MX2018012192A - Composicion oftalmica estable en almacenamiento. - Google Patents
Composicion oftalmica estable en almacenamiento.Info
- Publication number
- MX2018012192A MX2018012192A MX2018012192A MX2018012192A MX2018012192A MX 2018012192 A MX2018012192 A MX 2018012192A MX 2018012192 A MX2018012192 A MX 2018012192A MX 2018012192 A MX2018012192 A MX 2018012192A MX 2018012192 A MX2018012192 A MX 2018012192A
- Authority
- MX
- Mexico
- Prior art keywords
- storage
- ophthalmic composition
- stable ophthalmic
- free
- stable
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229940014041 hyaluronate Drugs 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a una composición oftálmica de múltiples fases, estable en almacenamiento, que forma gotas que comprende por lo menos una fase acuosa líquida y por lo menos una fase hidrofóbica líquida, caracterizada en que está libre de emulsionantes y libre de soluciones amortiguadoras y comprende ácido hialurónico y/o hialuronato.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16165546.9A EP3231417B1 (de) | 2016-04-15 | 2016-04-15 | Lagerungsstabile, ophthalmische zusammensetzung |
| PCT/EP2017/058825 WO2017178544A1 (de) | 2016-04-15 | 2017-04-12 | Lagerungsstabile, ophthalmische zusammensetzung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018012192A true MX2018012192A (es) | 2019-02-11 |
| MX376724B MX376724B (es) | 2025-03-07 |
Family
ID=55759507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018012192A MX376724B (es) | 2016-04-15 | 2017-04-12 | Composicion oftalmica estable en almacenamiento. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11413304B2 (es) |
| EP (1) | EP3231417B1 (es) |
| JP (1) | JP7240175B2 (es) |
| CN (1) | CN109069415B (es) |
| CA (1) | CA3018636C (es) |
| ES (1) | ES2704918T3 (es) |
| MX (1) | MX376724B (es) |
| PL (1) | PL3231417T3 (es) |
| WO (1) | WO2017178544A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11510924B2 (en) | 2017-05-09 | 2022-11-29 | CARDIX Therapeutics, LLC | Deuterated pharmaceutical compositions and methods of treating cardiovascular diseases |
| JOP20190219A1 (ar) | 2017-05-09 | 2019-09-22 | Cardix Therapeutics LLC | تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية |
| KR20200029374A (ko) * | 2018-09-10 | 2020-03-18 | 삼성바이오에피스 주식회사 | 단백질을 포함하는 액상 조성물 |
| US20230287577A1 (en) * | 2022-03-12 | 2023-09-14 | Razor Keep, LLC | Blade Preserving Products and Methods for Manufacturing |
| FR3151481A1 (fr) | 2023-07-28 | 2025-01-31 | Horus Pharma | Emulsion de type huile dans eau comprenant de l’acide hyaluronique et du dexpanthenol |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19511322C2 (de) * | 1995-03-28 | 1999-09-02 | Mann Gerhard Chem Pharm Fab | Sterile Augengele mit einem Gehalt an mittelkettigen Triglyceriden und Verfahren zu deren Herstellung |
| US5814660A (en) * | 1995-12-22 | 1998-09-29 | Alcon Laboratories, Inc. | 9-oxa prostaglandin analogs as ocular hypotensives |
| JP5301069B2 (ja) | 2004-04-15 | 2013-09-25 | ロート製薬株式会社 | アズレン含有水性液剤 |
| AU2005244059A1 (en) * | 2004-05-07 | 2005-11-24 | S.K. Pharmaceuticals, Inc. | Stabilized hyaluronan preparations and related methods |
| DE102005035986B4 (de) | 2005-07-28 | 2009-10-15 | Bausch & Lomb Incorporated | Steriles tropfbares mehrphasiges emulgatorfreies ophthalmisches Präparat |
| DE102006049091A1 (de) | 2006-10-18 | 2008-04-24 | Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh | Emulgatorfreies ophthalmisches Präparat enthaltend Pflanzenöl |
| JP5083502B2 (ja) | 2006-12-25 | 2012-11-28 | ライオン株式会社 | 眼科用組成物 |
| DE102009009758A1 (de) * | 2009-02-20 | 2010-08-26 | Beiersdorf Ag | Hautpflege-Formulierungen mit einem sofort spürbaren Straffungseffekt |
| US9278132B2 (en) * | 2012-02-13 | 2016-03-08 | Bausch & Lomb Incorporated | Ophthalmic pharmaceutical compositions and methods of making and using same |
| EP2630952A1 (en) * | 2012-02-23 | 2013-08-28 | Novagali Pharma S.A. | Self-preserved oil dispersions comprising boric acid |
| DE102012221224A1 (de) * | 2012-11-20 | 2014-05-22 | Beiersdorf Ag | Hydrodispersion mit verbesserter Leistung |
| JP6215306B2 (ja) * | 2013-03-19 | 2017-10-18 | 千寿製薬株式会社 | スクワランを含む二層分離型点眼液 |
| DE102014202377A1 (de) * | 2014-02-10 | 2015-08-13 | Beiersdorf Ag | Stabile kosmetische Hydrodispersion |
| CN104306430B (zh) | 2014-10-29 | 2015-10-28 | 东莞市达庆医疗器械有限公司 | 一种医用生物眼部冷疗敷料及其制备方法 |
-
2016
- 2016-04-15 PL PL16165546T patent/PL3231417T3/pl unknown
- 2016-04-15 ES ES16165546T patent/ES2704918T3/es active Active
- 2016-04-15 EP EP16165546.9A patent/EP3231417B1/de active Active
-
2017
- 2017-04-12 MX MX2018012192A patent/MX376724B/es active IP Right Grant
- 2017-04-12 JP JP2018549558A patent/JP7240175B2/ja active Active
- 2017-04-12 CA CA3018636A patent/CA3018636C/en active Active
- 2017-04-12 CN CN201780023702.3A patent/CN109069415B/zh active Active
- 2017-04-12 WO PCT/EP2017/058825 patent/WO2017178544A1/de not_active Ceased
- 2017-04-12 US US16/089,715 patent/US11413304B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3231417A1 (de) | 2017-10-18 |
| US11413304B2 (en) | 2022-08-16 |
| PL3231417T3 (pl) | 2019-05-31 |
| CA3018636C (en) | 2021-05-11 |
| ES2704918T3 (es) | 2019-03-20 |
| WO2017178544A1 (de) | 2017-10-19 |
| JP2019515882A (ja) | 2019-06-13 |
| EP3231417B1 (de) | 2018-12-05 |
| US20190111075A1 (en) | 2019-04-18 |
| JP7240175B2 (ja) | 2023-03-15 |
| CN109069415A (zh) | 2018-12-21 |
| MX376724B (es) | 2025-03-07 |
| CN109069415B (zh) | 2022-04-29 |
| CA3018636A1 (en) | 2017-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |