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MX2018007782A - Forma cristalina de gemcitabina. - Google Patents

Forma cristalina de gemcitabina.

Info

Publication number
MX2018007782A
MX2018007782A MX2018007782A MX2018007782A MX2018007782A MX 2018007782 A MX2018007782 A MX 2018007782A MX 2018007782 A MX2018007782 A MX 2018007782A MX 2018007782 A MX2018007782 A MX 2018007782A MX 2018007782 A MX2018007782 A MX 2018007782A
Authority
MX
Mexico
Prior art keywords
gemcitabine
crystalline form
alaninyl
benzoxy
phenyl
Prior art date
Application number
MX2018007782A
Other languages
English (en)
Other versions
MX385579B (es
Inventor
Griffith Hugh
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NuCana plc filed Critical NuCana plc
Publication of MX2018007782A publication Critical patent/MX2018007782A/es
Publication of MX385579B publication Critical patent/MX385579B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Esta invención se refiere a una forma cristalina de gemcitabina-[fenil-benzoxi-L-alaninil)]-(S)-fosfato.
MX2018007782A 2015-12-23 2016-12-21 Forma cristalina de gemcitabina. MX385579B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1522771.3A GB201522771D0 (en) 2015-12-23 2015-12-23 Crystalline form of a phosphate derivative
PCT/GB2016/054017 WO2017109485A1 (en) 2015-12-23 2016-12-21 Crystalline form of gemcitabine

Publications (2)

Publication Number Publication Date
MX2018007782A true MX2018007782A (es) 2018-08-15
MX385579B MX385579B (es) 2025-03-18

Family

ID=55311540

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018007782A MX385579B (es) 2015-12-23 2016-12-21 Forma cristalina de gemcitabina.

Country Status (13)

Country Link
US (1) US11377467B2 (es)
EP (1) EP3394077A1 (es)
JP (1) JP6840151B2 (es)
KR (1) KR20180096685A (es)
CN (1) CN108699099A (es)
AU (1) AU2016375860B2 (es)
BR (1) BR112018012943A2 (es)
CA (1) CA3008556A1 (es)
GB (1) GB201522771D0 (es)
HK (1) HK1255112A1 (es)
MX (1) MX385579B (es)
SG (1) SG11201805061YA (es)
WO (1) WO2017109485A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3150616T3 (pl) 2012-11-16 2017-09-29 University College Cardiff Consultants Limited Mieszanina Rp/Sp gemcytabino-[fenylo-(benzyloksy-l-alaninylo)]-fosforynu
RS60968B1 (sr) 2014-06-25 2020-11-30 NuCana plc Prolekovi gemcitabina
CN106470672B (zh) 2014-06-25 2019-11-05 努卡那生物医药有限责任公司 包括吉西他滨前药的制剂
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
CN108135920A (zh) 2015-10-05 2018-06-08 努卡那有限公司 组合疗法
PL3386998T3 (pl) 2015-12-11 2022-02-07 NuCana plc Diastereoselektywna synteza pochodnych fosforanu i proleku gemcytabiny nuc-1031
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
FR2954310B1 (fr) 2009-12-18 2014-07-25 Univ Rouen Procede de dedoublement d'enantiomeres par evapocristallisation preferentielle
PL3150616T3 (pl) 2012-11-16 2017-09-29 University College Cardiff Consultants Limited Mieszanina Rp/Sp gemcytabino-[fenylo-(benzyloksy-l-alaninylo)]-fosforynu
WO2014204856A1 (en) 2013-06-17 2014-12-24 Catabasis Pharmaceuticals, Inc. Fatty acid anticancer derivatives and their uses
EP3074411A2 (en) 2013-11-27 2016-10-05 Idenix Pharmaceuticals LLC Nucleotides for the treatment of liver cancer
CN106470672B (zh) 2014-06-25 2019-11-05 努卡那生物医药有限责任公司 包括吉西他滨前药的制剂
RS60968B1 (sr) 2014-06-25 2020-11-30 NuCana plc Prolekovi gemcitabina
CN106795198B (zh) 2014-07-22 2019-09-06 努卡那公共有限公司 用于制备吉西他滨-[苯基(苄氧基-l-丙氨酸基)]磷酸酯的方法
GB201417644D0 (en) * 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
US9848863B2 (en) * 2015-02-25 2017-12-26 Globus Medical, Inc Surgical retractor systems and methods
ES2668377T3 (es) 2015-05-14 2018-05-17 NuCana plc Tratamientos contra el cáncer
CN106543252A (zh) * 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的制备方法及其中间体
CN106543220A (zh) * 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 氨基磷酸酯化合物及其制备方法和晶体
CN106539810B (zh) * 2015-09-16 2021-03-09 济南高合医疗科技有限公司 一种富集了nuc-1031单一异构体的组合物及其制备方法和用途
CN108135920A (zh) 2015-10-05 2018-06-08 努卡那有限公司 组合疗法
PL3386998T3 (pl) 2015-12-11 2022-02-07 NuCana plc Diastereoselektywna synteza pochodnych fosforanu i proleku gemcytabiny nuc-1031
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
CA3008769A1 (en) 2015-12-23 2017-06-29 NuCana plc Combination therapy comprising nuc-1031 and cisplatin
PT3393478T (pt) 2015-12-23 2020-03-24 NuCana plc Terapia combinada
CN107652342A (zh) 2016-07-23 2018-02-02 江苏万高药业股份有限公司 核苷氨基磷酸酯类前药的多晶型及其制备方法

Also Published As

Publication number Publication date
BR112018012943A2 (pt) 2018-12-11
MX385579B (es) 2025-03-18
EP3394077A1 (en) 2018-10-31
JP6840151B2 (ja) 2021-03-10
CA3008556A1 (en) 2017-06-29
WO2017109485A1 (en) 2017-06-29
CN108699099A (zh) 2018-10-23
JP2018538341A (ja) 2018-12-27
HK1255112A1 (zh) 2019-08-02
GB201522771D0 (en) 2016-02-03
KR20180096685A (ko) 2018-08-29
AU2016375860B2 (en) 2021-06-03
SG11201805061YA (en) 2018-07-30
US20210188893A1 (en) 2021-06-24
US11377467B2 (en) 2022-07-05
AU2016375860A1 (en) 2018-07-05

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