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MX2018012468A - Construcciones de union a antigeno multiespecificas dirigidas a agentes inmunoterapeuticos. - Google Patents

Construcciones de union a antigeno multiespecificas dirigidas a agentes inmunoterapeuticos.

Info

Publication number
MX2018012468A
MX2018012468A MX2018012468A MX2018012468A MX2018012468A MX 2018012468 A MX2018012468 A MX 2018012468A MX 2018012468 A MX2018012468 A MX 2018012468A MX 2018012468 A MX2018012468 A MX 2018012468A MX 2018012468 A MX2018012468 A MX 2018012468A
Authority
MX
Mexico
Prior art keywords
antigen
binding
binding constructs
specific antigen
binds
Prior art date
Application number
MX2018012468A
Other languages
English (en)
Inventor
m mills David
Original Assignee
Zymeworks Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymeworks Inc filed Critical Zymeworks Inc
Publication of MX2018012468A publication Critical patent/MX2018012468A/es

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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
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    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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Abstract

Se describen construcciones de unión a antígeno multiespecíficas dirigidas a agentes inmunoterapéuticos. Las construcciones de unión a antígeno multiespecíficas comprenden una primera construcción polipeptídica de unión a antígeno que se une a un agente inmunoterapéutico (tal como un captador de linfocitos T biespecífico o un linfocito T con CAR) y una segunda construcción polipeptídica de unión a antígeno que se une a un antígeno asociado a tumores. También se describen métodos para utilizar las construcciones de unión a antígeno multiespecíficas para redirigir o potenciar la unión del agente inmunoterapéutico a una célula tumoral y métodos para tratar pacientes con recaídas o para quienes el tratamiento con el agente inmunoterapéutico no fue exitoso.
MX2018012468A 2016-04-15 2017-04-13 Construcciones de union a antigeno multiespecificas dirigidas a agentes inmunoterapeuticos. MX2018012468A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662323432P 2016-04-15 2016-04-15
PCT/CA2017/050463 WO2017177337A1 (en) 2016-04-15 2017-04-13 Multi-specific antigen-binding constructs targeting immunotherapeutics

Publications (1)

Publication Number Publication Date
MX2018012468A true MX2018012468A (es) 2019-06-06

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MX2018012468A MX2018012468A (es) 2016-04-15 2017-04-13 Construcciones de union a antigeno multiespecificas dirigidas a agentes inmunoterapeuticos.

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Country Link
US (1) US20190111079A1 (es)
EP (1) EP3443014A4 (es)
JP (1) JP2019513777A (es)
KR (1) KR20180135460A (es)
CN (1) CN109153727A (es)
AU (1) AU2017251116A1 (es)
BR (1) BR112018070676A2 (es)
CA (1) CA3021634A1 (es)
MX (1) MX2018012468A (es)
RU (1) RU2018139811A (es)
WO (1) WO2017177337A1 (es)

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