[go: up one dir, main page]

MX2018010272A - Composicion farmaceutica que comprende compuesto heterociclico de seis miembros fusionado con pirrolo. - Google Patents

Composicion farmaceutica que comprende compuesto heterociclico de seis miembros fusionado con pirrolo.

Info

Publication number
MX2018010272A
MX2018010272A MX2018010272A MX2018010272A MX2018010272A MX 2018010272 A MX2018010272 A MX 2018010272A MX 2018010272 A MX2018010272 A MX 2018010272A MX 2018010272 A MX2018010272 A MX 2018010272A MX 2018010272 A MX2018010272 A MX 2018010272A
Authority
MX
Mexico
Prior art keywords
pharmaceutical composition
heterociclic
pirrolo
composite fused
methyl
Prior art date
Application number
MX2018010272A
Other languages
English (en)
Other versions
MX380108B (es
Inventor
Lu Yun
Zhang Xinhua
Wang Chenyang
Liu Tonghui
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2018010272A publication Critical patent/MX2018010272A/es
Publication of MX380108B publication Critical patent/MX380108B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención proporciona una composición farmacéutica que comprende un compuesto heterocíclico de seis miembros fusionado con pirrolo o una sal farmacéuticamente aceptable del compuesto. Específicamente, la invención proporciona una composición farmacéutica que comprende 5-(2-dietilamino-etil)-2-(5 -fluoro-2-oxo-1,2-dihidro-indol-3-iliden-metil)-3-5 metil-1,5,6,7-tetrahidro-pirrol o[3,2-c]piridín-4-ona o una sal farmacéuticamente aceptable de lo mismo, y al menos un agente de relleno hidrosoluble. La composición farmacéutica de la invención presenta una rápida disolución y buena estabilidad.
MX2018010272A 2016-03-01 2017-02-28 Composicion farmaceutica que comprende compuesto heterociclico de seis miembros fusionado con pirrolo MX380108B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610116472 2016-03-01
PCT/CN2017/075111 WO2017148359A1 (zh) 2016-03-01 2017-02-28 一种含有吡咯并六元杂环化合物或其可药用盐的药物组合物

Publications (2)

Publication Number Publication Date
MX2018010272A true MX2018010272A (es) 2018-12-19
MX380108B MX380108B (es) 2025-03-11

Family

ID=59743470

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018010272A MX380108B (es) 2016-03-01 2017-02-28 Composicion farmaceutica que comprende compuesto heterociclico de seis miembros fusionado con pirrolo

Country Status (17)

Country Link
US (1) US10973807B2 (es)
EP (1) EP3424500B1 (es)
JP (1) JP6948760B2 (es)
KR (1) KR20180112066A (es)
CN (1) CN107530331B (es)
AU (1) AU2017226420B2 (es)
BR (1) BR112018017155A2 (es)
CA (1) CA3015249A1 (es)
DK (1) DK3424500T3 (es)
ES (1) ES2907376T3 (es)
HU (1) HUE057830T2 (es)
MX (1) MX380108B (es)
PL (1) PL3424500T3 (es)
PT (1) PT3424500T (es)
RU (1) RU2737734C2 (es)
TW (1) TWI750152B (es)
WO (1) WO2017148359A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111184693B (zh) * 2019-05-29 2023-07-21 百济神州(苏州)生物科技有限公司 一种raf激酶抑制剂制剂及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101007814A (zh) 2006-01-27 2007-08-01 上海恒瑞医药有限公司 吡咯并六元杂环化合物及其在医药上的用途
DK1973910T3 (da) * 2006-01-27 2013-08-12 Shanghai Hengrui Pharm Co Ltd Pyrrolo[3,2-c]pyridin-4-on-2-indolinon-proteinkinaseinhibitorer
CN101007815B (zh) * 2006-01-27 2010-06-23 江苏恒瑞医药股份有限公司 吡咯并六元杂环化合物及其在医药上的用途
EP2113248A1 (en) * 2008-04-29 2009-11-04 Ratiopharm GmbH Pharmaceutical composition comprising N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2-,4-dimethyl-1H-pyrrole-3-carboxamide
EP2468258A1 (en) * 2010-12-22 2012-06-27 LEK Pharmaceuticals d.d. Process for the preparation of a pharmaceutical composition comprising a low soluble pharmaceutically active ingredient
CN102266300B (zh) 2011-07-14 2013-01-02 广东药学院 一种吉非替尼分散片及其制备方法和应用

