MX2018015068A - Solucion inyectable a ph 7 que comprende por lo menos una insulina basal cuyo pi esta comprendido entre 5.8 y 8.5 y co-poliamino acido que porta cargas de carboxilatos y radicales hidrofobicos. - Google Patents
Solucion inyectable a ph 7 que comprende por lo menos una insulina basal cuyo pi esta comprendido entre 5.8 y 8.5 y co-poliamino acido que porta cargas de carboxilatos y radicales hidrofobicos.Info
- Publication number
- MX2018015068A MX2018015068A MX2018015068A MX2018015068A MX2018015068A MX 2018015068 A MX2018015068 A MX 2018015068A MX 2018015068 A MX2018015068 A MX 2018015068A MX 2018015068 A MX2018015068 A MX 2018015068A MX 2018015068 A MX2018015068 A MX 2018015068A
- Authority
- MX
- Mexico
- Prior art keywords
- basal insulin
- acid bearing
- injectable solution
- carboxylate charges
- bearing carboxylate
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 102000004877 Insulin Human genes 0.000 title abstract 2
- 108090001061 Insulin Proteins 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007942 carboxylates Chemical class 0.000 title abstract 2
- 230000002209 hydrophobic effect Effects 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- 229940102223 injectable solution Drugs 0.000 title 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se relaciona con composiciones estables físicamente en la forma de una solución acuosa inyectable, cuyo pH es de 6.0 a 8.0, que comprende por lo menos: a) una insulina basal cuyo punto isoeléctrico (pI) es de 5.8 a 8.5, b) un co-poliamino ácido que porta cargas de carboxilato y por lo menos un radical hidrofóbico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1655222A FR3052072A1 (fr) | 2016-06-07 | 2016-06-07 | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| PCT/EP2017/063865 WO2017211903A1 (fr) | 2016-06-07 | 2017-06-07 | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018015068A true MX2018015068A (es) | 2019-05-09 |
Family
ID=57348773
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018015067A MX2018015067A (es) | 2016-06-07 | 2017-06-07 | Solucion inyectable a ph 7 que comprende por lo menos una insulina basal cuyo pi esta comprendido entre 5.8 y 8.5, una insulina prandial y/o una hormona gastrointestinal y un co-poliamino acido que porta cargas de carboxilatos y de radicales hidrofobicos. |
| MX2018015068A MX2018015068A (es) | 2016-06-07 | 2017-06-07 | Solucion inyectable a ph 7 que comprende por lo menos una insulina basal cuyo pi esta comprendido entre 5.8 y 8.5 y co-poliamino acido que porta cargas de carboxilatos y radicales hidrofobicos. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018015067A MX2018015067A (es) | 2016-06-07 | 2017-06-07 | Solucion inyectable a ph 7 que comprende por lo menos una insulina basal cuyo pi esta comprendido entre 5.8 y 8.5, una insulina prandial y/o una hormona gastrointestinal y un co-poliamino acido que porta cargas de carboxilatos y de radicales hidrofobicos. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10383920B2 (es) |
| EP (2) | EP3463293B1 (es) |
| JP (1) | JP2019517555A (es) |
| CN (2) | CN109640953B (es) |
| BR (2) | BR112018075151A2 (es) |
| EA (2) | EA039363B1 (es) |
| FR (1) | FR3052072A1 (es) |
| MX (2) | MX2018015067A (es) |
| PH (1) | PH12018502558B1 (es) |
| SA (2) | SA518400588B1 (es) |
| SG (2) | SG11201810935SA (es) |
