[go: up one dir, main page]

MX2018014841A - Dispositivo integrado para detectar y analizar moleculas. - Google Patents

Dispositivo integrado para detectar y analizar moleculas.

Info

Publication number
MX2018014841A
MX2018014841A MX2018014841A MX2018014841A MX2018014841A MX 2018014841 A MX2018014841 A MX 2018014841A MX 2018014841 A MX2018014841 A MX 2018014841A MX 2018014841 A MX2018014841 A MX 2018014841A MX 2018014841 A MX2018014841 A MX 2018014841A
Authority
MX
Mexico
Prior art keywords
integrated device
region
distance
trench region
excitation energy
Prior art date
Application number
MX2018014841A
Other languages
English (en)
Other versions
MX394779B (es
Inventor
Kabiri Ali
W Sickler Jason
Lackey Jeremy
Schmid Gerard
CIPRIANY Benjamin
e glenn Paul
M Rothberg Jonathan
G Fife Keith
C West Lawrence
GHASEMI Farshid
Beach James
Preston Kyle
Original Assignee
Quantum Si Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Si Inc filed Critical Quantum Si Inc
Publication of MX2018014841A publication Critical patent/MX2018014841A/es
Publication of MX394779B publication Critical patent/MX394779B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Optical Measuring Cells (AREA)
  • Optical Integrated Circuits (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Sistema y metodos para analizar moleculas unicas y realizar la secuenciacion de acido nucleico; un dispositivo integrado puede incluir multiples pixeles con pozos de muestras configurados para recibir una muestra, que cuando se excita, emite radiacion; el dispositivo integrado incluye una superficie que tiene una region de trinchera empotrada desde una porcion de la superficie y una serie de pozos de muestra, dispuestos en la region de trinchera; el dispositivo integrado tambien incluye una guia de onda configurada para acoplar energia de excitacion a al menos un pozo de muestra en la serie y posicionada a una primera distancia desde una superficie de la region de trinchera y a una segunda distancia desde la superficie en una region separada de la region de trinchera; la primera distancia es mas pequena que la segunda distancia; el sistema tambien incluye un instrumento que hace interfaz con el dispositivo integrado; el instrumento puede incluir una fuente de energia de excitacion para proveer energia de excitacion al dispositivo integrado por acoplamiento a una energia de region de acoplamiento de excitacion del dispositivo integrado.
MX2018014841A 2016-06-01 2017-06-01 Dispositivo integrado para detectar y analizar moléculas. MX394779B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662344123P 2016-06-01 2016-06-01
PCT/US2017/035412 WO2018013243A1 (en) 2016-06-01 2017-06-01 Integrated device for detecting and analyzing molecules

Publications (2)

Publication Number Publication Date
MX2018014841A true MX2018014841A (es) 2019-03-14
MX394779B MX394779B (es) 2025-03-24

Family

ID=59062092

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018014841A MX394779B (es) 2016-06-01 2017-06-01 Dispositivo integrado para detectar y analizar moléculas.

Country Status (10)

