MX2019001376A - Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabolicos relacionados. - Google Patents
Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabolicos relacionados.Info
- Publication number
- MX2019001376A MX2019001376A MX2019001376A MX2019001376A MX2019001376A MX 2019001376 A MX2019001376 A MX 2019001376A MX 2019001376 A MX2019001376 A MX 2019001376A MX 2019001376 A MX2019001376 A MX 2019001376A MX 2019001376 A MX2019001376 A MX 2019001376A
- Authority
- MX
- Mexico
- Prior art keywords
- orlistat
- composition
- modified release
- acarbosa
- obesity
- Prior art date
Links
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 title abstract 5
- 229960001243 orlistat Drugs 0.000 title abstract 5
- CEMXHAPUFJOOSV-XGWNLRGSSA-N (2r,3r,4r,5r)-4-[(2r,3r,4r,5s,6r)-5-[(2r,3r,4s,5s,6r)-3,4-dihydroxy-6-methyl-5-[[(1s,4r,5s,6s)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanal Chemical compound O([C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)[C@H](O)[C@H]1O CEMXHAPUFJOOSV-XGWNLRGSSA-N 0.000 title 1
- 208000008589 Obesity Diseases 0.000 title 1
- 208000030159 metabolic disease Diseases 0.000 title 1
- 235000020824 obesity Nutrition 0.000 title 1
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 abstract 4
- 229960002632 acarbose Drugs 0.000 abstract 4
- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 abstract 4
- -1 b) a second part Chemical compound 0.000 abstract 1
Classifications
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
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- Diabetes (AREA)
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- Gynecology & Obstetrics (AREA)
- Child & Adolescent Psychology (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
La presente invención se refiere a una composición de liberación modificada que comprende orlistat y acarbosa, que comprende partes individualmente distintas con diferentes patrones de liberación: a) una primera parte, G1, que comprende de aproximadamente 5 a aproximadamente 70% p/p de la dosis total de acarbosa, b) una segunda parte, G2A, que comprende de aproximadamente 30 a aproximadamente 95% p/p de la dosis total de acarbosa, c) una tercera parte, G2B, que comprende de aproximadamente 10 a aproximadamente 90% p/p de la dosis total de orlistat, y d) una cuarta parte, G3, que comprende de aproximadamente 10 a aproximadamente 80% p/p de la dosis total de orlistat, y la concentración total de acarbosa y orlistat, respectivamente, en la composición es de 100% p/p.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14198468 | 2014-12-17 | ||
| PCT/EP2015/080265 WO2016097170A1 (en) | 2014-12-17 | 2015-12-17 | A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019001376A true MX2019001376A (es) | 2019-05-30 |
| MX382196B MX382196B (es) | 2025-03-13 |
Family
ID=52146175
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019001376A MX382196B (es) | 2014-12-17 | 2015-12-17 | Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabolicos relacionados. |
| MX2017007493A MX2017007493A (es) | 2014-12-17 | 2015-12-17 | Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabolicos relacionados. |
| MX2021003905A MX2021003905A (es) | 2014-12-17 | 2017-06-08 | Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabolicos relacionados. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017007493A MX2017007493A (es) | 2014-12-17 | 2015-12-17 | Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabolicos relacionados. |
| MX2021003905A MX2021003905A (es) | 2014-12-17 | 2017-06-08 | Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabolicos relacionados. |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10561617B2 (es) |
| EP (3) | EP3943076A3 (es) |
| JP (1) | JP6607955B2 (es) |
| KR (2) | KR101937069B1 (es) |
| CN (1) | CN107405309B (es) |
| AU (1) | AU2015367422B2 (es) |
| BR (1) | BR112017012714B1 (es) |
| CA (1) | CA2970991C (es) |
| CL (1) | CL2017001574A1 (es) |
| CO (1) | CO2017005834A2 (es) |
| DK (1) | DK3233066T3 (es) |
| EA (1) | EA033448B1 (es) |
| EC (1) | ECSP17035750A (es) |
| ES (1) | ES2901122T3 (es) |
| HU (1) | HUE057093T2 (es) |
| IL (1) | IL252865B2 (es) |
| MX (3) | MX382196B (es) |
| MY (1) | MY195038A (es) |
| NZ (1) | NZ732241A (es) |
| PE (1) | PE20171243A1 (es) |
| PH (1) | PH12017550023A1 (es) |
| PL (1) | PL3233066T3 (es) |
| SA (1) | SA517381713B1 (es) |
| SG (1) | SG11201704470PA (es) |
| SI (1) | SI3233066T1 (es) |
| UA (1) | UA122403C2 (es) |
| WO (1) | WO2016097170A1 (es) |
| ZA (1) | ZA201704590B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101937069B1 (ko) | 2014-12-17 | 2019-04-03 | 엠프로스 파마 악티에볼라그 | 비만 및 관련 대사 장애의 치료를 위한 오를리스타트 및 아카르보스의 변형 방출형 조성물 |
| EP3470065A4 (en) * | 2016-06-09 | 2020-03-18 | DS Pharma Animal Health Co. Ltd. | PREPARATION WITH DELAYED RELEASE FOR ANIMALS |
| GB201803363D0 (en) | 2018-03-01 | 2018-04-18 | Sigrid Therapeutics Ab | New materials and uses thereof |
| WO2020227437A1 (en) * | 2019-05-06 | 2020-11-12 | Axial Biotherapeutics, Inc. | Sustained release solid dosage forms for modulating the colonic microbiome |
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