MX2019005617A - Linfocitos infiltrantes de tumores remanentes y metodos de preparacion y uso de los mismos. - Google Patents
Linfocitos infiltrantes de tumores remanentes y metodos de preparacion y uso de los mismos.Info
- Publication number
- MX2019005617A MX2019005617A MX2019005617A MX2019005617A MX2019005617A MX 2019005617 A MX2019005617 A MX 2019005617A MX 2019005617 A MX2019005617 A MX 2019005617A MX 2019005617 A MX2019005617 A MX 2019005617A MX 2019005617 A MX2019005617 A MX 2019005617A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- infiltrating lymphocytes
- remnant
- tumors
- preparing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/065—Modulators of histone acetylation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2304—Interleukin-4 (IL-4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En algunas modalidades, se describen métodos para administrar una cantidad terapéuticamente eficaz de un número expandido de linfocitos infiltrantes de tumores obtenidos de remanentes tumorales a un paciente que lo necesite, para el tratamiento de un cáncer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662423750P | 2016-11-17 | 2016-11-17 | |
| US201762460441P | 2017-02-17 | 2017-02-17 | |
| PCT/US2017/062219 WO2018094167A1 (en) | 2016-11-17 | 2017-11-17 | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019005617A true MX2019005617A (es) | 2019-08-14 |
| MX419719B MX419719B (es) | 2025-01-14 |
Family
ID=60766134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019005617A MX419719B (es) | 2016-11-17 | 2017-11-17 | Linfocitos infiltrantes de tumores remanentes y metodos de preparacion y uso de los mismos. |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US11401507B2 (es) |
| EP (1) | EP3541930A1 (es) |
| JP (2) | JP7125392B2 (es) |
| KR (1) | KR102618948B1 (es) |
| CN (1) | CN110199016B (es) |
| AU (1) | AU2017362418B2 (es) |
| BR (1) | BR112019009925A2 (es) |
| CA (1) | CA3044250A1 (es) |
| IL (1) | IL266655A (es) |
| MA (1) | MA46916A (es) |
| MX (1) | MX419719B (es) |
| TW (1) | TWI826360B (es) |
| WO (1) | WO2018094167A1 (es) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
| KR20240150531A (ko) * | 2016-10-26 | 2024-10-15 | 이오반스 바이오테라퓨틱스, 인크. | 냉동보존된 종양 침윤 림프구의 재자극 |
| MX419719B (es) | 2016-11-17 | 2025-01-14 | Iovance Biotherapeutics Inc | Linfocitos infiltrantes de tumores remanentes y metodos de preparacion y uso de los mismos. |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| EP3635097A1 (en) | 2017-06-05 | 2020-04-15 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
| JP7558563B2 (ja) | 2018-03-15 | 2024-10-01 | ケーエスキュー セラピューティクス, インコーポレイテッド | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
| US12473532B2 (en) | 2018-05-10 | 2025-11-18 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| TW202031273A (zh) * | 2018-08-31 | 2020-09-01 | 美商艾歐凡斯生物治療公司 | 抗pd-1抗體難治療性之非小細胞肺癌(nsclc)病患的治療 |
| AU2019342749B2 (en) * | 2018-09-20 | 2025-07-10 | Iovance Biotherapeutics, Inc. | Expansion of tils from cryopreserved tumor samples |
| CN112969469A (zh) * | 2018-11-05 | 2021-06-15 | 艾欧凡斯生物治疗公司 | 抗pd-1抗体难治性nsclc患者的治疗 |
| AU2019374761A1 (en) | 2018-11-05 | 2021-06-10 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| US20230039976A1 (en) * | 2018-11-05 | 2023-02-09 | Iovance Biotherapeutics, Inc. | Selection of improved tumor reactive t-cells |
| GB201818243D0 (en) | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
