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MX2018004794A - Forma cristalina de 2-(2,6-diclorofenil)-1-[ (1s,3r)-3-(hidroximet l)-5-(3-hidroxi-3-metil-butil)-metil-3,4-dihidrosoquinolin-2(1h)- il]etanona para el tratamiento de enfermedad de parkinson. - Google Patents

Forma cristalina de 2-(2,6-diclorofenil)-1-[ (1s,3r)-3-(hidroximet l)-5-(3-hidroxi-3-metil-butil)-metil-3,4-dihidrosoquinolin-2(1h)- il]etanona para el tratamiento de enfermedad de parkinson.

Info

Publication number
MX2018004794A
MX2018004794A MX2018004794A MX2018004794A MX2018004794A MX 2018004794 A MX2018004794 A MX 2018004794A MX 2018004794 A MX2018004794 A MX 2018004794A MX 2018004794 A MX2018004794 A MX 2018004794A MX 2018004794 A MX2018004794 A MX 2018004794A
Authority
MX
Mexico
Prior art keywords
ethanone
methylbutyl
dichlorophenyl
methyl
crystalline form
Prior art date
Application number
MX2018004794A
Other languages
English (en)
Inventor
Alan Stephenson Gregory
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2018004794A publication Critical patent/MX2018004794A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a una forma cristalina de 2-(2,6-diclorofenil)-1-[(1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-m etilbutil)-1-metil-3,4-dihidroisoquinolin-2(1H)-il]etanona y composiciones farmacéuticas de la misma. La invención además proporciona métodos para usar una forma cristalina de 2-(2,6-diclorofenil)-1- [(1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-m etilbutil)-1-metil-3,4-dihidroisoquinolin-2(1H)-il]etanona para tratar deterioro cognitivo asociado con la enfermedad de Parkinson o esquizofrenia.
MX2018004794A 2015-10-23 2016-10-18 Forma cristalina de 2-(2,6-diclorofenil)-1-[ (1s,3r)-3-(hidroximet l)-5-(3-hidroxi-3-metil-butil)-metil-3,4-dihidrosoquinolin-2(1h)- il]etanona para el tratamiento de enfermedad de parkinson. MX2018004794A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562245391P 2015-10-23 2015-10-23
PCT/US2016/057447 WO2017070068A1 (en) 2015-10-23 2016-10-18 Crystalline form of 2-(2,6-dichlorophenyl)-1-[(1s,3r)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1h)-yl]ethanone for the treatment of parkinson's disease

Publications (1)

Publication Number Publication Date
MX2018004794A true MX2018004794A (es) 2018-06-19

Family

ID=57233858

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018004794A MX2018004794A (es) 2015-10-23 2016-10-18 Forma cristalina de 2-(2,6-diclorofenil)-1-[ (1s,3r)-3-(hidroximet l)-5-(3-hidroxi-3-metil-butil)-metil-3,4-dihidrosoquinolin-2(1h)- il]etanona para el tratamiento de enfermedad de parkinson.

Country Status (13)

Country Link
CN (1) CN108137506A (es)
AR (1) AR106332A1 (es)
AU (1) AU2016341115A1 (es)
CA (1) CA2999332A1 (es)
DO (1) DOP2018000103A (es)
EA (1) EA201890525A1 (es)
EC (1) ECSP18030976A (es)
IL (1) IL257872A (es)
MX (1) MX2018004794A (es)
PE (1) PE20181296A1 (es)
PH (1) PH12018500859A1 (es)
TW (1) TW201725199A (es)
WO (1) WO2017070068A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI725408B (zh) * 2018-04-20 2021-04-21 美商美國禮來大藥廠 多巴胺d1受體正向異位調節劑
MD3897578T2 (ro) 2018-12-18 2025-04-30 Lilly Co Eli Regimuri de dozare pentru utilizarea LY3154207 în tratamentul tulburărilor dopaminergice ale SNC
TWI825323B (zh) * 2019-06-18 2023-12-11 美商美國禮來大藥廠 用於製備2-(2,6-二氯苯基)-1-[(1s,3r)-3-(羥甲基)-5-(3-羥基-3-甲基丁基)-1-甲基-3,4-二氫異喹啉-2(1h)-基]乙烯酮之方法及中間物
AU2022234744B2 (en) * 2021-03-08 2025-06-26 Eli Lilly And Company Use of mevidalen and other d1 positive allosteric modulators in the treatment of hallucinations and dementia-related psychosis
AU2022234226B2 (en) * 2021-03-09 2025-08-14 Eli Lilly And Company Use of mevidalen and other d1 positive allosteric modulators for slowing of parkinson's disease progression
CN113264926A (zh) * 2021-05-31 2021-08-17 东北林业大学 一种牡荆素与利血平的共晶及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5236934A (en) * 1992-08-26 1993-08-17 E. I. Du Pont De Nemours And Company 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders
EP2125741A1 (en) * 2007-03-01 2009-12-02 Janssen Pharmaceutica, N.V. Tetrahydroisoquinoline compounds as modulators of the histamine h3 receptor
US20120252853A1 (en) * 2011-04-01 2012-10-04 H. Lundbeck A/S Positive allosteric modulators of nicotinic acetylcholine receptor
JO3316B1 (ar) * 2013-05-30 2019-03-13 Lilly Co Eli مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل

Also Published As

Publication number Publication date
PE20181296A1 (es) 2018-08-07
CA2999332A1 (en) 2017-04-27
AU2016341115A1 (en) 2018-04-12
CN108137506A (zh) 2018-06-08
DOP2018000103A (es) 2018-10-31
ECSP18030976A (es) 2018-05-31
AR106332A1 (es) 2018-01-03
TW201725199A (zh) 2017-07-16
PH12018500859A1 (en) 2018-10-29
EA201890525A1 (ru) 2018-09-28
WO2017070068A1 (en) 2017-04-27
IL257872A (en) 2018-06-03

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