MX2018006969A - Método de preparación de la forma ii hidrato del cocristal de valasartán y ahu-377 trisódico. - Google Patents
Método de preparación de la forma ii hidrato del cocristal de valasartán y ahu-377 trisódico.Info
- Publication number
- MX2018006969A MX2018006969A MX2018006969A MX2018006969A MX2018006969A MX 2018006969 A MX2018006969 A MX 2018006969A MX 2018006969 A MX2018006969 A MX 2018006969A MX 2018006969 A MX2018006969 A MX 2018006969A MX 2018006969 A MX2018006969 A MX 2018006969A
- Authority
- MX
- Mexico
- Prior art keywords
- crystal form
- solvent
- diovan
- ahu
- trisodium salt
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 8
- 239000004072 C09CA03 - Valsartan Substances 0.000 title abstract 3
- 229940074619 diovan Drugs 0.000 title abstract 3
- 230000005496 eutectics Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 title abstract 2
- ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 239000012296 anti-solvent Substances 0.000 abstract 2
- PYNXFZCZUAOOQC-UTKZUKDTSA-N sacubitril Chemical compound C1=CC(C[C@H](C[C@@H](C)C(=O)OCC)NC(=O)CCC(O)=O)=CC=C1C1=CC=CC=C1 PYNXFZCZUAOOQC-UTKZUKDTSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- -1 diovan trisodium salt compound Chemical class 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente divulgación se refiere a un método de preparación de una forma II hidrato del cocristal de Valsartán y AUH-377 trisódico; el método de preparación comprende: en primer lugar, preparar una solución transparente de AHU-377 trisódico y Valsartán, el disolvente de la solución transparente comprende un antidisolvente y un buen solvente del producto objetivo que es la Forma II, y el punto de ebullición del buen disolvente es inferior a aquel del antidisolvente; en segundo lugar, evaporar la solución bajo vacío para eliminar el buen disolvente y agua del sistema; y finalmente, opcionalmente agregar cristales semilla de la Forma II o no y reponer una mezcla de agua y un disolvente portador para agitar para cristalización; el método de la presente divulgación puede preparar la Forma II con éxito, y el proceso es consistente y controlable; el producto que es la Forma II obtenida tiene alta pureza química, pureza cristalina buena fluidez; y el proceso se puede llevar a cabo a una mayor escala y cumplir con los requisitos de producción a gran escala.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510902127.7A CN106854187B (zh) | 2015-12-08 | 2015-12-08 | 一种ahu-377和缬沙坦三钠盐共晶水合物晶型ii的制备方法 |
| PCT/CN2016/105335 WO2017097085A1 (zh) | 2015-12-08 | 2016-11-10 | 一种ahu-377和缬沙坦三钠盐共晶水合物晶型ii的制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018006969A true MX2018006969A (es) | 2018-11-29 |
Family
ID=59013701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018006969A MX2018006969A (es) | 2015-12-08 | 2016-11-10 | Método de preparación de la forma ii hidrato del cocristal de valasartán y ahu-377 trisódico. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10442775B2 (es) |
| EP (1) | EP3385256B1 (es) |
| JP (1) | JP6628884B2 (es) |
| KR (1) | KR102070392B1 (es) |
| CN (1) | CN106854187B (es) |
| AU (1) | AU2016368863B2 (es) |
| CA (1) | CA3007864C (es) |
