MX2019006343A - Sintesis de acido tiosulfonico por un paso de acoplamiento oxidativo mediado por peryodato de un acido tiosulfonico con una anilina. - Google Patents
Sintesis de acido tiosulfonico por un paso de acoplamiento oxidativo mediado por peryodato de un acido tiosulfonico con una anilina.Info
- Publication number
- MX2019006343A MX2019006343A MX2019006343A MX2019006343A MX2019006343A MX 2019006343 A MX2019006343 A MX 2019006343A MX 2019006343 A MX2019006343 A MX 2019006343A MX 2019006343 A MX2019006343 A MX 2019006343A MX 2019006343 A MX2019006343 A MX 2019006343A
- Authority
- MX
- Mexico
- Prior art keywords
- thiosulfonic acid
- formula
- aniline
- synthesis
- oxidative coupling
- Prior art date
Links
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 238000005691 oxidative coupling reaction Methods 0.000 title abstract 2
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B55/00—Azomethine dyes
- C09B55/009—Azomethine dyes, the C-atom of the group -C=N- being part of a ring (Image)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/04—Thiosulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B21/00—Thiazine dyes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
La presente invención se refiere en general al campo de la síntesis química, y más particularmente a los métodos para la síntesis química de un ácido tiosulfónico de Fórmula (1) mediante un paso de acoplamiento oxidativo mediado por peryodato de un ácido tiosulfónico de Fórmula (2) con una anilina. de Fórmula (3), como se describe en el presente documento. La presente invención también se refiere a tales métodos que incorporan uno o más pasos adicionales (posteriores y/o anteriores), por ejemplo, para preparar compuestos de Fórmula (5) a partir de compuestos de Fórmula (1); para preparar compuestos de Fórmula (6) a partir de compuestos de Fórmula (5); y para preparar compuestos de Fórmula (2) a partir de compuestos de Fórmula (4), como se describe en el presente documento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1621817.4A GB201621817D0 (en) | 2016-12-21 | 2016-12-21 | Methods of chemical synthesis |
| PCT/EP2017/084111 WO2018115292A1 (en) | 2016-12-21 | 2017-12-21 | Synthesis of a thiosulfonic acid by a step of periodate mediated oxidative coupling of a thiosulfonic acid with an aniline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019006343A true MX2019006343A (es) | 2019-08-14 |
Family
ID=58284684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019006343A MX2019006343A (es) | 2016-12-21 | 2017-12-21 | Sintesis de acido tiosulfonico por un paso de acoplamiento oxidativo mediado por peryodato de un acido tiosulfonico con una anilina. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10968174B2 (es) |
| EP (1) | EP3559122B1 (es) |
| JP (1) | JP6991214B6 (es) |
| CN (1) | CN110249007B (es) |
| AU (1) | AU2017381914B2 (es) |
| BR (1) | BR112019011486B1 (es) |
| CA (1) | CA3047849A1 (es) |
| ES (1) | ES3012496T3 (es) |
| GB (1) | GB201621817D0 (es) |
| HR (1) | HRP20250417T1 (es) |
| MX (1) | MX2019006343A (es) |
| MY (1) | MY196769A (es) |
| PL (1) | PL3559122T3 (es) |
| WO (1) | WO2018115292A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2912571T3 (es) | 2006-07-11 | 2022-05-26 | Wista Lab Ltd | Procedimientos de síntesis y/o de purificación de compuestos de diaminofenotiazinio |
| ES2989458T3 (es) | 2018-07-26 | 2024-11-26 | Wista Lab Ltd | Dosis optimizada de diaminofenotiazinas en poblaciones |