| WO (2) | WO2017211916A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3070264A1 (fr) * | 2017-08-24 | 2019-03-01 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris de 5,8 a 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| FR3083089A1 (fr) * | 2018-06-29 | 2020-01-03 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| WO2019115411A1 (fr) * | 2017-12-07 | 2019-06-20 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide |
| IL275146B2 (en) | 2017-12-07 | 2025-01-01 | Adocia | Preparations in the form of an aqueous solution for injection comprising amylin, an amylin receptor agonist or an amylin analog and a copolyamino acid |
| JP7637965B2 (ja) | 2017-12-07 | 2025-03-03 | アドシア | ５．８～８．５のｐＩを有する少なくとも１つの基礎インスリンならびにカルボキシレート電荷および疎水性ラジカルを有するコポリアミノ酸を含むｐＨ７の注射溶液 |
| US11129877B2 (en) | 2017-12-07 | 2021-09-28 | Adocia | Compositions in the form of an injectable aqueous solution comprising amylin, an amylin agonist receptor or an amylin analogue and a co-polyamino acid |
| FR3083086A1 (fr) * | 2018-06-29 | 2020-01-03 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide |
| CN111836616B (zh) | 2017-12-07 | 2024-01-16 | 阿道恰公司 | 包含至少一种pi在5.8与8.5之间的基础胰岛素和带有羧酸根电荷及疏水基的共聚氨基酸的ph 7为7的可注射溶液 |
| EP3740195A1 (fr) * | 2017-12-07 | 2020-11-25 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide |
| EP4671300A2 (fr) | 2017-12-07 | 2025-12-31 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| FR3067247A1 (fr) * | 2018-06-07 | 2018-12-14 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant du glucagon humain et un co-polyaminoacide |
| WO2019243628A1 (fr) * | 2018-06-22 | 2019-12-26 | Adocia | Composition injectable a ph 7 comprenant un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes et au moins une insuline basale presentant au moins un effet prandial et un effet basal |
| FR3084585B1 (fr) * | 2018-08-03 | 2020-11-06 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un compose amphiphile porteur de radicaux hydrophobes |
| FR3084586B1 (fr) * | 2018-08-03 | 2020-11-06 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un compose amphiphile porteur de radicaux hydrophobes |
| WO2020115334A1 (fr) * | 2018-12-07 | 2020-06-11 | Adocia | Procede de preparation d'une composition stable sous forme d'une solution aqueuse injectable |
| US20200179489A1 (en) * | 2018-12-07 | 2020-06-11 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin which pi is from 5.8 to 8.5 and a co-polyamino-acid bearing carboxylate charges and hydrophobic radicals and a limited amount of m-cresol |
| WO2020245470A1 (fr) | 2019-06-07 | 2020-12-10 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5, du liraglutide et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0160103B1 (en) | 1983-10-26 | 1990-06-20 | Kanebo, Ltd. | Proteinous emulsifier, process for its preparation, and emulsified cosmetic preparation containing same |
| DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| FR2801226B1 (fr) | 1999-11-23 | 2002-01-25 | Flamel Tech Sa | Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation |
| CZ2004710A3 (cs) | 2001-12-20 | 2005-02-16 | Eli Lilly And Company | Inzulínová sloučenina s protrahovaným účinkem |
| FR2840614B1 (fr) | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
| WO2004096854A2 (en) | 2003-04-29 | 2004-11-11 | Eli Lilly And Company | Insulin analogs having protracted time action |
| FR2862535B1 (fr) * | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee d'interleukines et leurs applications therapeutiques |
| FR2915683B1 (fr) * | 2007-05-03 | 2009-08-07 | Flamel Technologies Sa | Formulations pharmaceutiques auto-precipitantes pour la liberation modifiee de principe actif |
