MX2018004144A - Una composicion para aclarar la piel. - Google Patents
Una composicion para aclarar la piel.Info
- Publication number
- MX2018004144A MX2018004144A MX2018004144A MX2018004144A MX2018004144A MX 2018004144 A MX2018004144 A MX 2018004144A MX 2018004144 A MX2018004144 A MX 2018004144A MX 2018004144 A MX2018004144 A MX 2018004144A MX 2018004144 A MX2018004144 A MX 2018004144A
- Authority
- MX
- Mexico
- Prior art keywords
- skin lightening
- niacinamide
- melanocytes
- composition
- melanosome transfer
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 206010040829 Skin discolouration Diseases 0.000 title abstract 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 abstract 4
- 229960003966 nicotinamide Drugs 0.000 abstract 4
- 235000005152 nicotinamide Nutrition 0.000 abstract 4
- 239000011570 nicotinamide Substances 0.000 abstract 4
- 210000002752 melanocyte Anatomy 0.000 abstract 3
- 210000002780 melanosome Anatomy 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 230000036564 melanin content Effects 0.000 abstract 2
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 abstract 2
- 230000002195 synergetic effect Effects 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 210000002510 keratinocyte Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se encuentra en el campo de las composiciones para el cuidado personal; en particular, de composiciones para aclarar la piel. Se cree que la niacinamida reduce la transferencia de los melanosomas desde los melanocitos hacia los queratinocitos, produciendo así el aclaramiento de la piel. Sin embargo, se sabe que la niacinamida tiene un efecto directo escaso o nulo sobre el contenido de melanina en los melanocitos. De este modo, sigue deseándose obtener una composición que presente múltiples modos de acción, que combine la reducción de transferencia de los melanosomas con la reducción del contenido de melanina en los melanocitos. Por consiguiente, constituye un objeto de la presente invención proporcionar una composición con cantidades sinérgicas de picolinamida y niacinamida, que proporcionen una mejor inhibición de la transferencia de melanosoma. Se ha hallado que se obtiene un efecto sinérgico de aclaramiento de la piel cuando la niacinamida se combina con su isómero, la picolinamida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15188360 | 2015-10-05 | ||
| PCT/EP2016/073617 WO2017060211A1 (en) | 2015-10-05 | 2016-10-04 | A skin lightening composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018004144A true MX2018004144A (es) | 2018-06-13 |
| MX365369B MX365369B (es) | 2019-05-31 |
Family
ID=54256684
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018004144A MX365369B (es) | 2015-10-05 | 2016-10-04 | Una composición para aclarar la piel. |
| MX2018004143A MX2018004143A (es) | 2015-10-05 | 2016-10-04 | Composicion que comprende niacinamida y picolinamida. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018004143A MX2018004143A (es) | 2015-10-05 | 2016-10-04 | Composicion que comprende niacinamida y picolinamida. |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10660840B2 (es) |
