MX2019001781A - Compuestos de tiofeno condensado utiles como inhibidores de napi-iib. - Google Patents
Compuestos de tiofeno condensado utiles como inhibidores de napi-iib.Info
- Publication number
- MX2019001781A MX2019001781A MX2019001781A MX2019001781A MX2019001781A MX 2019001781 A MX2019001781 A MX 2019001781A MX 2019001781 A MX2019001781 A MX 2019001781A MX 2019001781 A MX2019001781 A MX 2019001781A MX 2019001781 A MX2019001781 A MX 2019001781A
- Authority
- MX
- Mexico
- Prior art keywords
- napi
- iib
- inhibitors
- compounds useful
- thiophene compounds
- Prior art date
Links
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical class C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 201000005991 hyperphosphatemia Diseases 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La invención proporciona compuestos de la fórmula: (A), sales farmacéuticamente aceptables, composiciones farmacéuticas de estos y métodos para usar estos compuestos, sales o composiciones para tratar la hiperfosfatemia, la enfermedad renal crónica y/o la enfermedad cardiovascular asociada con la enfermedad renal crónica. (ver Fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662375169P | 2016-08-15 | 2016-08-15 | |
| PCT/US2017/045843 WO2018034883A1 (en) | 2016-08-15 | 2017-08-08 | Condensed thiophene derivatives useful as napi-iib inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019001781A true MX2019001781A (es) | 2019-07-04 |
| MX376202B MX376202B (es) | 2025-03-07 |
Family
ID=59677343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019001781A MX376202B (es) | 2016-08-15 | 2017-08-08 | Compuestos de tiofeno condensado utiles como inhibidores de napi-iib. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US10934280B2 (es) |
| EP (1) | EP3497091B1 (es) |
| JP (1) | JP6653410B2 (es) |
| KR (1) | KR102266143B1 (es) |
| CN (1) | CN109563070B (es) |
| AU (1) | AU2017312783B2 (es) |
| CA (1) | CA3033628C (es) |
| CY (1) | CY1123576T1 (es) |
| DK (1) | DK3497091T3 (es) |
| EA (1) | EA037376B1 (es) |
| ES (1) | ES2830444T3 (es) |
| HR (1) | HRP20202025T1 (es) |
| HU (1) | HUE052351T2 (es) |
| IL (1) | IL264785B (es) |
| LT (1) | LT3497091T (es) |
| MX (1) | MX376202B (es) |
| PL (1) | PL3497091T3 (es) |
| PT (1) | PT3497091T (es) |
| RS (1) | RS61165B1 (es) |
| SA (1) | SA519401049B1 (es) |
| SI (1) | SI3497091T1 (es) |
| WO (1) | WO2018034883A1 (es) |
| ZA (1) | ZA201900305B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3039345T3 (en) * | 2018-11-19 | 2025-10-20 | 11949098 Canada Inc | 4,5,6,7-tetrahydro-l-benzothiophene modulators of retinoic acid receptor related (rar) orphan nuclear receptors (rors) |
| KR20240110086A (ko) * | 2019-05-16 | 2024-07-12 | 일라이 릴리 앤드 캄파니 | 나트륨-수소 교환기 3 억제제 화합물 |
| TW202220967A (zh) * | 2020-07-24 | 2022-06-01 | 美商伊尼製藥股份有限公司 | 噻吩hsd17b13抑制劑及其用途 |
| EP4244210A4 (en) | 2020-11-13 | 2024-10-30 | Inipharm, Inc. | Dichlorophenol hsd17b13 inhibitors and uses thereof |
| AR126060A1 (es) | 2021-06-08 | 2023-09-06 | Chugai Pharmaceutical Co Ltd | Método para producir derivado de dihidropiridazin-3,5-diona |
| EP4353233A4 (en) | 2021-06-08 | 2025-06-25 | Chugai Seiyaku Kabushiki Kaisha | PREPARATION CONTAINING A DIHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE |
| JPWO2023219127A1 (es) * | 2022-05-11 | 2023-11-16 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12012501851A1 (en) * | 2010-04-28 | 2013-02-04 | Astellas Pharma Inc | Tetrahydrobenzothiophene compound |
| MX342521B (es) * | 2011-10-27 | 2016-10-03 | Astellas Pharma Inc | Derivado de n-tienilbenzamida sustituido con aminoalquilo. |
| WO2014003153A1 (ja) * | 2012-06-28 | 2014-01-03 | 協和発酵キリン株式会社 | 置換アミド化合物 |
| WO2016026372A1 (zh) * | 2014-08-22 | 2016-02-25 | 江苏恒瑞医药股份有限公司 | 噻吩并环烷基或噻吩并杂环基类衍生物、其制备方法及其在医药上的应用 |
-
2017
- 2017-08-08 EA EA201990095A patent/EA037376B1/ru not_active IP Right Cessation
- 2017-08-08 AU AU2017312783A patent/AU2017312783B2/en active Active
- 2017-08-08 DK DK17754914.4T patent/DK3497091T3/da active
- 2017-08-08 EP EP17754914.4A patent/EP3497091B1/en active Active
- 2017-08-08 CN CN201780049441.2A patent/CN109563070B/zh active Active
- 2017-08-08 HU HUE17754914A patent/HUE052351T2/hu unknown
