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MX2017015814A - Dimeros de benzodiazepina macrociclica, conjugados de los mismos, preparacion y usos. - Google Patents

Dimeros de benzodiazepina macrociclica, conjugados de los mismos, preparacion y usos.

Info

Publication number
MX2017015814A
MX2017015814A MX2017015814A MX2017015814A MX2017015814A MX 2017015814 A MX2017015814 A MX 2017015814A MX 2017015814 A MX2017015814 A MX 2017015814A MX 2017015814 A MX2017015814 A MX 2017015814A MX 2017015814 A MX2017015814 A MX 2017015814A
Authority
MX
Mexico
Prior art keywords
macrocyclic
conjugates
preparation
benzodiazepine dimers
dimers
Prior art date
Application number
MX2017015814A
Other languages
English (en)
Inventor
Zhang Yong
F Donnell Andrew
J Tebben Andrew
M Borzilleri Robert
M Stang Erik
M Schroeder Gretchen
L Perez Heidi
D Wei Donna
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of MX2017015814A publication Critical patent/MX2017015814A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Los dímeros de benzodiazepina macrocíclicos que tienen una estructura representada por la fórmula (I) en donde A y B son independientemente de acuerdo con las fórmulas (la) o (Ib) ]; y las otras variables en las fórmulas (I), (la) y (Ib) son como se define en la solicitud. Tales dímeros son útiles como agentes anticancerosos, especialmente cuando se usan como el componente de fármaco en un conjugado de anticuerpo-fármaco (ADC).
MX2017015814A 2015-06-23 2016-06-22 Dimeros de benzodiazepina macrociclica, conjugados de los mismos, preparacion y usos. MX2017015814A (es)

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