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MX2018006146A - DIANA MODIFICATION FOR MONITORING AND DETECTION. - Google Patents

DIANA MODIFICATION FOR MONITORING AND DETECTION.

Info

Publication number
MX2018006146A
MX2018006146A MX2018006146A MX2018006146A MX2018006146A MX 2018006146 A MX2018006146 A MX 2018006146A MX 2018006146 A MX2018006146 A MX 2018006146A MX 2018006146 A MX2018006146 A MX 2018006146A MX 2018006146 A MX2018006146 A MX 2018006146A
Authority
MX
Mexico
Prior art keywords
target molecule
detection
diana
monitoring
modification
Prior art date
Application number
MX2018006146A
Other languages
Spanish (es)
Inventor
A Heller Daniel
J Morin Trevor
b dunbar William
Shropshire Tyler
Original Assignee
Two Pore Guys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Two Pore Guys Inc filed Critical Two Pore Guys Inc
Publication of MX2018006146A publication Critical patent/MX2018006146A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9453—Cardioregulators, e.g. antihypotensives, antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/631—Detection means characterised by use of a special device being a biochannel or pore
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8827—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The present invention is directed to a target molecule modified to facilitate detection in a nanopore deice. The present invention further relates to a method of detecting such a modified target molecule using a nanopore device. It also disclose a method of using such a modified target molecule for tracking and verification of pharmaceutical, chemical or biological products and for measuring various conditions of a sample comprising the modified target molecule.
MX2018006146A 2015-11-23 2016-11-23 DIANA MODIFICATION FOR MONITORING AND DETECTION. MX2018006146A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562259012P 2015-11-23 2015-11-23
PCT/US2016/063597 WO2017091724A1 (en) 2015-11-23 2016-11-23 Target modification for tracking and detection

Publications (1)

Publication Number Publication Date
MX2018006146A true MX2018006146A (en) 2019-05-27

Family

ID=58764396

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018006146A MX2018006146A (en) 2015-11-23 2016-11-23 DIANA MODIFICATION FOR MONITORING AND DETECTION.

Country Status (9)

Country Link
US (1) US20180328919A1 (en)
EP (1) EP3380834A4 (en)
JP (1) JP2018537673A (en)
KR (1) KR20180085742A (en)
CN (1) CN108474760A (en)
CA (1) CA3005299A1 (en)
HK (1) HK1256108A1 (en)
MX (1) MX2018006146A (en)
WO (1) WO2017091724A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4003382A4 (en) * 2019-07-31 2023-10-11 Axbio Inc. SYSTEMS AND METHODS FOR EVALUATION OF A TARGET MOLECULE
GB202007911D0 (en) * 2020-05-27 2020-07-08 Imperial College Innovations Ltd Analyte detection method
CN115112729B (en) * 2022-07-04 2024-05-24 南京师范大学 Solid-state nanopore detection of phosphate molecules based on lanthanum-based metal-organic cages
CN118609666B (en) * 2024-07-19 2024-11-26 中国疾病预防控制中心环境与健康相关产品安全所 Methods for identifying associations between environmental pollutants and health effects and analyzing their mechanisms

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070054276A1 (en) * 2004-08-12 2007-03-08 Sampson Jeffrey R Polynucleotide analysis and methods of using nanopores
US20130071837A1 (en) * 2004-10-06 2013-03-21 Stephen N. Winters-Hilt Method and System for Characterizing or Identifying Molecules and Molecular Mixtures
WO2010082860A1 (en) * 2009-01-19 2010-07-22 Instituto De Biologia Experimental E Tecnologia (Ibet) Method and device for nanopore based single-molecule protein/ protein interaction detection
US20100243449A1 (en) * 2009-03-27 2010-09-30 Oliver John S Devices and methods for analyzing biomolecules and probes bound thereto
US20140335513A9 (en) * 2009-09-30 2014-11-13 Quantapore, Inc. Hybrid nanopore device with optical detection and methods of using same
US8557529B2 (en) * 2010-04-09 2013-10-15 International Business Machines Corporation Nanopore capture system
US9121059B2 (en) * 2010-12-22 2015-09-01 Genia Technologies, Inc. Nanopore-based single molecule characterization
US9528107B2 (en) * 2012-01-31 2016-12-27 Pacific Biosciences Of California, Inc. Compositions and methods for selection of nucleic acids
EP2994751B1 (en) * 2013-05-06 2018-10-10 Two Pore Guys, Inc. A method of biological target detection using a nanopore and a fusion protein binding agent
EP3014264A4 (en) * 2013-06-25 2016-11-16 Two Pore Guys Inc QUANTIFICATION OF MULTIPLEXED BIOMARKERS BY ANALYSIS OF NANOPORES OF BIOMARKER-POLYMER COMPLEXES
US20170074855A1 (en) * 2014-05-15 2017-03-16 Two Pore Guys, Inc. Scaffold Data Storage and Target Detection in a Sample Using a Nanopore
RU2712245C2 (en) * 2015-02-02 2020-01-27 Онтера Инк. Labile linkers for detecting biomarker
CA2973753A1 (en) * 2015-02-02 2016-08-11 Two Pore Guys, Inc. Nanopore detection of target polynucleotides from sample background
KR101945366B1 (en) * 2015-03-11 2019-02-07 투 포어 가이즈, 인코포레이티드 Detection of Nanopore of Low Molecule by Competition Test

Also Published As

Publication number Publication date
CA3005299A1 (en) 2017-06-01
EP3380834A4 (en) 2019-08-21
EP3380834A1 (en) 2018-10-03
WO2017091724A1 (en) 2017-06-01
US20180328919A1 (en) 2018-11-15
CN108474760A (en) 2018-08-31
KR20180085742A (en) 2018-07-27
HK1256108A1 (en) 2019-09-13
JP2018537673A (en) 2018-12-20

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MX2018006146A (en) DIANA MODIFICATION FOR MONITORING AND DETECTION.