MX2019006767A - Solucion de conservacion de acido nucleico y metodos de elaboracion y uso. - Google Patents
Solucion de conservacion de acido nucleico y metodos de elaboracion y uso.Info
- Publication number
- MX2019006767A MX2019006767A MX2019006767A MX2019006767A MX2019006767A MX 2019006767 A MX2019006767 A MX 2019006767A MX 2019006767 A MX2019006767 A MX 2019006767A MX 2019006767 A MX2019006767 A MX 2019006767A MX 2019006767 A MX2019006767 A MX 2019006767A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- nucleic acid
- biological sample
- compositions
- manufacture
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 239000003761 preservation solution Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 6
- 239000012472 biological sample Substances 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
- YUJLIIRMIAGMCQ-CIUDSAMLSA-N Ser-Leu-Ser Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O YUJLIIRMIAGMCQ-CIUDSAMLSA-N 0.000 abstract 1
- 239000007983 Tris buffer Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- JIWBIWFOSCKQMA-LTKCOYKYSA-N all-cis-octadeca-6,9,12,15-tetraenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/CCCCC(O)=O JIWBIWFOSCKQMA-LTKCOYKYSA-N 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 230000003196 chaotropic effect Effects 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003172 expectorant agent Substances 0.000 abstract 1
- ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 abstract 1
- 229940066491 mucolytics Drugs 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 229940098465 tincture Drugs 0.000 abstract 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 1
- 230000000007 visual effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Se describen composiciones de conservación de ácido nucleico y métodos de elaboración y usos de estas. Las composiciones incluyen un portador, un agente caotrópico, un agente amortiguador, un agente quelante, un tensioactivo, un alcohol, un ácido, y un agente mucolítico. Las composiciones como soluciones acuosas pueden incluir agua como un portador. Las formas de realización preferidas incluyen agua, tiocianato de guanidina, Tris, EDTA, SLS, SDA 3C, HCI y N-acetil-L-cisteína. Algunas formas de realización incluyen una tintura coloreada como un indicador visual. Los métodos de elaboración incluyen combinar los componentes en una mezcla, tal como una solución acuosa. Los métodos de uso incluyen proporcionar una muestra biológica que incluya ácido nucleico y poner en contacto la muestra biológica con la composición. Los kits incluyen la composición dispuesta en una parte de un aparato de recolección de muestras biológicas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762446818P | 2017-01-16 | 2017-01-16 | |
| PCT/US2018/013862 WO2018132827A1 (en) | 2017-01-16 | 2018-01-16 | Nucleic acid preservation solution and methods of manufacture and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019006767A true MX2019006767A (es) | 2019-08-22 |
| MX374141B MX374141B (es) | 2025-03-05 |
Family
ID=62839045
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019006767A MX374141B (es) | 2017-01-16 | 2018-01-16 | Solucion de conservacion de acido nucleico y metodos de elaboracion y uso. |
| MX2020003996A MX2020003996A (es) | 2017-01-16 | 2019-06-10 | Solucion de conservacion de acido nucleico y metodos de elaboracion y uso. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020003996A MX2020003996A (es) | 2017-01-16 | 2019-06-10 | Solucion de conservacion de acido nucleico y metodos de elaboracion y uso. |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US10174362B2 (es) |