| ES (1) | ES2862204T3 (es) |
| IL (1) | IL259871A (es) |
| MX (1) | MX2018006969A (es) |
| PL (1) | PL3385256T3 (es) |
| WO (1) | WO2017097085A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3229799T (pt) * | 2014-12-08 | 2019-01-29 | Crystal Pharmatech Co Ltd | Formas cristalinas de complexo supramolecular trissódico compreendendo valsartan e ahu-377 e métodos das mesmas |
| EP3522886A4 (en) | 2016-10-10 | 2020-02-19 | Laurus Labs Limited | STABLE AMORPHE FORM OF THE SACUBITRIL VALSARTAN TRINATRIUM COMPLEX AND METHOD FOR THE PRODUCTION THEREOF |
| EP3840746A1 (en) | 2018-08-23 | 2021-06-30 | Novartis AG | New pharmaceutical use for the treatment of heart failure |
| WO2020039394A1 (en) | 2018-08-24 | 2020-02-27 | Novartis Ag | New drug combinations |
| KR102543230B1 (ko) | 2019-05-24 | 2023-06-14 | 주식회사 파마코스텍 | 발사르탄/사쿠비트릴 3소듐염 수화물의 결정형 및 그 제조방법 |
| CN116646606B (zh) * | 2023-07-13 | 2024-05-03 | 常州千沐新能源有限公司 | 一种采用磺酸酯基深共晶溶剂的电解液、制备方法以及锂离子电池 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR057882A1 (es) * | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| PT3229799T (pt) * | 2014-12-08 | 2019-01-29 | Crystal Pharmatech Co Ltd | Formas cristalinas de complexo supramolecular trissódico compreendendo valsartan e ahu-377 e métodos das mesmas |
| CN104557600B (zh) * | 2015-01-26 | 2016-05-04 | 苏州明锐医药科技有限公司 | 沙库比曲的制备方法 |
| CN104860894B (zh) * | 2015-06-10 | 2017-05-17 | 北京博全健医药科技有限公司 | 一种抗心衰药lcz696的制备方法 |
| CN105037289B (zh) * | 2015-07-17 | 2017-08-22 | 华东理工大学 | 血管紧张素受体拮抗剂和中性内肽酶抑制剂超分子复合体的新晶型 |
-
2015
- 2015-12-08 CN CN201510902127.7A patent/CN106854187B/zh active Active
-
2016
- 2016-11-10 PL PL16872277T patent/PL3385256T3/pl unknown
- 2016-11-10 KR KR1020187019105A patent/KR102070392B1/ko not_active Expired - Fee Related
- 2016-11-10 ES ES16872277T patent/ES2862204T3/es active Active
- 2016-11-10 US US16/060,909 patent/US10442775B2/en not_active Expired - Fee Related
- 2016-11-10 MX MX2018006969A patent/MX2018006969A/es unknown
- 2016-11-10 WO PCT/CN2016/105335 patent/WO2017097085A1/zh not_active Ceased
- 2016-11-10 EP EP16872277.5A patent/EP3385256B1/en active Active
- 2016-11-10 CA CA3007864A patent/CA3007864C/en not_active Expired - Fee Related
- 2016-11-10 AU AU2016368863A patent/AU2016368863B2/en not_active Ceased
- 2016-11-10 JP JP2018529268A patent/JP6628884B2/ja not_active Expired - Fee Related
-
2018
- 2018-06-07 IL IL259871A patent/IL259871A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3007864C (en) | 2021-03-23 |
| WO2017097085A1 (zh) | 2017-06-15 |
| CA3007864A1 (en) | 2017-06-15 |
| JP2019503999A (ja) | 2019-02-14 |
| PL3385256T3 (pl) | 2021-09-27 |
| EP3385256B1 (en) | 2021-02-24 |
| AU2016368863B2 (en) | 2019-11-14 |
| US10442775B2 (en) | 2019-10-15 |
| KR102070392B1 (ko) | 2020-01-28 |
| CN106854187A (zh) | 2017-06-16 |
| JP6628884B2 (ja) | 2020-01-15 |
| AU2016368863A1 (en) | 2018-07-26 |
| IL259871A (en) | 2018-07-31 |
| EP3385256A1 (en) | 2018-10-10 |
| EP3385256A4 (en) | 2018-12-19 |
| ES2862204T3 (es) | 2021-10-07 |
| KR20180090346A (ko) | 2018-08-10 |
| CN106854187B (zh) | 2020-04-14 |
| US20180354916A1 (en) | 2018-12-13 |
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