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MX2018007860A - Vacunas recombinantes contra el zika. - Google Patents

Vacunas recombinantes contra el zika.

Info

Publication number
MX2018007860A
MX2018007860A MX2018007860A MX2018007860A MX2018007860A MX 2018007860 A MX2018007860 A MX 2018007860A MX 2018007860 A MX2018007860 A MX 2018007860A MX 2018007860 A MX2018007860 A MX 2018007860A MX 2018007860 A MX2018007860 A MX 2018007860A
Authority
MX
Mexico
Prior art keywords
zika virus
recombinant
immunogenic
nucleic acid
zika
Prior art date
Application number
MX2018007860A
Other languages
English (en)
Inventor
Tauber Erich
Schrauf Sabrina
Müllner Matthias
Ramsauer Katrin
Irmler Angelika
Csar Patrick
Original Assignee
Themis Bioscience Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Themis Bioscience Gmbh filed Critical Themis Bioscience Gmbh
Publication of MX2018007860A publication Critical patent/MX2018007860A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/165—Mumps or measles virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18441—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18443—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
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Abstract

La presente invención se refiere al suministro de composiciones inmunogénicas o de vacuna que comprenden al menos un antígeno recombinante del virus del Zika, en donde al menos un antígeno recombinante del virus Zika está codificado por al menos una secuencia de ácido nucleico que codifica al menos una proteína E del virus del Zika o un fragmento funcional del mismo. Adicionalmente, se proporcionan moléculas de ácido nucleico y un virus quimérico recombinante que codifica y/o que comprende antígenos seleccionados de un virus del Zika, los cuales son adecuados como composiciones de vacuna. Preferiblemente, las secuencias que codifican al menos un antígeno de virus del Zika adecuado para provocar una respuesta inmune están operativamente ligadas a una estructura principal del vector no derivada de flavivirus. Adicionalmente, se proporcionan métodos para purificar las partículas de virus quimérico recombinante o la composición inmunogénica. Finalmente, se proporciona una composición inmunogénica/de vacuna para su uso en un método para prevenir o tratar una enfermedad del virus del Zika.
MX2018007860A 2015-12-23 2016-12-23 Vacunas recombinantes contra el zika. MX2018007860A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15202480.8A EP3184119A1 (en) 2015-12-23 2015-12-23 Chromatography based purification strategies for measles scaffold based viruses
EP16162688.2A EP3184118B1 (en) 2015-12-23 2016-03-29 Recombinant zika vaccines
PCT/EP2016/082659 WO2017109222A1 (en) 2015-12-23 2016-12-23 Recombinant zika vaccines

Publications (1)

Publication Number Publication Date
MX2018007860A true MX2018007860A (es) 2018-11-09

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MX2018007860A MX2018007860A (es) 2015-12-23 2016-12-23 Vacunas recombinantes contra el zika.

Country Status (17)

Country Link
US (2) US11110162B2 (es)
EP (5) EP3184119A1 (es)
BR (1) BR112018012962A2 (es)
CY (1) CY1124202T1 (es)
DK (1) DK3393505T3 (es)
ES (1) ES2867954T3 (es)
HR (1) HRP20210591T1 (es)
HU (1) HUE054847T2 (es)
LT (1) LT3393505T (es)
MX (1) MX2018007860A (es)
PL (1) PL3393505T3 (es)
PT (1) PT3393505T (es)
RS (1) RS61939B1 (es)
SG (2) SG11201804496UA (es)
SI (1) SI3393505T1 (es)
WO (2) WO2017109211A1 (es)
ZA (2) ZA201804071B (es)

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