| EP (2) | EP3359124B1 (es) |
| JP (2) | JP6907196B2 (es) |
| KR (1) | KR102643373B1 (es) |
| CN (2) | CN108135824B (es) |
| AR (1) | AR106261A1 (es) |
| BR (1) | BR112018005742B1 (es) |
| CA (2) | CA3000296A1 (es) |
| EA (2) | EA035440B1 (es) |
| MX (2) | MX365369B (es) |
| PH (1) | PH12018500619A1 (es) |
| WO (2) | WO2017060213A1 (es) |
| ZA (2) | ZA201802005B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3359124B1 (en) * | 2015-10-05 | 2020-06-03 | Unilever NV | Composition comprising niacinamide and picolinamide |
| EP3727315B1 (en) | 2017-12-18 | 2021-10-13 | Unilever Global IP Limited | A topical composition comprising n-cyclopropyl nicotinamide |
| KR102883281B1 (ko) * | 2018-11-09 | 2025-11-13 | (주)아모레퍼시픽 | 색소 침착 모델 세포용 세포배양액, 이를 이용한 색소 침착 모델 세포, 색소 침착 모델 세포 제조방법, 색소 침착 모델 세포를 이용한 피부 미백 물질 스크리닝 방법 및 피부 미백용 조성물 |
| KR102792650B1 (ko) * | 2018-11-13 | 2025-04-08 | (주)아모레퍼시픽 | 색소 침착 모델 세포용 세포배양액, 이를 이용한 색소 침착 모델 세포, 색소 침착 모델 세포 제조방법, 색소 침착 모델 세포를 이용한 피부 미백 물질 스크리닝 방법 및 피부 미백용 조성물 |
| MX2022000347A (es) * | 2019-07-12 | 2022-02-03 | Unilever Ip Holdings B V | Combinaciones bioenergeticas y metodos de uso del mismo. |
| WO2021249760A1 (en) * | 2020-06-10 | 2021-12-16 | Unilever Ip Holdings B.V. | A cosmetic composition comprising 6-methyl-picolinamide |
| US11696889B2 (en) | 2020-08-07 | 2023-07-11 | David Levy | Botanical antimicrobial composition |
| EP4326062A4 (en) * | 2021-04-22 | 2025-02-19 | Surgiwipe LLC | TOPICAL ANTISEPTIC |
| JP2025508187A (ja) * | 2022-03-18 | 2025-03-21 | ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ | 皮膚ブライトニング組成物 |
| WO2025228618A1 (en) * | 2024-05-01 | 2025-11-06 | Unilever Ip Holdings B.V. | A personal care composition |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1370236A (en) * | 1972-01-11 | 1974-10-16 | Unilever Ltd | Skin composition |
| GB1533119A (en) * | 1975-04-10 | 1978-11-22 | Unilever Ltd | Skin lightening compositions |
| GB8910366D0 (en) * | 1989-05-05 | 1989-06-21 | Unilever Plc | Skin composition |
| TW233264B (es) | 1992-02-03 | 1994-11-01 | Otsuka Pharma Co Ltd | |
| US5411741A (en) | 1993-07-29 | 1995-05-02 | Zaias; Nardo | Method and composition for skin depigmentation |
| WO1999047141A1 (en) | 1998-03-16 | 1999-09-23 | The Procter & Gamble Company | Method of treating skin irritation |
| JP2003529590A (ja) | 2000-03-21 | 2003-10-07 | アスション デヴェロップメント エーピーエス | ピリジンカルボキシ誘導体およびｈ２ヒスタミン受容体アンタゴニストからなる化学的複合体 |
| US20030105034A1 (en) | 2001-07-05 | 2003-06-05 | Astion Deveopment A/S | Pyridine carboxy derivatives and an aminosugar |
| FR2827763B1 (fr) | 2001-07-24 | 2005-09-23 | Cs | Substance alkyloside inhibant la fixation de microorganismes, utilisation topique et composition contenant au moins une telle substance |
| JP3908969B2 (ja) * | 2002-03-18 | 2007-04-25 | ピアス株式会社 | 化粧料 |
| ES2274236T3 (es) | 2002-06-20 | 2007-05-16 | Astion Dermatology A/S | Complejos novedosos de esteres de acidos grasos de polihidroxialcanos y nacinamida. |
| JP2004123554A (ja) * | 2002-09-30 | 2004-04-22 | Pias Arise Kk | 皮膚バリア機能改善物質、皮膚のしわ改善物質、および該物質を含む皮膚外用剤、化粧料および医薬部外品 |