Also Published As

Publication number Publication date
JP6948760B2 (ja) 2021-10-13
EP3424500A1 (en) 2019-01-09
AU2017226420B2 (en) 2022-07-07
EP3424500A4 (en) 2019-10-02
DK3424500T3 (da) 2022-02-21
JP2019507151A (ja) 2019-03-14
AU2017226420A1 (en) 2018-08-30
US10973807B2 (en) 2021-04-13
CN107530331A (zh) 2018-01-02
ES2907376T3 (es) 2022-04-25
KR20180112066A (ko) 2018-10-11
TWI750152B (zh) 2021-12-21
BR112018017155A2 (pt) 2018-12-26
MX380108B (es) 2025-03-11
RU2018132929A (ru) 2020-04-01
US20190054073A1 (en) 2019-02-21
WO2017148359A1 (zh) 2017-09-08
RU2737734C2 (ru) 2020-12-02
EP3424500B1 (en) 2022-01-26
CA3015249A1 (en) 2017-09-08
PT3424500T (pt) 2022-02-07
PL3424500T3 (pl) 2022-04-04
CN107530331B (zh) 2018-12-04
HUE057830T2 (hu) 2022-06-28
TW201731508A (zh) 2017-09-16
RU2018132929A3 (es) 2020-05-13

Similar Documents

Publication Publication Date Title
SV2017005426A (es) Derivados de feniltriazol sustituido con hidroxialquilo y sus usos
HUE054690T2 (hu) 8-Oxetán-3-il-3,8-diazabiciklo[3.2.1]oktán-3-il-csoporttal szubsztituált vegyületek HIV inhibitorokként
DOP2017000306A (es) Formulaciones farmacéuticas que contienen tenofovir y emtricitabina
PE20170523A1 (es) Formulacion en forma de tableta de 2-fluor-n-metil-4-[7-(quinolin-6-ylmetil)imidazo[1,2- b][1,2,4]triazin-2-il]benzamida
CL2017001483A1 (es) Formulación de relación fija de insulina glargina/lixisenatida
PL3402480T4 (pl) Kompozycje i sposoby dożylnego podawania 2-bromo-1-(3,3-dinitroazetydyn-1-ylo)etanonu
WO2017135791A8 (en) Anti-c-met antibodies and uses thereof
WO2015181624A3 (en) Nucleoside derivatives for the treatment of cancer
CO2019015102A2 (es) Nuevos derivados de xantina sustituidos
MX2019003097A (es) Composicion farmaceutica.
CU24650B1 (es) Combinaciones que incluyen abx196 útiles en el tratamiento del cáncer
EP3539978A4 (en) FRAGMENT OF NKX3.2 AND PHARMACEUTICAL COMPOSITION CONSISTING IT AS AN ACTIVE SUBSTANCE
MX2018010272A (es) Composicion farmaceutica que comprende compuesto heterociclico de seis miembros fusionado con pirrolo.
BR112017024126B8 (pt) Composições farmacêuticas, composto a micronizado e/ou pelo menos um sal farmaceuticamente aceitável micronizado do composto a e uso dos mesmos
MX2019005708A (es) Bolsa medica con dos compartimientos que incluye una pesta?a.
Baran An exceptional isomorphism between level 13 modular curves via Torelli’s theorem
CL2017000026A1 (es) Formas de dosificación farmacéutica
IL264538B2 (en) A new use of n,n-bis-2-mercaptoethyl isophthalamide
EA202091403A1 (ru) Производные 2-оксо-1-пирролидинилимидазотиадиазола
WO2016045616A3 (zh) 一种含有银杏内酯b和血小板前列素环氧酶抑制剂的药物组合物及其制备方法和用途
Uzer Fever, diarrhoea and rash: case report
BR112019007459A2 (pt) pós secos antifúngicos
HK1230926A1 (en) Pharmaceutical agent
HK40000756A (en) Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone
IT201700082381A1 (it) Procedimento per l'ottenimento di una protezione per pantaloni o pantaloncini da ciclisti.