-23
AU2020203823A1 (en) 2020-07-02
US10461449B2 (en) 2019-10-29
MY169250A (en) 2019-03-19
AU2018201392A1 (en) 2018-03-15
RU2015111635A (ru) 2016-11-20
BR112015006505B1 (pt) 2022-03-15
HUE043285T2 (hu) 2019-08-28
EP3904358A1 (en) 2021-11-03
CN108586487B (zh) 2021-11-05
MX2015003745A (es) 2015-06-24
SMT201900170T1 (it) 2019-05-10
AU2020203823B2 (en) 2021-12-09
CA2884873A1 (en) 2014-04-03
RS58493B1 (sr) 2019-04-30
ZA201501898B (en) 2019-06-26
RU2018109295A3 (es) 2021-06-24
BR112015006505A2 (pt) 2017-07-04
JP2016500657A (ja) 2016-01-14
BR122021022582B1 (pt) 2023-01-10
AU2013323572B2 (en) 2017-12-07
CA2884873C (en) 2021-11-23
CA3133906C (en) 2023-05-02
JP6517693B2 (ja) 2019-05-22
RU2648992C2 (ru) 2018-03-29
HRP20190473T1 (hr) 2019-05-03
US20170137440A1 (en) 2017-05-18
PL2900676T3 (pl) 2019-06-28
ES2880754T3 (es) 2021-11-25
AU2018201392B2 (en) 2020-03-12
ES2716561T3 (es) 2019-06-13
SG11201501918UA (en) 2015-05-28
CN108586487A (zh) 2018-09-28
TR201903625T4 (tr) 2019-04-22
US9469655B2 (en) 2016-10-18
EP3486248A1 (en) 2019-05-22
NZ706019A (en) 2018-03-23
US20180099980A1 (en) 2018-04-12
MX366701B (es) 2019-07-22
CA3133906A1 (en) 2014-04-03
US20240145953A1 (en) 2024-05-02
LT2900676T (lt) 2019-03-25
WO2014052537A1 (en) 2014-04-03
SMT202100390T1 (it) 2021-09-14

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