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MX2018000242A - Compuesto novedoso que se une especificamente a receptor de acido alfa-amino-3-hidroxi-5-metil-4-isoxazol-propionico (ampa). - Google Patents

Compuesto novedoso que se une especificamente a receptor de acido alfa-amino-3-hidroxi-5-metil-4-isoxazol-propionico (ampa).

Info

Publication number
MX2018000242A
MX2018000242A MX2018000242A MX2018000242A MX2018000242A MX 2018000242 A MX2018000242 A MX 2018000242A MX 2018000242 A MX2018000242 A MX 2018000242A MX 2018000242 A MX2018000242 A MX 2018000242A MX 2018000242 A MX2018000242 A MX 2018000242A
Authority
MX
Mexico
Prior art keywords
ampa receptor
independently represents
specifically binds
novel compound
formula
Prior art date
Application number
MX2018000242A
Other languages
English (en)
Other versions
MX386015B (es
Inventor
Tetsuya Suhara
Takahashi Takuya
Miyazaki Tomoyuki
Higuchi Makoto
Cho Meiei
Original Assignee
Public Univ Corp Yokohama City Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Public Univ Corp Yokohama City Univ filed Critical Public Univ Corp Yokohama City Univ
Publication of MX2018000242A publication Critical patent/MX2018000242A/es
Publication of MX386015B publication Critical patent/MX386015B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona un compuesto representado por la Fórmula (I), (ver Fórmula) una sal farmacéuticamente aceptable del mismo o un solvato del mismo; este compuesto es capaz de unirse específicamente a un receptor de AMPA, y muestra absorción del cerebro extremadamente alta; (en la fórmula, cada uno de A y Z independientemente representa CO, SO o SO2, cada uno de X e Y independientemente representa S u O; cada uno de R1 a R4 independientemente representa hidrógeno, alquilo, alquenilo, alquinilo o halo; cada R5 independientemente representa alquilo, alquenilo, alquinilo o halo; y n representa un número entero de 0 a 4).
MX2018000242A 2015-07-06 2016-07-05 Compuesto novedoso que se une específicamente a receptor de ácido alfa-amino-3-hidroxi-5-metil-4-isoxazol-propiónico (ampa). MX386015B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015135124 2015-07-06
PCT/JP2016/069896 WO2017006931A1 (ja) 2015-07-06 2016-07-05 Ａｍｐａ受容体に特異的に結合する新規化合物

Publications (2)

Publication Number Publication Date
MX2018000242A true MX2018000242A (es) 2018-03-08
MX386015B MX386015B (es) 2025-03-18

Family

ID=57685631

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018000242A MX386015B (es) 2015-07-06 2016-07-05 Compuesto novedoso que se une específicamente a receptor de ácido alfa-amino-3-hidroxi-5-metil-4-isoxazol-propiónico (ampa).

Country Status (17)

Country Link
US (1) US10335503B2 (es)
EP (1) EP3321252B1 (es)
JP (1) JP6425817B2 (es)
KR (1) KR101997699B1 (es)
CN (1) CN107922328B (es)
AU (1) AU2016289031C1 (es)
BR (1) BR112017028639B1 (es)
CA (1) CA2991400C (es)
DK (1) DK3321252T3 (es)
ES (1) ES2829638T3 (es)
IL (1) IL256735B (es)
MX (1) MX386015B (es)
PL (1) PL3321252T3 (es)
RU (1) RU2705595C2 (es)
SG (1) SG11201800071PA (es)
TW (1) TWI675820B (es)
WO (1) WO2017006931A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017151487A1 (en) * 2016-02-29 2017-09-08 Neurovation Labs, Inc. Detection of glua1 in brain to identify the presence of glua1 -mediated ptsd
JP2020045285A (ja) * 2017-01-11 2020-03-26 公立大学法人横浜市立大学 Ａｍｐａ受容体に関連する疾患の予防及び／又は治療剤
JP6241974B1 (ja) * 2017-01-11 2017-12-06 公立大学法人横浜市立大学 霊長類生体の脳内ａｍｐａ受容体のイメージング方法、プログラム、及びスクリーニング方法
WO2019046240A1 (en) * 2017-08-28 2019-03-07 Neurovation Labs, Inc. COMPOSITIONS AND METHODS FOR DETECTING GLUA1 IN THE BRAIN AND IDENTIFYING GLUA1-INDUCED POST-TRAUMATIC STRESS DISORDER
CN110483343B (zh) * 2019-09-03 2021-08-27 泰州职业技术学院 一种新型的磺酰氯衍生物、其制备方法及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189211A (en) 1990-08-01 1993-02-23 Taisho Pharmaceutical Co., Ltd. Sulfonamide derivatives
DE69611437T2 (de) * 1995-02-21 2001-08-23 Nippon Suisan Kaisha, Ltd. Gluteminsäurerezeptor agonisten
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
HU229553B1 (en) 2000-06-12 2014-01-28 Eisai R & D Man Co 1,2-dihydropyridine compound, process for preparation of the same and use thereof
FR2854634B1 (fr) 2003-05-05 2005-07-08 Servier Lab Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK2346847T3 (da) * 2008-09-17 2013-08-05 Suven Life Sciences Ltd Arylsulfonamidaminforbindelser og deres anvendelse som 5-ht6-ligander
JP5455396B2 (ja) 2009-02-27 2014-03-26 知之 西崎 プロテインホスファターゼ−１阻害剤
WO2011002096A1 (ja) 2009-07-03 2011-01-06 独立行政法人理化学研究所 Ｐｅｔ用標識化合物
EP2981531A1 (en) 2013-04-04 2016-02-10 Eisai R&D Management Co., Ltd. [11 c]and [18f]labeled 1,3-diphenyl-5-(pyrimidin-2-yl)-pyridin-2(1 h)-one derivatives and their use for pet imaging of the ampa receptor
US9987381B2 (en) * 2013-10-31 2018-06-05 Bristol-Myers Squibb Company Radioligands for imaging the LPA-1 receptor

Also Published As

Publication number Publication date
JPWO2017006931A1 (ja) 2018-06-21
TW201706242A (zh) 2017-02-16
PL3321252T3 (pl) 2021-04-06
US20180200391A1 (en) 2018-07-19
CN107922328B (zh) 2020-05-19
RU2018104555A (ru) 2019-08-06
DK3321252T3 (da) 2020-11-16
CA2991400A1 (en) 2017-01-12
EP3321252B1 (en) 2020-10-21
JP6425817B2 (ja) 2018-11-21
AU2016289031B2 (en) 2019-07-18
AU2016289031A1 (en) 2018-01-25
US10335503B2 (en) 2019-07-02
TWI675820B (zh) 2019-11-01
RU2018104555A3 (es) 2019-08-06
AU2016289031C1 (en) 2019-10-17
IL256735A (en) 2018-03-29
BR112017028639A2 (pt) 2018-09-11
WO2017006931A1 (ja) 2017-01-12
ES2829638T3 (es) 2021-06-01
HK1250230A1 (zh) 2018-12-07
BR112017028639B1 (pt) 2023-03-21
SG11201800071PA (en) 2018-02-27
CN107922328A (zh) 2018-04-17
RU2705595C2 (ru) 2019-11-11
KR20180025951A (ko) 2018-03-09
EP3321252A1 (en) 2018-05-16
IL256735B (en) 2021-02-28
KR101997699B1 (ko) 2019-07-08
EP3321252A4 (en) 2019-03-13
MX386015B (es) 2025-03-18
CA2991400C (en) 2020-05-12

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