MX2019004822A - Derivado del pirazol 3,4-bipiridilo y metodo de preparacion del mismo y aplicacion medica del mismo. - Google Patents
Derivado del pirazol 3,4-bipiridilo y metodo de preparacion del mismo y aplicacion medica del mismo.Info
- Publication number
- MX2019004822A MX2019004822A MX2019004822A MX2019004822A MX2019004822A MX 2019004822 A MX2019004822 A MX 2019004822A MX 2019004822 A MX2019004822 A MX 2019004822A MX 2019004822 A MX2019004822 A MX 2019004822A MX 2019004822 A MX2019004822 A MX 2019004822A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- derivative
- bipyridyl
- method therefor
- medical application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a un derivado del pirazol 3,4-bipiridilo y a un método de preparación del mismo y a una aplicación médica del mismo. Específicamente, la presente invención se refiere a un derivado nuevo del pirazol 3,4-bipiridilo, como se muestra en la fórmula (I); a un método de preparación del derivado; a una composición farmacéutica que contiene el derivado; a un uso del derivadocomo agente terapéutico, en particular, como inhibidor del TGF-ß y a un uso del derivado en la preparación de un fármaco que trata, previene o reduce el cáncer mediado por la sobreexpresión del TGF- ß. Los sustituyentes en la fórmula (I) tienen las mismas definiciones que en la descripción. (ver formula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610998317 | 2016-11-14 | ||
| PCT/CN2017/110686 WO2018086609A1 (zh) | 2016-11-14 | 2017-11-13 | 3,4-二吡啶基吡唑类衍生物、其制备方法及其在医药上的应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019004822A true MX2019004822A (es) | 2019-09-11 |
Family
ID=62110384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019004822A MX2019004822A (es) | 2016-11-14 | 2017-11-13 | Derivado del pirazol 3,4-bipiridilo y metodo de preparacion del mismo y aplicacion medica del mismo. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10899741B2 (es) |
| EP (1) | EP3539957A4 (es) |
| JP (1) | JP2020500177A (es) |
| KR (1) | KR20190077048A (es) |
| CN (1) | CN108779100B (es) |
| AU (1) | AU2017357333A1 (es) |
| BR (1) | BR112019008516A2 (es) |
| CA (1) | CA3043383A1 (es) |
| MX (1) | MX2019004822A (es) |
| TW (1) | TW201817726A (es) |
| WO (1) | WO2018086609A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112341477B (zh) * | 2019-08-09 | 2023-07-21 | 四川科伦博泰生物医药股份有限公司 | 含有并环基团的咪唑并嘧啶类化合物、其制备方法及用途 |
| WO2021120890A1 (en) | 2019-12-20 | 2021-06-24 | Novartis Ag | Pyrazolyl derivatives useful as anti-cancer agents |
| WO2022089604A1 (en) * | 2020-10-30 | 2022-05-05 | Novartis Ag | New crystalline forms of a kras g12c inhibitor compound |
| KR20250051688A (ko) * | 2022-08-08 | 2025-04-17 | 메디노 파마슈티컬 테크놀로지 (주하이) 컴퍼니 리미티드 | TGF-β 억제제 화합물 및 그 사용 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859215A (en) * | 1995-10-25 | 1999-01-12 | Wallac Oy | Biospecific binding reactants labelled with luminescent lanthanide chelates and their use |
| WO2002066462A1 (en) * | 2001-02-02 | 2002-08-29 | Glaxo Group Limited | Pyrazole derivatives against tgf overexpression |
| AR040726A1 (es) | 2002-07-31 | 2005-04-20 | Smithkline Beecham Corp | Compuesto de 2- fenilpiridin-4-il-heterociclico, composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento |
| CA2496295C (en) * | 2002-09-18 | 2010-11-23 | Michael John Munchhof | Novels pyrazole compounds as transforming growth factor (tgf) inhibitors |
