MX2019000925A - Proteinas biespecificas y metodo de su preparacion. - Google Patents
Proteinas biespecificas y metodo de su preparacion.Info
- Publication number
- MX2019000925A MX2019000925A MX2019000925A MX2019000925A MX2019000925A MX 2019000925 A MX2019000925 A MX 2019000925A MX 2019000925 A MX2019000925 A MX 2019000925A MX 2019000925 A MX2019000925 A MX 2019000925A MX 2019000925 A MX2019000925 A MX 2019000925A
- Authority
- MX
- Mexico
- Prior art keywords
- domain
- bispecific proteins
- heavy chain
- methods
- preparing same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C07K16/108—
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
Abstract
La presente invención se refiere a una proteína biespecífica y un método de su preparación, en que la mutación es introducida en cadenas pesadas y/o cadenas ligeras para incrementar la heterodimerización entre una cadena pesada (domino CH3 o Fc) y una cadena pesada (dominio CH3 o Fc) y la dimerización entre una cadena pesada (dominio CH1) y una cadena ligera, en que ambos se dirigen al mismo material, de forma a construir proteínas biespecíficas heterodiméricas con alta pureza. Las proteínas biespecíficas según la presente invención pueden encontrar aplicaciones en una serie de campos que comprenden la terapia del cáncer, regulación de selección, diagnósticos etc.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160091157 | 2016-07-19 | ||
| PCT/KR2017/007791 WO2018016881A1 (ko) | 2016-07-19 | 2017-07-19 | 이중 특이성 단백질 및 이의 제조 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019000925A true MX2019000925A (es) | 2019-06-03 |
Family
ID=60992392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019000925A MX2019000925A (es) | 2016-07-19 | 2017-07-19 | Proteinas biespecificas y metodo de su preparacion. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20230075499A1 (es) |
| EP (1) | EP3489262A4 (es) |
| JP (2) | JP2019530641A (es) |
| KR (4) | KR102098919B1 (es) |
| CN (2) | CN109476763B (es) |
| AU (3) | AU2017298535B2 (es) |
| CA (2) | CA3031082C (es) |
| IL (1) | IL264249B2 (es) |
| MX (1) | MX2019000925A (es) |
| MY (1) | MY200137A (es) |
| NZ (1) | NZ772558A (es) |
| PH (1) | PH12019500138A1 (es) |
| RU (1) | RU2745648C2 (es) |
| SA (1) | SA519400924B1 (es) |
| SG (1) | SG11201900373WA (es) |
| WO (1) | WO2018016881A1 (es) |
| ZA (1) | ZA201900347B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101962483B1 (ko) | 2010-11-17 | 2019-03-29 | 추가이 세이야쿠 가부시키가이샤 | 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자 |
| PT2647707T (pt) | 2010-11-30 | 2018-11-15 | Chugai Pharmaceutical Co Ltd | Agente terapêutico indutor de toxicidade |
| KR102398736B1 (ko) | 2011-10-31 | 2022-05-16 | 추가이 세이야쿠 가부시키가이샤 | 중쇄와 경쇄의 회합이 제어된 항원 결합 분자 |
| WO2017110980A1 (ja) | 2015-12-25 | 2017-06-29 | 中外製薬株式会社 | 増強された活性を有する抗体及びその改変方法 |
| NZ746002A (en) | 2016-04-28 | 2025-08-29 | Chugai Pharmaceutical Co Ltd | Antibody-containing preparation |
| BR112020005834A2 (pt) | 2017-09-29 | 2020-09-24 | Chugai Seiyaku Kabushiki Kaisha | molécula multiespecífica de ligação ao antígeno tendo atividade de substituição de função de cofator do fator viii de coagulação sanguínea (fviii), e formulação farmacêutica contendo a referida molécula como ingrediente ativo |