| US20090105188A1 (en) | 2007-10-17 | 2009-04-23 | Nationwide Children's Hospital, Inc. | Compositions and Methods for Treating Necrotizing Enterocolitis |
| US20090317341A1 (en) | 2008-06-18 | 2009-12-24 | Conopco, Inc., D/B/A Unilever | Compositions for Lightening Skin Color |
| EP2313074A4 (en) | 2008-06-30 | 2015-04-15 | Elc Man Llc | TOPICAL COMPOSITIONS CONTAINING ISONICOTINAMIDE |
| CN102209701B (zh) * | 2008-11-11 | 2014-10-15 | 西格纳姆生物科学公司 | 异戊二烯基化合物和其方法 |
| US20130052162A1 (en) | 2010-04-20 | 2013-02-28 | Cedars-Sinai Medical Center | Boosting immune defense by upregulating ccaat/enhancer binding protein epsilon |
| EP2522331A1 (en) | 2011-05-09 | 2012-11-14 | DSM IP Assets B.V. | Use of resveratrol and niacinamide |
| WO2013030794A2 (en) * | 2011-08-31 | 2013-03-07 | Behrooz Kasraee | Use of substituted pyridines as skin depigmenting compounds |
| US20140161750A1 (en) * | 2012-12-12 | 2014-06-12 | Thomas Christopher Balshi | Sunscreen composition with pigment correcting properties |
| EP2742942B1 (en) * | 2012-12-14 | 2019-05-22 | Unilever N.V. | Niacinamide for inducing generation of antimicrobial peptides |
| WO2015061512A1 (en) | 2013-10-24 | 2015-04-30 | The Procter & Gamble Company | Skin lightening cosmetic compositions and methods |
| EA031758B1 (ru) | 2014-05-12 | 2019-02-28 | Юнилевер Н.В. | Ниацинамид для стимуляции продуцирования антимикробных пептидов |
| EP3359124B1 (en) | 2015-10-05 | 2020-06-03 | Unilever NV | Composition comprising niacinamide and picolinamide |
-
2016
- 2016-10-04 EP EP16775715.2A patent/EP3359124B1/en active Active
- 2016-10-04 EA EA201890886A patent/EA035440B1/ru not_active IP Right Cessation
- 2016-10-04 EP EP16778325.7A patent/EP3359261B1/en active Active
- 2016-10-04 WO PCT/EP2016/073626 patent/WO2017060213A1/en not_active Ceased
- 2016-10-04 CN CN201680058538.5A patent/CN108135824B/zh active Active
- 2016-10-04 CA CA3000296A patent/CA3000296A1/en active Pending
- 2016-10-04 EA EA201890889A patent/EA035789B1/ru not_active IP Right Cessation
- 2016-10-04 KR KR1020187008919A patent/KR102643373B1/ko active Active
- 2016-10-04 CN CN201680058411.3A patent/CN108136232B/zh active Active
- 2016-10-04 JP JP2018517293A patent/JP6907196B2/ja active Active
- 2016-10-04 MX MX2018004144A patent/MX365369B/es active IP Right Grant
- 2016-10-04 US US15/765,015 patent/US10660840B2/en active Active
- 2016-10-04 JP JP2018517350A patent/JP6880011B2/ja active Active
- 2016-10-04 CA CA3000880A patent/CA3000880A1/en active Pending
- 2016-10-04 US US15/764,968 patent/US10952952B2/en active Active
- 2016-10-04 MX MX2018004143A patent/MX2018004143A/es active IP Right Grant
- 2016-10-04 WO PCT/EP2016/073617 patent/WO2017060211A1/en not_active Ceased
- 2016-10-04 BR BR112018005742-8A patent/BR112018005742B1/pt active IP Right Grant
- 2016-10-05 AR ARP160103044A patent/AR106261A1/es unknown
-
2018
- 2018-03-21 PH PH12018500619A patent/PH12018500619A1/en unknown
- 2018-03-26 ZA ZA2018/02005A patent/ZA201802005B/en unknown
- 2018-04-05 ZA ZA2018/02233A patent/ZA201802233B/en unknown
-
2020
- 2020-03-18 US US16/822,183 patent/US11298312B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |