[go: up one dir, main page]

MX2018005944A - Metodo para obtener un extracto acuoso enriquecido con arns pequeños de material de planta y extractos que se originan del metodo. - Google Patents

Metodo para obtener un extracto acuoso enriquecido con arns pequeños de material de planta y extractos que se originan del metodo.

Info

Publication number
MX2018005944A
MX2018005944A MX2018005944A MX2018005944A MX2018005944A MX 2018005944 A MX2018005944 A MX 2018005944A MX 2018005944 A MX2018005944 A MX 2018005944A MX 2018005944 A MX2018005944 A MX 2018005944A MX 2018005944 A MX2018005944 A MX 2018005944A
Authority
MX
Mexico
Prior art keywords
plant material
aqueous extract
small rnas
obtaining
extract enriched
Prior art date
Application number
MX2018005944A
Other languages
English (en)
Inventor
Portolan Frédérique
Oger Elodie
LEQUOY Valérie
Original Assignee
Isp Investments Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isp Investments Llc filed Critical Isp Investments Llc
Publication of MX2018005944A publication Critical patent/MX2018005944A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a un método para obtener un extracto acuoso enriquecido con ARN pequeño que tiene una longitud máxima de 150 nucleótidos, de material de planta. La invención se caracteriza en que comprende los siguientes pasos de acuerdos con los cuales: a) el material de planta se pone en contacto con agua; b) ácido etilendiamintetracético (EDTA) tetrasódico se agrega a la mezcla obtenida en a) en un pH entre 10.5 y 11; c) después, el pH de la mezcla obtenido en b) se ajusta a un valor entre 6 y 8; d) la mezcla obtenida en c) se purifica de tal manera para eliminar de esta manera el material de planta y para recuperar un extracto crudo acuoso; y e) el pH se verifica y se reajusta si es necesario a un valor entre 6 y 8. La invención también se refiere a un extracto acuoso del material de planta, enriquecido con ARNs pequeños que tienen una longitud máxima de 150 nucleótidos, que se pueden obtener por tal método, así como a las composiciones que comprenden tal extracto y a sus usos cosméticos para combatir los signos de envejecimiento de la piel y para mejorar la hidratación de la piel.
MX2018005944A 2015-11-17 2016-11-10 Metodo para obtener un extracto acuoso enriquecido con arns pequeños de material de planta y extractos que se originan del metodo. MX2018005944A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1502361A FR3043695B1 (fr) 2015-11-17 2015-11-17 Procede d'obtention d'un extrait aqueux enrichi en petits arn a partir d'une matiere vegetal et extraits issus du procede
PCT/EP2016/077231 WO2017084958A1 (fr) 2015-11-17 2016-11-10 Procede d'obtention d'un extrait aqueux enrichi en petits arn a partir d'une matiere vegetale et extraits issus du procede

Publications (1)

Publication Number Publication Date
MX2018005944A true MX2018005944A (es) 2018-08-14

Family

ID=55948859

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018005944A MX2018005944A (es) 2015-11-17 2016-11-10 Metodo para obtener un extracto acuoso enriquecido con arns pequeños de material de planta y extractos que se originan del metodo.

Country Status (12)

