MX2018015208A - Andrografolido para tratar formas progresivas de esclerosis multiple. - Google Patents
Andrografolido para tratar formas progresivas de esclerosis multiple.Info
- Publication number
- MX2018015208A MX2018015208A MX2018015208A MX2018015208A MX2018015208A MX 2018015208 A MX2018015208 A MX 2018015208A MX 2018015208 A MX2018015208 A MX 2018015208A MX 2018015208 A MX2018015208 A MX 2018015208A MX 2018015208 A MX2018015208 A MX 2018015208A
- Authority
- MX
- Mexico
- Prior art keywords
- multiple sclerosis
- andrographolid
- progressive forms
- treat progressive
- treat
- Prior art date
Links
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 title abstract 2
- 201000006417 multiple sclerosis Diseases 0.000 title abstract 2
- 230000000750 progressive effect Effects 0.000 title abstract 2
- KHQNSSJNIXVKMK-UHFFFAOYSA-N 14-deoxy-12R-hydroxyandrographolide Natural products C=C1CCC2C(C)(CO)C(O)CCC2(C)C1CC(O)C1=CCOC1=O KHQNSSJNIXVKMK-UHFFFAOYSA-N 0.000 title 1
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
El Andrografólido de 240 mg/día oralmente es el primer tratamiento que muestra formas progresivas significativamente benéficas de Esclerosis Múltiple en pacientes humanos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662347218P | 2016-06-08 | 2016-06-08 | |
| PCT/US2017/036463 WO2017214346A1 (en) | 2016-06-08 | 2017-06-08 | Andrographolide treats progressive forms of multiple sclerosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018015208A true MX2018015208A (es) | 2019-09-19 |
| MX386393B MX386393B (es) | 2025-03-18 |
Family
ID=60578163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018015208A MX386393B (es) | 2016-06-08 | 2017-06-08 | Andrografólido para tratar formas progresivas de esclerosis múltiple. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10722492B2 (es) |
| EP (1) | EP3468553B1 (es) |
| JP (2) | JP6928963B2 (es) |
| CN (1) | CN109562097B (es) |
| CA (1) | CA3026770C (es) |
| DK (1) | DK3468553T3 (es) |
| MX (1) | MX386393B (es) |
| WO (1) | WO2017214346A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019126759A1 (en) * | 2017-12-22 | 2019-06-27 | Convelo Therapeutics, Inc. | Compounds and methods of promoting myelination |
| CN109223770A (zh) * | 2018-11-14 | 2019-01-18 | 株洲千金药业股份有限公司 | 一种具有镇痛作用的化合物及其在制备镇痛药物中的应用 |
| CN109293607A (zh) * | 2018-11-14 | 2019-02-01 | 株洲千金药业股份有限公司 | 一种具有抗炎作用的化合物及其在制备抗炎药物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002360696A1 (en) * | 2001-12-21 | 2003-07-30 | Ilex Oncology, Inc. | Combination comprising anti-cd52 antibodies and other therapeutic agents for treatment for multiple sclerosis |
| BRPI0418053A (pt) * | 2004-02-03 | 2007-04-17 | Univ Austral De Chile | composição de labdano diterpenos extraìdos a partir de andrographis paniculata, util para o tratamento de doenças autoimunes, e doença de alzheimer por ativação de receptores ppr-gama |
| AU2012359081B2 (en) | 2011-12-21 | 2015-09-17 | Innobioscience, Llc | Combination therapy with interferon and andrographolides for multiple sclerosis |
-
2017
- 2017-06-08 JP JP2018564301A patent/JP6928963B2/ja active Active
- 2017-06-08 CA CA3026770A patent/CA3026770C/en active Active
- 2017-06-08 WO PCT/US2017/036463 patent/WO2017214346A1/en not_active Ceased
- 2017-06-08 US US15/774,604 patent/US10722492B2/en active Active
- 2017-06-08 EP EP17810987.2A patent/EP3468553B1/en active Active
- 2017-06-08 DK DK17810987.2T patent/DK3468553T3/da active
- 2017-06-08 MX MX2018015208A patent/MX386393B/es unknown
- 2017-06-08 CN CN201780035899.2A patent/CN109562097B/zh active Active
-
2021
- 2021-07-08 JP JP2021113384A patent/JP2021165304A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019517550A (ja) | 2019-06-24 |
| JP2021165304A (ja) | 2021-10-14 |
| DK3468553T3 (da) | 2023-07-03 |
| CN109562097B (zh) | 2022-06-07 |
| CA3026770C (en) | 2024-05-28 |
| US10722492B2 (en) | 2020-07-28 |
| CA3026770A1 (en) | 2017-12-14 |
| WO2017214346A1 (en) | 2017-12-14 |
| CN109562097A (zh) | 2019-04-02 |
| JP6928963B2 (ja) | 2021-09-01 |
| US20190083458A1 (en) | 2019-03-21 |
| MX386393B (es) | 2025-03-18 |
| EP3468553B1 (en) | 2023-05-24 |
| EP3468553A4 (en) | 2020-02-12 |
| EP3468553A1 (en) | 2019-04-17 |
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