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MX2019007256A - Inhibidores de las fosfodiesterasas y métodos de tratamiento microbiano. - Google Patents

Inhibidores de las fosfodiesterasas y métodos de tratamiento microbiano.

Info

Publication number
MX2019007256A
MX2019007256A MX2019007256A MX2019007256A MX2019007256A MX 2019007256 A MX2019007256 A MX 2019007256A MX 2019007256 A MX2019007256 A MX 2019007256A MX 2019007256 A MX2019007256 A MX 2019007256A MX 2019007256 A MX2019007256 A MX 2019007256A
Authority
MX
Mexico
Prior art keywords
methods
phosphodiesterase inhibitors
microbial treatment
enhancing
disclosed
Prior art date
Application number
MX2019007256A
Other languages
English (en)
Inventor
N Dietsch Gregory
Michael Gallatin William
Original Assignee
Mavupharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mavupharma Inc filed Critical Mavupharma Inc
Publication of MX2019007256A publication Critical patent/MX2019007256A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/473—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used alpha-Glycoproteins
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En el presente documento se describen métodos y compuestos para tratar, aumentar y mejorar la producción de IFN de tipo I in vivo. En algunas realizaciones del presente documento, también se describen métodos para activar y mejorar la respuesta de cGAS-STING y el uso de un inhibidor de una fosfodiesterasa para el tratamiento de una infección microbiana.
MX2019007256A 2016-12-22 2017-12-21 Inhibidores de las fosfodiesterasas y métodos de tratamiento microbiano. MX2019007256A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662438344P 2016-12-22 2016-12-22
PCT/US2017/068044 WO2018119328A1 (en) 2016-12-22 2017-12-21 Phosphodiesterase inhibitors and methods of microbial treatment

Publications (1)

Publication Number Publication Date
MX2019007256A true MX2019007256A (es) 2019-11-18

Family

ID=62627591

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019007256A MX2019007256A (es) 2016-12-22 2017-12-21 Inhibidores de las fosfodiesterasas y métodos de tratamiento microbiano.

Country Status (12)

Country Link
US (1) US20200085828A1 (es)
EP (1) EP3558352A1 (es)
JP (1) JP2020504740A (es)
KR (1) KR20190126283A (es)
CN (1) CN110446503A (es)
AU (1) AU2017382297A1 (es)
BR (1) BR112019012618A2 (es)
CA (1) CA3047589A1 (es)
EA (1) EA201991556A1 (es)
IL (1) IL267455A (es)
MX (1) MX2019007256A (es)
WO (1) WO2018119328A1 (es)

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IL321754A (en) 2017-06-30 2025-08-01 Univ California Compositions and methods for modulating hair growth
BR112020004209A2 (pt) * 2017-08-31 2020-09-01 Abbvie Inc. inibidores da ectonucleotide piofosfatase-phosfodiesterase 1 (enpp-1) e uso dos mesmos
WO2020150147A1 (en) * 2019-01-14 2020-07-23 The Regents Of The University Of California Compositions and methods for treating ocular conditions
WO2020190912A1 (en) 2019-03-19 2020-09-24 Stingray Therapeutics, Inc. Quinoline and quinazoline compounds and methods of use thereof
KR20210151873A (ko) * 2019-04-12 2021-12-14 리보사이언스 엘엘씨 엑토뉴클레오티드 피로포스파타제 포스포디에스테라제 1 억제제로서의 두고리 헤테로아릴 유도체
US20230106238A1 (en) * 2020-03-11 2023-04-06 Samsung Life Public Welfare Foundation Pharmaceutical composition for preventing or treating nk/t-celllymphoma or nk-cell leukemia, comprising phosphodiesterase type 5 inhibitor
KR102682428B1 (ko) 2020-05-08 2024-07-05 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도
WO2021225407A1 (ko) 2020-05-08 2021-11-11 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도
EP4149927A1 (en) * 2020-05-14 2023-03-22 VIR Biotechnology, Inc. Enpp1 modulators and uses thereof
CA3200318A1 (en) 2020-10-30 2022-05-05 1Cbio, Inc. Ectonucleotide pyrophosphatase-phosphodiesterase-1 (enpp1) inhibitors and uses thereof
CN116600813A (zh) * 2020-12-09 2023-08-15 斯汀格瑞治疗股份有限公司 作为enpp1和cdnp抑制剂的膦酸盐
MX2023007670A (es) 2020-12-29 2023-07-07 Txinno Bioscience Inc Nuevo derivado de naftiridinona que tiene actividad inhibidora contra la ectonucleotido pirofosfatasa -fosfodiesterasa y uso del mismo.
KR102720206B1 (ko) 2020-12-29 2024-10-21 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도
KR102686866B1 (ko) 2021-01-29 2024-07-19 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도
CA3204409A1 (en) 2021-01-29 2022-08-04 Chan Sun Park Novel benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase, and use thereof
WO2022197734A1 (en) * 2021-03-16 2022-09-22 Riboscience Llc Bicyclic heteroaryl boronate derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors
KR102635126B1 (ko) 2021-05-27 2024-02-13 한국과학기술연구원 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 피롤로피리미딘 유도체 및 이들의 용도
KR102726416B1 (ko) 2021-12-15 2024-11-05 한국과학기술연구원 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 피리도피리미딘 유도체 및 이들의 용도
JP2024545220A (ja) * 2021-12-16 2024-12-05 ベイジーン スイッツァランド ゲーエムベーハー Ｓｔｉｎｇアンタゴニストとしての３，４－ジヒドロイソキノリン－１（２ｈ）－オン誘導体及びその使用
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