Country Link
US (2) US11673905B2 (es)
EP (2) EP3377623B1 (es)
JP (2) JP6862442B2 (es)
KR (2) KR102268324B1 (es)
CN (2) CN108291222B (es)
BR (1) BR112018009930A2 (es)
CA (1) CA3005605C (es)
ES (1) ES2898669T3 (es)
FR (2) FR3043695B1 (es)
HK (1) HK1251015A1 (es)
MX (1) MX2018005944A (es)
WO (2) WO2017087245A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3043695B1 (fr) * 2015-11-17 2019-10-25 ISP Investments LLC. Procede d'obtention d'un extrait aqueux enrichi en petits arn a partir d'une matiere vegetal et extraits issus du procede
KR20190067936A (ko) * 2016-11-09 2019-06-17 이엘씨 매니지먼트 엘엘씨 피부 세포에서 Mir-146a를 자극하기 위한 국소 조성물 및 방법
KR102041867B1 (ko) * 2018-02-23 2019-11-06 주식회사 위노바 오크라, 퀴노아, 석류, 들깨, 편백 추출 혼합물과 프로폴리스 및 합성펩타이드를 함유하는 피부화장료 조성물
TWI746917B (zh) * 2018-12-22 2021-11-21 大江生醫股份有限公司 代代花萃取物用於減緩皮膚老化及減少細胞中脂肪含量的用途
KR102237543B1 (ko) * 2019-02-22 2021-04-07 (주)모아캠 알로에 속 식물 유래 dna의 제조방법, 및 알로에 속 식물 유래 dna를 유효성분으로 포함하는 항노화 및 항염증용 조성물
JP7197676B2 (ja) * 2019-03-04 2022-12-27 三井化学株式会社 細胞壁を有する生物の存在状態の判定方法、及び細胞壁を有する生物の同定方法
JP7356808B2 (ja) * 2019-03-04 2023-10-05 株式会社ノエビア 皮膚外用剤
FR3106754B1 (fr) 2020-02-04 2022-01-07 Isp Investments Llc Procede d’obtention d’un extrait aqueux de lavande, compositions comprenant un tel extrait et leurs utilisations cosmetiques
JP2022043935A (ja) * 2020-09-04 2022-03-16 三井化学株式会社 細胞壁を有する生物の生細胞数の測定方法、及び細胞壁を有する生物の試験物質に対する抵抗性の評価方法
JP7676121B2 (ja) * 2020-09-04 2025-05-14 三井化学株式会社 ｓＲＮＡの抽出方法及び生物の存在状態の判定方法
FR3116438B1 (fr) 2020-11-23 2022-10-14 Isp Investments Llc Procede d’obtention d’extraits aqueux de feuilles de thes, compositions comprenant de tels extraits et leurs utilisations cosmetiques
FR3125425B1 (fr) 2021-07-22 2024-09-13 Isp Investments Llc Extrait de feuilles de the noir, compositions le comprenant et ses utilisations cosmetiques
EP4134439A1 (en) * 2021-08-11 2023-02-15 Valagro S.p.A. Plant extract and uses thereof in agriculture
CN114058665A (zh) * 2021-12-02 2022-02-18 浙江宜格企业管理集团有限公司 一种复合花肽的制备方法及其在制备化妆品中的应用
FR3132436A1 (fr) 2022-02-08 2023-08-11 Isp Investments Llc Procede d’obtention d’extraits vegetaux comprenant une etape d’autofermentation, compositions comprenant de tels extraits et leurs utilisations cosmetiques
KR102682937B1 (ko) * 2023-08-11 2024-07-09 주식회사 바이오에프디엔씨 식물세포로부터 pdrn 생산 방법
FR3153251A1 (fr) * 2023-09-25 2025-03-28 Etienne Soudant Extrait hydrosoluble de graines délipidées de Adansonia digitata et ses utilisations cosmétiques.
CN121335913A (zh) 2024-02-06 2026-01-13 Isp投资有限公司 包含用于增加线粒体衍生肽的表达的合成或植物提取物的化妆品组合物和/或药物组合物
KR102863315B1 (ko) * 2024-07-16 2025-09-24 주식회사 네트론 생약 복합 추출물을 유효 성분으로 포함하는 피부 개선용 화장료 조성물