| CN119161488A (zh) | 2017-11-01 | 2024-12-20 | 中外制药株式会社 | 具有降低的生物活性的抗体变体和同种型 |
| WO2020198683A1 (en) * | 2019-03-28 | 2020-10-01 | Ab Studio Inc. | Heteromultimeric proteins and methods of use thereof |
| BR112021020843A2 (pt) * | 2019-04-25 | 2022-02-01 | Hoffmann La Roche | Conjunto de polipeptídeos precursores heterodiméricos, polipeptídeos heterodiméricos, métodos para gerar um polipeptídeo heterodimérico e para identificar um polipeptídeo heterodimérico multiespecífico, polipeptídeo heterodimérico multiespecífico, primeiro e segundo polipeptídeo precursor heterodimérico |
| WO2021067404A2 (en) * | 2019-09-30 | 2021-04-08 | Adimab, Llc | Ch1 domain variants engineered for preferential light chain pairing and multispecific antibodies comprising the same |
| CN112646041B (zh) * | 2019-10-12 | 2023-11-10 | 上海睿智化学研究有限公司 | 包含抗体ch3域的异源二聚体及含其的抗体、融合蛋白 |
| CN113121696A (zh) * | 2019-12-31 | 2021-07-16 | 周易 | Fab改造诱导形成的双特异性抗体及其制备方法和用途 |
| CA3165045A1 (en) * | 2020-01-23 | 2021-07-29 | Adagene Ag | Heterodimeric proteins with fc mutations |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| GB202005879D0 (en) * | 2020-04-22 | 2020-06-03 | Petmedix Ltd | Heterodimeric proteins |
| JP2023526630A (ja) * | 2020-05-21 | 2023-06-22 | メルス ナムローゼ フェンノートシャップ | Ｉｇ様分子の製造のための方法および手段 |
| BR112022022004A2 (pt) * | 2020-06-01 | 2022-12-13 | Mustbio Co Ltd | Complexo proteico, método para preparar um complexo proteico, composição farmacêutica para prevenir ou tratar câncer, uso da composição e uso do completo proteico |
| CN114437226A (zh) * | 2020-11-05 | 2022-05-06 | 杭州菁因康生物科技有限公司 | 制备双特异性抗体的方法 |
| CA3167854A1 (en) * | 2020-12-03 | 2022-06-09 | Eric Escobar-Cabrera | Heterodimeric iga fc constructs and methods of use thereof |
| EP4288460A4 (en) * | 2021-02-05 | 2025-04-02 | Phanes Therapeutics, Inc. | BISPECIFIC ANTIBODIES WITH CHARGE PAIRS AND USES THEREOF |
| CN118339188A (zh) * | 2021-09-21 | 2024-07-12 | 齐鲁普吉湾生物治疗公司 | 用于制备融合蛋白和双特异性抗体的异二聚体Fc |
| CN117586413A (zh) * | 2022-08-09 | 2024-02-23 | 三生国健药业（上海）股份有限公司 | 异多聚体蛋白质及其制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006265936A1 (en) * | 2005-07-01 | 2007-01-11 | Medimmune, Llc | An integrated approach for generating multidomain protein therapeutics |
| PL2178916T3 (pl) * | 2007-07-31 | 2015-08-31 | Regeneron Pharma | Ludzkie przeciwciała przeciwko ludzkiemu CD20 i sposób ich zastosowania |
| ES2425269T3 (es) * | 2007-12-14 | 2013-10-14 | Bristol-Myers Squibb Company | Moléculas de unión al receptor OX40 humano |
| AU2009204501B2 (en) * | 2008-01-07 | 2015-02-12 | Amgen Inc. | Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects |
| EP2603526A1 (en) * | 2010-08-13 | 2013-06-19 | Medimmune Limited | Monomeric polypeptides comprising variant fc regions and methods of use |
| HUE047228T2 (hu) * | 2010-11-05 | 2020-04-28 | Zymeworks Inc | Stabil heterodimer antitest-kialakítás az FC doménben mutációval |
| BR112013023653A2 (pt) | 2011-03-17 | 2016-12-13 | Univ Ramot | anticorpo biespecífico, método de preparação do anticorpo, e composição farmacêutica |
| KR20200052383A (ko) * | 2011-03-25 | 2020-05-14 | 아이크노스 사이언스 에스. 아. | 헤테로 이량체 면역글로불린 |