| EP (3) | EP3568475B1 (es) |
| JP (4) | JP6652692B2 (es) |
| CN (2) | CN110072999B (es) |
| CA (1) | CA3042088A1 (es) |
| CY (1) | CY1126046T1 (es) |
| DK (1) | DK3568475T3 (es) |
| ES (1) | ES2942577T3 (es) |
| FI (1) | FI3568475T3 (es) |
| HR (1) | HRP20230345T1 (es) |
| HU (1) | HUE062204T2 (es) |
| LT (1) | LT3568475T (es) |
| MX (2) | MX374141B (es) |
| PL (1) | PL3568475T3 (es) |
| PT (1) | PT3568475T (es) |
| SI (1) | SI3568475T1 (es) |
| WO (1) | WO2018132827A1 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX374141B (es) * | 2017-01-16 | 2025-03-05 | Spectrum Solutions L L C | Solucion de conservacion de acido nucleico y metodos de elaboracion y uso. |
| WO2020102570A1 (en) * | 2018-11-14 | 2020-05-22 | Spectrum Solutions L.L.C. | Rna preservation solution and methods of manufacture and use |
| MY207327A (en) | 2018-11-20 | 2025-02-19 | Spectrum Solutions Llc | Sample collection system including sealing cap and valve |
| US11701094B2 (en) | 2019-06-20 | 2023-07-18 | Spectrum Solutions L.L.C. | Sample collection system including valve and plug assemblies |
| CN114096668B (zh) * | 2019-09-18 | 2024-04-05 | 株式会社骏河生物技术研究所 | 样本保存液以及使用它的分析用装置和分析方法 |
| CN110747193B (zh) * | 2019-09-25 | 2021-08-31 | 广州市达瑞生物技术股份有限公司 | 一种基于二代测序平台的肺癌多基因联合检测试剂盒质控品 |
| CN110643679A (zh) * | 2019-09-26 | 2020-01-03 | 李润成 | 一种水环境dna采集保存卡及其制作方法 |
| CN113133996B (zh) * | 2020-01-20 | 2023-07-04 | 山东威高宏瑞医学科技有限公司 | 乙酰半胱氨酸或其化学上可接受的盐/酯在制备结缔组织的分离制剂中的应用 |
| CN111172239A (zh) * | 2020-02-28 | 2020-05-19 | 上海思路迪医学检验所有限公司 | 一种病毒样本保存液、核酸提取试剂及病毒核酸提取方法 |
| WO2021205470A1 (en) * | 2020-04-06 | 2021-10-14 | 30M Genomics Private Limited | Buffer composition for one step nucleic acid sample preparation and storage from biological samples |
| CN115397453A (zh) * | 2020-04-14 | 2022-11-25 | 光谱解决方案有限责任公司 | 用于检测病毒核酸的产品和方法 |
| CN111218444B (zh) * | 2020-04-24 | 2020-09-01 | 广州安必平医药科技股份有限公司 | 一种痰液保存液 |
| CN111690640B (zh) * | 2020-06-22 | 2023-10-03 | 广州东盛生物科技有限公司 | 一种高度兼容磁珠法病毒核酸提取试剂盒的病毒保存液 |
| CN112280775A (zh) * | 2020-08-10 | 2021-01-29 | 广州捷倍斯生物科技有限公司 | 一种生物样品核酸保护液及应用 |
| WO2022045303A1 (ja) * | 2020-08-28 | 2022-03-03 | 花王株式会社 | Ｒｎａの保存方法 |
| CN112029824A (zh) * | 2020-09-15 | 2020-12-04 | 北京康美天鸿生物科技有限公司 | 一种通用于多种样本的核酸保存液 |
| AT18096U1 (de) * | 2020-09-18 | 2024-01-15 | Procomcure Biotech Gmbh | Kit zur Entnahme von Speichelproben |
| JP2023549013A (ja) * | 2020-09-18 | 2023-11-22 | プロコムキュア バイオテック ゲーエムベーハー | 唾液サンプル採取用キット |
| CN112176025B (zh) * | 2020-10-12 | 2022-05-24 | 广东南芯医疗科技有限公司 | 一种核酸保存液及其制备方法和应用 |
| CN114369646B (zh) * | 2020-10-15 | 2026-01-09 | 中国疾病预防控制中心 | 一种痰液液化方法及其专用液化试剂 |
| CN112760318B (zh) * | 2020-12-30 | 2023-11-17 | 苏州白垩纪生物科技有限公司 | 一种用于稳定核酸分子的试剂组合物及其应用 |
| KR20230169935A (ko) | 2021-01-12 | 2023-12-18 | 데피니티브 바이오테크놀로지스 엘엘씨 | 생물학적 시료들에서 핵산을 검출하기 위한 디바이스및 방법 |
| CN114847272B (zh) * | 2021-02-03 | 2025-12-30 | 上海究本生物科技有限公司 | 一种稳定化生物学样本遗传信息物质的组合物 |
| CN113373031B (zh) * | 2021-08-13 | 2021-11-16 | 北京健为医学检验实验室有限公司 | 一种喷雾型的游离dna样本保存管及应用 |
| CN113736755B (zh) * | 2021-08-18 | 2024-01-19 | 江苏默乐生物科技股份有限公司 | 一种可常温保存的灭活型病毒保存液及其制备方法 |
| CN114235986A (zh) * | 2021-11-25 | 2022-03-25 | 浙江艾兰得生物科技有限公司 | 维生素b1、b2、b6、烟酸、烟酰胺含量的高效液相色谱检测方法 |
| CN115369149B (zh) * | 2022-06-30 | 2026-01-09 | 河北鑫乐医疗器械科技股份有限公司 | 一种尿液游离dna保存剂以及一种尿液保存管 |
| CN116555248B (zh) * | 2023-07-10 | 2023-10-20 | 北京凡知医学科技有限公司 | 一种细菌中高分子量dna提取试剂盒及提取方法 |
| CN117165580B (zh) * | 2023-11-03 | 2024-01-26 | 青岛金域医学检验实验室有限公司 | 一种用于稳定样本中核酸的组合物、制备方法及其应用 |
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