Country Link
US (5) US11226290B2 (es)
EP (2) EP4113104A3 (es)
JP (2) JP7309364B2 (es)
KR (2) KR102414666B1 (es)
CN (2) CN114674788A (es)
AU (1) AU2017297185B2 (es)
CA (1) CA3025431A1 (es)
MX (1) MX394779B (es)
TW (2) TWI844783B (es)
WO (1) WO2018013243A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018013243A1 (en) * 2016-06-01 2018-01-18 Quantum-Si Incorporated Integrated device for detecting and analyzing molecules
BR112019012414A2 (pt) 2016-12-19 2020-02-27 Quantum-Si Incorporated Carregamento de moléculas em poços de amostra para análise
EP3619323A4 (en) 2017-05-05 2021-01-27 Quantum-si Incorporated SUBSTRATES WITH MODIFIED SURFACE REACTIVITY AND AGING-INHIBITIVE PROPERTIES IN BIOLOGICAL REACTIONS
JP7212030B2 (ja) 2017-07-24 2023-01-24 クアンタム－エスアイ インコーポレイテッド 光拒絶フォトニック構造
AU2019205383B8 (en) 2018-01-08 2023-09-28 Quantum-Si Incorporated System and methods for electrokinetic loading of sub-micron-scale reaction chambers
US11226459B2 (en) * 2018-02-13 2022-01-18 Apple Inc. Integrated photonics device having integrated edge outcouplers
TWI840365B (zh) * 2018-05-24 2024-05-01 加拿大商光子公司 包含在具有局部資訊狀態之半導體中之發光局部缺陷之系統、裝置、製品及方法
AU2019330998B2 (en) * 2018-08-29 2025-04-10 Quantum-Si Incorporated Sample well fabrication techniques and structures for integrated sensor devices
US12179204B2 (en) * 2018-12-03 2024-12-31 Quantum-Si Incorporated Sample well fabrication techniques and structures for integrated sensor
EP3891490A1 (en) * 2019-01-03 2021-10-13 Quantum-Si Incorporated Optical waveguides and couplers for delivering light to an array of photonic elements
CN109945776B (zh) * 2019-02-01 2021-05-25 天津大学 一种电化学中基于荧光颗粒标记与主动光学测量的位移/应变测量方法
WO2020264546A1 (en) * 2019-06-28 2020-12-30 Illumina Cambridge Limited Flowcells with linear waveguides
JP2022539633A (ja) * 2019-07-08 2022-09-13 イルミナ インコーポレイテッド 光検出デバイス上の光結合構造による導波路統合
AU2020364058A1 (en) 2019-10-11 2022-05-26 Quantum-Si Incorporated Surface modification in the vapor phase
AU2021207899A1 (en) * 2020-01-14 2022-09-08 Quantum-Si Incorporated Waveguide excitation uniformity
US12535420B2 (en) * 2020-02-18 2026-01-27 Pacific Biosciences Of California, Inc. Highly multiplexed nucleic acid sequencing systems
US11592618B2 (en) 2020-06-10 2023-02-28 Taiwan Semiconductor Manufacturing Co., Ltd. Photonic semiconductor device and method of manufacture
JP7742256B2 (ja) * 2020-09-24 2025-09-19 旭化成エレクトロニクス株式会社 光学式化学分析装置
US11442230B2 (en) * 2020-11-13 2022-09-13 Taiwan Semiconductor Manufacturing Company Limited Silicon photonics coupling structure using an etch stop layer and methods of forming the same
WO2022212657A1 (en) * 2021-03-31 2022-10-06 Carnegie Mellon University Laser-based fast micromanufacturing of test device for rapid detection of pathogens
WO2022235794A1 (en) 2021-05-04 2022-11-10 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices with reduced-scale unit cell
CN113740300A (zh) * 2021-08-27 2021-12-03 电子科技大学 一种片上光学丙酮气体传感器及其制备工艺和应用
TWI848815B (zh) * 2023-09-12 2024-07-11 漢磊科技股份有限公司 生物晶片及其製造方法

