MX2018011384A - Arn de replicacion en trans. - Google Patents
Arn de replicacion en trans.Info
- Publication number
- MX2018011384A MX2018011384A MX2018011384A MX2018011384A MX2018011384A MX 2018011384 A MX2018011384 A MX 2018011384A MX 2018011384 A MX2018011384 A MX 2018011384A MX 2018011384 A MX2018011384 A MX 2018011384A MX 2018011384 A MX2018011384 A MX 2018011384A
- Authority
- MX
- Mexico
- Prior art keywords
- present
- rna
- protein
- alphavirus
- trans
- Prior art date
Links
- 241000710929 Alphavirus Species 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108010026228 mRNA guanylyltransferase Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 230000014616 translation Effects 0.000 abstract 2
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07048—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere en general a sistemas y métodos adecuados para la producción de proteínas de alto nivel. Aunque uno o más elementos de la presente invención se derivan de un alfavirus, la presente invención no requiere la propagación de partículas de virus. En particular, se prevé un sistema que comprende dos moléculas de ARN separadas, comprendiendo cada una una secuencia de nucleótidos derivada de un alfavirus: una molécula de ARN comprende una construcción de ARN para expresar la replicasa de alfavirus, y una molécula de ARN comprende un replicón de ARN que puede replicarse mediante la replicasa en trans. La construcción de ARN para expresar la replicasa de alfavirus comprende una caperuza 5'. De manera inesperada, se descubrió que la caperuza es adecuada para dirigir eficazmente la expresión de un transgén desde el replicón en trans. El sistema de la presente invención permite la expresión de una proteína de interés en una célula u organismo, pero no está asociado con la formación de partículas de virus no deseadas. Por lo tanto, la presente invención es adecuada para producir de manera eficiente y segura una proteína de interés, por ejemplo, una proteína terapéutica o una proteína antigénica, tal como una vacuna, en un organismo objetivo. En la presente se proporcionan métodos respectivos de producción de proteínas in vitro e in vivo, así como usos médicos. La presente invención también proporciona ADN que codifica las moléculas de ARN de la invención, y células que comprenden las moléculas de ARN de la invención.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2016/056160 WO2017162265A1 (en) | 2016-03-21 | 2016-03-21 | Trans-replicating rna |
| PCT/EP2017/055813 WO2017162461A1 (en) | 2016-03-21 | 2017-03-13 | Trans-replicating rna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018011384A true MX2018011384A (es) | 2019-02-13 |
Family
ID=55586324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018011384A MX2018011384A (es) | 2016-03-21 | 2017-03-13 | Arn de replicacion en trans. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US12338448B2 (es) |
| EP (2) | EP3964584A1 (es) |
| JP (2) | JP7105193B2 (es) |
| KR (1) | KR102441725B1 (es) |
| CN (2) | CN115386596A (es) |
| AU (1) | AU2017236240B2 (es) |
| BR (1) | BR112018068391A2 (es) |
