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MX2018010727A - Acido (2s,4r)-5-(5'-cloro-2'-fluoro-[1,1'-bifenil]-4-il)-2-(etoxim etil)-4-(3-hidroxiisoxazol-5-carboxamido)-2-metilpentanoico cristalino, y sus usos. - Google Patents

Acido (2s,4r)-5-(5'-cloro-2'-fluoro-[1,1'-bifenil]-4-il)-2-(etoxim etil)-4-(3-hidroxiisoxazol-5-carboxamido)-2-metilpentanoico cristalino, y sus usos.

Info

Publication number
MX2018010727A
MX2018010727A MX2018010727A MX2018010727A MX2018010727A MX 2018010727 A MX2018010727 A MX 2018010727A MX 2018010727 A MX2018010727 A MX 2018010727A MX 2018010727 A MX2018010727 A MX 2018010727A MX 2018010727 A MX2018010727 A MX 2018010727A
Authority
MX
Mexico
Prior art keywords
crystalline
methylpenthane
ethyxim
bifenil
hydroxyisoxazol
Prior art date
Application number
MX2018010727A
Other languages
English (en)
Other versions
MX377177B (es
Inventor
Fleury Melissa
Rapta Miroslav
d hughes Adam
Timothy Fass Gene
R Thalladi Venkat
Simeone Michael
Michael Baldwin R
L Bourdet David
Original Assignee
Theravance Biopharma R&D Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58387911&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2018010727(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
Publication of MX2018010727A publication Critical patent/MX2018010727A/es
Publication of MX377177B publication Critical patent/MX377177B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

En un aspecto, la invención se refiere a una forma cristalina de la estructura: (ver Fórmula) o una sal farmacéuticamente aceptable de la misma, que tiene actividad inhibitoria de la neprilisina. En otro aspecto, la invención se refiere a composiciones farmacéuticas que comprenden esta forma cristalina; métodos de uso de esta forma cristalina y su forma soluble (I); y procesos para preparar formas solubles (I) y cristalinas (I´).
MX2018010727A 2016-03-08 2017-03-07 Acido (2s,4r)-5-(5'-cloro-2'-fluoro-[1,1'-bifenil]-4-il)-2-(etoximetil)-4-(3-hidroxiisoxazol-5-carboxamido)-2-metilpentanoico cristalino, y sus usos. MX377177B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662305393P 2016-03-08 2016-03-08
US201662346336P 2016-06-06 2016-06-06
PCT/US2017/021172 WO2017156009A1 (en) 2016-03-08 2017-03-07 Crystalline(2s,4r)-5-(5'-chloro-2'-fluoro-[1,1'-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof

Publications (2)

Publication Number Publication Date
MX2018010727A true MX2018010727A (es) 2019-01-24
MX377177B MX377177B (es) 2025-03-07

Family

ID=58387911

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018010727A MX377177B (es) 2016-03-08 2017-03-07 Acido (2s,4r)-5-(5'-cloro-2'-fluoro-[1,1'-bifenil]-4-il)-2-(etoximetil)-4-(3-hidroxiisoxazol-5-carboxamido)-2-metilpentanoico cristalino, y sus usos.

Country Status (30)

Country Link
US (6) US10100021B2 (es)
EP (1) EP3408260B1 (es)
JP (2) JP7306828B2 (es)
KR (2) KR20220035991A (es)
CN (1) CN108779084A (es)
AU (1) AU2017229466C1 (es)
CA (1) CA3015505C (es)
CL (1) CL2018002539A1 (es)
CO (1) CO2018010568A2 (es)
CY (1) CY1124397T1 (es)
DK (1) DK3408260T3 (es)
ES (1) ES2880123T3 (es)
HR (1) HRP20211169T1 (es)
HU (1) HUE055546T2 (es)
IL (1) IL261244B (es)
LT (1) LT3408260T (es)
MX (1) MX377177B (es)
MY (1) MY198185A (es)
PH (1) PH12018501876A1 (es)
PL (1) PL3408260T3 (es)
PT (1) PT3408260T (es)
RS (1) RS62172B1 (es)
RU (1) RU2756223C2 (es)
SA (1) SA518392325B1 (es)
SG (1) SG11201807591VA (es)
SI (1) SI3408260T1 (es)
SM (1) SMT202100434T1 (es)
TW (1) TWI731943B (es)
WO (1) WO2017156009A1 (es)
ZA (1) ZA201805840B (es)

