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MX2018012777A - Métodos para preparación de ácido obeticólico y derivados de los mismos. - Google Patents

Métodos para preparación de ácido obeticólico y derivados de los mismos.

Info

Publication number
MX2018012777A
MX2018012777A MX2018012777A MX2018012777A MX2018012777A MX 2018012777 A MX2018012777 A MX 2018012777A MX 2018012777 A MX2018012777 A MX 2018012777A MX 2018012777 A MX2018012777 A MX 2018012777A MX 2018012777 A MX2018012777 A MX 2018012777A
Authority
MX
Mexico
Prior art keywords
derivatives
preparation
methods
obeticholic acid
paraldehyde
Prior art date
Application number
MX2018012777A
Other languages
English (en)
Other versions
MX374550B (es
Inventor
List Benjamin
De Chandra
Wang Qinggang
Original Assignee
Intercept Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc
Publication of MX2018012777A publication Critical patent/MX2018012777A/es
Publication of MX374550B publication Critical patent/MX374550B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente solicitud se refiere a un método para preparar un derivado de ácido biliar, o una sal, solvato o conjugado de aminoácidos farmacéuticamente aceptable del mismo, que comprende hacer reaccionar el Compuesto 2 con paraldehído para formar el Compuesto 3: véase formula.
MX2018012777A 2016-04-19 2017-04-18 Métodos para preparación de ácido obeticólico y derivados de los mismos. MX374550B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662324405P 2016-04-19 2016-04-19
PCT/US2017/028130 WO2017184598A1 (en) 2016-04-19 2017-04-18 Methods for the preparation of obeticholic acid and derivatives thereof

Publications (2)

Publication Number Publication Date
MX2018012777A true MX2018012777A (es) 2019-01-28
MX374550B MX374550B (es) 2025-03-06

Family

ID=60116337

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018012777A MX374550B (es) 2016-04-19 2017-04-18 Métodos para preparación de ácido obeticólico y derivados de los mismos.

Country Status (14)

Country Link
US (1) US10550146B2 (es)
EP (1) EP3445370B1 (es)
JP (1) JP2019515906A (es)
KR (1) KR20180134405A (es)
CN (1) CN109069517A (es)
AR (1) AR108237A1 (es)
AU (1) AU2017254480A1 (es)
BR (1) BR112018071441A2 (es)
CA (1) CA3021322A1 (es)
ES (1) ES2907425T3 (es)
IL (1) IL262405A (es)
MX (1) MX374550B (es)
TW (1) TW201738254A (es)
WO (1) WO2017184598A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108299539B (zh) * 2018-03-09 2021-07-06 中山百灵生物技术股份有限公司 利用连续流微反应器生产6-亚乙基鹅去氧胆酸的方法
CN110204587B (zh) * 2019-07-19 2020-05-12 中山百灵生物技术有限公司 一种奥贝胆酸的合成方法
CN113387992A (zh) * 2020-03-11 2021-09-14 成都倍特药业股份有限公司 奥贝胆酸杂质及其制备方法和检测方法
KR20230044603A (ko) 2021-09-27 2023-04-04 (주) 테라베스트 약물 이합체를 포함하는 나노입자 및 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1895945A (en) 1928-12-20 1933-01-31 Goodrich Co B F Method of making aldehyde-amines
US7138390B2 (en) 2001-03-12 2006-11-21 Intercept Pharmaceuticals Steroids as agonists for FXR
EP1568706A1 (en) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
ITMI20050912A1 (it) * 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
SG11201408501UA (en) * 2012-06-19 2015-01-29 Intercept Pharmaceuticals Inc Preparation, uses and solid forms of obeticholic acid
AU2013334122B2 (en) * 2012-10-26 2017-11-02 Intercept Pharmaceuticals, Inc. Process for preparing bile acid derivatives
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
CN106046095B (zh) 2016-06-06 2017-02-22 南京理工大学 奥贝胆酸的合成方法

Also Published As

Publication number Publication date
CN109069517A (zh) 2018-12-21
KR20180134405A (ko) 2018-12-18
EP3445370B1 (en) 2021-12-01
BR112018071441A2 (pt) 2019-02-05
MX374550B (es) 2025-03-06
TW201738254A (zh) 2017-11-01
ES2907425T3 (es) 2022-04-25
CA3021322A1 (en) 2017-10-26
IL262405A (en) 2018-12-31
AU2017254480A1 (en) 2018-11-15
JP2019515906A (ja) 2019-06-13
US20190211052A1 (en) 2019-07-11
EP3445370A1 (en) 2019-02-27
WO2017184598A1 (en) 2017-10-26
US10550146B2 (en) 2020-02-04
EP3445370A4 (en) 2019-12-25
AR108237A1 (es) 2018-08-01

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