MX2017014958A - Metodo de produccion de forma cristalina de enzalutamida. - Google Patents
Metodo de produccion de forma cristalina de enzalutamida.Info
- Publication number
- MX2017014958A MX2017014958A MX2017014958A MX2017014958A MX2017014958A MX 2017014958 A MX2017014958 A MX 2017014958A MX 2017014958 A MX2017014958 A MX 2017014958A MX 2017014958 A MX2017014958 A MX 2017014958A MX 2017014958 A MX2017014958 A MX 2017014958A
- Authority
- MX
- Mexico
- Prior art keywords
- enzalutamide
- producing
- crystals
- crystal form
- crystalline form
- Prior art date
Links
- WXCXUHSOUPDCQV-UHFFFAOYSA-N enzalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C(C)(C)C(=O)N(C=2C=C(C(C#N)=CC=2)C(F)(F)F)C1=S WXCXUHSOUPDCQV-UHFFFAOYSA-N 0.000 title abstract 7
- 229960004671 enzalutamide Drugs 0.000 title abstract 7
- 239000013078 crystal Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- 238000002425 crystallisation Methods 0.000 abstract 3
- 230000008025 crystallization Effects 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012046 mixed solvent Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B33/00—After-treatment of single crystals or homogeneous polycrystalline material with defined structure
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Glass Compositions (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Abstract
La presente invención se relaciona con un método de producción de una forma cristalina de enzalutamida, en la que los cristales húmedos de enzalutamida se obtienen en una etapa de cristalización en el proceso de producción de la forma cristalina de enzalutamida, y luego 2-propanol que se solvata con enzalutamida y se reducen los cristales de tipo B. La presente invención se relaciona con un método de producción de una forma cristalina de enzalutamida, que comprende una etapa de cristalización para obtener cristales húmedos de enzalutamida, y una etapa de secado de los cristales húmedos, y comprende una etapa de lavado usando un solvente mixto de un solvente rico y un solvente pobre despuós de la etapa de cristalización.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015109805 | 2015-05-29 | ||
| PCT/JP2016/065729 WO2016194813A1 (ja) | 2015-05-29 | 2016-05-27 | エンザルタミド結晶形の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017014958A true MX2017014958A (es) | 2018-07-06 |
| MX385084B MX385084B (es) | 2025-03-14 |
Family
ID=57442345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017014958A MX385084B (es) | 2015-05-29 | 2016-05-27 | Método de producción de forma cristalina de enzalutamida. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10118899B2 (es) |
| EP (1) | EP3305770B1 (es) |
| JP (1) | JP6753396B2 (es) |
| KR (1) | KR102666017B1 (es) |
| CN (1) | CN107635969B (es) |
| CA (1) | CA2987563C (es) |
| ES (1) | ES2942618T3 (es) |
| MX (1) | MX385084B (es) |
| PL (1) | PL3305770T3 (es) |
| PT (1) | PT3305770T (es) |
| WO (1) | WO2016194813A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3143111A1 (en) * | 2019-06-27 | 2020-12-30 | Synthon B.V. | Process for preparation of enzalutamide |
| WO2021064123A1 (en) | 2019-10-03 | 2021-04-08 | Synthon B.V. | Pharmaceutical composition comprising enzalutamide |
| CN111217757B (zh) * | 2020-01-06 | 2021-03-19 | 武汉大学 | 一种恩杂鲁胺化合物及其药物组合物制剂 |
| CN111303042A (zh) * | 2020-03-25 | 2020-06-19 | 北京赛思源生物医药技术有限公司 | 一种恩杂鲁胺的新晶型 |
| CN114591246A (zh) * | 2022-03-25 | 2022-06-07 | 重庆华邦制药有限公司 | 一种恩扎卢胺的纯化方法 |
| CN115536591B (zh) * | 2022-09-27 | 2024-06-25 | 爱斯特（成都）生物制药股份有限公司 | 一种连续流制备恩扎卢胺的方法 |
| WO2025125565A1 (en) | 2023-12-13 | 2025-06-19 | Krka, D.D., Novo Mesto | Tablet comprising enzalutamide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101782236B1 (ko) | 2005-05-13 | 2017-09-26 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 디아릴히단토인 화합물 |
| WO2011106570A1 (en) | 2010-02-24 | 2011-09-01 | Medivation Prostate Therapeutics, Inc. | Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds |
| KR20130105803A (ko) * | 2010-06-14 | 2013-09-26 | 솔베이 스페셜티 폴리머스 이태리 에스.피.에이. | Pvdf 코팅 조성물 |
| CN104768935A (zh) | 2012-09-11 | 2015-07-08 | 雷迪博士实验室有限公司 | 恩杂鲁胺的多晶型形式及其制备 |
| CN105188699B (zh) | 2013-10-14 | 2017-04-26 | 杭州普晒医药科技有限公司 | 恩杂鲁胺的固态形式及其制备方法和用途 |
| US9611225B2 (en) | 2014-01-27 | 2017-04-04 | Cadila Healthcare Limited | Process for preparation of androgen receptor antagonist |
| EP3166931A4 (en) | 2014-07-11 | 2018-05-09 | Shilpa Medicare Limited | An improved process for the preparation of enzalutamide |
| CN104610158A (zh) | 2015-02-03 | 2015-05-13 | 江苏慧博生物科技有限公司 | 一种恩杂鲁胺的精制方法 |
| ITUB20151204A1 (it) | 2015-05-28 | 2016-11-28 | Olon Spa | Procedimento per la preparazione di enzalutamide |
-
2016
- 2016-05-27 EP EP16803248.0A patent/EP3305770B1/en active Active
- 2016-05-27 PL PL16803248.0T patent/PL3305770T3/pl unknown
- 2016-05-27 US US15/577,007 patent/US10118899B2/en active Active
- 2016-05-27 CA CA2987563A patent/CA2987563C/en active Active
- 2016-05-27 JP JP2017521901A patent/JP6753396B2/ja active Active
- 2016-05-27 CN CN201680029674.1A patent/CN107635969B/zh active Active
- 2016-05-27 WO PCT/JP2016/065729 patent/WO2016194813A1/ja not_active Ceased
- 2016-05-27 ES ES16803248T patent/ES2942618T3/es active Active
- 2016-05-27 MX MX2017014958A patent/MX385084B/es unknown
- 2016-05-27 PT PT168032480T patent/PT3305770T/pt unknown
- 2016-05-27 KR KR1020177037241A patent/KR102666017B1/ko active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PT3305770T (pt) | 2023-04-26 |
| CN107635969B (zh) | 2021-08-17 |
| ES2942618T3 (es) | 2023-06-05 |
| PL3305770T3 (pl) | 2023-06-26 |
| CN107635969A (zh) | 2018-01-26 |
| WO2016194813A1 (ja) | 2016-12-08 |
| JPWO2016194813A1 (ja) | 2018-06-07 |
| EP3305770B1 (en) | 2023-03-29 |
| CA2987563C (en) | 2024-04-09 |
| KR102666017B1 (ko) | 2024-05-16 |
| EP3305770A1 (en) | 2018-04-11 |
| EP3305770A4 (en) | 2018-12-12 |
| HK1251218A1 (en) | 2019-01-25 |
| US10118899B2 (en) | 2018-11-06 |
| US20180148417A1 (en) | 2018-05-31 |
| CA2987563A1 (en) | 2016-12-08 |
| MX385084B (es) | 2025-03-14 |
| JP6753396B2 (ja) | 2020-09-09 |
| KR20180014015A (ko) | 2018-02-07 |
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