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MX2019003168A - Anticuerpos contra proteina alfa reguladora de se?al y metodos de uso. - Google Patents

Anticuerpos contra proteina alfa reguladora de se?al y metodos de uso.

Info

Publication number
MX2019003168A
MX2019003168A MX2019003168A MX2019003168A MX2019003168A MX 2019003168 A MX2019003168 A MX 2019003168A MX 2019003168 A MX2019003168 A MX 2019003168A MX 2019003168 A MX2019003168 A MX 2019003168A MX 2019003168 A MX2019003168 A MX 2019003168A
Authority
MX
Mexico
Prior art keywords
polypeptide
extracellular domain
human
sirp
methods
Prior art date
Application number
MX2019003168A
Other languages
English (en)
Inventor
Pons Jaume
Janet Sim Bang
Elliot Kauder Steven
Wan Hong
Chia-Chien Kuo Tracy
Don Harriman William
Izquierdo Shelley
Original Assignee
Alx Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alx Oncology Inc filed Critical Alx Oncology Inc
Publication of MX2019003168A publication Critical patent/MX2019003168A/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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Abstract

Entre otras cosas, en la presente se proveen anticuerpos aislados que se unen a un dominio extracelular de un polipéptido SIRP-a v1 humano (por ejemplo, el dominio D1), un dominio extracelular de un polipéptido SIRP-a v2 humano o ambos. En algunas modalidades, los anticuerpos también se unen a un dominio extracelular de un polipéptido SIRP-a de mono, un dominio extracelular de un polipéptido SIRP-a de ratón, un dominio extracelular SIRP-ß humano y/o un dominio extracelular de un polipéptido SIRP-? humano. En algunas modalidades, los anticuerpos bloquean o no la unión entre un dominio extracelular de un polipéptido SIRP-a humano y un dominio IgSF de un polipéptido CD47 humano, mientras que, en algunas modalidades, los anticuerpos reducen la afinidad de un polipéptido SIRP-a humano para la unión a un dominio IgSF de un polipéptido CD47 humano. También se proveen en la presente métodos, polinucleótidos, vectores y células hospedadoras relacionadas a estos.
MX2019003168A 2016-09-21 2017-09-20 Anticuerpos contra proteina alfa reguladora de se?al y metodos de uso. MX2019003168A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662397752P 2016-09-21 2016-09-21
US201762515480P 2017-06-05 2017-06-05
PCT/US2017/052592 WO2018057669A1 (en) 2016-09-21 2017-09-20 Antibodies against signal-regulatory protein alpha and methods of use

Publications (1)

Publication Number Publication Date
MX2019003168A true MX2019003168A (es) 2019-06-10

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MX2019003168A MX2019003168A (es) 2016-09-21 2017-09-20 Anticuerpos contra proteina alfa reguladora de se?al y metodos de uso.

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US (5) US11401338B2 (es)
EP (2) EP3515490B8 (es)
JP (3) JP7181874B2 (es)
KR (1) KR102601298B1 (es)
CN (3) CN109862915B (es)
AU (1) AU2017332285B2 (es)
BR (1) BR112019003027A2 (es)
CA (1) CA3034480A1 (es)
CL (2) CL2019000668A1 (es)
CO (1) CO2019003809A2 (es)
DK (1) DK3515490T3 (es)
ES (1) ES2932602T3 (es)
GE (4) GEP20237528B (es)
HR (1) HRP20221323T1 (es)
HU (1) HUE060170T2 (es)
IL (2) IL265439B2 (es)
JO (1) JOP20190009A1 (es)
LT (1) LT3515490T (es)
MA (1) MA46290A (es)
MX (1) MX2019003168A (es)
MY (1) MY197854A (es)
NZ (1) NZ750161A (es)
PE (1) PE20190575A1 (es)
PH (1) PH12019500600A1 (es)
PL (1) PL3515490T3 (es)
PT (1) PT3515490T (es)
RS (1) RS63658B1 (es)
SA (1) SA519401371B1 (es)
SG (1) SG10201912878UA (es)
SI (1) SI3515490T1 (es)
SM (1) SMT202200426T1 (es)
UA (1) UA126281C2 (es)
WO (1) WO2018057669A1 (es)
ZA (1) ZA201900937B (es)

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JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
JP7173971B2 (ja) 2016-12-09 2022-11-16 アレクトル エルエルシー 抗ＳＩＲＰ－α抗体及びその使用方法
KR20190117670A (ko) * 2017-02-17 2019-10-16 오제 이뮈노테라프틱스 항-SIRPg 항체의 새로운 용도
IL315837A (en) 2017-04-13 2024-11-01 Sairopa B V Anti-SIRP-alpha antibodies
US11203611B2 (en) 2017-04-14 2021-12-21 Tollnine, Inc. Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use
SG11202000053TA (en) 2017-08-02 2020-02-27 Phanes Therapeutics Inc Anti-cd47 antibodies and uses thereof
US11292850B2 (en) * 2018-03-21 2022-04-05 ALX Oncology Inc. Antibodies against signal-regulatory protein α and methods of use
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