MX2018006495A - Derivados novedosos de diamino piridina. - Google Patents
Derivados novedosos de diamino piridina.Info
- Publication number
- MX2018006495A MX2018006495A MX2018006495A MX2018006495A MX2018006495A MX 2018006495 A MX2018006495 A MX 2018006495A MX 2018006495 A MX2018006495 A MX 2018006495A MX 2018006495 A MX2018006495 A MX 2018006495A MX 2018006495 A MX2018006495 A MX 2018006495A
- Authority
- MX
- Mexico
- Prior art keywords
- diamino pyridine
- pyridine derivatives
- compounds
- methods
- present
- Prior art date
Links
- ZZYXNRREDYWPLN-UHFFFAOYSA-N pyridine-2,3-diamine Chemical class NC1=CC=CN=C1N ZZYXNRREDYWPLN-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención describe derivados novedosos de diamino piridina que uestran propiedades de modulación de JAK. La presente invención también se refiere a composiciones farmacéuticas que comprenden estos nuevos compuestos, métodos de uso de dichos compuestos en el tratamiento de diversas enfermedades y trastornos que son susceptibles a la modulación de JAK, y procedimientos para preparar los compuestos descritos más adelante.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15196542 | 2015-11-26 | ||
| PCT/IB2016/057105 WO2017089985A1 (en) | 2015-11-26 | 2016-11-24 | Diamino pyridine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018006495A true MX2018006495A (es) | 2018-08-15 |
| MX379776B MX379776B (es) | 2025-03-11 |
Family
ID=54705130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018006495A MX379776B (es) | 2015-11-26 | 2016-11-24 | Derivados de diamino piridina para usarse en el tratamiento de dermatitis atópica o psoriasis. |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US10570096B2 (es) |
| EP (2) | EP3757097B1 (es) |
| JP (1) | JP6634157B2 (es) |
| KR (1) | KR102097878B1 (es) |
| CN (2) | CN108349937B (es) |
| AU (1) | AU2016359438B2 (es) |
| BR (1) | BR112018009540A2 (es) |
| CA (1) | CA3005159A1 (es) |
| CL (1) | CL2018001370A1 (es) |
| CO (1) | CO2018005354A2 (es) |
| CR (1) | CR20180285A (es) |
| CU (1) | CU24506B1 (es) |
| CY (1) | CY1123543T1 (es) |
| DK (1) | DK3380465T3 (es) |
| DO (1) | DOP2018000127A (es) |
| EA (1) | EA035899B1 (es) |
| EC (1) | ECSP18041731A (es) |
| ES (2) | ES2829052T3 (es) |
| HR (1) | HRP20201662T1 (es) |
| HU (1) | HUE052345T2 (es) |
| IL (1) | IL259360B (es) |
| LT (1) | LT3380465T (es) |
| MX (1) | MX379776B (es) |
| MY (1) | MY195905A (es) |
| PE (1) | PE20181071A1 (es) |
| PH (1) | PH12018501019B1 (es) |
| PL (2) | PL3757097T3 (es) |
| PT (2) | PT3757097T (es) |
| RS (1) | RS60946B1 (es) |
| RU (2) | RU2730007C2 (es) |
| SA (1) | SA518391657B1 (es) |
| SG (1) | SG11201803760VA (es) |
| SI (1) | SI3380465T1 (es) |
| WO (1) | WO2017089985A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10570096B2 (en) * | 2015-11-26 | 2020-02-25 | Novartis Ag | Diamino pyridine derivatives |
| US20220117949A1 (en) | 2019-01-11 | 2022-04-21 | Novartis Ag | Lta4h inhibitors for the treatment of hidradenitis suppurativa |
| TW202342048A (zh) | 2022-02-28 | 2023-11-01 | 瑞士商諾華公司 | 使用ｌｏｕ０６４治療化膿性汗腺炎之方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
| KR101149295B1 (ko) * | 2006-12-08 | 2012-07-05 | 아이알엠 엘엘씨 | 단백질 키나제 억제제로서의 화합물 |
| DK2134689T3 (da) * | 2007-03-16 | 2014-06-30 | Scripps Research Inst | Inhibitorer af fokal adhæsionskinase |
| EP2361902A4 (en) | 2008-11-21 | 2012-04-25 | Astellas Pharma Inc | 4,6-DIAMINONICOTINSÄUREAMIDVERBINDUNG |
| JP5542692B2 (ja) | 2008-11-28 | 2014-07-09 | 興和株式会社 | ピリジン−３−カルボキシアミド誘導体 |
| SI2565193T1 (sl) * | 2009-01-23 | 2014-07-31 | Rigel Pharmaceuticals, Inc. | Sestavki in metode inhibicije JAK poti |
| US8415381B2 (en) * | 2009-07-30 | 2013-04-09 | Novartis Ag | Heteroaryl compounds and their uses |
| EP2635557A2 (en) | 2010-11-01 | 2013-09-11 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
| US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| RU2015116532A (ru) | 2012-10-19 | 2016-12-10 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы тирозинкиназы syk |
| CA2890981C (en) * | 2012-11-08 | 2022-07-05 | Bristol-Myers Squibb Company | Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn.alpha. responses |