| CY (1) | CY1124689T1 (es) |
| DK (1) | DK3433368T3 (es) |
| ES (1) | ES2896927T3 (es) |
| HR (1) | HRP20211715T1 (es) |
| HU (1) | HUE058889T2 (es) |
| IL (1) | IL261327B2 (es) |
| LT (1) | LT3433368T (es) |
| MA (1) | MA44479B1 (es) |
| MD (1) | MD3433368T2 (es) |
| MX (1) | MX2018011384A (es) |
| PL (1) | PL3433368T3 (es) |
| PT (1) | PT3433368T (es) |
| RS (1) | RS62543B1 (es) |
| RU (1) | RU2752580C2 (es) |
| SG (1) | SG11201807378SA (es) |
| SI (1) | SI3433368T1 (es) |
| SM (1) | SMT202100634T1 (es) |
| WO (2) | WO2017162265A1 (es) |
| ZA (2) | ZA201805520B (es) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4218805A1 (en) | 2015-07-21 | 2023-08-02 | ModernaTX, Inc. | Infectious disease vaccines |
| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
| WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
| CN111094549B (zh) * | 2017-09-13 | 2024-11-01 | 生物技术公司 | 用于将体细胞重编程的rna复制子 |
| JP7389741B2 (ja) * | 2017-09-13 | 2023-11-30 | バイオエヌテック セル アンド ジーン セラピーズ ゲーエムベーハー | Ｔ細胞受容体または人工ｔ細胞受容体を発現するためのｒｎａレプリコン |
| WO2019055807A1 (en) | 2017-09-14 | 2019-03-21 | Modernatx, Inc. | RNA VACCINES AGAINST ZIKA VIRUS |
| US10736957B2 (en) | 2017-12-19 | 2020-08-11 | President And Fellows Of Harvard College | Enhanced immunogenicity of mRNA with co-encoded adjuvant sequences |
| US12070495B2 (en) | 2019-03-15 | 2024-08-27 | Modernatx, Inc. | HIV RNA vaccines |
| CN114072513A (zh) * | 2019-06-27 | 2022-02-18 | Emd密理博公司 | 用表达永生化蛋白的自我复制型rna载体的细胞扩增 |
| IL294290A (en) | 2019-12-31 | 2022-08-01 | Elixirgen Therapeutics Inc | Temperature-based transient delivery of nucleic acids and proteins to cells and tissues |
| CA3167611A1 (en) | 2020-02-13 | 2021-08-19 | Etienne Simon-Loriere | Nucleic acid vaccine against the sars-cov-2 coronavirus |
| KR102462990B1 (ko) * | 2020-03-17 | 2022-11-07 | 에이비온 주식회사 | 인비트로 트랜스크립트 mRNA 및 이를 함유하는 약학조성물 |
| WO2022002783A1 (en) | 2020-06-29 | 2022-01-06 | Glaxosmithkline Biologicals Sa | Adjuvants |
| US11771652B2 (en) | 2020-11-06 | 2023-10-03 | Sanofi | Lipid nanoparticles for delivering mRNA vaccines |
| GB202020063D0 (en) | 2020-12-17 | 2021-02-03 | Imperial College Innovations Ltd | RNA construct |
| GB202020061D0 (en) | 2020-12-17 | 2021-02-03 | Imp College Innovations Ltd | RNA construct |
| GB202020064D0 (en) | 2020-12-17 | 2021-02-03 | Imperial College Innovations Ltd | RNA construct |
| CN112852841A (zh) | 2021-02-03 | 2021-05-28 | 郑州大学 | 一种高效表达目的蛋白的顺式复制子rna构建体 |
| US20240181038A1 (en) | 2021-03-26 | 2024-06-06 | Glaxosmithkline Biologicals Sa | Immunogenic compositions |
| KR20240006575A (ko) | 2021-04-26 | 2024-01-15 | 앵스띠뛰 파스퇴르 | SARS-CoV-2에 대한 사람 중화 모노클로날 항체 및 이의 용도 |
| JP2024517848A (ja) * | 2021-05-04 | 2024-04-23 | モグリファイ リミテッド | 細胞変換 |
| EP4346894A1 (en) | 2021-05-24 | 2024-04-10 | GlaxoSmithKline Biologicals S.A. | Adjuvants |
| US20220396798A1 (en) * | 2021-06-12 | 2022-12-15 | Shi-Lung Lin | Novel mrna composition and production method for use in anti-viral and anti-cancer vaccines |
| AU2022294274A1 (en) | 2021-06-18 | 2024-02-01 | Sanofi Pasteur Inc. | Multivalent influenza vaccines |