| CN113522364B (zh) * | 2021-07-19 | 2022-05-06 | 中国地质大学（北京） | 化学发光增强剂及制备和在过氧化氢高碘酸盐体系的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1866C (de) | Gebr. Japy & Cie. in Paris | Taschen-Weckeruhr | ||
| US4212971A (en) | 1979-03-08 | 1980-07-15 | American Cyanamid Company | Process for preparing methylene blue |
| US5344928A (en) | 1991-04-26 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Phenothiazine derivatives, their production and use |
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| AU5357498A (en) * | 1997-11-13 | 1999-06-07 | Zila, Inc. | (in vivo) stain composition, process of manufacture, and methods of use to identify dysplastic tissue |
| US6194573B1 (en) | 1997-11-13 | 2001-02-27 | Zila, Inc. | Process for manufacture of in vivo stain composition |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| SI1799662T1 (sl) | 2004-09-23 | 2013-08-30 | Wista Laboratories Ltd. | Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC) |
| ES2349322T7 (es) | 2006-03-29 | 2019-10-17 | Wista Lab Ltd | Sales de 3,7-diamino-10H-fenotiazina y su utilización |
| ES2659030T3 (es) | 2006-03-29 | 2018-03-13 | Wista Laboratories Ltd. | Compuestos de tioninio y su uso |
| ES2912571T3 (es) | 2006-07-11 | 2022-05-26 | Wista Lab Ltd | Procedimientos de síntesis y/o de purificación de compuestos de diaminofenotiazinio |
| CN100436431C (zh) | 2006-12-15 | 2008-11-26 | 贵州同济堂制药有限公司 | 药用亚甲蓝的合成方法 |
| US8691979B2 (en) | 2009-05-12 | 2014-04-08 | Wista Laboratories Ltd. | Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants |
| PL2673266T3 (pl) | 2011-02-11 | 2017-01-31 | Wista Lab Ltd | Fenotiazynowe sole diaminiowe i ich zastosowanie |
| GB201317702D0 (en) * | 2013-10-07 | 2013-11-20 | Wista Lab Ltd | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
| CN105130926B (zh) * | 2015-07-31 | 2018-02-13 | 江苏恒润制药有限公司 | 一种亚甲基蓝的制备方法 |
-
2016
- 2016-12-21 GB GBGB1621817.4A patent/GB201621817D0/en not_active Ceased
-
2017
- 2017-12-21 BR BR112019011486-6A patent/BR112019011486B1/pt active IP Right Grant
- 2017-12-21 AU AU2017381914A patent/AU2017381914B2/en active Active
- 2017-12-21 ES ES17822293T patent/ES3012496T3/es active Active
- 2017-12-21 CA CA3047849A patent/CA3047849A1/en active Pending
- 2017-12-21 JP JP2019528739A patent/JP6991214B6/ja active Active
- 2017-12-21 CN CN201780079246.4A patent/CN110249007B/zh active Active
- 2017-12-21 EP EP17822293.1A patent/EP3559122B1/en active Active
- 2017-12-21 MY MYPI2019003299A patent/MY196769A/en unknown
- 2017-12-21 WO PCT/EP2017/084111 patent/WO2018115292A1/en not_active Ceased
- 2017-12-21 PL PL17822293.1T patent/PL3559122T3/pl unknown
- 2017-12-21 HR HRP20250417TT patent/HRP20250417T1/hr unknown
- 2017-12-21 US US16/471,674 patent/US10968174B2/en active Active
- 2017-12-21 MX MX2019006343A patent/MX2019006343A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112019011486A2 (pt) | 2019-10-22 |
| JP2020502073A (ja) | 2020-01-23 |
| EP3559122A1 (en) | 2019-10-30 |
| CN110249007A (zh) | 2019-09-17 |
| CN110249007B (zh) | 2021-06-29 |
| AU2017381914A1 (en) | 2019-06-20 |
| JP6991214B2 (ja) | 2022-02-03 |
| PL3559122T3 (pl) | 2025-06-09 |
| EP3559122B1 (en) | 2025-01-22 |
| GB201621817D0 (en) | 2017-02-01 |
| CA3047849A1 (en) | 2018-06-28 |
| ES3012496T3 (en) | 2025-04-09 |
| EP3559122C0 (en) | 2025-01-22 |
| BR112019011486B1 (pt) | 2023-04-18 |
| JP6991214B6 (ja) | 2023-12-14 |
| WO2018115292A1 (en) | 2018-06-28 |
| US10968174B2 (en) | 2021-04-06 |
| HRP20250417T1 (hr) | 2025-06-06 |
| US20200115335A1 (en) | 2020-04-16 |
| MY196769A (en) | 2023-05-03 |
| AU2017381914B2 (en) | 2021-08-19 |
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