| EP3908678A1 (en) * | 2019-01-10 | 2021-11-17 | Iovance Biotherapeutics, Inc. | System and methods for monitoring adoptive cell therapy clonality and persistence |
| GB201911066D0 (en) | 2019-08-02 | 2019-09-18 | Achilles Therapeutics Ltd | T cell therapy |
| CN110938594A (zh) * | 2019-09-12 | 2020-03-31 | 夏建川 | 一种功能增强型til细胞的培养方法 |
| IL293874B2 (en) * | 2019-12-18 | 2024-03-01 | Cbio As | Improved process for culturing tumor-infiltrating lymphocytes for therapeutic use |
| WO2021123832A1 (en) | 2019-12-20 | 2021-06-24 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
| EP4110799B1 (en) * | 2020-02-27 | 2024-11-06 | Turnstone Biologics Corp. | Methods for ex vivo enrichment and expansion of tumor reactive t cells and related compositions thereof |
| EP4143300A1 (en) | 2020-04-28 | 2023-03-08 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| US20230226110A1 (en) | 2020-04-28 | 2023-07-20 | Achilles Therapeutics Uk Limited | T cell therapy |
| US20230193203A1 (en) * | 2020-04-30 | 2023-06-22 | The Translational Genomics Research Institute | Neoantigen-informed tumor-infiltrating lymphocyte cancer immunotherapy |
| CN111705051A (zh) * | 2020-07-28 | 2020-09-25 | 金紫晶(南京)生物医药技术有限公司 | 一种复合消化酶及复合消化酶冻干粉 |
| CN114901805B (zh) | 2020-11-19 | 2023-07-25 | 苏州沙砾生物科技有限公司 | 肿瘤浸润淋巴细胞的培养方法及其用途 |
| CN114686430A (zh) * | 2020-12-31 | 2022-07-01 | 上海赛比曼生物科技有限公司 | 一种制备til的方法 |
| WO2022166947A1 (zh) * | 2021-02-08 | 2022-08-11 | 苏州沙砾生物科技有限公司 | 肿瘤浸润淋巴细胞的制备方法及其用途 |
| IL306072A (en) | 2021-03-25 | 2023-11-01 | Iovance Biotherapeutics Inc | Methods and preparations for T-cell coculture potency assays and use with cellular therapy products |
| EP4320435A1 (en) | 2021-04-09 | 2024-02-14 | Achilles Therapeutics UK Limited | Batch release assay for pharmaceutical products relating to t cell therapies |
| GB202109886D0 (en) | 2021-07-08 | 2021-08-25 | Achilles Therapeutics Uk Ltd | Assay |
| CA3216691A1 (en) * | 2021-04-16 | 2022-10-20 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Culture of tumor infiltrating lymphocytes from tumor digest |
| IL309200A (en) | 2021-06-22 | 2024-02-01 | Achilles Therapeutics Uk Ltd | A method for producing antigen-specific t cells |
| CN113244389B (zh) * | 2021-07-06 | 2021-09-17 | 诺赛联合(北京)生物医学科技有限公司 | 一种TILs细胞制备方法及在肿瘤治疗的用途 |
| CN113755529B (zh) * | 2021-09-15 | 2022-09-23 | 皖南医学院第一附属医院(皖南医学院弋矶山医院) | 一种肿瘤增强型肿瘤浸润淋巴细胞的制备方法 |
| WO2023043787A1 (en) * | 2021-09-15 | 2023-03-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of amplifying tumor-reactive immune populations using organoids |
| WO2023137472A2 (en) | 2022-01-14 | 2023-07-20 | Tune Therapeutics, Inc. | Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression |
| WO2023137471A1 (en) | 2022-01-14 | 2023-07-20 | Tune Therapeutics, Inc. | Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation |
| JP2025531268A (ja) | 2022-09-19 | 2025-09-19 | チューン セラピューティクス インコーポレイテッド | T細胞機能を調節するための組成物、システム、および方法 |
| WO2025021860A1 (en) * | 2023-07-24 | 2025-01-30 | Vivia Biotech, S.L. | Method for producing immune cells for immunotherapy |
| EP4497821A1 (en) * | 2023-07-24 | 2025-01-29 | Vivia Biotech, S.L. | Method for producing immune cells for immunotherapy |
| WO2025029840A1 (en) | 2023-07-31 | 2025-02-06 | Tune Therapeutics, Inc. | Compositions and methods for multiplexed activation and repression of t cell gene expression |