| SG11201503397YA (en) * | 2012-11-08 | 2015-05-28 | Bristol Myers Squibb Co | Heteroaryl substituted pyridyl compounds useful as kinase modulators |
| EP2922841B8 (en) * | 2012-11-08 | 2017-08-02 | Bristol-Myers Squibb Company | Alkyl-amide-substituted pyridyl compounds useful as modulators of il-12, il-23 and/or ifn alpha responses |
| US20140343034A1 (en) | 2013-04-25 | 2014-11-20 | Japan Tobacco Inc. | Skin barrier function improving agent |
| WO2014181287A1 (en) | 2013-05-09 | 2014-11-13 | Piramal Enterprises Limited | Heterocyclyl compounds and uses thereof |
| WO2014203132A1 (en) | 2013-06-19 | 2014-12-24 | Olema Pharmaceuticals, Inc. | Substituted benzopyran compounds, compositions and uses thereof |
| JP2015014960A (ja) | 2013-07-05 | 2015-01-22 | ソニー株式会社 | 情報処理装置、および記憶媒体 |
| WO2015061665A1 (en) | 2013-10-24 | 2015-04-30 | Abbvie Inc. | Jak1 selective inhibitor and uses thereof |
| CA2969590A1 (en) | 2014-12-03 | 2016-06-09 | Rxi Pharmaceuticals Corporation | Methods for the treatment of alopecia areata utilizing gene modulation approaches |
| US10570096B2 (en) * | 2015-11-26 | 2020-02-25 | Novartis Ag | Diamino pyridine derivatives |
-
2016
- 2016-11-24 US US15/778,783 patent/US10570096B2/en active Active
- 2016-11-24 SI SI201630959T patent/SI3380465T1/sl unknown
- 2016-11-24 CU CU2018000044A patent/CU24506B1/es unknown
- 2016-11-24 CA CA3005159A patent/CA3005159A1/en not_active Abandoned
- 2016-11-24 CN CN201680065351.8A patent/CN108349937B/zh not_active Expired - Fee Related
- 2016-11-24 BR BR112018009540A patent/BR112018009540A2/pt not_active Application Discontinuation
- 2016-11-24 KR KR1020187014470A patent/KR102097878B1/ko not_active Expired - Fee Related
- 2016-11-24 CN CN202110135667.2A patent/CN112851578A/zh not_active Withdrawn
- 2016-11-24 MX MX2018006495A patent/MX379776B/es unknown
- 2016-11-24 RU RU2018122953A patent/RU2730007C2/ru active
- 2016-11-24 DK DK16805218.1T patent/DK3380465T3/da active
- 2016-11-24 PL PL20185507.9T patent/PL3757097T3/pl unknown
- 2016-11-24 EP EP20185507.9A patent/EP3757097B1/en active Active
- 2016-11-24 RU RU2020124922A patent/RU2020124922A/ru unknown
- 2016-11-24 PL PL16805218T patent/PL3380465T3/pl unknown
- 2016-11-24 CR CR20180285A patent/CR20180285A/es unknown
- 2016-11-24 EA EA201891258A patent/EA035899B1/ru not_active IP Right Cessation
- 2016-11-24 EP EP16805218.1A patent/EP3380465B1/en active Active
- 2016-11-24 AU AU2016359438A patent/AU2016359438B2/en not_active Ceased
- 2016-11-24 PT PT201855079T patent/PT3757097T/pt unknown
- 2016-11-24 LT LTEP16805218.1T patent/LT3380465T/lt unknown
- 2016-11-24 RS RS20201234A patent/RS60946B1/sr unknown
- 2016-11-24 WO PCT/IB2016/057105 patent/WO2017089985A1/en not_active Ceased
- 2016-11-24 PE PE2018001004A patent/PE20181071A1/es unknown
- 2016-11-24 ES ES16805218T patent/ES2829052T3/es active Active
- 2016-11-24 MY MYPI2018701770A patent/MY195905A/en unknown
- 2016-11-24 PH PH1/2018/501019A patent/PH12018501019B1/en unknown
- 2016-11-24 ES ES20185507T patent/ES2916582T3/es active Active
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- 2016-11-24 JP JP2018527091A patent/JP6634157B2/ja not_active Expired - Fee Related
- 2016-11-24 HU HUE16805218A patent/HUE052345T2/hu unknown
- 2016-11-24 HR HRP20201662TT patent/HRP20201662T1/hr unknown
- 2016-11-24 PT PT168052181T patent/PT3380465T/pt unknown
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2018
- 2018-05-14 IL IL259360A patent/IL259360B/en active IP Right Grant
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- 2018-05-22 CL CL2018001370A patent/CL2018001370A1/es unknown
- 2018-05-22 CO CONC2018/0005354A patent/CO2018005354A2/es unknown
- 2018-05-23 SA SA518391657A patent/SA518391657B1/ar unknown
- 2018-05-31 EC ECIEPI201841731A patent/ECSP18041731A/es unknown
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2020
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2022
- 2022-02-22 US US17/677,538 patent/US20220177432A1/en not_active Abandoned
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