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MX2019007950A - Inhibidores tripeptidicos de la epoxicetona proteasa. - Google Patents

Inhibidores tripeptidicos de la epoxicetona proteasa.

Info

Publication number
MX2019007950A
MX2019007950A MX2019007950A MX2019007950A MX2019007950A MX 2019007950 A MX2019007950 A MX 2019007950A MX 2019007950 A MX2019007950 A MX 2019007950A MX 2019007950 A MX2019007950 A MX 2019007950A MX 2019007950 A MX2019007950 A MX 2019007950A
Authority
MX
Mexico
Prior art keywords
protease inhibitors
epoxy ketone
ketone protease
tripeptide epoxy
compositions
Prior art date
Application number
MX2019007950A
Other languages
English (en)
Other versions
MX390369B (es
Inventor
Mcminn Dustin
Johnson Henry
Bowers Simeon
C Moebius David
Original Assignee
Onyx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ARP140100970A external-priority patent/AR095426A1/es
Application filed by Onyx Therapeutics Inc filed Critical Onyx Therapeutics Inc
Publication of MX2019007950A publication Critical patent/MX2019007950A/es
Publication of MX390369B publication Critical patent/MX390369B/es

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    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
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Abstract

Se proporcionan en la presente inhibidores tripeptídicos de epoxi cetona proteasa, métodos para su preparación, composiciones farmacéuticas relacionadas y métodos de uso de ellos. Por ejemplo, se proporcionan en la presente compuestos de la fórmula (X): y sales farmacéuticamente aceptables y composiciones que los incluyen. Los compuestos y composiciones proporcionados en la presente se pueden usar, por ejemplo, en el tratamiento de enfermedades que incluyen inflamación y enfermedad neurodegenerativa.
MX2019007950A 2013-03-14 2014-03-14 Inhibidores tripeptidicos de la epoxicetona proteasa MX390369B (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201361786086P 2013-03-14 2013-03-14
US201361785608P 2013-03-14 2013-03-14
US201361847780P 2013-07-18 2013-07-18
US201361856847P 2013-07-22 2013-07-22
US201361883843P 2013-09-27 2013-09-27
US201361883798P 2013-09-27 2013-09-27
US201461941798P 2014-02-19 2014-02-19
ARP140100970A AR095426A1 (es) 2013-03-14 2014-03-13 Inhibidores tripeptídicos de la epoxicetona proteasa
PCT/US2014/026987 WO2014152134A1 (en) 2013-03-14 2014-03-14 Tripeptide epoxy ketone protease inhibitors

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TWI751178B (zh) * 2016-06-29 2022-01-01 美商基澤生命科學公司 肽環氧酮免疫蛋白酶體抑制劑的結晶鹽
IL302234A (en) * 2016-06-29 2023-06-01 Kezar Life Sciences Process of preparing a peptide epoxyketone immunoproteasome inhibitor, and precursors thereof
WO2024140736A1 (zh) * 2022-12-27 2024-07-04 上海美悦生物科技发展有限公司 三肽环氧酮化合物、药物组合物及其制备方法和用途

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