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560273B2 (en) 2002-07-23 2009-07-14 Applied Biosystems, Llc Slip cover for heated platen assembly
JPH08271744A (ja) 1995-02-03 1996-10-18 Nhk Spring Co Ltd 光分岐デバイス
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5625617A (en) * 1995-09-06 1997-04-29 Lucent Technologies Inc. Near-field optical apparatus with a laser having a non-uniform emission face
US6825921B1 (en) * 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
JP2003532123A (ja) 2000-04-28 2003-10-28 エッジライト バイオサイエンシズ インコーポレイテッド マイクロアレーエバネッセント波蛍光検出装置
US6917726B2 (en) 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US20020059449A1 (en) 2000-06-27 2002-05-16 Matthias Wandel System and method for implementing local base stations
FR2813121A1 (fr) 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
US20040146917A1 (en) * 2001-08-03 2004-07-29 Nanosphere, Inc. Nanoparticle imaging system and method
DE10145701A1 (de) * 2001-09-17 2003-04-10 Infineon Technologies Ag Fluoreszenz-Biosensorchip und Fluoreszenz-Biosensorchip-Anordnung
US6782166B1 (en) * 2001-12-21 2004-08-24 United States Of America As Represented By The Secretary Of The Air Force Optically transparent electrically conductive charge sheet poling electrodes to maximize performance of electro-optic devices
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
FR2846745B1 (fr) * 2002-10-30 2004-12-24 Genewave Dispositif de support d'elements chromophores.
CN1742358A (zh) * 2002-11-20 2006-03-01 瑞威欧公司 在基板上制造多层器件的方法和系统
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
WO2005073407A1 (en) * 2003-10-07 2005-08-11 Ut-Battelle, Llc Advanced integrated circuit biochip
US9813152B2 (en) 2004-01-14 2017-11-07 Luxtera, Inc. Method and system for optoelectronics transceivers integrated on a CMOS chip
WO2005118773A2 (en) 2004-05-28 2005-12-15 Wafergen, Inc. Apparatus and methods for multiplex analyses
EP1831742A4 (en) 2004-12-09 2008-05-14 Rpo Pty Ltd OPTICAL POWER DISTRIBUTION DEVICES
US7483140B1 (en) 2004-12-10 2009-01-27 University Of Central Florida Research Foundation, Inc. Micro integrated planar optical waveguide type SPR sensor
TWI247886B (en) 2005-01-06 2006-01-21 Univ Nat Taiwan Improved linear wave-guide type surface plasmon resonance micro sensor
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
US7426322B2 (en) 2005-07-20 2008-09-16 Searete Llc. Plasmon photocatalysis
FR2892196B1 (fr) * 2005-10-18 2008-06-20 Genewave Soc Par Actions Simpl Procede de fabrication d'un biocapteur a detection integree
US9528939B2 (en) * 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US8637436B2 (en) * 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray
WO2008030666A2 (en) * 2006-07-25 2008-03-13 The Board Of Trustees Of The University Of Illinois Multispectral plasmonic crystal sensors
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
WO2008028160A2 (en) 2006-09-01 2008-03-06 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
KR100795447B1 (ko) 2006-09-11 2008-01-16 노키아 코포레이션 광 가이드, 광가이드 제조 장치, 제조 시스템, 및 제조 방법
WO2008060415A1 (en) 2006-11-09 2008-05-22 The Board Of Trustees Of The University Of Illinois Photonic crystal sensors with integrated fluid containment structure
FR2908888B1 (fr) 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
AU2008209561A1 (en) * 2007-01-22 2008-07-31 Wafergen, Inc. Apparatus for high throughput chemical reactions
US9475051B2 (en) * 2007-02-27 2016-10-25 Sony Corporation Nucleic acid amplifier