| WO2025029835A1 (en) | 2023-07-31 | 2025-02-06 | Tune Therapeutics, Inc. | Compositions and methods for modulating il-2 gene expression |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3201325A (en) | 1963-02-15 | 1965-08-17 | Miles Lab | Process for the recovery of collagenase |
| US3705083A (en) | 1966-07-08 | 1972-12-05 | Agricultural Biolog Corp | Process for producing collagenase |
| US3821364A (en) | 1966-07-08 | 1974-06-28 | Advance Biofactures Corp | Process of producing collagenase |
| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| GB8504025D0 (en) | 1985-02-16 | 1985-03-20 | Biopharm Ltd | Hyaluronidase |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| AU7873187A (en) | 1986-08-08 | 1988-02-24 | University Of Minnesota | Method of culturing leukocytes |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US7479269B2 (en) | 1988-11-23 | 2009-01-20 | Genetics Institute, Llc | Methods for selectively enriching TH1 and TH2 cells |
| DE68925966T2 (de) | 1988-12-22 | 1996-08-29 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
| ATE358176T1 (de) | 1988-12-23 | 2007-04-15 | Genentech Inc | Menschliche dnase |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5126132A (en) | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
| US5177017A (en) | 1990-03-22 | 1993-01-05 | Trigen, Inc. | Molecular cloning of the genes responsible for collagenase production from Clostridium histolyticum |
| US5279823A (en) | 1992-06-08 | 1994-01-18 | Genentech, Inc. | Purified forms of DNASE |
| US5593877A (en) | 1993-03-11 | 1997-01-14 | The Rockefeller University | Nucleic acid and recombinant production of vespid venom hyaluronidase |
| US5422261A (en) | 1993-04-16 | 1995-06-06 | Baxter International Inc. | Composition containing collagenase and chymopapain for hydrolyzing connective tissue to isolate cells |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US5989888A (en) | 1996-01-24 | 1999-11-23 | Roche Diagnostics Corporation | Purified mixture of collagenase I, collagenase II and two other proteases |
| US6391607B1 (en) | 1996-06-14 | 2002-05-21 | Genentech, Inc. | Human DNase I hyperactive variants |
| US5958750A (en) | 1996-07-03 | 1999-09-28 | Inctye Pharmaceuticals, Inc. | Human hyaluronidase |
| US6123938A (en) | 1996-10-17 | 2000-09-26 | The Regents Of The University Of California | Human urinary hyaluronidase |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| AU2000202A (en) | 2000-10-31 | 2002-05-15 | Pr Pharmaceuticals Inc | Methods and compositions for enhanced delivery of bioactive molecules |
| US20050084967A1 (en) | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| ES2422193T3 (es) | 2002-06-28 | 2013-09-09 | Life Technologies Corp | Métodos para restaurar el repertorio inmune en pacientes con defectos inmunológicos relacionados con la autoinmunidad y trasplante de órganos o de células madre hematopoyéticas |
| AU2003265948B8 (en) | 2002-09-06 | 2009-09-03 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
| EP2311973A1 (en) | 2003-03-05 | 2011-04-20 | Halozyme, Inc. | Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
| EP3450538B1 (en) | 2003-10-08 | 2021-08-25 | Wilson Wolf Manufacturing Corporation | Cell culture methods and devices utilizing gas permeable materials |
| EP2439273B1 (en) | 2005-05-09 | 2019-02-27 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
| HRP20151102T1 (xx) | 2005-07-01 | 2015-11-20 | E. R. Squibb & Sons, L.L.C. | Humana monoklonska antitijela za ligand programirane smrti 1 (pd-l1) |