| EA201100463A1 (ru) * | 2011-04-05 | 2012-05-30 | Федеральное Государственное Бюджетное Учреждение "Научно-Исследовательский Институт Эпидемиологии И Микробиологии Имени Почетного Академика Н.Ф. Гамалеи" Министерства Здравоохранения И Социального Развития Российской Федерации | Рекомбинантная псевдоаденовирусная наночастица, фармацевтическая композиция для профилактики или терапии гриппа (варианты), способ профилактики или терапии гриппа |
| AU2012245116A1 (en) * | 2011-04-20 | 2013-11-07 | Genmab A/S | Bispecific antibodies against HER2 and CD3 |
| EP2543680A1 (en) * | 2011-07-07 | 2013-01-09 | Centre National de la Recherche Scientifique | Multispecific mutated antibody Fab fragments |
| KR102049803B1 (ko) * | 2011-10-27 | 2019-11-29 | 젠맵 에이/에스 | 이종이량체 단백질의 생산 |
| KR102398736B1 (ko) * | 2011-10-31 | 2022-05-16 | 추가이 세이야쿠 가부시키가이샤 | 중쇄와 경쇄의 회합이 제어된 항원 결합 분자 |
| KR101749316B1 (ko) * | 2011-12-15 | 2017-06-21 | (주) 에이프로젠 | Ｈ１ｎ１―감염된 환자들로부터 유도된 매우 잠재력 있는 넓은-스펙트럼 중화 단일클론 항체 및 이를 포함하는 바이러스의 치료용 조성물 |
| JP6351572B2 (ja) * | 2012-05-10 | 2018-07-04 | ザイムワークス，インコーポレイテッド | Ｆｃドメインに突然変異を有する免疫グロブリン重鎖のヘテロ多量体構築物 |
| UY35148A (es) * | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| KR101522954B1 (ko) * | 2012-11-27 | 2015-05-27 | 아주대학교산학협력단 | 항체 중쇄불변부위의 이종이중체 고효율 형성을 유도하는 ch3 도메인 변이체 쌍, 이의 제조방법, 및 용도 |
| US10738132B2 (en) * | 2013-01-14 | 2020-08-11 | Xencor, Inc. | Heterodimeric proteins |
| MX2015010350A (es) * | 2013-02-26 | 2015-10-29 | Roche Glycart Ag | Moleculas de union a antigeno biespecificas que activan la celula t. |
| EP3486255A3 (en) * | 2013-03-13 | 2019-11-13 | Ibentrus Inc. | Protein in which electrical interaction is introduced within hydrophobic interaction site and preparation method therefor |
| MX385936B (es) * | 2014-03-28 | 2025-03-11 | Xencor Inc | Anticuerpos biespecíficos que se unen a cd38 y cd3. |
| CN106661125B (zh) * | 2014-05-02 | 2021-10-01 | 动量制药公司 | 涉及工程化Fc构建体的组合物和方法 |
| EA036985B1 (ru) * | 2014-10-31 | 2021-01-25 | НДжМ БИОФАРМАСЬЮТИКАЛЗ, ИНК. | Композиции и способы лечения метаболических расстройств |
| WO2016086186A2 (en) * | 2014-11-26 | 2016-06-02 | Xencor, Inc. | Heterodimeric antibodies including binding to cd8 |
| IL252467B (en) * | 2014-11-26 | 2022-06-01 | Xencor Inc | Heterodimeric antibodies that bind cd3 and cd38 |
| PE20171324A1 (es) * | 2014-11-26 | 2017-09-11 | Xencor Inc | Anticuerpos heterodimericos que se unen a cd3 y a antigenos tumorales |
| EP3227328B1 (en) * | 2014-12-05 | 2022-10-05 | Merck Patent GmbH | Domain-exchanged antibody |
-
2017
- 2017-07-19 MX MX2019000925A patent/MX2019000925A/es unknown
- 2017-07-19 AU AU2017298535A patent/AU2017298535B2/en active Active
- 2017-07-19 CA CA3031082A patent/CA3031082C/en active Active
- 2017-07-19 CN CN201780044935.1A patent/CN109476763B/zh active Active
- 2017-07-19 SG SG11201900373WA patent/SG11201900373WA/en unknown
- 2017-07-19 KR KR1020170091758A patent/KR102098919B1/ko active Active
- 2017-07-19 CN CN202311086544.XA patent/CN117143247A/zh active Pending
- 2017-07-19 WO PCT/KR2017/007791 patent/WO2018016881A1/ko not_active Ceased
- 2017-07-19 JP JP2019502596A patent/JP2019530641A/ja active Pending
- 2017-07-19 CA CA3203613A patent/CA3203613A1/en active Pending
- 2017-07-19 MY MYPI2018002707A patent/MY200137A/en unknown