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* Cited by examiner, † Cited by third party
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SMT202100434T1 (it) 2016-03-08 2021-09-14 Theravance Biopharma R&D Ip Llc Acido (2s,4r)-5-(5’-cloro-2-fluoro-[1,1’-bifenil]-4-il)-2-(etossimetil)-4-(3-idrossiisossazol-5-carbossammido)-2-metilpentanoico cristallino e suoi usi
JP7316449B2 (ja) * 2019-09-20 2023-07-27 シェンヅェン サルブリス ファーマシューティカルズ カンパニー リミテッド 心不全治療におけるアンジオテンシンｉｉ受容体アンタゴニスト代謝産物とｎｅｐ阻害剤との複合体の使用
KR102485499B1 (ko) * 2022-07-15 2023-01-09 오가노이드사이언스 주식회사 신장 질환의 치료 또는 예방용 조성물

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SMT202100434T1 (it) 2016-03-08 2021-09-14 Theravance Biopharma R&D Ip Llc Acido (2s,4r)-5-(5’-cloro-2-fluoro-[1,1’-bifenil]-4-il)-2-(etossimetil)-4-(3-idrossiisossazol-5-carbossammido)-2-metilpentanoico cristallino e suoi usi

Also Published As

Publication number Publication date
ZA201805840B (en) 2019-07-31
AU2017229466A1 (en) 2018-09-13
PH12018501876A1 (en) 2019-01-28
US20200157061A1 (en) 2020-05-21
MY198185A (en) 2023-08-09
AU2017229466B2 (en) 2020-08-13
ES2880123T3 (es) 2021-11-23
HUE055546T2 (hu) 2021-12-28
PT3408260T (pt) 2021-07-23
CA3015505A1 (en) 2017-09-14
SA518392325B1 (ar) 2022-08-03
CY1124397T1 (el) 2022-07-22
TWI731943B (zh) 2021-07-01
RU2018135072A (ru) 2020-04-08
US10472335B2 (en) 2019-11-12
EP3408260A1 (en) 2018-12-05
RU2756223C2 (ru) 2021-09-28
US11718591B2 (en) 2023-08-08
CA3015505C (en) 2024-03-05
US20240327360A1 (en) 2024-10-03
TW201741290A (zh) 2017-12-01
US12351561B2 (en) 2025-07-08
WO2017156009A1 (en) 2017-09-14
JP2022017433A (ja) 2022-01-25
KR20180114225A (ko) 2018-10-17
IL261244A (en) 2018-10-31
US20170275259A1 (en) 2017-09-28
US20220242836A1 (en) 2022-08-04
CL2018002539A1 (es) 2018-10-26
RU2018135072A3 (es) 2020-10-15
US20190002416A1 (en) 2019-01-03
BR112018068170A2 (pt) 2019-01-29
AU2017229466C1 (en) 2021-02-11
US10100021B2 (en) 2018-10-16
SI3408260T1 (sl) 2021-08-31
JP2019509286A (ja) 2019-04-04
EP3408260B1 (en) 2021-05-05
SG11201807591VA (en) 2018-10-30
JP7306828B2 (ja) 2023-07-11
HRP20211169T1 (hr) 2021-11-12
RS62172B1 (sr) 2021-08-31
DK3408260T3 (da) 2021-08-02
CO2018010568A2 (es) 2018-10-22
US11230536B2 (en) 2022-01-25
SMT202100434T1 (it) 2021-09-14
KR20220035991A (ko) 2022-03-22
IL261244B (en) 2022-02-01
MX377177B (es) 2025-03-07
US20210061776A1 (en) 2021-03-04
CN108779084A (zh) 2018-11-09
US10752599B2 (en) 2020-08-25
LT3408260T (lt) 2021-07-26
PL3408260T3 (pl) 2021-11-08

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