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1540597C3 (de) 1965-11-29 1975-01-16 Siemens Ag, 1000 Berlin Und 8000 Muenchen Hochspannungsdurchführung
FR2543438B1 (fr) 1983-03-30 1987-07-31 Duraffourd Alain Composition pour la regeneration des cellules et des tissus de la peau et son procede d'obtention
US6270780B1 (en) 1997-07-25 2001-08-07 Chesebrough-Pond's Usa Co., Division Of Conopco Cosmetic compositions containing resveratrol
DE19820629A1 (de) * 1998-05-08 1999-11-11 Forschungsanstalt Geisenheim Schnellextraktionsverfahren zur Gewinnung von DNA und RNA aus holzigen und krautigen Teilen verholzender und nichtverholzender Pflanzen
FR2817748B1 (fr) 2000-12-13 2003-01-17 Seporga Composition cosmetique et/ou dermatologique contenant un extrait d'artemia salina
JP2004523229A (ja) * 2001-01-16 2004-08-05 インヴィトロジェン コーポレーション Ｒｎａ単離のための試薬
FR2827170B1 (fr) 2001-07-13 2004-07-16 Soc Extraction Principes Actif Utilisation de peptides pour augmenter l'adhesion cellulaire
FR2831168B1 (fr) * 2001-10-22 2004-02-06 Rocher Yves Biolog Vegetale Procede d'obtention d'un extrait riche en acides nucleiques a partir d'une matiere vegetale
FR2837098B1 (fr) 2002-03-18 2004-05-28 Vincience Composition cosmetique ou pharmaceutique comprenant des peptides, procedes de traitement et utilisations
FR2840217B1 (fr) * 2002-06-03 2005-06-24 Oreal Compositions cosmetiques comprenant au moins un oligonucleotide d'arn double brin (dsrna)et leurs utilisations
ES2342826T3 (es) * 2002-06-03 2010-07-15 L'oreal Utilizacion por via topica de al menos un oligonucleotido de arn de doble helice (dsrna) anti-tirosina.
FR2841781B1 (fr) 2002-07-03 2005-12-16 Utilisation de peptides pour favoriser la regeneration cutannee
FR2846883B1 (fr) 2002-11-08 2004-12-24 Vincience Composition cosmetique comprenant, comme ingredient actif, au moins un peptide et utilisation de ce peptide
WO2004046305A2 (en) * 2002-11-18 2004-06-03 Agency For Science, Technology And Research Method and system for cell and/or nucleic acid molecules isolation
US20050074521A1 (en) * 2003-10-01 2005-04-07 Sensient Flavors Inc. Method for the production of natural botanical extracts
FR2885808B1 (fr) * 2005-05-19 2007-07-06 Oreal Vectorisation de dsrna par des particules cationiques et utilisation topique.
US9139850B2 (en) 2005-05-19 2015-09-22 L'oreal Vectorization of dsRNA by cationic particles and topical use
JP5025253B2 (ja) 2006-03-31 2012-09-12 日生バイオ株式会社 基礎化粧品用配合剤及び基礎化粧品
US20080161229A1 (en) 2006-12-21 2008-07-03 Nissei Bio Co., Ltd. Compounding ingredients for basic cosmetics and basic cosmetics
FR2912313B1 (fr) * 2007-02-13 2012-07-06 Rocher Yves Biolog Vegetale Composition d'extrait de ble et d'esculine et utilisation en cosmetique.
CN101601635A (zh) * 2008-06-13 2009-12-16 殷勤伟 小rna/dna美白产品的配方和制造方法
US8357672B2 (en) * 2008-06-13 2013-01-22 Bio-Rad Laboratories, Inc. Cell lysis reagent for isolation of RNA
FR2940112B1 (fr) * 2008-12-22 2011-03-25 Rocher Yves Biolog Vegetale Procede d'extraction de composes presents au sein d'un materiau vegetal frais par cryobroyage et enzymolyse
FR2951946B1 (fr) 2009-11-03 2012-05-11 Isp Investments Inc Utilisation d'un hydrolysat peptidique de levure en tant qu'agent actif pour renforcer le cheveu
FR2944526B1 (fr) 2009-04-15 2013-05-10 Isp Investments Inc Composition cosmetique et/ou pharmaceutique comprenant un hydrolysat peptidique capable de renforcer la fonction barriere
JP2011016760A (ja) * 2009-07-09 2011-01-27 Noevir Co Ltd ユリ属植物の球根及び／又はカルス抽出物を有効成分とする皮膚外用剤、経口用剤、保湿剤、抗老化剤、美白剤、抗酸化剤
FR2956818B1 (fr) 2010-02-26 2012-07-20 Isp Investments Inc Utilisation d'un hydrolysat peptidique de lin dans une composition pour apaiser la peau
CN102146374B (zh) * 2011-01-27 2012-10-31 四川农业大学 一种动物dna提取的细胞裂解液、试剂盒和方法
CN103211728B (zh) * 2011-09-27 2015-09-16 浙江欧诗漫生物股份有限公司 一种含雪莲花及白花百合花提取物的焕颜修容霜组合物
CN102776174A (zh) 2012-08-21 2012-11-14 昆明理工大学 一种从百合组织中同时提取dna和rna的方法
CN103705392B (zh) * 2012-09-29 2015-02-18 黄兵 一种小核酸美白祛斑霜及其制备方法
CN104138346B (zh) 2014-08-07 2016-09-21 广州雅纯化妆品制造有限公司 一种抗皱化妆品组合物及其制备方法
FR3043695B1 (fr) * 2015-11-17 2019-10-25 ISP Investments LLC. Procede d'obtention d'un extrait aqueux enrichi en petits arn a partir d'une matiere vegetal et extraits issus du procede

