MX2019003908A - Metodo por multiproteasa. - Google Patents
Metodo por multiproteasa.Info
- Publication number
- MX2019003908A MX2019003908A MX2019003908A MX2019003908A MX2019003908A MX 2019003908 A MX2019003908 A MX 2019003908A MX 2019003908 A MX2019003908 A MX 2019003908A MX 2019003908 A MX2019003908 A MX 2019003908A MX 2019003908 A MX2019003908 A MX 2019003908A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- protease
- proteases
- protein
- combination
- Prior art date
Links
- 239000004365 Protease Substances 0.000 title abstract 5
- 108091005804 Peptidases Proteins 0.000 abstract 4
- 102000035195 Peptidases Human genes 0.000 abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000017854 proteolysis Effects 0.000 abstract 2
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención se refiere a métodos para identificar un epítope en una proteína que se puede unir por un anticuerpo. Los métodos de la invención normalmente implican una etapa de proteólisis limitada o restringida de una proteína utilizando una única primera proteasa o una combinación de primeras proteasas, y una etapa de proteólisis adicional mediante el uso de una única segunda proteasa o una combinación de segundas proteasas. La invención también se refiere a epítopes identificados y a anticuerpos que se unen a epítopes que han sido identificados mediante los métodos de la invención.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1617002.9A GB201617002D0 (en) | 2016-10-06 | 2016-10-06 | Multi-protease method |
| PCT/EP2017/075532 WO2018065599A1 (en) | 2016-10-06 | 2017-10-06 | Multi-protease method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019003908A true MX2019003908A (es) | 2019-06-10 |
Family
ID=57610568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019003908A MX2019003908A (es) | 2016-10-06 | 2017-10-06 | Metodo por multiproteasa. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11408883B2 (es) |
| EP (1) | EP3523659B1 (es) |
| JP (1) | JP7046931B2 (es) |
| KR (1) | KR102411384B1 (es) |
| CN (1) | CN109891247B (es) |
| AU (1) | AU2017339096B2 (es) |
| BR (1) | BR112019006624A2 (es) |
| CA (1) | CA3039064A1 (es) |
| ES (1) | ES2994658T3 (es) |
| GB (1) | GB201617002D0 (es) |
| IL (1) | IL265612B2 (es) |
| MA (1) | MA46454A (es) |
| MX (1) | MX2019003908A (es) |
| NZ (1) | NZ752437A (es) |
| WO (1) | WO2018065599A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA41842A (fr) | 2015-03-31 | 2018-02-06 | Oblique Therapeutics Ab | Nouveaux procédés de sélection d'épitope |
| GB201918103D0 (en) * | 2019-12-10 | 2020-01-22 | Oblique Therapeutics Ab | Epitopes and antibodies |
| CN113501869A (zh) * | 2020-03-23 | 2021-10-15 | 浙江京新药业股份有限公司 | 具有创面修复作用的肽 |
| CN114853855B (zh) * | 2022-04-14 | 2023-06-20 | 安徽省华信生物药业股份有限公司 | 一种具有促降血糖激素glp-1分泌作用的富铬酵母活性肽 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1281404A3 (en) | 1990-10-18 | 2004-04-07 | Cancerforskningsfonden af 1989 (fonden til fremme af eksperimentel cancerforskning) | Use of antibodies against the urokinase receptor |
| IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| IL138946A0 (en) * | 2000-10-11 | 2001-11-25 | Compugen Ltd | Method for the identification of peptides and proteins |
| US7939295B2 (en) | 2001-07-13 | 2011-05-10 | Merck Patent Gmbh | Methods for reducing immunogenicity of polypeptides |
| US7632686B2 (en) | 2002-10-03 | 2009-12-15 | Anderson Forschung Group | High sensitivity quantitation of peptides by mass spectrometry |
| WO2004031730A2 (en) * | 2002-10-03 | 2004-04-15 | Norman Leigh Anderson | High sensitivity quantitation of peptides by mass spectrometry |
| TWI385180B (zh) * | 2003-07-15 | 2013-02-11 | 安美基公司 | 作為選擇性神經生長因子（ｎｇｆ）通道抑制劑之人類抗-ｎｇｆ中和抗體 |
