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MX2017015100A - Preparacion de citrato de sufentanilo y base de sufentanilo. - Google Patents

Preparacion de citrato de sufentanilo y base de sufentanilo.

Info

Publication number
MX2017015100A
MX2017015100A MX2017015100A MX2017015100A MX2017015100A MX 2017015100 A MX2017015100 A MX 2017015100A MX 2017015100 A MX2017015100 A MX 2017015100A MX 2017015100 A MX2017015100 A MX 2017015100A MX 2017015100 A MX2017015100 A MX 2017015100A
Authority
MX
Mexico
Prior art keywords
sufentanil
citrate
base
preparation
forming
Prior art date
Application number
MX2017015100A
Other languages
English (en)
Other versions
MX381426B (es
Inventor
Helmut Klemm George
Orr Brian
Mcclenaghan Joel
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of MX2017015100A publication Critical patent/MX2017015100A/es
Publication of MX381426B publication Critical patent/MX381426B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporciona en la presente procesos para formar citrato de sufentanilo a partir de la base de sufentanilo. Un proceso comprende formar citrato de sufentanilo en presencia de un solvente no acuoso polar. Otros procesos comprenden formar citrato de sufentanilo en presencia de agua.
MX2017015100A 2015-05-27 2016-05-25 Preparacion de citrato de sufentanilo y base de sufentanilo. MX381426B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562166911P 2015-05-27 2015-05-27
PCT/US2016/034091 WO2016191472A1 (en) 2015-05-27 2016-05-25 Preparation of sufentanil citrate and sufentanil base

Publications (2)

Publication Number Publication Date
MX2017015100A true MX2017015100A (es) 2018-08-09
MX381426B MX381426B (es) 2025-03-12

Family

ID=57393664

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017015100A MX381426B (es) 2015-05-27 2016-05-25 Preparacion de citrato de sufentanilo y base de sufentanilo.

Country Status (10)

Country Link
US (5) US10227335B2 (es)
EP (1) EP3302473B1 (es)
JP (4) JP2018515580A (es)
AU (1) AU2016268344B2 (es)
BR (1) BR112017025115B1 (es)
CA (1) CA2986764A1 (es)
ES (1) ES2806631T3 (es)
MX (1) MX381426B (es)
PL (1) PL3302473T3 (es)
WO (1) WO2016191472A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2986764A1 (en) * 2015-05-27 2016-12-01 Mallinckrodt Llc Preparation of sufentanil citrate and sufentanil base

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179569A (en) * 1975-03-14 1979-12-18 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-N-phenylamides
US3998834A (en) * 1975-03-14 1976-12-21 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-n-phenylamides and -carbamates
US5039804A (en) * 1989-12-13 1991-08-13 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
US5489689A (en) 1993-09-30 1996-02-06 Mallinckrodt Chemical, Inc. Preparation of piperidine derivatives
US6342250B1 (en) 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
JP2003515588A (ja) 1999-12-06 2003-05-07 マリンクロッド・インコーポレイテッド アルフェンタニル、スフェンタニルおよびレミフェンタニルの新合成法
EP1436057B1 (en) * 2001-10-17 2006-04-19 E.I. du Pont de Nemours and Company Rotor-stator apparatus and process for the formation of particles
WO2008005423A1 (en) 2006-07-03 2008-01-10 Cambrex Charles City, Inc. Improved method of making sufentanil
CA2677281C (en) * 2007-02-09 2019-10-29 Durect Corporation Transoral dosage forms comprising sufentanil and naloxone
WO2010027770A1 (en) * 2008-09-04 2010-03-11 Mallinckrodt Inc. Crystalline forms of sufentanil citrate
WO2010053944A1 (en) * 2008-11-04 2010-05-14 Cambrex Charles City, Inc. Improved method of making piperidine derivatives
WO2012037309A2 (en) * 2010-09-17 2012-03-22 Mallinckrodt Llc Improved process for the preparation of sufentanil base and related compounds
EP2455377B1 (de) 2010-11-11 2014-07-09 hameln rds gmbh Synthese von Fentanyl Analoga
CN102060753B (zh) * 2010-12-29 2013-01-09 宜昌人福药业有限责任公司 一种4-苯胺基哌啶类镇痛药的精制方法
JP6146613B2 (ja) 2013-09-04 2017-06-14 東芝ライテック株式会社 自動車用照明装置、および自動車用灯具
CA2986764A1 (en) 2015-05-27 2016-12-01 Mallinckrodt Llc Preparation of sufentanil citrate and sufentanil base

Also Published As

Publication number Publication date
JP2018515580A (ja) 2018-06-14
EP3302473A4 (en) 2019-04-17
JP2021059609A (ja) 2021-04-15
JP7525589B2 (ja) 2024-07-30
US20160347743A1 (en) 2016-12-01
EP3302473B1 (en) 2020-07-08
US12371423B2 (en) 2025-07-29
ES2806631T3 (es) 2021-02-18
JP2024138039A (ja) 2024-10-07
MX381426B (es) 2025-03-12
US20210061793A1 (en) 2021-03-04
US10227335B2 (en) 2019-03-12
BR112017025115B1 (pt) 2023-03-14
EP3302473A1 (en) 2018-04-11
WO2016191472A1 (en) 2016-12-01
US20190152961A1 (en) 2019-05-23
US20230074804A1 (en) 2023-03-09
US10899749B2 (en) 2021-01-26
US20250368630A1 (en) 2025-12-04
CA2986764A1 (en) 2016-12-01
AU2016268344A1 (en) 2017-11-30
PL3302473T3 (pl) 2020-12-14
AU2016268344B2 (en) 2020-03-26
BR112017025115A2 (pt) 2018-07-31
JP2023036903A (ja) 2023-03-14

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