| WO2023020993A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023020994A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| EP4387596A1 (en) | 2021-08-16 | 2024-06-26 | GlaxoSmithKline Biologicals SA | Low-dose lyophilized rna vaccines and methods for preparing and using the same |
| US20240350410A1 (en) | 2021-08-16 | 2024-10-24 | Glaxosmithkline Biologicals Sa | Freeze-drying of lipid nanoparticles (lnps) encapsulating rna and formulations thereof |
| WO2023020992A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| AU2021461416A1 (en) | 2021-08-24 | 2024-02-22 | BioNTech SE | In vitro transcription technologies |
| WO2023056980A1 (zh) * | 2021-10-09 | 2023-04-13 | 吴可行 | 自复制rna分子设计及其应用 |
| WO2023066874A1 (en) | 2021-10-18 | 2023-04-27 | BioNTech SE | Methods for determining mutations for increasing modified replicable rna function and related compositions and their use |
| EP4169578A1 (en) | 2021-10-22 | 2023-04-26 | BioNTech SE | Oligosaccharide compounds and complexes |
| EP4186528A1 (en) | 2021-11-30 | 2023-05-31 | BioNTech SE | Oligosaccharide complexes and uses |
| EP4402149A1 (en) | 2021-10-22 | 2024-07-24 | BioNTech SE | Disulfide oligosaccharide compounds and complexes |
| EP4285932A1 (en) | 2022-05-30 | 2023-12-06 | BioNTech SE | Oligosaccharide complexes and uses |
| EP4285933A1 (en) | 2022-05-30 | 2023-12-06 | BioNTech SE | Oligosaccharide complexes and uses |
| EP4169579A1 (en) | 2021-10-22 | 2023-04-26 | BioNTech SE | Disulfide oligosaccharide compounds and complexes |
| WO2023067125A1 (en) | 2021-10-22 | 2023-04-27 | BioNTech SE | Oligosaccharide complexes and uses |
| EP4401838A1 (en) | 2021-10-22 | 2024-07-24 | BioNTech SE | Oligosaccharide compounds and complexes |
| WO2023067126A1 (en) | 2021-10-22 | 2023-04-27 | BioNTech SE | Oligosaccharide compounds and complexes |
| JP2024540979A (ja) | 2021-10-22 | 2024-11-06 | ビオンテック・ソシエタス・エウロパエア | オリゴ糖複合体及び用途 |
| EP4286394A1 (en) | 2022-05-30 | 2023-12-06 | BioNTech SE | Oligosaccharide compounds and complexes |
| EP4286004A1 (en) | 2022-05-30 | 2023-12-06 | BioNTech SE | Disulfide oligosaccharide compounds and complexes |
| EP4169534A1 (en) | 2021-10-22 | 2023-04-26 | BioNTech SE | Oligosaccharide complexes and uses |
| EP4169580A1 (en) | 2021-10-22 | 2023-04-26 | BioNTech SE | Oligosaccharide compounds and complexes |
| EP4286003A1 (en) | 2022-05-30 | 2023-12-06 | BioNTech SE | Oligosaccharide compounds and complexes |
| US20230302112A1 (en) | 2021-11-05 | 2023-09-28 | Sanofi | Respiratory synctial virus rna vaccine |
| WO2023083434A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Rna encoding peptidoglycan hydrolase and use thereof for treating bacterial infection |
| EP4448103A1 (en) | 2021-12-17 | 2024-10-23 | Sanofi | Lyme disease rna vaccine |
| KR20250008765A (ko) | 2022-05-06 | 2025-01-15 | 사노피 | 핵산 백신에 대한 신호 서열 |
| JP2025518221A (ja) | 2022-05-30 | 2025-06-12 | ビオンテック・ソシエタス・エウロパエア | 核酸の送達のための複合体 |
| AU2023330867A1 (en) | 2022-08-22 | 2025-03-06 | Sanofi Pasteur Inc. | Vaccines against coronaviruses |
| WO2024068674A1 (en) | 2022-09-26 | 2024-04-04 | BioNTech SE | Nucleic acid complexes and uses thereof |