WO2008115871A1 (en) 2007-03-16 2008-09-25 Ia, Inc. Biosensor cartridge and biosensor mounting system with integral fluid storage and fluid selection mechanisms
US7880882B2 (en) * 2007-06-07 2011-02-01 Praevium Research, Inc. Multi-wavelength light source for spectroscopy
US7767441B2 (en) * 2007-10-25 2010-08-03 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
WO2009082706A1 (en) 2007-12-21 2009-07-02 The Trustees Of Columbia University In The City Of New York Active cmos sensor array for electrochemical biomolecular detection
US20100320363A1 (en) * 2008-02-25 2010-12-23 Koninklijke Philips Electronics N.V. Optical sensor for measuring emission light from an analyte
US7974504B2 (en) 2008-03-28 2011-07-05 Infinera Corporation Reflection suppression in a photonic integrated circuit
EP2110694B1 (en) 2008-04-18 2013-08-14 Sony DADC Austria AG Method for manufacturing an optical waveguide, optical waveguide, and sensor arrangement
ES2368043B1 (es) * 2008-04-29 2012-10-15 Consejo Superior De Investigaciones Científicas Acoplador de red de difracción y sistema y procedimiento para la caracterización de un especimen mediante su acoplamiento lumínico a éste.
WO2010033193A2 (en) * 2008-09-16 2010-03-25 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8218151B2 (en) 2009-03-12 2012-07-10 Tel Aviv University Future Technology Development Ltd Light-emitting intra-cavity interferometric sensors
US8636955B2 (en) 2009-08-03 2014-01-28 Omega Optics, Inc. Packaged chip for multiplexing photonic crystal waveguide and photonic crystal slot waveguide devices for chip-integrated label-free detection and absorption spectroscopy with high throughput, sensitivity, and specificity
US8278728B2 (en) 2009-10-17 2012-10-02 Florida Institute Of Technology Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels
US20110267623A1 (en) 2009-11-02 2011-11-03 Matejka Steven R Multi-Wavelength Reference Microplate For Label-Independent Optical Reader
US8791405B2 (en) 2009-12-03 2014-07-29 Samsung Electronics Co., Ltd. Optical waveguide and coupler apparatus and method of manufacturing the same
JP6017107B2 (ja) * 2009-12-28 2016-10-26 ソニー株式会社 イメージセンサ及びその製造方法、並びにセンサデバイス
AU2011217862B9 (en) 2010-02-19 2014-07-10 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US20120156100A1 (en) 2010-12-20 2012-06-21 Industrial Technology Research Institute Apparatus for single molecule detection and method thereof
JP5810565B2 (ja) * 2011-03-16 2015-11-11 セイコーエプソン株式会社 光学センサー及び電子機器
US8358419B2 (en) * 2011-04-05 2013-01-22 Integrated Plasmonics Corporation Integrated plasmonic sensing device and apparatus
EP2771103B1 (en) 2011-10-28 2017-08-16 Illumina, Inc. Microarray fabrication system and method
US9606060B2 (en) 2012-01-13 2017-03-28 California Institute Of Technology Filterless time-domain detection of one or more fluorophores
US9372308B1 (en) * 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
EP2677307B1 (en) * 2012-06-21 2016-05-11 Nxp B.V. Integrated circuit with sensors and manufacturing method
EP3699577B1 (en) * 2012-08-20 2023-11-08 Illumina, Inc. System for fluorescence lifetime based sequencing
EP2904378B1 (en) 2012-10-08 2018-03-28 Agency For Science, Technology And Research Refractive index sensor for analyzing an analyte, and method of fabrication thereof
TW201416061A (zh) 2012-10-19 2014-05-01 Nat Univ Chung Cheng 雙面光柵波導生物感測器
CN103001120A (zh) * 2012-12-14 2013-03-27 武汉光迅科技股份有限公司 阵列波导光栅芯片与半导体光放大器芯片倒装集成的方法
WO2014099776A1 (en) * 2012-12-18 2014-06-26 Pacific Biosciences Of California, Inc. Illumination of optical analytical devices
