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MX2018009738A - Anticuerpos monoclonales de proteína ns1 anti-virus del dengue. - Google Patents

Anticuerpos monoclonales de proteína ns1 anti-virus del dengue.

Info

Publication number
MX2018009738A
MX2018009738A MX2018009738A MX2018009738A MX2018009738A MX 2018009738 A MX2018009738 A MX 2018009738A MX 2018009738 A MX2018009738 A MX 2018009738A MX 2018009738 A MX2018009738 A MX 2018009738A MX 2018009738 A MX2018009738 A MX 2018009738A
Authority
MX
Mexico
Prior art keywords
dengue virus
present
sample
matching
serotypes
Prior art date
Application number
MX2018009738A
Other languages
English (en)
Inventor
BOSCH Irene
Schifferli-Hamad Kimberly
MARQUEZ-GOMEZ Jose
De Puig Helena
Gehrke Lee
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of MX2018009738A publication Critical patent/MX2018009738A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C07K16/116—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)

Abstract

La presente invencion proporciona pares de anticuerpos coincidentes para la deteccion especifica de uno o mas de los cuatro serotipos del virus del dengue en una muestra biologica que puede contener uno o mas de tales serotipos del virus del dengue. Cada par de anticuerpos coincidentes es capaz de detectar no mas de un serotipo de la proteina NS1 del virus del dengue que puede estar presente en la muestra y no tendra reaccion cruzada con otros serotipos que puedan estar presentes en la muestra. Se pueden usar multiples pares coincidentes para detectar uno o mas serotipos del virus del dengue que pueden estar presentes en una muestra. Dichos anticuerpos de pares coincidentes facilitan el desarrollo de pruebas diagnosticas confirmatorias in vitro tales como inmunoensayos intercalados, que detectan y distinguen la presencia de uno o mas serotipos del virus del dengue en una muestra biologica, preferiblemente una muestra derivada de un sujeto humano. La invencion tambien proporciona kits que comprenden los pares de anticuerpos coincidentes de la invencion y metodos para usar los kits para inmunoensayos para la deteccion especifica de uno o mas serotipos del virus del dengue en una poblacion de pacientes. La presente invencion tambien proporciona anticuerpos monoclonales especificos para la proteina NS1 del virus del dengue y composiciones terapeuticas y metodos para tratar la infeccion por el virus del dengue.
MX2018009738A 2016-02-11 2017-02-10 Anticuerpos monoclonales de proteína ns1 anti-virus del dengue. MX2018009738A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662293990P 2016-02-11 2016-02-11
PCT/US2017/017385 WO2017139587A2 (en) 2016-02-11 2017-02-10 Anti-dengue virus ns1 protein monoclonal antibodies

Publications (1)

Publication Number Publication Date
MX2018009738A true MX2018009738A (es) 2019-02-07

Family

ID=58098711

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018009738A MX2018009738A (es) 2016-02-11 2017-02-10 Anticuerpos monoclonales de proteína ns1 anti-virus del dengue.

Country Status (6)

