MX2018000175A - Compuestos de arilsulfonamida como inhibidores de la anhidrasa carbonica y su uso terapeutico. - Google Patents
Compuestos de arilsulfonamida como inhibidores de la anhidrasa carbonica y su uso terapeutico.Info
- Publication number
- MX2018000175A MX2018000175A MX2018000175A MX2018000175A MX2018000175A MX 2018000175 A MX2018000175 A MX 2018000175A MX 2018000175 A MX2018000175 A MX 2018000175A MX 2018000175 A MX2018000175 A MX 2018000175A MX 2018000175 A MX2018000175 A MX 2018000175A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- inhibitors
- carbonic
- arilsulfonamide
- anhidrasa
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 abstract 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se describen en la presente los compuestos que tienen la siguiente estructura, útiles como inhibidores de la anhidrasa carbónica IX (CAIX) y XII, y particularmente útiles para reducir o eliminar metástasis, véase la Fórmula (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187636P | 2015-07-01 | 2015-07-01 | |
| PCT/US2016/040736 WO2017004543A1 (en) | 2015-07-01 | 2016-07-01 | Aryl sulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018000175A true MX2018000175A (es) | 2018-03-26 |
| MX387267B MX387267B (es) | 2025-03-18 |
Family
ID=56411955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018000175A MX387267B (es) | 2015-07-01 | 2016-07-01 | Compuestos de arilsulfonamida como inhibidores de la anhidrasa carbonica y su uso terapeutico. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10562859B2 (es) |
| EP (1) | EP3317255B1 (es) |
| JP (1) | JP6795525B2 (es) |
| KR (1) | KR102637759B1 (es) |
| CN (1) | CN107922345B (es) |
| AU (1) | AU2016287587B2 (es) |
| BR (1) | BR112018000065B1 (es) |
| CA (1) | CA2991168C (es) |
| IL (1) | IL256527B (es) |
| MX (1) | MX387267B (es) |
| WO (1) | WO2017004543A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS63755B1 (sr) * | 2017-04-05 | 2022-12-30 | Harvard College | Makrociklično jedinjenje i njegova upotreba |
| KR20210000564A (ko) | 2019-06-25 | 2021-01-05 | 공주대학교 산학협력단 | 신규 아만타딘 유도체 화합물 및 이의 용도 |
| CN111233786B (zh) * | 2020-02-04 | 2021-11-26 | 中国人民解放军军事科学院军事医学研究院 | 含五元杂环的苯磺酰胺类化合物及其制备方法和用途 |
| CA3178176A1 (en) * | 2020-06-02 | 2021-12-09 | Fikrettin Sahin | 2-(3-(2-methyl-6-(p-tolyl) pyridine-3-yl) ureido) benzenesulfonamide and derivatives as inhibitor of carbonic anhydrase ix for the treatment of cancer |
| TR202014185A2 (tr) * | 2020-09-08 | 2022-03-21 | Anadolu Ueniversitesi | BAZI YENİ 4-(2-((5-(SÜBSTİTÜEAMİNO)-1,3,4-TİYADİAZOL-2-İL)TİYO)ASETİL)BENZENSÜLFONAMİD TÜREVLERİ ve SÖZ KONUSU TÜREVLERİN SENTEZİ İÇİN BİR YÖNTEM |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0211836A (pt) * | 2001-08-10 | 2004-12-14 | Pharmacia Corp | Inibidor de anidrase carbÈnica |
| WO2008077597A1 (en) * | 2006-12-22 | 2008-07-03 | Novartis Ag | 1-aminomethyl- l- phenyl- cyclohexane derivatives as ddp-iv inhibitors |
| EP2590938B1 (en) | 2010-07-09 | 2017-06-07 | Welichem Biotech Inc. | Novel sulfonamide compounds for inhibition of metastatic tumor growth |
| CA2844783C (en) | 2011-08-16 | 2019-10-29 | Universite Laval | Substituted 2-imidazolidinones and 2-imidazolones and their use in the treatment of cancer |
-
2016
- 2016-07-01 EP EP16738988.1A patent/EP3317255B1/en active Active
- 2016-07-01 MX MX2018000175A patent/MX387267B/es unknown
- 2016-07-01 JP JP2017568244A patent/JP6795525B2/ja active Active
- 2016-07-01 KR KR1020187003119A patent/KR102637759B1/ko active Active
- 2016-07-01 AU AU2016287587A patent/AU2016287587B2/en active Active
- 2016-07-01 BR BR112018000065-5A patent/BR112018000065B1/pt active IP Right Grant
- 2016-07-01 WO PCT/US2016/040736 patent/WO2017004543A1/en not_active Ceased
- 2016-07-01 CA CA2991168A patent/CA2991168C/en active Active
- 2016-07-01 CN CN201680046227.7A patent/CN107922345B/zh active Active
- 2016-07-01 US US15/743,601 patent/US10562859B2/en active Active
-
2017
- 2017-12-24 IL IL256527A patent/IL256527B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016287587A1 (en) | 2018-01-25 |
| CA2991168A1 (en) | 2017-01-05 |
| US10562859B2 (en) | 2020-02-18 |
| HK1248228A1 (en) | 2018-10-12 |
| MX387267B (es) | 2025-03-18 |
| IL256527B (en) | 2021-04-29 |
| EP3317255A1 (en) | 2018-05-09 |
| AU2016287587B2 (en) | 2020-04-30 |
| CA2991168C (en) | 2022-04-26 |
| US20180201584A1 (en) | 2018-07-19 |
| CN107922345B (zh) | 2021-03-23 |
| JP2018519332A (ja) | 2018-07-19 |
| CN107922345A (zh) | 2018-04-17 |
| WO2017004543A1 (en) | 2017-01-05 |
| KR102637759B1 (ko) | 2024-02-19 |
| EP3317255B1 (en) | 2021-09-01 |
| KR20180023990A (ko) | 2018-03-07 |
| JP6795525B2 (ja) | 2020-12-02 |
| IL256527A (en) | 2018-02-28 |
| BR112018000065A2 (pt) | 2018-09-11 |
| BR112018000065B1 (pt) | 2023-11-07 |
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