US9624540B2 (en) 2013-02-22 2017-04-18 Pacific Biosciences Of California, Inc. Integrated illumination of optical analytical devices
CN105144511B (zh) * 2013-03-13 2018-10-19 希捷科技有限公司 具有布置在沟槽区内的阴极金属层的半导体激光器
US9568677B2 (en) * 2013-05-30 2017-02-14 Taiwan Semiconductor Manufacturing Co., Ltd. Waveguide structure and method for fabricating the same
JP2016537999A (ja) * 2013-11-17 2016-12-08 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ 生物学的な試料及び化学的な試料の迅速な分析のためのアクティブ・ソース・ピクセル集積デバイス
WO2015110614A1 (en) 2014-01-23 2015-07-30 Imec Vzw Integrated waveguide structure for fluorescence analysis
JP6548581B2 (ja) 2014-01-24 2019-07-24 技術研究組合光電子融合基盤技術研究所 グレーティングカプラ
US9765395B2 (en) 2014-04-28 2017-09-19 Nanomedical Diagnostics, Inc. System and method for DNA sequencing and blood chemistry analysis
US9453969B2 (en) * 2014-04-29 2016-09-27 Corning Optical Communications LLC Grating-coupler assembly with small mode-field diameter for photonic-integrated-circuit systems
AU2015274800A1 (en) * 2014-06-09 2017-01-05 Stc.Unm Integrated bound-mode spectral/angular sensors
EP2977801B1 (en) 2014-07-24 2019-11-06 IMEC vzw Integrated grating coupler and power splitter
CN104155244B (zh) 2014-08-08 2017-05-03 浙江大学 一种应用于智能手机上的光波导生物传感器
CN112903639B (zh) * 2014-08-08 2022-09-13 宽腾矽公司 用于对分子进行探测、检测和分析的带外部光源的集成装置
MX383892B (es) * 2014-08-08 2025-03-14 Quantum Si Inc Sistema optico y circuito integrado de valoración para sondear, detectar y analizar moleculas.
KR101569515B1 (ko) * 2014-08-13 2015-11-27 (주)옵토레인 측광형 발광소자가 내장된 바이오칩 및 그 제조방법
US9606068B2 (en) * 2014-08-27 2017-03-28 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices
WO2016060680A1 (en) 2014-10-17 2016-04-21 Amcor Limited Multi-function container base
US9488615B2 (en) * 2014-12-17 2016-11-08 Taiwan Semiconductor Manufacturing Co., Ltd. Biosensor with a sensing surface on an interlayer dielectric
US9666748B2 (en) 2015-01-14 2017-05-30 International Business Machines Corporation Integrated on chip detector and zero waveguide module structure for use in DNA sequencing
JP2016133510A (ja) * 2015-01-16 2016-07-25 パーソナル ジェノミクス タイワン インコーポレイテッドＰｅｒｓｏｎａｌ Ｇｅｎｏｍｉｃｓ Ｔａｉｗａｎ，Ｉｎｃ． 導光機能を有する光学センサー及びその製造方法
CN107615121B (zh) 2015-03-16 2021-04-16 加利福尼亚太平洋生物科学股份有限公司 用于自由空间光耦合的集成装置及系统
JP2016197020A (ja) 2015-04-02 2016-11-24 富士通株式会社 光センサ
EP3567336B1 (en) 2015-04-02 2020-11-25 Milwaukee Electric Tool Corporation Tape measure
JP6878306B2 (ja) 2015-05-20 2021-05-26 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ パルスレーザ及び生物分析システム
CA2986237A1 (en) 2015-05-20 2016-11-24 Quantum-Si Incorporated Method of determining the sequence of a nucleic acid using time resolved luminescence
US10246742B2 (en) * 2015-05-20 2019-04-02 Quantum-Si Incorporated Pulsed laser and bioanalytic system
WO2016201387A1 (en) 2015-06-12 2016-12-15 Pacific Biosciences Of California, Inc. Integrated target waveguide devices and systems for optical coupling
US10488639B2 (en) * 2015-10-08 2019-11-26 Visera Technologies Company Limited Detection device for specimens
WO2017145239A1 (ja) * 2016-02-22 2017-08-31 株式会社日立製作所 生体試料分析チップ、生体試料分析装置、及び生体試料分析方法
CA3026061A1 (en) * 2016-06-01 2017-12-07 Quantum-Si Incorporated Pulse caller and base caller
WO2018013243A1 (en) 2016-06-01 2018-01-18 Quantum-Si Incorporated Integrated device for detecting and analyzing molecules
MX2019007070A (es) * 2016-12-16 2019-08-01 Quantum Si Inc Acoplador optico y sistema de guia de ondas.
AU2017378337A1 (en) * 2016-12-16 2019-06-20 Quantum-Si Incorporated Compact beam shaping and steering assembly