| WO2024086549A1 (en) * | 2022-10-17 | 2024-04-25 | The University Of North Carolina At Chapel Hill | Chimeric alphaviruses for directed evolution |
| EP4605010A1 (en) | 2022-10-21 | 2025-08-27 | BioNTech SE | Nucleic acid complexes and uses thereof |
| WO2024083345A1 (en) | 2022-10-21 | 2024-04-25 | BioNTech SE | Methods and uses associated with liquid compositions |
| CN120152987A (zh) | 2022-11-04 | 2025-06-13 | 赛诺菲巴斯德有限公司 | 呼吸道合胞病毒rna疫苗接种 |
| EP4619531A1 (en) | 2022-11-18 | 2025-09-24 | Trustees of Boston University | Self-replicating rna and uses thereof |
| WO2024126847A1 (en) | 2022-12-15 | 2024-06-20 | Sanofi | Mrna recombinant capping enzymes |
| EP4637812A1 (en) | 2022-12-19 | 2025-10-29 | GlaxoSmithKline Biologicals S.A. | Hepatitis b compositions |
| WO2024133550A1 (en) | 2022-12-22 | 2024-06-27 | Vector Biopharma Ag | Eukaryotic self-amplifying system |
| EP4669348A1 (en) | 2023-02-24 | 2025-12-31 | BioNTech SE | IMMUNOGENEOUS COMPOSITIONS |
| AR132053A1 (es) | 2023-03-02 | 2025-05-21 | Sanofi Pasteur | Composiciones para su uso en el tratamiento de clamidia |
| EP4442276A1 (en) | 2023-04-07 | 2024-10-09 | Institut Pasteur | Combined antibodies against sarbecoviruses and uses thereof |
| TW202500750A (zh) | 2023-05-05 | 2025-01-01 | 法商賽諾菲公司 | 用於治療痤瘡的組成物 |
| TW202508620A (zh) | 2023-05-10 | 2025-03-01 | 尼可拉斯 克拉克 | 呼吸道mrna組合疫苗 |
| WO2024236192A1 (en) | 2023-05-17 | 2024-11-21 | Institut Pasteur | Heterodimer of poxvirus a16 and g9 proteins as an immunogen |
| EP4474015A1 (en) | 2023-06-05 | 2024-12-11 | Veterna Srl | Noda-like rna-vaccine pharmacon and production and uses thereof |
| AR133317A1 (es) | 2023-07-19 | 2025-09-17 | Sanofi Sa | Constructos antigénicos de porphyromonas gingivalis |
| WO2025027089A1 (en) | 2023-08-01 | 2025-02-06 | BioNTech SE | Ionizable thiolipids and uses thereof |
| WO2025026545A1 (en) | 2023-08-01 | 2025-02-06 | BioNTech SE | Ionizable thioplipids and uses thereof |
| WO2025052001A1 (en) | 2023-09-07 | 2025-03-13 | Mnemo Therapeutics | Methods and compositions for improving immune response |
| EP4520334A1 (en) | 2023-09-07 | 2025-03-12 | Mnemo Therapeutics | Methods and compositions for improving immune response |
| KR20250055419A (ko) * | 2023-10-16 | 2025-04-24 | 한국생명공학연구원 | 단백질 번역 효율 향상용 RNA 구조체, 이를 포함하는 mRNA 구조체 및 이의 용도 |
| WO2025096982A1 (en) * | 2023-11-02 | 2025-05-08 | Amplitude Therapeutics, Inc. | Trans amplifying rnas comprising chemically modified nucleobases |
| WO2025124711A1 (en) | 2023-12-13 | 2025-06-19 | BioNTech SE | Glycolipid compositions |
| TW202525287A (zh) | 2023-12-21 | 2025-07-01 | 德商拜恩技術運輸科技有限責任公司 | 可離子化脂質 |
| WO2025134066A1 (en) | 2023-12-21 | 2025-06-26 | Biontech Delivery Technologies Gmbh | Ionizable lipids |
| WO2025153707A1 (en) | 2024-01-19 | 2025-07-24 | Spikimm | Broadly sars-cov-2 neutralizing monoclonal antibodies and uses thereof |
| WO2025157249A1 (zh) * | 2024-01-24 | 2025-07-31 | 南京金斯瑞生物科技有限公司 | 一种自复制rna及其用途 |
| WO2025217136A2 (en) * | 2024-04-08 | 2025-10-16 | Amplitude Therapeutics, Inc. | Trans-amplifying rnas encoding immunomodulators |
