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MX2017015151A - Un proceso mejorado para la preparación de apremilast y novedosos polimorfos del mismo. - Google Patents

Un proceso mejorado para la preparación de apremilast y novedosos polimorfos del mismo.

Info

Publication number
MX2017015151A
MX2017015151A MX2017015151A MX2017015151A MX2017015151A MX 2017015151 A MX2017015151 A MX 2017015151A MX 2017015151 A MX2017015151 A MX 2017015151A MX 2017015151 A MX2017015151 A MX 2017015151A MX 2017015151 A MX2017015151 A MX 2017015151A
Authority
MX
Mexico
Prior art keywords
apremilast
preparation
improved process
novel polymorphs
provides
Prior art date
Application number
MX2017015151A
Other languages
English (en)
Inventor
Mahadeorao Lande Hemraj
Gokuldas Varade SHANTANU
Dasharath Surwase Mithun
Bhikaji SHIVDAVKAR Radhakrishna
Dnyanoba Ausekar GOVIND
Baban Bhise Nandu
Chandra Ray Purna
Digambar Patil Arunkumar
Pal Singh Girij
Pundlik Sapdhare Ananda
Pal Singh Gurvinder
Sanphui Palash
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of MX2017015151A publication Critical patent/MX2017015151A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención proporciona un proceso mejorado para la preparación de un intermedio de apremilast. La presente invención también proporciona un proceso mejorado para la preparación de apremilast. Esta invención también proporciona polimorfos novedosos de apremilast. La presente invención también proporciona composiciones farmacéuticas de polimorfos novedosos de apremilast. Esta invención también proporciona un proceso para la preparación de polimorfos novedosos de apremilast, los cuales son rentables, sólidos y viables a escala de planta.
MX2017015151A 2015-05-26 2016-05-26 Un proceso mejorado para la preparación de apremilast y novedosos polimorfos del mismo. MX2017015151A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2046MU2015 2015-05-26
IN2048MU2015 2015-05-26
PCT/IB2016/053083 WO2016189486A1 (en) 2015-05-26 2016-05-26 An improved process for preparation of apremilast and novel polymorphs thereof

Publications (1)

Publication Number Publication Date
MX2017015151A true MX2017015151A (es) 2018-08-15

Family

ID=56121137

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017015151A MX2017015151A (es) 2015-05-26 2016-05-26 Un proceso mejorado para la preparación de apremilast y novedosos polimorfos del mismo.

Country Status (5)

Country Link
US (1) US10377712B2 (es)
JP (1) JP2018516912A (es)
BR (1) BR112017025262A2 (es)
MX (1) MX2017015151A (es)
WO (1) WO2016189486A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104761484B (zh) * 2014-11-24 2018-03-27 上海优拓医药科技有限公司 一种稳定的不含溶剂化物的阿普司特晶型ii及其制备方法
US10544097B2 (en) * 2015-08-27 2020-01-28 Msn Laboratories Private Limited Solid state forms of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide and process for preparation thereof
US9765026B2 (en) 2015-08-28 2017-09-19 Scinopharm Taiwan, Ltd. Forms of apremilast and the process of making the same
US10919855B2 (en) 2017-05-04 2021-02-16 Unichem Laboratories Ltd Process to prepare n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulphonyl) ethyl]-1, 3-dioxo-2,3-dihydro-1h-isoindol-4yl]acetamide
CN108440381A (zh) * 2018-03-15 2018-08-24 威海迪素制药有限公司 一种阿普斯特新晶型h及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en) * 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7256300B2 (en) * 2004-03-30 2007-08-14 Boehringer Ingelheim Pharmaceuticals, Inc. Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
US8242310B2 (en) 2008-09-10 2012-08-14 Celgene Corporation Processes for the preparation of aminosulfone compounds
US9126906B2 (en) 2012-02-21 2015-09-08 Celgene Corporation Asymmetric synthetic processes for the preparation of aminosulfone compounds

Also Published As

Publication number Publication date
WO2016189486A1 (en) 2016-12-01
US20180230097A1 (en) 2018-08-16
US10377712B2 (en) 2019-08-13
JP2018516912A (ja) 2018-06-28
BR112017025262A2 (pt) 2018-07-31

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