| WO2007071388A1 (en) | 2005-12-21 | 2007-06-28 | Sentoclone Ab | Improved method for expansion of tumour-reactive t-lymphocytes for immunotherapy of patients with cancer |
| WO2007071409A1 (en) | 2005-12-21 | 2007-06-28 | Sentoclone Ab | Method for treating colon cancer |
| AU2006328945B2 (en) | 2005-12-21 | 2011-06-30 | Sentoclone International Ab | Method for treating malignant melanoma |
| JP5205275B2 (ja) | 2005-12-21 | 2013-06-05 | セントクローネ インターナショナル エービー | 散在性ガンの治療法 |
| AU2007223093A1 (en) * | 2006-03-06 | 2007-09-13 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Autologous natural killer cells and lymphodepleting chemotherapy for the treatment of cancer |
| US7951365B2 (en) | 2007-06-27 | 2011-05-31 | Deifiera Falun Ab | Method for expansion of tumour-reactive T-lymphocytes for immunotherapy of patients with specific cancer types |
| US20150320798A1 (en) | 2012-11-27 | 2015-11-12 | The Johns Hopkins University | Use of Post-Transplant Cyclophosphamide Treated Allogeneic Marrow Infiltrating Lymphocytes to Augment Anti-Tumor Immunity |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| US8956860B2 (en) | 2009-12-08 | 2015-02-17 | Juan F. Vera | Methods of cell culture for adoptive cell therapy |
| US20130115617A1 (en) | 2009-12-08 | 2013-05-09 | John R. Wilson | Methods of cell culture for adoptive cell therapy |
| CA2783550A1 (en) | 2009-12-08 | 2011-06-16 | Wilson Wolf Manufacturing Corporation | Improved methods of cell culture for adoptive cell therapy |
| ES2385239B1 (es) | 2010-09-30 | 2013-06-19 | Proteos Biotech S.L.U. | Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno. |
| MX388465B (es) | 2010-11-12 | 2025-03-20 | Nektar Therapeutics | Conjugados de un resto de interleucina-2 y un polímero. |
| US20120244133A1 (en) * | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| KR102028340B1 (ko) | 2011-04-13 | 2019-10-04 | 이뮤니쿰 에이비 | 항원-특이적 t 세포의 증식 방법 |
| DK2768939T3 (en) | 2011-10-21 | 2016-11-07 | Cell Medica Ltd | Device for aseptic expansion of cells |
| GB201121308D0 (en) | 2011-12-12 | 2012-01-25 | Cell Medica Ltd | Process |
| EP3800242A1 (en) | 2012-05-18 | 2021-04-07 | Wilson Wolf Manufacturing Corporation | Improved methods of cell culture for adoptive cell therapy |
| EP2859093A4 (en) | 2012-06-11 | 2016-08-17 | Wolf Wilson Mfg Corp | IMPROVED METHODS FOR CELL CULTURES FOR ADOPTIVE CELL THERAPIES |
| PT2925329T (pt) | 2012-11-27 | 2021-03-29 | Ivan Marques Borrello | Utilização de linfócitos infiltrantes de medula alogénica tratados com ciclofosfamida pós-transplante para aumentar a imunidade antitumoral |
| CN105163745B (zh) | 2013-03-01 | 2020-06-12 | 美国卫生和人力服务部 | 从外周血中产生肿瘤反应性t细胞富集群的方法 |
| JP6416131B2 (ja) | 2013-03-01 | 2018-10-31 | アメリカ合衆国 | 濃縮された腫瘍反応性t細胞集団を腫瘍から作製する方法 |
| SG11201510526VA (en) | 2013-06-24 | 2016-01-28 | Wolf Wilson Mfg Corp | Closed system device and methods for gas permeable cell culture process |
| US10233425B2 (en) | 2013-09-16 | 2019-03-19 | The Trustees Of The University Of Pennsylvania | CD137 enrichment for efficient tumor infiltrating lymphocyte selection |
| ES2776407T3 (es) | 2014-03-20 | 2020-07-30 | H Lee Moffitt Cancer Ct & Res | Linfocitos infiltrantes de tumor para terapia celular adoptiva |
| EP3154350B1 (en) | 2014-04-10 | 2024-03-27 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy |
| JP7413639B2 (ja) * | 2014-06-11 | 2024-01-16 | ポリバイオセプト ゲーエムベーハー | 能動的細胞免疫療法のためのサイトカイン組成物を用いたリンパ球の増殖 |