Also Published As

Publication number Publication date
BR112018009930A2 (pt) 2018-11-13
HK1251015A1 (zh) 2019-01-18
CN108473980A (zh) 2018-08-31
FR3043554A1 (fr) 2017-05-19
US20200246252A1 (en) 2020-08-06
KR20180080319A (ko) 2018-07-11
KR102268324B1 (ko) 2021-06-24
CN108291222A (zh) 2018-07-17
FR3043695B1 (fr) 2019-10-25
CA3005605A1 (en) 2017-05-26
US11673905B2 (en) 2023-06-13
CN108473980B (zh) 2022-10-21
CA3005605C (en) 2020-10-13
JP6862442B2 (ja) 2021-04-21
EP3377623A1 (fr) 2018-09-26
US11021505B2 (en) 2021-06-01
HK1256880A1 (zh) 2019-10-04
EP3377623B1 (fr) 2021-10-20
JP2018537455A (ja) 2018-12-20
JP2018533615A (ja) 2018-11-15
US20180371000A1 (en) 2018-12-27
JP6826597B2 (ja) 2021-02-03
FR3043695A1 (fr) 2017-05-19
KR20180081800A (ko) 2018-07-17
ES2898669T3 (es) 2022-03-08
FR3043554B1 (fr) 2019-07-12
WO2017087245A1 (en) 2017-05-26
EP3377624B1 (en) 2021-07-21
WO2017084958A1 (fr) 2017-05-26
EP3377624A1 (en) 2018-09-26
CN108291222B (zh) 2022-10-21

Similar Documents

Publication Publication Date Title
MX2018005944A (es) Metodo para obtener un extracto acuoso enriquecido con arns pequeños de material de planta y extractos que se originan del metodo.
PH12018501226A1 (en) Methods for treating huntingtons disease
PH12018500856A1 (en) Respiratory syncytial virus vaccine
MY192848A (en) Compositions and methods for the treatment of hemoglobinopathies
MY206637A (en) Generation of peroxyformic acid through polyhydric alcohol formate
BR112016029178A2 (pt) composições e métodos para a expressão de rnas guia de crispr usando o promotor h1
PH12016502050B1 (en) Homovanillinic acid ester, in particular, for creating a hot and/or pungent taste sensation
BR112012028507A2 (pt) processo para recuperação de etanol com extrações laterais para regular as concentrações de c3 + alcoóis
NZ752560A (en) A thermo-responsive solution, and method of use therefor
BR112015029660A2 (pt) método para recuperar um álcool a partir de uma corrente aquosa, método para tratar uma corrente de produção, e, método para extrair um álcool a partir de uma corrente de produto aquoso
MX2023010247A (es) Proceso para preparar extracto de chicharos.
MY198780A (en) Process for the biological production of methacrylic acid and derivatives thereof
SG11201901752RA (en) Method for improving aftertaste of alcoholic beverages using allulose
MX2019005639A (es) Tratamiento de impurezas en corrientes de procesos.
MX2014005404A (es) Composicion cosmetica.
MX2019011489A (es) Alimento y cosmeticos saludables para aumentar la cantidad de celulas apoptoticas y para disminuir la cantidad de celulas necroticas y un metodo de fabricacion de un ingrediente derivado de semilla de uva con crecimiento forzado de brotes para aumentar la cantidad de celulas apoptoticas y para disminuir la cantidad de celulas necroticas.
WO2018093731A3 (en) Method for treating lamivudine-resistant hepatitis b
CL2012000649A1 (es) Ácido nucleico aislado, vector que lo comprende, metodo para producir una planta de remolacha azucarera transgenica que comprende dichos acidos nucleicos; y su uso para la inhibicion del espigado y la floracion despues de la vernalizacion.
MX2016012851A (es) Un metodo para producir 1,1,2,3-tetracloropropeno con alto rendimiento.
WO2015197197A8 (en) Process and plant for the purification of acrylic acid
MD901Y (ro) Procedeu de tratare a seminţelor de castraveţi înainte de semănat
MX2023004496A (es) Procesos para purificar acido acetico e hidratar un anhidrido.
PH12017501869A1 (en) (s)-2'-vinyl-abscisic acid derivatives
UA113021C2 (uk) Перетворювач іржі, композиція для його одержання і спосіб одержання
WO2016059269A8 (es) Compuestos derivados de acrilato de 3-alouilamino-1h- indolilo y su uso en el tratamiento de enfermedades neurodegenerativas