Country Link
US (2) US10551381B2 (es)
EP (2) EP3750916A3 (es)
BR (1) BR112018016337A2 (es)
CO (1) CO2018009434A2 (es)
MX (1) MX2018009738A (es)
WO (1) WO2017139587A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019039557A1 (ja) * 2017-08-24 2019-02-28 富士レビオ株式会社 ジカウイルスを検出する方法及びキット
KR102064862B1 (ko) * 2018-01-22 2020-01-10 한국세라믹기술원 금속나노입자-어피바디를 포함하는 elisa 키트 및 상기 키트를 이용한 표적 물질의 검출 방법
CN109081869B (zh) * 2018-08-28 2022-06-03 东莞市朋志生物科技有限公司 Ns1蛋白的结合蛋白
CN109134647B (zh) 2018-08-28 2020-08-04 东莞市朋志生物科技有限公司 Ns1蛋白的结合蛋白
CN109053883B (zh) * 2018-08-28 2022-06-03 东莞市朋志生物科技有限公司 Ns1蛋白的结合蛋白
BR112021008217A2 (pt) * 2018-10-31 2021-08-17 Icahn School Of Medicine At Mount Sinai anticorpos humanos que têm como alvo vírus zika ns1, polipeptídeos ns1 e seus usos
KR102048812B1 (ko) * 2018-12-19 2019-11-26 주식회사 엠디헬스케어 뎅기 바이러스 ediii에 특이적으로 결합하는 dna 압타머 및 이의 용도
CN110346557B (zh) * 2019-07-15 2023-03-31 深圳海思安生物技术有限公司 一种检测试剂盒
KR102061769B1 (ko) * 2019-11-25 2020-01-02 한국세라믹기술원 금속나노입자-어피바디를 포함하는 뎅기열 바이러스 elisa 키트 및 상기 키트를 이용한 뎅기열 바이러스의 검출 방법
CN110917213A (zh) * 2019-12-30 2020-03-27 温州激光与光电子协同创新中心 纳米碳粉外用治疗皮肤炎症的药物及其制备和应用
US20230078330A1 (en) * 2020-01-27 2023-03-16 Vanderbilt University Human anti-dengue antibodies and methods of use therefor
WO2022010736A1 (en) * 2020-07-08 2022-01-13 E25Bio, Inc. High throughput screening for monoclonal antibody pairs
WO2022169665A1 (en) * 2021-02-05 2022-08-11 Unm Rainforest Innovations Bacteriophage virus-like particle vaccines against flavivirus non-structural protein 1
EP4308276A1 (en) 2021-03-19 2024-01-24 Global Life Sciences Solutions Operations UK Ltd Viral filter and method of viral filtration
CN113683691B (zh) * 2021-08-19 2023-05-23 中国科学院微生物研究所 黄病毒抗体及其应用
CN115785262B (zh) * 2021-09-10 2023-09-22 东莞市朋志生物科技有限公司 一种抗登革ns1蛋白的抗体及其应用
CN116082499B (zh) * 2021-11-08 2023-10-27 东莞市朋志生物科技有限公司 一种抗登革ns1蛋白的抗体及其应用
CN119241691B (zh) * 2023-08-30 2025-06-20 东莞市朋志生物科技有限公司 一种抗登革病毒或其ns1蛋白的抗体及其应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104812A (en) 1989-11-27 1992-04-14 Syntex (U.S.A.) Inc. Device and method for interrupting capillary flow
US6596476B1 (en) 1989-12-22 2003-07-22 Abbott Laboratories Hepatitis C assay
IT1270951B (it) 1993-06-07 1997-05-26 Boehringer Mannheim Italia Metodo e dispositivo per il rilevamento simultano di neisseria gonorrhoeae, chlamydia trachomatis e mycoplasma
GB9324310D0 (en) 1993-11-26 1994-01-12 Univ Birmingham Liquid transfer device
IL134939A (en) 1997-10-07 2004-05-12 Ucb Sa Standard for testing substances dissolved in aqueous milk product
FR2794865B1 (fr) 1999-06-09 2003-04-18 Pasteur Institut Methode de detection precoce des flavivirus et ses applications
GB0025245D0 (en) 2000-10-14 2000-11-29 Lee Helen Multiple target detection
BR0315935A (pt) 2002-10-31 2005-09-20 Health Research Inc Teste de diagnóstico para o vìrus do nilo ocidental
JP4787938B2 (ja) 2003-03-28 2011-10-05 ザ・プロウボウスト・フェロウズ・ファウンデーション・スカラーズ・アンド・ザ・アザー・メンバーズ・オブ・ボード・オブ・ザ・カレッジ・オブ・ザ・ホリー・アンド・アンデバイデッド・トリニティ・オブ・クイーン 銀ナノ粒子を用いた検体検出用センサ
US7622113B2 (en) 2003-12-08 2009-11-24 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies that bind or neutralize dengue virus