| CN107109364A (zh) | 2014-09-04 | 2017-08-29 | 约翰霍普金斯大学 | 缺氧与常氧交替条件下的骨髓浸润淋巴细胞的激活 |
| AU2014407539B2 (en) | 2014-10-02 | 2020-10-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating T cell receptors having antigenic specificity for a cancer-specific mutation |
| EP3034092A1 (en) | 2014-12-17 | 2016-06-22 | Université de Lausanne | Adoptive immunotherapy for treating cancer |
| RU2017125957A (ru) | 2015-01-04 | 2019-02-04 | Проталикс Лтд. | Модифицированная днказа и ее применения |
| EP3288581B1 (en) | 2015-04-27 | 2020-11-11 | Cancer Research Technology Limited | Method for treating cancer |
| CA2984234C (en) | 2015-05-01 | 2023-10-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating t cells and t cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood |
| FR3038324B1 (fr) | 2015-06-30 | 2020-10-30 | Lab Francais Du Fractionnement | Procede de cryoconservation de cellules a visee therapeutique |
| FR3040396A1 (fr) | 2015-06-30 | 2017-03-03 | Chu Nantes | Procede de cryoconservation de lymphocytes infiltrant la tumeur |
| WO2017048614A1 (en) | 2015-09-15 | 2017-03-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating tumor-reactive t cell receptors from tumor or peripheral blood |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| EP3368659A1 (en) | 2015-10-28 | 2018-09-05 | Life Technologies AS | Selective expansion of different subpopulations of t cells by the alteration of cell surfacing signals and signal ratio |
| JP7034955B2 (ja) | 2016-06-28 | 2022-03-14 | ジーニアス・バイオテクノロジー・インコーポレイテッド | 免疫療法向けのt細胞組成物 |
| CN106244538A (zh) | 2016-08-04 | 2016-12-21 | 英普乐孚生物技术(上海)有限公司 | 一种恶性腹水来源的til细胞的分离培养方法 |
| KR20240150531A (ko) | 2016-10-26 | 2024-10-15 | 이오반스 바이오테라퓨틱스, 인크. | 냉동보존된 종양 침윤 림프구의 재자극 |
| MX419719B (es) | 2016-11-17 | 2025-01-14 | Iovance Biotherapeutics Inc | Linfocitos infiltrantes de tumores remanentes y metodos de preparacion y uso de los mismos. |
| WO2018102761A1 (en) | 2016-12-02 | 2018-06-07 | City Of Hope | Methods for manufacturing and expanding t cells expressing chimeric antigen receptors and other receptors |
| CN106591232A (zh) | 2017-01-04 | 2017-04-26 | 安徽安龙基因医学检验所有限公司 | 一种高效的pd‑1‑cd8+t细胞的培养方法 |
| US20200077644A1 (en) | 2017-03-14 | 2020-03-12 | Juno Therapeutics, Inc. | Methods for cryogenic storage |
| CN107384867B (zh) | 2017-08-04 | 2020-09-11 | 北京世纪劲得生物技术有限公司 | 一种肿瘤组织til细胞制备方法及专用培养基 |
-
2017
- 2017-11-17 MX MX2019005617A patent/MX419719B/es unknown
- 2017-11-17 CN CN201780083537.0A patent/CN110199016B/zh active Active
- 2017-11-17 WO PCT/US2017/062219 patent/WO2018094167A1/en not_active Ceased
- 2017-11-17 CA CA3044250A patent/CA3044250A1/en active Pending
- 2017-11-17 JP JP2019525747A patent/JP7125392B2/ja active Active
- 2017-11-17 MA MA046916A patent/MA46916A/fr unknown
- 2017-11-17 BR BR112019009925A patent/BR112019009925A2/pt unknown
- 2017-11-17 KR KR1020197016785A patent/KR102618948B1/ko active Active
- 2017-11-17 AU AU2017362418A patent/AU2017362418B2/en active Active
- 2017-11-17 EP EP17817949.5A patent/EP3541930A1/en active Pending
- 2017-11-17 TW TW106139868A patent/TWI826360B/zh active
- 2017-11-17 US US16/462,056 patent/US11401507B2/en active Active
-
2019
- 2019-05-15 IL IL266655A patent/IL266655A/en unknown
-
2021
- 2021-01-05 US US17/141,454 patent/US11293009B2/en active Active
- 2021-02-19 US US17/180,200 patent/US11220670B2/en active Active
-
2022
- 2022-06-09 US US17/836,998 patent/US12233075B2/en active Active
- 2022-08-12 JP JP2022128638A patent/JP7675688B2/ja active Active
