[go: up one dir, main page]

MX2018004192A - Formulaciones de análogos de proteína relacionada con la hormona paratiroidea (pthrp), parches transdérmicos de las mismas y usos de las mismas. - Google Patents

Formulaciones de análogos de proteína relacionada con la hormona paratiroidea (pthrp), parches transdérmicos de las mismas y usos de las mismas.

Info

Publication number
MX2018004192A
MX2018004192A MX2018004192A MX2018004192A MX2018004192A MX 2018004192 A MX2018004192 A MX 2018004192A MX 2018004192 A MX2018004192 A MX 2018004192A MX 2018004192 A MX2018004192 A MX 2018004192A MX 2018004192 A MX2018004192 A MX 2018004192A
Authority
MX
Mexico
Prior art keywords
formulations
patches
bone
transdermal patches
methods
Prior art date
Application number
MX2018004192A
Other languages
English (en)
Inventor
Hattersley Gary
Harris Alan
Saeh Jamal
Hamed Ehab
Original Assignee
Radius Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radius Health Inc filed Critical Radius Health Inc
Publication of MX2018004192A publication Critical patent/MX2018004192A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen formulaciones de análogos de PTHrP para la administración transdérmica de una cantidad eficaz para uso terapéutico de un análogo de PTHrP, así como también parches transdérmicos mediante el uso de estas formulaciones, métodos de preparación de las formulaciones y parches descritos, y métodos de uso de estas formulaciones y parches para tratar la osteoporosis , la osteopenia, la osteoartritis, y/o una fractura ósea, mejorar la densidad mineral ósea (BMD), mejorar la puntuación de hueso trabecular (TBS), y tratar, prevenir y/o reducir las fracturas óseas.
MX2018004192A 2015-10-09 2016-10-08 Formulaciones de análogos de proteína relacionada con la hormona paratiroidea (pthrp), parches transdérmicos de las mismas y usos de las mismas. MX2018004192A (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562239801P 2015-10-09 2015-10-09
US201562239774P 2015-10-09 2015-10-09
US201562239773P 2015-10-09 2015-10-09
US201662324336P 2016-04-18 2016-04-18
US201662353249P 2016-06-22 2016-06-22
US201662396196P 2016-09-18 2016-09-18
PCT/US2016/056196 WO2017062922A1 (en) 2015-10-09 2016-10-08 Formulations of pthrp analogues, transdermal patches thereof, and uses thereof

Publications (1)

Publication Number Publication Date
MX2018004192A true MX2018004192A (es) 2018-09-26

Family

ID=58488710

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018004192A MX2018004192A (es) 2015-10-09 2016-10-08 Formulaciones de análogos de proteína relacionada con la hormona paratiroidea (pthrp), parches transdérmicos de las mismas y usos de las mismas.

Country Status (23)

