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MX2017015189A - Neutralizacion de moleculas de union anti-influenza y usos de las mismas. - Google Patents

Neutralizacion de moleculas de union anti-influenza y usos de las mismas.

Info

Publication number
MX2017015189A
MX2017015189A MX2017015189A MX2017015189A MX2017015189A MX 2017015189 A MX2017015189 A MX 2017015189A MX 2017015189 A MX2017015189 A MX 2017015189A MX 2017015189 A MX2017015189 A MX 2017015189A MX 2017015189 A MX2017015189 A MX 2017015189A
Authority
MX
Mexico
Prior art keywords
influenza
neutralization
same
molecules
union
Prior art date
Application number
MX2017015189A
Other languages
English (en)
Other versions
MX389708B (es
Inventor
Gao Changshou
Gao Cuihua
Kallewaard-Lelay Nicole
Zhu Qing
Kasturirangan Srinath
Jonah Rainey Godfrey
Original Assignee
Medimmune Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Llc filed Critical Medimmune Llc
Publication of MX2017015189A publication Critical patent/MX2017015189A/es
Publication of MX389708B publication Critical patent/MX389708B/es

Links

Classifications

    • C07K16/108—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen moléculas de unión, que incluyen anticuerpos biespecíficos que incluyen al menos dos dominios de unión anti-influenza, que incluyen moléculas de unión que tienen un primer dominio de unión que se une específicamente al virus de influenza A y un segundo dominio de unión que se une específicamente al virus de influenza B.
MX2017015189A 2015-06-01 2016-05-31 Neutralizacion de moleculas de union anti-influenza y usos de las mismas. MX389708B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562169272P 2015-06-01 2015-06-01
PCT/US2016/035026 WO2016196470A1 (en) 2015-06-01 2016-05-31 Neutralizing anti-influenza binding molecules and uses thereof

Publications (2)

Publication Number Publication Date
MX2017015189A true MX2017015189A (es) 2018-04-13
MX389708B MX389708B (es) 2025-03-20

Family

ID=56118059

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017015189A MX389708B (es) 2015-06-01 2016-05-31 Neutralizacion de moleculas de union anti-influenza y usos de las mismas.
MX2022001220A MX2022001220A (es) 2015-06-01 2017-11-27 Neutralizacion de moleculas de union anti-influenza y usos de las mismas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022001220A MX2022001220A (es) 2015-06-01 2017-11-27 Neutralizacion de moleculas de union anti-influenza y usos de las mismas.

Country Status (21)

Country Link
US (4) US10442854B2 (es)
EP (2) EP3960761A1 (es)
JP (3) JP6867306B2 (es)
CN (2) CN113480640B (es)
AU (2) AU2016271323B2 (es)
BR (1) BR112017025496A2 (es)
CA (1) CA2987816C (es)
CY (1) CY1125793T1 (es)
DK (1) DK3303384T3 (es)
ES (1) ES2894777T3 (es)
HR (1) HRP20211510T1 (es)
HU (1) HUE056407T2 (es)
LT (1) LT3303384T (es)
MX (2) MX389708B (es)
PL (1) PL3303384T3 (es)
PT (1) PT3303384T (es)
RS (1) RS62446B1 (es)
RU (1) RU2721706C2 (es)
SI (1) SI3303384T1 (es)
SM (1) SMT202100591T1 (es)
WO (1) WO2016196470A1 (es)

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Also Published As

Publication number Publication date
WO2016196470A1 (en) 2016-12-08
RU2017145094A3 (es) 2019-11-06
US11926657B2 (en) 2024-03-12
AU2016271323B2 (en) 2022-08-25
EP3303384B1 (en) 2021-08-25
CN107667114B (zh) 2021-07-02
DK3303384T3 (da) 2021-10-18
AU2016271323A1 (en) 2018-01-18
AU2022271473A1 (en) 2022-12-22
RU2721706C2 (ru) 2020-05-21
PT3303384T (pt) 2021-10-14
CN113480640B (zh) 2024-07-30
SI3303384T1 (sl) 2021-11-30
MX389708B (es) 2025-03-20
EP3303384A1 (en) 2018-04-11
US20230112916A1 (en) 2023-04-13
ES2894777T3 (es) 2022-02-15
HRP20211510T1 (hr) 2021-12-24
JP2021112193A (ja) 2021-08-05
HUE056407T2 (hu) 2022-02-28
SMT202100591T1 (it) 2021-11-12
HK1250725A1 (zh) 2019-01-11
CA2987816C (en) 2024-02-20
CA2987816A1 (en) 2016-12-08
US11524993B2 (en) 2022-12-13
JP2023078352A (ja) 2023-06-06
US20180155413A1 (en) 2018-06-07
EP3960761A1 (en) 2022-03-02
HK1253092A1 (zh) 2019-06-06
CN107667114A (zh) 2018-02-06
US10882897B2 (en) 2021-01-05
JP2018518475A (ja) 2018-07-12
US20200109187A1 (en) 2020-04-09
US20210079069A1 (en) 2021-03-18
RU2017145094A (ru) 2019-07-09
JP6867306B2 (ja) 2021-04-28
RS62446B1 (sr) 2021-11-30
LT3303384T (lt) 2021-10-11
PL3303384T3 (pl) 2022-01-03
CN113480640A (zh) 2021-10-08
US10442854B2 (en) 2019-10-15
BR112017025496A2 (pt) 2018-08-07
CY1125793T1 (el) 2024-02-16
MX2022001220A (es) 2022-03-02

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