-
2025
- 2025-01-29 US US19/040,480 patent/US20260000690A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7125392B2 (ja) | 2022-08-24 |
| CN110199016A (zh) | 2019-09-03 |
| US20210123020A1 (en) | 2021-04-29 |
| US11293009B2 (en) | 2022-04-05 |
| TW201831682A (zh) | 2018-09-01 |
| WO2018094167A1 (en) | 2018-05-24 |
| AU2017362418A1 (en) | 2019-06-06 |
| EP3541930A1 (en) | 2019-09-25 |
| US20260000690A1 (en) | 2026-01-01 |
| US11401507B2 (en) | 2022-08-02 |
| MX419719B (es) | 2025-01-14 |
| JP7675688B2 (ja) | 2025-05-13 |
| US20210189339A1 (en) | 2021-06-24 |
| AU2017362418B2 (en) | 2024-05-02 |
| US20230106186A1 (en) | 2023-04-06 |
| BR112019009925A2 (pt) | 2019-10-08 |
| JP2022167931A (ja) | 2022-11-04 |
| JP2019534030A (ja) | 2019-11-28 |
| KR102618948B1 (ko) | 2023-12-27 |
| IL266655A (en) | 2019-07-31 |
| US12233075B2 (en) | 2025-02-25 |
| US11220670B2 (en) | 2022-01-11 |
| US20190276802A1 (en) | 2019-09-12 |
| CA3044250A1 (en) | 2018-05-24 |
| MA46916A (fr) | 2019-09-25 |
| CN110199016B (zh) | 2024-08-16 |
| KR20190084101A (ko) | 2019-07-15 |
| TWI826360B (zh) | 2023-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2019005617A (es) | Linfocitos infiltrantes de tumores remanentes y metodos de preparacion y uso de los mismos. | |
| CO2020016619A2 (es) | Anticuerpos biespecificos anti-pvrig/anti-tigit y métodos de uso | |
| AR126205A2 (es) | Métodos de uso de linfocitos infiltrantes de tumor en melanoma doble refractario | |
| CL2017002996A1 (es) | Compuestos alqueno tetrasustituidos y su uso | |
| MX2016013457A (es) | Inhibidores de mdm2 y metodos terapeuticos que utilizan el mismo. | |
| MX2020008977A (es) | Formulaciones de anticuerpos de her2 subcutaneas. | |
| CL2017001943A1 (es) | Terapias de combinación para el tratamiento de cánceres | |
| CO2019010698A2 (es) | Vacunas de peptidos | |
| CL2018001512A1 (es) | Anticuerpos anti-cd73 humanizados. | |
| CL2018001722A1 (es) | Nuevos anticuerpos anti-mfi2 y métodos de uso (divisional solicitud 201700506) | |
| MX390014B (es) | Compuestos de dinucleótidos cíclicos y métodos de uso. | |
| DOP2016000153A (es) | Anticuerpos y fragmentos anti-vista | |
| BR112018003269A2 (pt) | conjugados de fármaco-anticorpo anti-dll3 e métodos de utilização | |
| MX2018005544A (es) | Uso de agonistas del receptor tipo toll- 8 (tlr8) para tratar cancer. | |
| GT201700025A (es) | Inhibidores de la proteína quinasa c y métodos de su uso | |
| MX2018001755A (es) | Vacuna contra viruela para tratamiento del cancer. | |
| BR112018010279A2 (pt) | novos anticorpos anti-emr2 e métodos de uso | |
| EP4599893A3 (en) | Cg0070 for treating bcg resistant bladder carcinoma in situ | |
| MX2025003354A (es) | Anticuerpos que se unen a 5t4 | |
| MX2019012938A (es) | Uso del inhibidor mejorador de homologo zeste 2 (ezh2) combinado con el inhibidor tirosina cinasa de bruton (btk) en la preparacion de farmacos para tratar tumores. | |
| CO2020016151A2 (es) | Conjugados de fármaco y anticuerpo anti-sez6 y métodos de uso | |
| MX2022014792A (es) | Cocristales, composiciones farmaceuticas de los mismos y metodos de tratamiento que los implican. | |
| MX2018007818A (es) | Anticuerpos dirigidos contra upk1b novedosos y metodos para su uso. | |
| MX381617B (es) | Conjugados de peptido-curcumina y formulaciones de los mismos. | |
| MX393281B (es) | Conjugados y composiciones de texafirina-pt (iv) para su uso para superar la resistencia del platino. |