- 2017-07-19 NZ NZ772558A patent/NZ772558A/en unknown
- 2017-07-19 US US16/317,987 patent/US20230075499A1/en active Pending
- 2017-07-19 EP EP17831354.0A patent/EP3489262A4/en active Pending
- 2017-07-19 RU RU2019103238A patent/RU2745648C2/ru active
-
2019
- 2019-01-15 IL IL264249A patent/IL264249B2/en unknown
- 2019-01-17 ZA ZA2019/00347A patent/ZA201900347B/en unknown
- 2019-01-17 SA SA519400924A patent/SA519400924B1/ar unknown
- 2019-01-18 PH PH12019500138A patent/PH12019500138A1/en unknown
-
2020
- 2020-04-02 KR KR1020200040500A patent/KR102207261B1/ko active Active
- 2020-04-02 KR KR1020200040499A patent/KR102207260B1/ko active Active
- 2020-04-02 KR KR1020200040498A patent/KR20200042883A/ko not_active Ceased
-
2021
- 2021-01-22 AU AU2021200412A patent/AU2021200412A1/en not_active Abandoned
- 2021-05-26 JP JP2021088111A patent/JP7335634B2/ja active Active
-
2024
- 2024-07-01 AU AU2024204558A patent/AU2024204558A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2019000925A (es) | Proteinas biespecificas y metodo de su preparacion. | |
| CL2024000802A1 (es) | Anticuerpos que se fijan a gprc5d | |
| PE20190108A1 (es) | Moleculas de anticuerpo para el tratamiento del cancer | |
| MX2017006626A (es) | Cadenas ligeras comunes y metodos de uso. | |
| PE20230160A1 (es) | Anticuerpos especificos para cd47, pd-l1 y sus usos | |
| CO2019003945A2 (es) | Proteínas de fusión heterodiméricas biespecíficas que contienen proteínas de fusión fc il-15/il-15rα y fragmentos de anticuerpo pd-1 | |
| EA201990285A1 (ru) | Гетеродимерные иммуноглобулиновые конструкции и способы их получения | |
| BR112018067458A2 (pt) | anticorpos para tigit | |
| ECSP19011185A (es) | Proteínas de unión de tipo anticuerpo biespecíficas que se unen específicamente a CD3 y CD123 | |
| AR106555A1 (es) | Anticuerpos anti-il1rap, moléculas de unión a antígenos biespecíficas que se unen a il1rap y cd3, y usos de estas | |
| MX383464B (es) | Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y métodos de uso de los mismos. | |
| CL2016003346A1 (es) | Anticuerpos anti-tau humanizados | |
| GT201500054A (es) | Moléculas de enlace a il-18 | |
| CR20180162A (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t | |
| CU24437B1 (es) | Anticuerpos agonistas de anti-gitr y composiciones de los mismos | |
| PE20171764A1 (es) | Anticuerpos anti-cd3, anticuerpos anti-cd123 y anticuerpos biespecificos que se unen especificamente a cd3 y/o cd123 | |
| UY37377A (es) | Anticuerpos multiespecíficos que facilitan el emparejamiento selectivo de cadenas ligeras | |
| MX2017002230A (es) | Anticuerpos anti-lag3 y fragmentos de union a antigeno. | |
| CL2019001352A1 (es) | Anticuerpo biespecífico heterodimérico estructural de anticuerpo natural anti-pd-1/anti-her2 y método para preparar el mismo. | |
| MX2020002921A (es) | Anticuerpos para claudin6 y métodos para tratar el cáncer. | |
| CO2019009815A2 (es) | Combinaciones farmacéuticas | |
| CO2019010164A2 (es) | Anticuerpos que se unen a steap-1 | |
| CL2019002894A1 (es) | Anticuerpo monoclonal para pd-l1. | |
| MX2018013222A (es) | Anticuerpos de interferon beta y usos de los mismos. | |
| CO2017001724A2 (es) | Anticuerpos anti-vasa y métodos de producción de los mismos |