- 2017-08-08 WO PCT/US2017/045843 patent/WO2018034883A1/en not_active Ceased
- 2017-08-08 JP JP2019527785A patent/JP6653410B2/ja active Active
- 2017-08-08 ES ES17754914T patent/ES2830444T3/es active Active
- 2017-08-08 PT PT177549144T patent/PT3497091T/pt unknown
- 2017-08-08 US US16/321,575 patent/US10934280B2/en active Active
- 2017-08-08 SI SI201730453T patent/SI3497091T1/sl unknown
- 2017-08-08 RS RS20201471A patent/RS61165B1/sr unknown
- 2017-08-08 LT LTEP17754914.4T patent/LT3497091T/lt unknown
- 2017-08-08 KR KR1020197004106A patent/KR102266143B1/ko active Active
- 2017-08-08 HR HRP20202025TT patent/HRP20202025T1/hr unknown
- 2017-08-08 CA CA3033628A patent/CA3033628C/en active Active
- 2017-08-08 MX MX2019001781A patent/MX376202B/es active IP Right Grant
- 2017-08-08 PL PL17754914T patent/PL3497091T3/pl unknown
-
2019
- 2019-01-16 ZA ZA2019/00305A patent/ZA201900305B/en unknown
- 2019-02-07 SA SA519401049A patent/SA519401049B1/ar unknown
- 2019-02-11 IL IL264785A patent/IL264785B/en active IP Right Grant
-
2020
- 2020-11-16 CY CY20201101084T patent/CY1123576T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR102266143B1 (ko) | 2021-06-17 |
| KR20190026895A (ko) | 2019-03-13 |
| CY1123576T1 (el) | 2022-03-24 |
| PT3497091T (pt) | 2020-11-30 |
| JP2019527734A (ja) | 2019-10-03 |
| AU2017312783A1 (en) | 2019-01-24 |
| AU2017312783B2 (en) | 2020-02-06 |
| NZ750153A (en) | 2021-01-29 |
| PL3497091T3 (pl) | 2021-02-08 |
| SA519401049B1 (ar) | 2021-07-14 |
| ES2830444T3 (es) | 2021-06-03 |
| EP3497091B1 (en) | 2020-10-07 |
| HRP20202025T1 (hr) | 2021-02-19 |
| DK3497091T3 (da) | 2020-10-19 |
| US20200031813A1 (en) | 2020-01-30 |
| CA3033628A1 (en) | 2018-02-22 |
| HUE052351T2 (hu) | 2021-04-28 |
| EP3497091A1 (en) | 2019-06-19 |
| JP6653410B2 (ja) | 2020-02-26 |
| ZA201900305B (en) | 2020-12-23 |
| RS61165B1 (sr) | 2021-01-29 |
| CA3033628C (en) | 2021-01-12 |
| CN109563070B (zh) | 2021-02-26 |
| IL264785B (en) | 2021-04-29 |
| MX376202B (es) | 2025-03-07 |
| EA201990095A1 (ru) | 2019-07-31 |
| US10934280B2 (en) | 2021-03-02 |
| CN109563070A (zh) | 2019-04-02 |
| BR112019000929A2 (pt) | 2019-07-09 |
| EA037376B1 (ru) | 2021-03-22 |
| SI3497091T1 (sl) | 2020-11-30 |
| LT3497091T (lt) | 2020-12-28 |
| WO2018034883A1 (en) | 2018-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DOP2020000102A (es) | Compuestos útiles para inhibir a cdk7 | |
| MX2019001781A (es) | Compuestos de tiofeno condensado utiles como inhibidores de napi-iib. | |
| AR110381A2 (es) | Inhibidores biarilo de tirosina cinasa de bruton | |
| EA201891057A1 (ru) | Композиции и способы для ингибирования активности аргиназы | |
| EA201891024A1 (ru) | Соединения-ингибиторы tank-связывающей киназы | |
| JO3653B1 (ar) | ترايازول عوامل مساعدة لمستقبل apj | |
| EA201791420A1 (ru) | Соединения триазолопиримидина и их применения | |
| MX2017013797A (es) | Inhibidor de janus quinasa. | |
| EA201792205A1 (ru) | Гетероциклические соединения как ингибиторы lsd1 | |
| EA201692204A1 (ru) | Композиции и способы модулирования экспрессии фактора комплемента b | |
| EA201791576A1 (ru) | Ингибитор jak | |
| EA201690598A1 (ru) | Аминогетероарил бензамиды в качестве ингибиторов киназы | |
| BR112016015449A8 (pt) | compostos inibidores terapêuticos, composição farmacêutica os compreendendo e uso dos mesmos | |
| EA201590224A1 (ru) | Имидазотриазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
| EA201790785A1 (ru) | Производные тетрагидроизохинолина | |
| EA201690764A1 (ru) | Ингибитор грелин-o-ацилтрансферазы | |
| EA201490161A1 (ru) | Соединения - ингибиторы сигналинга, опосредуемого рецептором notch | |
| EA201790745A1 (ru) | Трициклические соединения | |
| EA201692470A1 (ru) | Фармацевтические комбинации | |
| CO2017001389A2 (es) | Compuestos de azetidiniloxifenilpirrolidina | |
| EA201790276A1 (ru) | Новые имидазопиридазиновые соединения и их применение | |
| EA201791432A1 (ru) | Композиции на основе пролекарства монометилфумарата | |
| EA201791992A1 (ru) | Ингибиторы грелин-o-ацилтрансферазы | |
| EA201792000A1 (ru) | Ингибиторы грелин-o-ацилтрансферазы | |
| EA201890534A1 (ru) | Новые аннелированные феноксиацетамиды |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |