[go: up one dir, main page]

MX2017009351A - Metodo y sistema para determinar el estado de cancer. - Google Patents

Metodo y sistema para determinar el estado de cancer.

Info

Publication number
MX2017009351A
MX2017009351A MX2017009351A MX2017009351A MX2017009351A MX 2017009351 A MX2017009351 A MX 2017009351A MX 2017009351 A MX2017009351 A MX 2017009351A MX 2017009351 A MX2017009351 A MX 2017009351A MX 2017009351 A MX2017009351 A MX 2017009351A
Authority
MX
Mexico
Prior art keywords
cancer status
determining cancer
platforms
systems
readable medium
Prior art date
Application number
MX2017009351A
Other languages
English (en)
Inventor
Zhang Kang
Hou Rui
Zheng Lianghong
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of MX2017009351A publication Critical patent/MX2017009351A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30—Data warehousing; Computing architectures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Genetics & Genomics (AREA)
  • Data Mining & Analysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

En la presente invención se divulgan métodos, sistemas, plataformas, un medio no transitorio legible por computadora, servicios y equipos para determinar un tipo de cáncer en un individuo. También se describen aquí métodos, sistemas, plataformas, un medio no transitorio legible por computadora, y composiciones para generar una base de datos de perfiles de metilación de CpG.
MX2017009351A 2015-01-18 2016-01-15 Metodo y sistema para determinar el estado de cancer. MX2017009351A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562104785P 2015-01-18 2015-01-18
US14/986,520 US9984201B2 (en) 2015-01-18 2015-12-31 Method and system for determining cancer status
PCT/US2016/013716 WO2016115530A1 (en) 2015-01-18 2016-01-15 Method and system for determining cancer status

Publications (1)

Publication Number Publication Date
MX2017009351A true MX2017009351A (es) 2017-10-24

Family

ID=56406499

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017009351A MX2017009351A (es) 2015-01-18 2016-01-15 Metodo y sistema para determinar el estado de cancer.

Country Status (13)

Country Link
US (2) US9984201B2 (es)
EP (1) EP3245604B1 (es)
JP (3) JP2018508228A (es)
KR (1) KR20170120595A (es)
CN (2) CN113724786B (es)
AU (1) AU2016206505B2 (es)
CA (1) CA2974097A1 (es)
EA (1) EA036566B1 (es)
IL (1) IL253546A0 (es)
MX (1) MX2017009351A (es)
SG (2) SG10202010694PA (es)
TW (2) TW201638815A (es)
WO (1) WO2016115530A1 (es)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015277059B2 (en) 2014-06-18 2021-06-17 Clear Gene, Inc. Methods, compositions, and devices for rapid analysis of biological markers
WO2016008451A1 (en) 2014-07-18 2016-01-21 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in dna mixture
US9984201B2 (en) * 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
CA3008273A1 (en) 2015-12-18 2017-06-22 Clear Gene, Inc. Methods, compositions, kits and devices for rapid analysis of biological markers
WO2017212428A1 (en) * 2016-06-07 2017-12-14 The Regents Of The University Of California Cell-free dna methylation patterns for disease and condition analysis
EP3907300A1 (en) 2016-06-08 2021-11-10 University Of Iowa Research Foundation Compositions for detecting predisposition to cardiovascular disease
US20190203303A1 (en) * 2016-06-29 2019-07-04 Sameer Chopra Classification of subtypes of kidney tumors using dna methylation
US10093986B2 (en) 2016-07-06 2018-10-09 Youhealth Biotech, Limited Leukemia methylation markers and uses thereof
CN107847515B (zh) * 2016-07-06 2021-01-29 优美佳生物技术有限公司 实体瘤甲基化标志物及其用途
US12359258B2 (en) 2016-07-06 2025-07-15 Helio Health Inc. Lung cancer methylation markers and uses thereof
CN109757109B (zh) * 2016-07-06 2023-05-02 卡斯西部储备大学 用于检测食道中的食道瘤形成和/或化生的方法和组合物
US12351876B2 (en) * 2016-07-06 2025-07-08 Helio Health, Inc. Colon cancer methylation markers and uses thereof
US20180203974A1 (en) * 2016-11-07 2018-07-19 Grail, Inc. Methods of identifying somatic mutational signatures for early cancer detection
WO2018099418A1 (en) 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples
EP3559270A2 (en) * 2016-12-22 2019-10-30 Guardant Health, Inc. Methods and systems for analyzing nucleic acid molecules
CN106544341A (zh) * 2017-01-17 2017-03-29 上海亿康医学检验所有限公司 高效检测样本中的ctDNA的方法
CN110603329B (zh) * 2017-03-02 2023-12-05 优美佳肿瘤技术有限公司 用于诊断肝细胞癌和肺癌的甲基化标志物
EP3612627A4 (en) * 2017-04-19 2020-12-30 Singlera Genomics, Inc. COMPOSITIONS AND METHODS FOR DETECTION OF GENOMIC VARIANCE AND OF DNA METHYLATION STATUS
EP3612641A4 (en) 2017-04-19 2021-01-20 Singlera Genomics, Inc. COMPOSITIONS AND PROCEDURES FOR LIBRARY CREATION AND SEQUENCE ANALYSIS
CA3063405A1 (en) * 2017-05-12 2018-11-15 President And Fellows Of Harvard College Universal early cancer diagnostics
ES2989479T3 (es) * 2017-05-15 2024-11-26 Univ Leuven Kath Método para analizar ácidos nucleicos libres de células
US12275994B2 (en) 2017-06-22 2025-04-15 Clear Gene, Inc. Methods and compositions for the analysis of cancer biomarkers
US12227737B2 (en) 2017-07-12 2025-02-18 University Health Network Cancer detection and classification using methylome analysis
EP3652741A4 (en) 2017-07-12 2021-04-21 University Health Network DETECTION AND CLASSIFICATION OF CANCER USING METHYLOMA ANALYSIS
WO2019055829A1 (en) 2017-09-15 2019-03-21 Nazarian Javad METHODS OF DETECTION OF CANCER BIOMARKERS
CA3076386A1 (en) * 2017-09-29 2019-04-04 Lukas Vrba Dna methylation biomarkers for cancer diagnosing
WO2019071161A1 (en) * 2017-10-06 2019-04-11 Youhealth Biotech, Limited METHYLATION MARKERS FOR THE DIAGNOSIS OF CANCER
US10748040B2 (en) * 2017-11-20 2020-08-18 Kavya Venkata Kota Sai KOPPARAPU System and method for automatic assessment of cancer
CN111742059B (zh) 2017-11-28 2024-07-09 格瑞尔有限责任公司 用于靶向测序的模型
WO2019157214A2 (en) * 2018-02-07 2019-08-15 Ai Technologies Inc. Deep learning-based diagnosis and referral of diseases and disorders
EP3765637A1 (en) * 2018-03-13 2021-01-20 Grail, Inc. Anomalous fragment detection and classification
WO2019195268A2 (en) 2018-04-02 2019-10-10 Grail, Inc. Methylation markers and targeted methylation probe panels
SG11202009866XA (en) * 2018-04-12 2020-11-27 Singlera Genomics Inc Compositions and methods for cancer or neoplasia assessment
CN112204666A (zh) * 2018-04-13 2021-01-08 格里尔公司 用于癌症侦测的多重化验预测模型
EP3802830A4 (en) * 2018-05-31 2022-03-09 The Regents of the University of California, A California Corporation Dna methylation based biomarkers for irritable bowel syndrome and irritable bowel disease
CN112888459B (zh) 2018-06-01 2023-05-23 格里尔公司 卷积神经网络系统及数据分类方法
CN108866192B (zh) * 2018-07-26 2021-06-22 上海奕谱生物科技有限公司 基于甲基化修饰的肿瘤标记物stamp-ep1
CN110791563B (zh) * 2018-08-01 2024-02-09 立森印迹诊断技术（无锡）有限公司 一种用于检测甲状腺肿瘤良恶性程度的分级模型及其应用
CN109022556A (zh) * 2018-08-29 2018-12-18 天津智鱼生物科技有限公司 一种dna甲基化程度的定量方法及应用
CA3110455A1 (en) * 2018-09-04 2020-03-12 3M Innovative Properties Company Visualization of social determinants of health
AU2019351130B2 (en) 2018-09-27 2025-10-23 GRAIL, Inc Methylation markers and targeted methylation probe panel
TWI687937B (zh) * 2018-10-05 2020-03-11 中國醫藥大學附設醫院 染色體異常檢測模型之建立方法、染色體異常檢測系統及染色體異常檢測方法
CN109182526A (zh) * 2018-10-10 2019-01-11 杭州翱锐生物科技有限公司 用于早期肝癌辅助诊断的试剂盒及其检测方法
CA3119749A1 (en) * 2018-11-15 2020-05-22 Ampel Biosolutions, Llc Machine learning disease prediction and treatment prioritization
GB201819452D0 (en) * 2018-11-29 2019-01-16 Ucl Business Plc Differential methylation
US11581062B2 (en) 2018-12-10 2023-02-14 Grail, Llc Systems and methods for classifying patients with respect to multiple cancer classes
US20200203016A1 (en) * 2018-12-19 2020-06-25 Grail, Inc. Cancer tissue source of origin prediction with multi-tier analysis of small variants in cell-free dna samples
CN113424263A (zh) * 2018-12-21 2021-09-21 格里尔公司 异常片段检测与分类
US12234514B2 (en) 2018-12-21 2025-02-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free DNA samples
KR102211240B1 (ko) * 2018-12-28 2021-02-01 아주대학교산학협력단 허혈성 심장질환에 대한 보조 의사 시스템에 의해 수행되는 허혈성 심장질환 진단 방법
SG11202012518WA (en) * 2019-01-24 2021-01-28 Illumina Inc Methods and systems for monitoring organ health and disease
CA3127762A1 (en) * 2019-01-25 2020-07-30 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
EP3921445B1 (en) * 2019-02-05 2024-09-04 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
KR102068310B1 (ko) 2019-02-28 2020-01-20 주식회사 레피다인 간암 재발 예측용 dna 메틸화 마커 및 이의 용도
JP7105460B2 (ja) * 2019-03-01 2022-07-25 国立大学法人佐賀大学 成人ｔ細胞白血病／リンパ腫の検出方法
EP3948872A4 (en) * 2019-03-28 2023-04-26 Phase Genomics Inc. SYSTEMS AND METHODS FOR KARYOTYPING BY SEQUENCING
US11773450B2 (en) 2019-04-03 2023-10-03 Grail, Llc Methylation-based false positive duplicate marking reduction
CN110157804A (zh) * 2019-04-04 2019-08-23 广州优泽生物技术有限公司 用于肺癌诊断、疗效预测或预后的甲基化位点、检测引物及试剂盒
US12009061B2 (en) 2019-04-10 2024-06-11 University of Pittsburgh—of the Commonwealth System of Higher Education Computational filtering of methylated sequence data for predictive modeling
CN110163102A (zh) * 2019-04-18 2019-08-23 麦克奥迪（厦门）医疗诊断系统有限公司 一种基于卷积神经网络的宫颈细胞图像分类识别方法
AU2020263307B2 (en) * 2019-04-22 2024-02-29 Behavioral Diagnostics, Llc Compositions and methods for correcting for cellular admixture in epigenetic analyses
US20220218847A1 (en) * 2019-04-23 2022-07-14 The Broad Institute, Inc. Compositions and methods characterizing metastasis
JP7590348B2 (ja) * 2019-05-13 2024-11-26 グレイル リミテッド ライアビリティ カンパニー モデルベースの特徴量化および分類
EP3830285A4 (en) * 2019-05-31 2022-04-27 Freenome Holdings, Inc. METHODS AND SYSTEMS FOR HIGH DEPTH SEQUENCING OF METHYLATED NUCLEIC ACID
CN111204867B (zh) * 2019-06-24 2021-12-10 北京工业大学 膜生物反应器-mbr膜污染智能决策方法
TWI765262B (zh) * 2019-06-26 2022-05-21 長佳智能股份有限公司 根據仿真分離重疊染色體之分離模型的訓練方法及利用該分離模型分離重疊染色體的方法及系統
WO2021050962A1 (en) * 2019-09-11 2021-03-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cancer detection and classification
WO2021067484A1 (en) 2019-09-30 2021-04-08 Guardant Health, Inc. Compositions and methods for analyzing cell-free dna in methylation partitioning assays
US11795495B1 (en) * 2019-10-02 2023-10-24 FOXO Labs Inc. Machine learned epigenetic status estimator
CA3158275A1 (en) * 2019-11-13 2021-05-20 Michael F. Berger Classifier models to predict tissue of origin from targeted tumor dna sequencing
CN110867254A (zh) * 2019-11-18 2020-03-06 北京市商汤科技开发有限公司 预测方法及装置、电子设备和存储介质
WO2021117772A1 (ja) * 2019-12-09 2021-06-17 学校法人慶應義塾 非アルコール性脂肪性肝炎から肝細胞がんを発症するリスクを判定する方法
EP4096694A4 (en) 2020-01-30 2024-01-24 Prognomiq Inc LUNG BIOMARKERS AND THEIR METHODS OF USE
US20230049979A1 (en) * 2020-02-06 2023-02-16 OncoHost Ltd. Machine learning prediction of therapy response
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
CN112662765A (zh) * 2020-03-17 2021-04-16 博尔诚（北京）科技有限公司 一种检测6种中国高发癌症的探针组合物
CA3178302A1 (en) * 2020-03-31 2021-10-07 Freenome Holdings, Inc. Methods and systems for detecting colorectal cancer via nucleic acid methylation analysis
CN111334572B (zh) * 2020-04-26 2020-10-27 江苏大学附属医院 Ctsz基因甲基化的新用途
WO2021226110A1 (en) * 2020-05-05 2021-11-11 The Board Of Trustees Of The Leland Stanford Junior University Cell-free dna biomarkers and their use in diagnosis, monitoring response to therapy, and selection of therapy for prostate cancer
CN113234825B (zh) * 2020-05-09 2024-11-19 广州燃石医学检验所有限公司 癌症预后方法
CN112391466B (zh) * 2020-05-19 2025-09-05 广州市基准医疗有限责任公司 用于检测乳腺癌的甲基化生物标记物或其组合和应用
CN111863138B (zh) * 2020-05-26 2024-07-30 浙江大学 人子宫组织细胞组成分析模型及其建立方法和应用
CA3186997A1 (en) * 2020-06-17 2021-12-23 Ucl Business Ltd Methods for detecting and predicting cancer and/or cin3
US11255762B1 (en) * 2020-08-11 2022-02-22 Specialty Diagnostic (SDI) Laboratories, Inc. Method and system for classifying sample data for robotically extracted samples
KR102461582B1 (ko) * 2020-08-11 2022-10-31 한림대학교 산학협력단 인공지능을 활용하여 검진 정보에 대응하는 진단 정보를 제공하기 위한 컴퓨터 프로그램
WO2022040306A1 (en) * 2020-08-19 2022-02-24 Mayo Foundation For Medical Education And Research Detecting non-hodgkin lymphoma
AU2021337736A1 (en) * 2020-09-04 2023-04-13 Cardio Diagnostics, Inc. Methods and compositions for predicting and/or monitoring cardiovascular disease and treatments therefor
WO2022061080A1 (en) * 2020-09-17 2022-03-24 The Regents Of The University Of Colorado, A Body Corporate Signatures in cell-free dna to detect disease, track treatment response, and inform treatment decisions
US12234518B2 (en) 2020-10-23 2025-02-25 Guardant Health, Inc. Compositions and methods for analyzing DNA using partitioning and base conversion
GB2617285A (en) * 2020-11-13 2023-10-04 Triplebar Bio Inc Multiparametric discovery and optimization platform
KR102811608B1 (ko) * 2020-11-20 2025-05-21 주식회사 레피다인 간암의 예후 예측을 위한 정보 제공 방법
KR102507489B1 (ko) * 2020-12-24 2023-03-08 가톨릭대학교 산학협력단 진단 분류 장치 및 방법
CN113095376A (zh) * 2021-03-24 2021-07-09 四川大学 一种基于深度学习的口腔上皮异常增生判别与分级设备及系统
WO2022212583A1 (en) 2021-03-31 2022-10-06 PrognomIQ, Inc. Multi-omic assessment
US20240194295A1 (en) * 2021-04-21 2024-06-13 Helio Health Inc. Cellular heterogeneity-adjusted clonal methylation (chalm): a methylation quantification method
JP2024514936A (ja) * 2021-04-23 2024-04-03 ポステック・リサーチ・アンド・ビジネス・ディベロップメント・ファウンデーション 遺伝子突然変異を検出する装置及び方法
CN113376199A (zh) * 2021-05-12 2021-09-10 兰立生物科技(苏州)有限公司 一种用于癌症检测的生化分析检测系统
WO2022243566A1 (en) 2021-05-21 2022-11-24 Ophiomics - Investigação E Desenvolvimento Em Biotecnologia Dna methylation biomarkers for hepatocellular carcinoma
US20240339216A1 (en) * 2021-07-14 2024-10-10 The Regents Of The University Of California Mycobiome in cancer
TWI808838B (zh) * 2021-07-23 2023-07-11 高雄醫學大學 二代荷爾蒙藥物於治療攝護腺癌療效評估之臨床治療藥物預測暨推薦系統及方法
IL310769A (en) 2021-08-11 2024-04-01 Oncohost Ltd Predicting patient response