| DK2741765T3 (en) * | 2011-08-10 | 2016-06-13 | Adocia | Injectable solution of at least one type of basal insulin |
| FR2985429B1 (fr) | 2012-01-09 | 2016-07-29 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un polyaminoacide substitue obtenu par un procede de polymerisation controle |
| BR112014016889A8 (pt) | 2012-01-09 | 2017-07-04 | Adocia | composição sob a forma de uma solução aquosa injetável, sujo ph está compreendido entre 6,0 e 8,0 e, formulação de dose unitária com ph compreendido entre 7 e 7,8 |
| FR3001896B1 (fr) | 2013-02-12 | 2015-07-03 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le point isolectrique est compris entre 5,8 et 8,5 et un polymere anionique hydrophobise |
| FR3001895B1 (fr) | 2013-02-12 | 2015-07-03 | Adocia | Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes |
-
2016
- 2016-06-07 FR FR1655222A patent/FR3052072A1/fr not_active Withdrawn
-
2017
- 2017-06-07 WO PCT/EP2017/063886 patent/WO2017211916A1/fr not_active Ceased
- 2017-06-07 EP EP17727910.6A patent/EP3463293B1/fr active Active
- 2017-06-07 CN CN201780047889.0A patent/CN109640953B/zh active Active
- 2017-06-07 SG SG11201810935SA patent/SG11201810935SA/en unknown
- 2017-06-07 SG SG11201810937WA patent/SG11201810937WA/en unknown
- 2017-06-07 PH PH1/2018/502558A patent/PH12018502558B1/en unknown
- 2017-06-07 US US15/616,128 patent/US10383920B2/en active Active
- 2017-06-07 EA EA201892737A patent/EA039363B1/ru unknown
- 2017-06-07 US US15/616,470 patent/US10548952B2/en active Active
- 2017-06-07 BR BR112018075151-0A patent/BR112018075151A2/pt not_active Application Discontinuation
- 2017-06-07 MX MX2018015067A patent/MX2018015067A/es unknown
- 2017-06-07 BR BR112018075140-5A patent/BR112018075140A2/pt not_active Application Discontinuation
- 2017-06-07 JP JP2018564355A patent/JP2019517555A/ja active Pending
- 2017-06-07 CN CN201780035320.2A patent/CN109379888B/zh active Active
- 2017-06-07 WO PCT/EP2017/063865 patent/WO2017211903A1/fr not_active Ceased
- 2017-06-07 EP EP17727906.4A patent/EP3463292B1/fr active Active
- 2017-06-07 MX MX2018015068A patent/MX2018015068A/es unknown
- 2017-06-07 EA EA201892736A patent/EA039333B1/ru unknown
-
2018
- 2018-12-04 SA SA518400588A patent/SA518400588B1/ar unknown
- 2018-12-05 SA SA518400596A patent/SA518400596B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12018502558B1 (en) | 2024-02-02 |
| US10548952B2 (en) | 2020-02-04 |
| CN109640953A (zh) | 2019-04-16 |
| JP2019517555A (ja) | 2019-06-24 |
| EP3463293B1 (fr) | 2021-05-12 |
| WO2017211903A1 (fr) | 2017-12-14 |
| MX2018015067A (es) | 2019-05-09 |
| FR3052072A1 (fr) | 2017-12-08 |
| CN109640953B (zh) | 2021-10-29 |
| BR112018075140A2 (pt) | 2019-03-26 |
| EA201892736A1 (ru) | 2019-05-31 |
| SG11201810937WA (en) | 2019-01-30 |
| EP3463293A1 (fr) | 2019-04-10 |
| EP3463292B1 (fr) | 2020-08-05 |
| EA039333B1 (ru) | 2022-01-14 |
| EA201892737A1 (ru) | 2019-05-31 |
| EA039363B1 (ru) | 2022-01-18 |
| BR112018075151A2 (pt) | 2019-03-26 |
| SA518400588B1 (ar) | 2022-03-07 |
| SG11201810935SA (en) | 2019-01-30 |
| US20170348396A1 (en) | 2017-12-07 |
| WO2017211916A1 (fr) | 2017-12-14 |
| US20170348423A1 (en) | 2017-12-07 |
| US10383920B2 (en) | 2019-08-20 |
| EP3463292A1 (fr) | 2019-04-10 |
| SA518400596B1 (ar) | 2022-03-16 |
| CN109379888A (zh) | 2019-02-22 |
| PH12018502558A1 (en) | 2019-10-14 |
| CN109379888B (zh) | 2021-10-29 |
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