US20050250141A1 (en) 2004-03-30 2005-11-10 Lambert James L Diagnostic assays including multiplexed lateral flow immunoassays with quantum dots
US7330050B2 (en) 2004-11-08 2008-02-12 Tabula, Inc. Storage elements for a configurable IC and method and apparatus for accessing data stored in the storage elements
AU2006242303A1 (en) 2005-05-02 2006-11-09 Anp Technologies, Inc. Polymer conjugate enhanced bioassays
WO2008070865A2 (en) 2006-12-07 2008-06-12 University Of Florida Research Foundation Inc. Materials and methods for efficient and accurate detection of analytes
CN101226196B (zh) * 2008-02-02 2012-05-09 南方医科大学 一种检测ⅱ型登革病毒ns1抗原的免疫诊断试剂盒
CN101576560A (zh) * 2008-05-08 2009-11-11 南方医科大学 检测ⅲ型登革病毒ns1抗原的免疫诊断试剂盒及其应用
US8377643B2 (en) 2009-03-16 2013-02-19 Abaxis, Inc. Split flow device for analyses of specific-binding partners
CN101551393B (zh) * 2009-04-02 2012-09-19 南方医科大学 一种检测ⅳ型登革病毒ns1抗原的免疫诊断试剂盒
CN101726593B (zh) * 2009-06-25 2012-10-17 南方医科大学 一种检测登革病毒ns1抗原的免疫诊断试剂盒及其应用
US8637035B2 (en) 2010-07-16 2014-01-28 Academia Sinica Anti-dengue virus antibodies
US9057702B2 (en) 2010-12-21 2015-06-16 The Regents Of The University Of California Compact wide-field fluorescent imaging on a mobile device
FR2974907B1 (fr) * 2011-05-06 2013-06-14 Biomerieux Sa Procede pour la detection et le serotypage precoce du virus de la dengue
WO2012162346A1 (en) 2011-05-23 2012-11-29 Charm Sciences, Inc. Lateral flow test kit and method for detecting a high molecular weight substance
EP2550945A1 (de) 2011-07-28 2013-01-30 Marlafin AG Tampon mit einem Hohlraum
CN103917870B (zh) 2011-11-16 2016-04-13 贝克顿·迪金森公司 用于检测样品中的分析物的方法和系统
GB2497750B (en) 2011-12-19 2015-02-25 Lumophore Ltd Analysis of colorimetric or fluorometric test assays
US8920804B2 (en) * 2011-12-22 2014-12-30 Inbios International, Inc. Methods and materials for the detection of dengue virus infection
WO2013163353A1 (en) 2012-04-24 2013-10-31 Arizona Board Of Regents, Acting For And On Behalf Of Northern Arizona University Rapid multiplex lateral flow assay device
WO2014025546A2 (en) 2012-08-07 2014-02-13 Massachusetts Institute Of Technology Anti-dengue virus antibodies and uses thereof
HK1215970A1 (zh) 2012-10-31 2016-09-30 阿斯图德医疗有限公司 定量的側向流測定法
GB201221015D0 (en) 2012-11-22 2013-01-09 Microlab Devices Ltd Test strip nd methods and apparatus for reading the same
EP2986987B1 (en) 2013-04-15 2018-08-08 Nanyang Technological University Electrochemical lateral flow bioassay and biosensor
US20150056687A1 (en) 2013-04-26 2015-02-26 Express Diagnostics Int'l., Inc. Lateral flow devices and methods of manufacture and use
WO2015054546A1 (en) 2013-10-10 2015-04-16 Song Diagnostic Research Llc. Improved lateral flow assays

Also Published As

Publication number Publication date
WO2017139587A2 (en) 2017-08-17
EP3414265A2 (en) 2018-12-19
EP3750916A3 (en) 2021-03-24
US10551381B2 (en) 2020-02-04
WO2017139587A3 (en) 2017-09-21
US20200363415A1 (en) 2020-11-19
US11320433B2 (en) 2022-05-03
CO2018009434A2 (es) 2018-12-14
BR112018016337A2 (pt) 2019-02-26
EP3750916A2 (en) 2020-12-16
US20170233460A1 (en) 2017-08-17

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