EP4399709A1 (en) 2021-09-06 2024-07-17 Christian-Albrechts-Universität zu Kiel Method for the diagnosis and/or classification of a disease in a subject
US12387508B2 (en) 2021-09-10 2025-08-12 PrognomIQ, Inc. Direct classification of raw biomolecule measurement data
JP2024534992A (ja) 2021-09-13 2024-09-26 プログノミック インコーポレイテッド 生体分子の増強された検出および定量
EP4417704A4 (en) * 2021-10-15 2025-02-26 FUJIFILM Corporation METHOD FOR GENERATING A BIOMARKER SUBSTITUTE FOR THE DETECTION OF CANCER
CN114003752B (zh) * 2021-11-24 2022-11-15 重庆邮电大学 基于粒球人脸聚类图像质量评估的数据库精简方法及系统
KR102893129B1 (ko) 2021-12-07 2025-12-03 한양대학교 에리카산학협력단 필터와 다중 진입점 구조를 이용한 캐싱 방법 및 장치
CN114657247B (zh) * 2022-02-28 2022-12-02 北京莱盟君泰国际医疗技术开发有限公司 用于早期肝癌检测的dna甲基化生物标记物或组合及其应用
US12073920B2 (en) * 2022-07-18 2024-08-27 Grail, Llc Dynamically selecting sequencing subregions for cancer classification
US20240055073A1 (en) * 2022-07-25 2024-02-15 Grail, Llc Sample contamination detection of contaminated fragments with cpg-snp contamination markers
CN116262942B (zh) * 2022-09-02 2025-05-06 南方医科大学 一种8CpG panel检测试剂盒以及体液分类的两种预测模型
WO2024137041A2 (en) * 2022-10-28 2024-06-27 Cedars-Sinai Medical Center Methods and systems of multi-omic approach for molecular profiling of tumors
CN115627541B (zh) * 2022-12-01 2023-03-28 中国医学科学院肿瘤医院 从微量DNA建立cfDNA库的方法、系统和应用
EP4677120A2 (en) * 2023-03-03 2026-01-14 H. Lee Moffitt Cancer Center & Research Institute, Inc. Assay for the detection of oropharyngeal cancer
PL443999A1 (pl) * 2023-03-07 2024-09-09 Pomorski Uniwersytet Medyczny W Szczecinie Sposób realizowany komputerowo i platforma obliczeniowa do charakteryzowania badanej próbki od osobnika z wykorzystaniem informacji o zmianie epigenetycznej
PL443998A1 (pl) * 2023-03-07 2024-09-09 Pomorski Uniwersytet Medyczny W Szczecinie Sposoby, systemy i powiązane produkty programów komputerowych do rozróżniania typu próbki biologicznej z organizmu z wykorzystaniem informacji o modyfikacjach epigenetycznych
PL444001A1 (pl) * 2023-03-07 2024-09-09 Pomorski Uniwersytet Medyczny W Szczecinie Sposób realizowany komputerowo i powiązane produkty programów komputerowych do określania wieku biologicznego oraz przewidywania stanu zdrowia osobnika z wykorzystaniem informacji o modyfikacjach epigenetycznych
PL444000A1 (pl) * 2023-03-07 2024-09-09 Pomorski Uniwersytet Medyczny W Szczecinie Sposób leczenia i diagnozowania nowotworu z wykorzystaniem informacji o modyfikacjach epigenetycznych
US20240304328A1 (en) * 2023-03-09 2024-09-12 Yun Xiang Investment Consulting Co., Ltd. Method of detecting early recurrence of liver cancer
WO2025019297A1 (en) * 2023-07-14 2025-01-23 Guardant Health, Inc. Classification of colorectal tumors using dna methylation from liquid biopsy
GB202317261D0 (en) * 2023-11-10 2023-12-27 Cancer Research Tech Ltd Methods for determining cancers
CN119359755B (zh) * 2024-10-08 2025-08-29 合肥膳之纤生物科技有限公司 一种石斛原球茎干细胞无激素培养生长监测方法