| CL2004000234A1 (es) * | 2003-02-12 | 2005-04-15 | Biogen Idec Inc | Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid |
| GB0313914D0 (en) | 2003-06-16 | 2003-07-23 | Smithkline Beecham Corp | Compounds |
| JO3126B1 (ar) | 2007-11-14 | 2017-09-20 | Janssen Pharmaceutica Nv | مثبطات ناقل نيوكليوسيد متوازن اي ان تي 1 |
| WO2009093029A1 (en) | 2008-01-22 | 2009-07-30 | Oxagen Limited | Compounds having crth2 antagonist activity |
| AU2009257795A1 (en) * | 2008-06-11 | 2009-12-17 | Merck Sharp & Dohme Corp. | Pyrazole derivatives useful as inhibitors of FAAH |
| US8993615B2 (en) * | 2008-08-08 | 2015-03-31 | The Johns Hopkins University | Compositions and methods for treatment of neurodegenerative disease |
| PE20130376A1 (es) | 2010-06-28 | 2013-03-30 | Merck Patent Gmbh | [1,8]naftiridinas sustituidas por 2,4-diarilo como inhibidores de quinasas para uso contra el cancer |
| US8080568B1 (en) | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
| KR101938368B1 (ko) | 2011-07-13 | 2019-01-14 | 주식회사 티움바이오 | Alk5 및/또는 alk4 억제제로서의 2-피리딜-치환된 이미다졸 |
| SI2766359T1 (sl) | 2011-10-14 | 2016-09-30 | Ambit Biosciences Corporation | Heterociklične spojine in njihova uporaba kot modulatorjev receptorja tirozin kinaze tipa III |
| WO2014049133A1 (en) | 2012-09-28 | 2014-04-03 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
| WO2016021192A1 (en) | 2014-08-08 | 2016-02-11 | Eisai R&D Management Co., Ltd. | Process for production of (s)-(tetrahydrofuran-3-yl)hydrazine |
| KR101635154B1 (ko) | 2014-08-28 | 2016-06-30 | (주)더블유에스 | 피리딜기가 결합된 트리아진 유도체 및 이를 포함한 유기 전계발광 소자 |
| TWI689497B (zh) | 2014-09-04 | 2020-04-01 | 南北兄弟藥業投資有限公司 | 芳雜環類衍生物及其在藥物中的應用 |
| TW201630907A (zh) | 2014-12-22 | 2016-09-01 | 必治妥美雅史谷比公司 | ＴＧＦβＲ拮抗劑 |
| EP3418276A4 (en) * | 2016-02-15 | 2019-07-31 | Taisho Pharmaceutical Co., Ltd. | AZOL SUBSTITUTED PYRIDINE COMPOUND |
| CN108069955B (zh) * | 2016-11-14 | 2021-04-06 | 江苏恒瑞医药股份有限公司 | 3-吡啶基-4-苯并噻唑基吡唑类衍生物、其制备方法及其在医药上的应用 |
-
2017
- 2017-11-13 TW TW106139178A patent/TW201817726A/zh unknown
- 2017-11-13 CA CA3043383A patent/CA3043383A1/en not_active Abandoned
- 2017-11-13 MX MX2019004822A patent/MX2019004822A/es unknown
- 2017-11-13 EP EP17868813.1A patent/EP3539957A4/en not_active Withdrawn
- 2017-11-13 AU AU2017357333A patent/AU2017357333A1/en not_active Abandoned
- 2017-11-13 CN CN201780016854.0A patent/CN108779100B/zh active Active
- 2017-11-13 JP JP2019523621A patent/JP2020500177A/ja active Pending
- 2017-11-13 WO PCT/CN2017/110686 patent/WO2018086609A1/zh not_active Ceased
- 2017-11-13 KR KR1020197015521A patent/KR20190077048A/ko not_active Withdrawn
- 2017-11-13 US US16/349,165 patent/US10899741B2/en not_active Expired - Fee Related
- 2017-11-13 BR BR112019008516A patent/BR112019008516A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA3043383A1 (en) | 2018-05-17 |
| CN108779100A (zh) | 2018-11-09 |
| BR112019008516A2 (pt) | 2019-07-09 |
| TW201817726A (zh) | 2018-05-16 |
| WO2018086609A1 (zh) | 2018-05-17 |
| US20190270724A1 (en) | 2019-09-05 |
| KR20190077048A (ko) | 2019-07-02 |
| AU2017357333A1 (en) | 2019-05-02 |
| CN108779100B (zh) | 2021-11-16 |
| JP2020500177A (ja) | 2020-01-09 |
| EP3539957A1 (en) | 2019-09-18 |
| US10899741B2 (en) | 2021-01-26 |
| EP3539957A4 (en) | 2020-05-13 |
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