| EP4656648A1 (en) | 2024-05-31 | 2025-12-03 | Consejo Superior De Investigaciones Científicas | Immunomodulatory thiourea and urea carbohydrate compounds and uses thereof |
| WO2025262460A1 (en) | 2024-06-21 | 2025-12-26 | BioNTech SE | Lipid compositions for nucleic acid delivery |
| WO2026008743A1 (en) | 2024-07-02 | 2026-01-08 | Sanofi Pasteur Inc. | Water-soluble polyanionic polymer as adjuvant for carrier-formulated nucleic acid |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2374534T3 (es) * | 1998-03-20 | 2012-02-17 | Commonwealth Scientific And Industrial Research Organisation | Control de la expresión de genes. |
| AU3618300A (en) | 1999-03-09 | 2000-09-28 | Large Scale Biology Corporation | Multiple component rna vector system for expression of foreign sequences |
| ATE373721T1 (de) * | 2000-08-29 | 2007-10-15 | Wyeth Corp | Verpackung von replikon-partikeln eines positiv- strängigen rna-virus |
| ES2624854T3 (es) * | 2001-05-31 | 2017-07-17 | Glaxosmithkline Biologicals Sa | Partículas de replicón de alfavirus quimérico |
| US20030232324A1 (en) * | 2001-05-31 | 2003-12-18 | Chiron Corporation | Chimeric alphavirus replicon particles |
| US7045335B2 (en) | 2001-09-06 | 2006-05-16 | Alphavax, Inc. | Alphavirus replicon vector systems |
| CA2480504A1 (en) | 2002-04-01 | 2003-10-16 | Evelina Angov | Method of designing synthetic nucleic acid sequences for optimal protein expression in a host cell |
| KR101518309B1 (ko) * | 2003-03-20 | 2015-05-08 | 알파벡스, 인크. | 개선된 알파바이러스 레플리콘 및 헬퍼 구축물 |
| EP1766034B1 (en) * | 2004-05-21 | 2014-03-19 | Novartis Vaccines and Diagnostics, Inc. | Alphavirus vectors for influenza virus vaccines |
| WO2008119827A1 (en) * | 2007-04-02 | 2008-10-09 | Fit Biotech Oy | Transreplicase constructs |
| ES2500515T3 (es) | 2007-06-19 | 2014-09-30 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Síntesis y utilización de análogos de fosforotioato antiinversos de la caperuza de ARN mensajero |
| EP2183368B1 (en) * | 2007-06-21 | 2016-08-10 | Alphavax, Inc. | Promoterless cassettes for expression of alphavirus structural proteins |
| DK3216802T3 (da) | 2007-08-20 | 2021-01-04 | Glaxo Group Ltd | Produktionsfremgangsmåde |
| PL215513B1 (pl) | 2008-06-06 | 2013-12-31 | Univ Warszawski | Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka |
| DE102008061522A1 (de) | 2008-12-10 | 2010-06-17 | Biontech Ag | Verwendung von Flt3-Ligand zur Verstärkung von Immunreaktionen bei RNA-Immunisierung |
| EP2281579A1 (en) | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
| CN103052400B (zh) * | 2010-07-06 | 2016-11-16 | 诺华股份有限公司 | 自我复制rna分子的病毒样递送颗粒 |
| ES2557382T3 (es) | 2010-07-06 | 2016-01-25 | Glaxosmithkline Biologicals Sa | Liposomas con lípidos que tienen un valor de pKa ventajoso para el suministro de ARN |
| US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
| CN108042799A (zh) | 2010-07-06 | 2018-05-18 | 诺华股份有限公司 | 阳离子水包油乳液 |
| EP4226941B1 (en) | 2010-08-31 | 2024-10-23 | GlaxoSmithKline Biologicals SA | Pegylated liposomes for delivery of immunogen-encoding rna |
| TR201908635T4 (tr) | 2010-08-31 | 2019-07-22 | Glaxosmithkline Biologicals Sa | Protein kodlayıcı rna?nın lipozomal verilmesine uygun lipitler. |
