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MX2018001472A - Uso de cannabinoides en el tratamiento de epilepsia. - Google Patents

Uso de cannabinoides en el tratamiento de epilepsia.

Info

Publication number
MX2018001472A
MX2018001472A MX2018001472A MX2018001472A MX2018001472A MX 2018001472 A MX2018001472 A MX 2018001472A MX 2018001472 A MX2018001472 A MX 2018001472A MX 2018001472 A MX2018001472 A MX 2018001472A MX 2018001472 A MX2018001472 A MX 2018001472A
Authority
MX
Mexico
Prior art keywords
cbda
treatment
epilepsy
extract
cannabinoids
Prior art date
Application number
MX2018001472A
Other languages
English (en)
Other versions
MX379255B (es
Inventor
Stott Colin
Whalley Benjamin
Jones Nicholas
Willilams Robin
Original Assignee
Gw Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gw Pharma Ltd filed Critical Gw Pharma Ltd
Publication of MX2018001472A publication Critical patent/MX2018001472A/es
Publication of MX379255B publication Critical patent/MX379255B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/348—Cannabaceae
    • A61K36/3482—Cannabis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona con el uso de una cantidad terapéuticamente efectiva de ácido cannabidiólico (CBDA) en el tratamiento de epilepsia. En una modalidad el CBDA se utiliza en el tratamiento de convulsiones generalizadas, de preferencia en convulsiones tónico-clónicas. De preferencia el CBDA utilizado está en la forma de un principio activo botánico en la que el contenido de CBDA es mayor que 60%, y de mayor preferencia, es un extracto altamente purificado de cannabis de modo que el CBDA se presenta en mayor que 95%, a 96% y 97% hasta de mayor preferencia, mayor que 98% del extracto total (p/p) y se caracterizan los otros componentes del extracto. En particular los cannabinoides tetrahidrocannabinol (THC) o ácido tetrahidrocannabinólico (THCA) se han removido sustancialmente. Alternativamente, el CBDA puede producirse sintéticamente.
MX2018001472A 2015-08-10 2016-07-29 Uso de cannabinoides en el tratamiento de epilepsia. MX379255B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1514079.1A GB2541191A (en) 2015-08-10 2015-08-10 Use of cannabinoids in the treatment of epilepsy
PCT/GB2016/052340 WO2017025712A1 (en) 2015-08-10 2016-07-29 Use of cannabinoids in the treatment of epilepsy

Publications (2)

Publication Number Publication Date
MX2018001472A true MX2018001472A (es) 2018-04-24
MX379255B MX379255B (es) 2025-03-11

Family

ID=54200465

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018001472A MX379255B (es) 2015-08-10 2016-07-29 Uso de cannabinoides en el tratamiento de epilepsia.
MX2021000814A MX2021000814A (es) 2015-08-10 2018-02-02 Uso de cannabinoides en el tratamiento de epilepsia.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021000814A MX2021000814A (es) 2015-08-10 2018-02-02 Uso de cannabinoides en el tratamiento de epilepsia.

Country Status (19)

Country Link
US (2) US11147783B2 (es)
EP (2) EP3334422B1 (es)
JP (2) JP6949822B2 (es)
AU (1) AU2016305545B2 (es)
CA (1) CA2992802C (es)
CY (1) CY1123351T1 (es)
DK (1) DK3334422T3 (es)
ES (1) ES2820333T3 (es)
GB (1) GB2541191A (es)
HR (1) HRP20201506T1 (es)
HU (1) HUE051476T2 (es)
LT (1) LT3334422T (es)
MX (2) MX379255B (es)
PL (1) PL3334422T3 (es)
PT (1) PT3334422T (es)
RS (1) RS60852B1 (es)
SI (1) SI3334422T1 (es)
SM (1) SMT202000514T1 (es)
WO (1) WO2017025712A1 (es)

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EP3334422A1 (en) 2018-06-20
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