Country Link
US (1) US20190091138A1 (es)
EP (2) EP3359241B1 (es)
JP (3) JP6867379B2 (es)
KR (1) KR20180067573A (es)
CN (2) CN115025068A (es)
AU (2) AU2016334378B2 (es)
BR (1) BR112018007159A2 (es)
CA (1) CA3000533C (es)
CY (1) CY1124657T1 (es)
DK (1) DK3359241T3 (es)
ES (1) ES2881461T3 (es)
HR (1) HRP20211127T1 (es)
HU (1) HUE055658T2 (es)
IL (2) IL287604B2 (es)
LT (1) LT3359241T (es)
MX (1) MX2018004192A (es)
PL (1) PL3359241T3 (es)
PT (1) PT3359241T (es)
RS (1) RS62394B1 (es)
SG (1) SG11201802871UA (es)
SI (1) SI3359241T1 (es)
SM (1) SMT202100411T1 (es)
WO (1) WO2017062922A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3265115B1 (en) * 2015-03-03 2022-06-22 Radius Health, Inc. Abaloparatide combined with alendronate for reducing non-vertebral bone fractures
ES2904891T3 (es) 2016-04-18 2022-04-06 Radius Health Inc Formulaciones de abaloparatida, parche transdérmico de la misma y usos de la misma
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
CA3167644A1 (en) * 2017-09-22 2019-03-28 Asahi Kasei Pharma Corporation Teriparatide-containing liquid pharmaceutical composition having excellent pharmacokinetics and/or safety
CN107674113A (zh) * 2017-10-20 2018-02-09 广东医科大学 一种小分子活性肽及其制备方法、及采用该活性肽的透皮贴剂的制备方法与其用途
CN110054679B (zh) * 2018-01-18 2021-05-04 成都圣诺生物制药有限公司 一种合成Abaloparatide的方法
CN109602911B (zh) * 2019-01-09 2020-11-10 厦门大学 硫酸钙晶须或其组合物在制备皮肤促渗剂中的用途
EP3930743A1 (en) 2019-02-28 2022-01-05 Radius Health, Inc. Transdermal system for the delivery of abaloparatide and method of use
BR112022004462A2 (pt) * 2019-09-12 2022-05-31 Radius Health Inc Métodos para melhorar a fusão espinhal com abaloparatida
US12214216B1 (en) * 2019-10-16 2025-02-04 Helen Feng Photon enhanced bone growth system and method
EP4110371A1 (en) 2020-01-24 2023-01-04 Radius Health, Inc. Methods of stimulating bone growth with abalopartide and denosumab
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US20220378881A1 (en) * 2021-05-25 2022-12-01 Radius Health, Inc. Treatment and prevention of osteoporosis in high body mass index individuals
WO2023281447A1 (en) 2021-07-07 2023-01-12 Radius Health, Inc. Methods of treating a cardiovascular ischemic event
CN119113134B (zh) * 2024-09-13 2025-05-16 南京羚诺生物医药技术研究院有限公司 一种提升阿巴帕肽半衰期的制备方法及其在治疗骨质疏松症中的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032698A1 (en) * 2003-07-14 2005-02-10 Nps Allelix Corp. Stabilized formulation of parathyroid hormone
JP2009530307A (ja) * 2006-03-15 2009-08-27 アルザ コーポレイション 骨減少症を予防し、または治療するための副甲状腺ホルモン薬の経皮送達のための装置、並びに方法
RS56164B1 (sr) * 2006-10-03 2017-11-30 Radius Health Inc Stabilna kompozicija koja sadrži pthrp i njene upotrebe
WO2009054988A1 (en) * 2007-10-23 2009-04-30 Alza Corporation Transdermal sustained release drug delivery
WO2010111617A2 (en) * 2009-03-27 2010-09-30 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
EP2540337B1 (en) * 2010-02-24 2019-04-03 Hisamitsu Pharmaceutical Co., Inc. Micro-needle device and preparation method
US8637458B2 (en) * 2010-05-12 2014-01-28 Biodel Inc. Insulin with a stable basal release profile
CA2833571A1 (en) * 2011-04-22 2012-10-26 Radius Health, Inc. Method of drug delivery for pth, pthrp and related peptides
CA2857502C (en) * 2011-11-30 2019-08-13 3M Innovative Properties Company Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same
CN102526220A (zh) * 2012-01-10 2012-07-04 上海市中医医院 一种治疗期前收缩的中药贴剂及其制备方法和应用
US9581438B2 (en) * 2012-12-31 2017-02-28 General Electric Company Systems and methods for control of a non-destructive testing system
CA2918369C (en) * 2013-07-18 2021-06-29 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
CN108135962A (zh) * 2015-10-07 2018-06-08 塞浦路迈德有限责任公司 用于口服递送肽类药物的药物制剂

Also Published As

Publication number Publication date
SG11201802871UA (en) 2018-05-30
KR20180067573A (ko) 2018-06-20
RS62394B1 (sr) 2021-10-29
CN115025068A (zh) 2022-09-09
CY1124657T1 (el) 2022-07-22
SMT202100411T1 (it) 2021-11-12
AU2021269361A1 (en) 2021-12-16
EP3909566A1 (en) 2021-11-17
CN108697881A (zh) 2018-10-23
PT3359241T (pt) 2021-07-21
BR112018007159A2 (pt) 2018-11-06
EP3359241B1 (en) 2021-04-14
HRP20211127T1 (hr) 2021-10-15
DK3359241T3 (da) 2021-07-19
JP2022174274A (ja) 2022-11-22
SI3359241T1 (sl) 2021-11-30
WO2017062922A1 (en) 2017-04-13
ES2881461T3 (es) 2021-11-29
IL287604B1 (en) 2023-12-01
LT3359241T (lt) 2021-10-11
AU2016334378B2 (en) 2021-12-02
EP3359241A4 (en) 2019-06-26
US20190091138A1 (en) 2019-03-28
JP6867379B2 (ja) 2021-04-28
AU2016334378A1 (en) 2018-04-19
EP3359241A1 (en) 2018-08-15
IL258441B (en) 2021-12-01
JP2018536631A (ja) 2018-12-13
IL258441A (en) 2018-05-31
CA3000533C (en) 2023-10-17
JP2021119141A (ja) 2021-08-12
PL3359241T3 (pl) 2021-12-20
JP7146011B2 (ja) 2022-10-03
IL287604B2 (en) 2024-04-01
CA3000533A1 (en) 2017-04-13
IL287604A (en) 2021-12-01
HUE055658T2 (hu) 2021-12-28

Similar Documents

Publication Publication Date Title
MX2018004192A (es) Formulaciones de análogos de proteína relacionada con la hormona paratiroidea (pthrp), parches transdérmicos de las mismas y usos de las mismas.
PH12017501934A1 (en) Methods for treating or preventing migraine headache
PH12017501057A1 (en) Substituted 2-anilinopyrimidine derivatives as egfr modulators
PH12016501966A1 (en) Compounds and compositions as toll-like receptor 7 agonists
MY195427A (en) Jak Kinase Inhibitor Compounds for Treatment of Respiratory Disease
MX2022009155A (es) Nuevos profarmacos polimericos de la hormona del crecimiento humana (hgh).
NZ751746A (en) Combination therapy with controlled-release cnp agonists
MX2017004618A (es) Inhibidores de la biosintesis de sulfato de heparano para el tratamiento de enfermedades.
SA519410320B1 (ar) مركبات فينيل -2-هيدروكسي-أسيتيل أمينو -2-ميثيل-فينيل
PH12018500315A1 (en) Fumagillol heterocyclic compounds and methods of making and using same
EP4137147A3 (en) Uses of abaloparatide in reducing fracture risk
IN2014MU00303A (es)
GEAP201914411A (en) Substituted 2-thioxo-imidazolidin-4-ones and spiro analogues thereof, active anti-cancer ingredient, pharmaceutical com¬position, medicinal prepara¬tion, method for treating prostate cancer
GB202203224D0 (en) Electronic patch for transdermal delivery of medical compositions
MD4780B1 (ro) Urei asimetrice p-substituite şi utilizările medicale ale acestora
MY176521A (en) Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereof
MX382930B (es) Tratamiento con cis-clomifeno de sofocos y pérdida ósea inducidos por privación de andrógeno terapéutica.
TW201613569A (en) Composition consisting of kukoamine A and/or kukoamine B and method of using thereof
JO3394B1 (ar) تركيبات ومنتجات للاستعمال في علاج كسور وعيوب العظام
TW201613921A (en) Serine derivatives as ghrelin receptor agonists
GB2587744B (en) Composition for improved bone fracture healing
HK40051588B (en) Composition for improved bone fracture healing
HK40051588A (en) Composition for improved bone fracture healing
TN2016000561A1 (en) Stabilized desmopressin
NZ725354A (en) Transdermal formulations of pergolide and uses thereof