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MX2019005007A - Protac dirigidos a la proteína tau y métodos asociados de uso. - Google Patents

Protac dirigidos a la proteína tau y métodos asociados de uso.

Info

Publication number
MX2019005007A
MX2019005007A MX2019005007A MX2019005007A MX2019005007A MX 2019005007 A MX2019005007 A MX 2019005007A MX 2019005007 A MX2019005007 A MX 2019005007A MX 2019005007 A MX2019005007 A MX 2019005007A MX 2019005007 A MX2019005007 A MX 2019005007A
Authority
MX
Mexico
Prior art keywords
tau protein
present disclosure
protac
targeted
associated methods
Prior art date
Application number
MX2019005007A
Other languages
English (en)
Inventor
P Crew Andrew
Berlin Michael
Dong Hanqing
J Flanagan John
Ishchenko Alexey
Original Assignee
Arvinas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62065318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019005007(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Arvinas Inc filed Critical Arvinas Inc
Publication of MX2019005007A publication Critical patent/MX2019005007A/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

La presente descripción se refiere a compuestos bifuncionales, que encuentran utilidad como moduladores de la proteína tau. En particular, la presente descripción se dirige a compuestos bifuncionales, que contienen sobre un extremo un ligando de VHL o cereblon que se une a la ligasa de la ubiquitina E3 y sobre el otro extremo una porción que se une a la proteína tau, de manera que la proteína tau se ubica en la proximidad de la ligasa de ubiquitina para efectuar la degradación (e inhibición) de tau. La presente descripción exhibe una amplia gama de actividades farmacológicas, asociadas con la degradación/inhibición de la proteína tau. Las enfermedades o trastornos que resultan de la agregación o acumulación de la proteína tau, se tratan o se previenen con los compuestos y composiciones de la presente descripción.
MX2019005007A 2016-11-01 2017-11-01 Protac dirigidos a la proteína tau y métodos asociados de uso. MX2019005007A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662415830P 2016-11-01 2016-11-01
PCT/US2017/059604 WO2018102067A2 (en) 2016-11-01 2017-11-01 Tau-protein targeting protacs and associated methods of use

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MX2019005007A true MX2019005007A (es) 2019-07-18

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MX2019005007A MX2019005007A (es) 2016-11-01 2017-11-01 Protac dirigidos a la proteína tau y métodos asociados de uso.
MX2022014690A MX2022014690A (es) 2016-11-01 2019-04-29 Protac dirigidos a la proteina tau y metodos asociados de uso.

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US (2) US11458123B2 (es)
EP (1) EP3535265A4 (es)
JP (2) JP7286539B2 (es)
KR (2) KR102570992B1 (es)
CN (1) CN110234646B (es)
AU (2) AU2017367872B2 (es)
CA (2) CA3042260C (es)
CO (1) CO2019005712A2 (es)
IL (3) IL304982A (es)
MX (2) MX2019005007A (es)
WO (1) WO2018102067A2 (es)

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