| US20070281986A1 (en) | 2004-02-03 | 2007-12-06 | Collier Gregory R | Methods and Compositions for Modulating Satiety |
| WO2006005472A1 (en) | 2004-07-15 | 2006-01-19 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with vanilloid receptor 1 (vr1) |
| US20060292639A1 (en) | 2004-08-13 | 2006-12-28 | Adolor Corporation | Splice variant of the vanilloid receptor VR1A |
| WO2006047417A2 (en) | 2004-10-21 | 2006-05-04 | University Of Florida Research Foundation, Inc. | Detection of cannabinoid receptor biomarkers and uses thereof |
| SE0403139D0 (sv) | 2004-12-23 | 2004-12-23 | Nanoxis Ab | Device and use thereof |
| JP2008175814A (ja) | 2006-12-21 | 2008-07-31 | Eisai R & D Management Co Ltd | 尿中タンパク質分子の検出・定量による糖尿病性腎症の検査方法及びそれに使用するキット |
| WO2008120684A1 (ja) | 2007-03-30 | 2008-10-09 | Yamaguchi University | 急性中枢神経障害の予後判定方法 |
| EP3059248A1 (en) | 2008-05-09 | 2016-08-24 | Abbvie Deutschland GmbH & Co. KG | Antibodies to receptor of advanced glycation end products (rage) and uses thereof |
| WO2010096385A2 (en) * | 2009-02-17 | 2010-08-26 | The Regents Of The University Of Colorado, A Body Corporate, A Colorado Non-Profit | Methods and compositions for the treatment of autoimmune disease |
| US9234037B2 (en) | 2009-10-27 | 2016-01-12 | Ucb Biopharma Sprl | Method to generate antibodies to ion channels |
| US9383367B1 (en) | 2010-12-07 | 2016-07-05 | Chunli Liu | Methods of detecting conjugation site-specific and hidden epitope/antigen |
| WO2013020557A1 (en) | 2011-08-08 | 2013-02-14 | Syddansk Universitet | Method and antibodies for the identification of ubiquitinated proteins and sites of ubiquitination |
| MA41842A (fr) * | 2015-03-31 | 2018-02-06 | Oblique Therapeutics Ab | Nouveaux procédés de sélection d'épitope |
-
2016
- 2016-10-06 GB GBGB1617002.9A patent/GB201617002D0/en not_active Ceased
-
2017
- 2017-10-06 MA MA046454A patent/MA46454A/fr unknown
- 2017-10-06 BR BR112019006624A patent/BR112019006624A2/pt unknown
- 2017-10-06 CN CN201780066643.8A patent/CN109891247B/zh active Active
- 2017-10-06 CA CA3039064A patent/CA3039064A1/en active Pending
- 2017-10-06 EP EP17786881.7A patent/EP3523659B1/en active Active
- 2017-10-06 WO PCT/EP2017/075532 patent/WO2018065599A1/en not_active Ceased
- 2017-10-06 IL IL265612A patent/IL265612B2/en unknown
- 2017-10-06 JP JP2019518531A patent/JP7046931B2/ja active Active
- 2017-10-06 AU AU2017339096A patent/AU2017339096B2/en active Active
- 2017-10-06 MX MX2019003908A patent/MX2019003908A/es unknown
- 2017-10-06 US US16/339,810 patent/US11408883B2/en active Active
- 2017-10-06 ES ES17786881T patent/ES2994658T3/es active Active
- 2017-10-06 KR KR1020197012549A patent/KR102411384B1/ko active Active
- 2017-10-06 NZ NZ752437A patent/NZ752437A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN109891247B (zh) | 2022-10-04 |
| GB201617002D0 (en) | 2016-11-23 |
| IL265612A (en) | 2019-05-30 |
| ES2994658T3 (en) | 2025-01-28 |
| MA46454A (fr) | 2019-08-14 |
| EP3523659A1 (en) | 2019-08-14 |
| KR20190062504A (ko) | 2019-06-05 |
| CN109891247A (zh) | 2019-06-14 |
| RU2019108573A3 (es) | 2021-01-21 |
| RU2019108573A (ru) | 2020-11-06 |
| CA3039064A1 (en) | 2018-04-12 |
| BR112019006624A2 (pt) | 2019-07-02 |
| WO2018065599A1 (en) | 2018-04-12 |
| US11408883B2 (en) | 2022-08-09 |
| US20200041499A1 (en) | 2020-02-06 |
| EP3523659C0 (en) | 2024-08-14 |
| KR102411384B1 (ko) | 2022-06-20 |
| NZ752437A (en) | 2022-12-23 |
| IL265612B1 (en) | 2023-12-01 |
| JP2020502482A (ja) | 2020-01-23 |
| EP3523659B1 (en) | 2024-08-14 |
| IL265612B2 (en) | 2024-04-01 |
| AU2017339096B2 (en) | 2023-03-30 |
| AU2017339096A1 (en) | 2019-05-02 |
| JP7046931B2 (ja) | 2022-04-04 |
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