| PT4008357T (pt) | 2010-08-31 | 2023-01-11 | Glaxosmithkline Biologicals Sa | Lipossomas pequenos para entrega de arn que codifica um imunogénio |
| KR102162111B1 (ko) | 2010-10-11 | 2020-10-07 | 노파르티스 아게 | 항원 전달 플랫폼 |
| JP6059220B2 (ja) | 2011-07-06 | 2017-01-18 | ノバルティス アーゲー | 核酸を含む水中油型エマルジョン |
| CN103796639B (zh) | 2011-07-06 | 2017-05-31 | 诺华股份有限公司 | 阳离子水包油乳液 |
| ES2861428T3 (es) | 2011-07-06 | 2021-10-06 | Glaxosmithkline Biologicals Sa | Liposomas que presentan una relación N:P útil para suministro de moléculas de ARN |
| EP3332802A1 (en) * | 2011-07-06 | 2018-06-13 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
| PT2750707T (pt) | 2011-08-31 | 2019-01-23 | Glaxosmithkline Biologicals Sa | Lipossomas peguilados para distribuição de arn que codifica imunogénio |
| MX2014004214A (es) | 2011-10-11 | 2014-05-07 | Novartis Ag | Moleculas de acido ribonucleico policistronicas auto-replicantes recombinantes. |
| MX387666B (es) | 2011-11-11 | 2025-03-18 | Variation Biotechnologies Inc | Composiciones y su uso en el tratamiento de citomegalovirus |
| WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
| ES2969742T3 (es) | 2012-03-27 | 2024-05-22 | CureVac SE | Moléculas artificiales de ácido nucleico para la expresión mejorada de proteínas o péptidos |
| BR112014023800A2 (pt) | 2012-03-27 | 2017-07-18 | Curevac Gmbh | moléculas de ácidos nucleicos artificiais |
| WO2014071963A1 (en) | 2012-11-09 | 2014-05-15 | Biontech Ag | Method for cellular rna expression |
| WO2014170493A2 (en) * | 2013-04-19 | 2014-10-23 | Novartis Ag | Alphavirus vector |
| WO2016005004A1 (en) | 2014-07-11 | 2016-01-14 | Biontech Rna Pharmaceuticals Gmbh | Stabilization of poly(a) sequence encoding dna sequences |
| EP4368702A3 (en) * | 2017-09-13 | 2024-08-14 | BioNTech SE | Method of enhancing rna expression in a cell |
-
2016
- 2016-03-21 WO PCT/EP2016/056160 patent/WO2017162265A1/en not_active Ceased
-
2017
- 2017-03-13 SM SM20210634T patent/SMT202100634T1/it unknown
- 2017-03-13 ES ES17710268T patent/ES2896927T3/es active Active
- 2017-03-13 HR HRP20211715TT patent/HRP20211715T1/hr unknown
- 2017-03-13 IL IL261327A patent/IL261327B2/en unknown
- 2017-03-13 PT PT177102688T patent/PT3433368T/pt unknown
- 2017-03-13 RS RS20211377A patent/RS62543B1/sr unknown
- 2017-03-13 MA MA44479A patent/MA44479B1/fr unknown
- 2017-03-13 LT LTEPPCT/EP2017/055813T patent/LT3433368T/lt unknown
- 2017-03-13 RU RU2018131783A patent/RU2752580C2/ru active
- 2017-03-13 DK DK17710268.8T patent/DK3433368T3/da active
- 2017-03-13 AU AU2017236240A patent/AU2017236240B2/en active Active
- 2017-03-13 WO PCT/EP2017/055813 patent/WO2017162461A1/en not_active Ceased
- 2017-03-13 BR BR112018068391A patent/BR112018068391A2/pt not_active Application Discontinuation
- 2017-03-13 CN CN202211115420.5A patent/CN115386596A/zh not_active Withdrawn
- 2017-03-13 US US16/086,127 patent/US12338448B2/en active Active
- 2017-03-13 EP EP21200788.4A patent/EP3964584A1/en active Pending
- 2017-03-13 SG SG11201807378SA patent/SG11201807378SA/en unknown