Also Published As

Publication number Publication date
US12259324B2 (en) 2025-03-25
AU2017297185B2 (en) 2022-05-26
US20170350818A1 (en) 2017-12-07
KR102414666B1 (ko) 2022-06-29
KR20190013965A (ko) 2019-02-11
US11422092B2 (en) 2022-08-23
TW202219491A (zh) 2022-05-16
JP7309364B2 (ja) 2023-07-18
TWI735587B (zh) 2021-08-11
US12259323B2 (en) 2025-03-25
US11226290B2 (en) 2022-01-18
WO2018013243A1 (en) 2018-01-18
TWI844783B (zh) 2024-06-11
KR20220098257A (ko) 2022-07-11
MX394779B (es) 2025-03-24
JP2023157910A (ja) 2023-10-26
CN109219743B (zh) 2022-04-26
EP4113104A2 (en) 2023-01-04
US20220349823A1 (en) 2022-11-03
US20210148821A1 (en) 2021-05-20
EP3465159B1 (en) 2023-04-05
TW201802454A (zh) 2018-01-16
EP4113104A3 (en) 2023-02-22
JP2019518994A (ja) 2019-07-04
CN109219743A (zh) 2019-01-15
CA3025431A1 (en) 2018-01-18
EP3465159A1 (en) 2019-04-10
AU2017297185A1 (en) 2018-12-06
KR102627237B1 (ko) 2024-01-23
US20250347624A1 (en) 2025-11-13
US20230375475A1 (en) 2023-11-23
CN114674788A (zh) 2022-06-28
BR112018074589A2 (pt) 2019-03-12

Similar Documents

Publication Publication Date Title
MX2018014841A (es) Dispositivo integrado para detectar y analizar moleculas.
MX2017001808A (es) Dispositivo integrado con fuente de luz externa para el sondeo, deteccion y analisis de moleculas.
MX2017001807A (es) Sistema optico y circuito integrado de valoración para sondear, detectar y analizar moleculas.
BR112016029542A2 (pt) análise não invasiva de substância
BR112016011052A2 (pt) Sistema óptico e chip de análise para investigar, detectar e analisar moléculas
CY1123331T1 (el) Συστημα διεξαγωγης αντιδρασεων
BR112016024554A2 (pt) ?conjunto de cabeça de trépano para recuperação de testemunhos?
AR094460A1 (es) Sistemas y métodos de monitoreo de formación de hidratos de gas en tiempo real
BR112018077001A2 (pt) aparelho de inspeção sólida e método de utilização
MX348963B (es) Instrumento portatil y dispositivo movil para analisis de fluorescencia de rayos x.
MX2016003032A (es) Metodo y analisis para el diseño holistico de tuberias de revestimiento para la planificacion y tiempo real.
PE20190483A1 (es) Sistemas y metodos para el analisis de nucleos mediante el uso de fluorescencia de rayos x
MX385922B (es) Sistemas y métodos para la proyección de imágenes de alta resolución
MX2017001405A (es) Deteccion de acidos nucleicos diana mediante el uso de hibridacion.
EP4220158A3 (en) Urine specimen analysis device and urine specimen analysis method
CO2019002608A2 (es) Biomarcadores de arn para angioedema hereditario
GB2545850A (en) System and method using a combined modality optical probe
CL2019003782A1 (es) Excitación con energía de luz de fluorescencia.
BR112017007461A2 (pt) ferramenta e método de fluorescência de óleo para analisar fragmentos e cascalhos de perfuração.
AR102261A1 (es) Detección de pozos mediante el uso de campos magnéticos inducidos
AR104712A1 (es) Fluidos de fracturamiento con fibras hidrofílicas
MX2021010984A (es) Analizador de concentracion en el punto de atencion.
MX2016012278A (es) Deteccion temprana de preeclampsia.
MX2015015015A (es) Metodo para diagnosticar cancer.
MX363554B (es) Detección de emulsiones utilizando dispositivos informáticos ópticos.