- 2017-03-13 HU HUE17710268A patent/HUE058889T2/hu unknown
- 2017-03-13 MX MX2018011384A patent/MX2018011384A/es unknown
- 2017-03-13 SI SI201730973T patent/SI3433368T1/sl unknown
- 2017-03-13 PL PL17710268T patent/PL3433368T3/pl unknown
- 2017-03-13 KR KR1020187027526A patent/KR102441725B1/ko active Active
- 2017-03-13 MD MDE20190126T patent/MD3433368T2/ro unknown
- 2017-03-13 JP JP2018549306A patent/JP7105193B2/ja active Active
- 2017-03-13 EP EP17710268.8A patent/EP3433368B1/en active Active
- 2017-03-13 CN CN201780018575.8A patent/CN109328233B/zh active Active
-
2018
- 2018-08-17 ZA ZA201805520A patent/ZA201805520B/en unknown
-
2019
- 2019-08-15 ZA ZA2019/05396A patent/ZA201905396B/en unknown
-
2021
- 2021-09-30 JP JP2021160491A patent/JP7421256B2/ja active Active
- 2021-11-03 CY CY20211100949T patent/CY1124689T1/el unknown
-
2025
- 2025-05-23 US US19/216,945 patent/US20250290095A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2018011384A (es) | Arn de replicacion en trans. | |
| MX2020006065A (es) | Metodos y productos para la produccion y administracion de acido nucleico. | |
| MX2020010871A (es) | Compuestos de 5'-caperuza-trinucleótidos u oligonucleótidos superiores y sus usos en estabilizar arn, que expresan proteínas y en la terapia. | |
| SA518400424B1 (ar) | جزيئات الجسم المضاد لعلاج السرطان | |
| MX2019004499A (es) | Sistemas de replicón de virus recombinante y usos de estos. | |
| MX2021000211A (es) | Metodos y productos para transfeccion de celulas. | |
| MX357803B (es) | Moléculas de ácido nucleico artificiales. | |
| SG10201906673WA (en) | Artificial nucleic acid molecules | |
| PH12020551039A1 (en) | Non-viral dna vectors and uses thereof for antibody and fusion protein production | |
| MX2018011383A (es) | Replicon de arn para la expresion genica versatil y eficiente. | |
| WO2014172470A3 (en) | Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal | |
| WO2017077329A3 (en) | Nucleic acids, peptides and methods | |
| DOP2022000060A (es) | Proteínas de fijación multiespecíficas para tratamiento contra el cáncer | |
| AU2016277883A8 (en) | PD-1-CD28 fusion proteins and their use in medicine | |
| EA201492202A1 (ru) | Способ экспрессии гетерологичных белков с использованием рекомбинантного вирусного вектора с минус-нитью рнк | |
| MX2013008836A (es) | Moleculas de acido nucleico que codifican novedosos antigenos de herpes, vacunas que las comprenden y metodos para su uso. | |
| MX2019002345A (es) | Moleculas artificiales de acido nucleico para la expresion mejorada de proteina o peptido. | |
| EA201692359A1 (ru) | Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса | |
| SG10201809146QA (en) | Recombinant host cell engineered to overexpress helper proteins | |
| MX2016009149A (es) | Variantes mejoradas de enzimas. | |
| MX2021009554A (es) | Produccion de virus en cultivos celulares. | |
| RU2015143513A (ru) | Микровезикула и способ ее получения | |
| AR100310A1 (es) | Moléculas para transporte de antígeno modular mejoradas y sus usos | |
| PH12019502442A1 (en) | Variants of human bmp7 protein | |
| WO2013046216A8 (en) | Two plasmid mammalian expression system |