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5525462A (en) 1991-05-02 1996-06-11 Toyo Boseki Kabushiki Kaisha Nucleic acid sequence amplification method, detection method, and reagent kit therefor
US6033854A (en) 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
WO1995006137A1 (en) 1993-08-27 1995-03-02 Australian Red Cross Society Detection of genes
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
GB9517955D0 (en) 1995-07-25 1995-11-08 Univ Strathclyde Nucleotide sequence detection and analysis
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP1736554B1 (en) 1996-05-29 2013-10-09 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5858665A (en) 1996-07-25 1999-01-12 Navix, Inc. Homogeneous diagnostic assay method utilizing simultaneous target and signal amplification
AU4667297A (en) 1996-10-04 1998-04-24 Chronix Biomedical, Inc. Diagnostic detection of nucleic acids
JPH10253632A (ja) 1997-03-10 1998-09-25 Nissui Pharm Co Ltd 分析方法、キット及び装置
US6558901B1 (en) 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
US6054276A (en) 1998-02-23 2000-04-25 Macevicz; Stephen C. DNA restriction site mapping
EP1082458A1 (en) 1998-05-01 2001-03-14 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and dna molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US6331393B1 (en) 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US6180349B1 (en) 1999-05-18 2001-01-30 The Regents Of The University Of California Quantitative PCR method to enumerate DNA copy number
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
DE10130800B4 (de) 2001-06-22 2005-06-23 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierung mit hoher Sensitivität
WO2003064701A2 (en) 2002-01-30 2003-08-07 Epigenomics Ag Method for the analysis of cytosine methylation patterns
AU2003302146B2 (en) 2002-06-26 2008-06-26 Cold Spring Harbor Laboratory Methods and compositions for determining methylation profiles
DK1660680T3 (da) 2003-07-31 2009-06-22 Sequenom Inc Fremgangsmåde til multipleks-polymerasekædereaktioner på höjt niveau og homogene masseforlængelsesreaktioner til genotypebestemmelse af polymorfismer
US20060183128A1 (en) 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
EP1682677B1 (en) 2003-10-21 2012-04-11 Orion Genomics, LLC Differential enzymatic fragmentation
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
CA2548528A1 (en) * 2003-12-01 2005-06-16 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
US7459274B2 (en) 2004-03-02 2008-12-02 Orion Genomics Llc Differential enzymatic fragmentation by whole genome amplification
JP2005328709A (ja) 2004-05-18 2005-12-02 Toyobo Co Ltd 高速ｄｎａポリメラーゼを用いた高速ｐｃｒ
EP1812589A2 (en) * 2004-09-30 2007-08-01 Epigenomics AG Epigenetic methods and nucleic acids for the detection of lung cell proliferative disorders
US7643818B2 (en) 2004-11-22 2010-01-05 Seven Networks, Inc. E-mail messaging to/from a mobile terminal
WO2006056480A2 (en) 2004-11-29 2006-06-01 Klinikum Der Universität Regensburg Means and methods for detecting methylated dna
US20080261217A1 (en) 2006-10-17 2008-10-23 Melnikov Anatoliy A Methylation Profile of Cancer
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20090075263A1 (en) * 2007-02-02 2009-03-19 Orion Genomics Llc Gene methylation in ovarian cancer diagnosis
US8911937B2 (en) 2007-07-19 2014-12-16 Brainreader Aps Method for detecting methylation status by using methylation-independent primers
WO2009021141A1 (en) 2007-08-07 2009-02-12 The Johns Hopkins University Comprehensive high throughput arrays for relative methylation
EP2053131A1 (en) 2007-10-19 2009-04-29 Ludwig-Maximilians-Universität München Method for determining methylation at deoxycytosine residues
US9850540B2 (en) * 2008-03-14 2017-12-26 Genomictree, Inc. Method for detecting lung cancer using lung cancer-specific methylation marker gene
WO2012031329A1 (en) 2010-09-10 2012-03-15 Murdoch Childrens Research Institute Assay for detection and monitoring of cancer
WO2012098215A1 (en) * 2011-01-20 2012-07-26 Université Libre de Bruxelles Epigenetic portraits of human breast cancers
GB201102014D0 (en) 2011-02-04 2011-03-23 Ucl Business Plc Method for predicting risk of developing cancer
WO2012138609A2 (en) * 2011-04-04 2012-10-11 The Board Of Trustees Of The Leland Stanford Junior University Methylation biomarkers for diagnosis of prostate cancer
WO2012149171A1 (en) 2011-04-27 2012-11-01 The Regents Of The University Of California Designing padlock probes for targeted genomic sequencing
RU2614254C2 (ru) * 2011-08-31 2017-03-24 Дженентек, Инк. Диагностические маркеры
US8846316B2 (en) 2012-04-30 2014-09-30 Industrial Technology Research Institute Biomarker for human liver cancer
WO2013174432A1 (en) * 2012-05-24 2013-11-28 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
WO2014046199A1 (ja) * 2012-09-19 2014-03-27 シスメックス株式会社 脳腫瘍に関する情報の取得方法、ならびに脳腫瘍に関する情報を取得するためのマーカーおよびキット
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US20140271455A1 (en) * 2013-03-14 2014-09-18 City Of Hope Dna methylation biomarkers for small cell lung cancer
US9984201B2 (en) 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status

Also Published As

Publication number Publication date
TW201638815A (zh) 2016-11-01
TW202011416A (zh) 2020-03-16
CA2974097A1 (en) 2016-07-21
AU2016206505A1 (en) 2017-08-31
US9984201B2 (en) 2018-05-29
US20180341745A1 (en) 2018-11-29
WO2016115530A1 (en) 2016-07-21
EA201791569A1 (ru) 2018-01-31
AU2016206505B2 (en) 2022-03-10
CN113724786A (zh) 2021-11-30
SG11201705878VA (en) 2017-08-30
IL253546A0 (en) 2017-09-28
CN108064314A (zh) 2018-05-22
EP3245604A4 (en) 2018-06-20
US20160210403A1 (en) 2016-07-21
KR20170120595A (ko) 2017-10-31
BR112017015413A2 (pt) 2018-08-07
NZ734255A (en) 2024-11-29
JP2021003108A (ja) 2021-01-14
CN108064314B (zh) 2021-03-09
JP2022078120A (ja) 2022-05-24
HK1248285A1 (zh) 2018-10-12
EP3245604B1 (en) 2022-03-02
CN113724786B (zh) 2025-01-14
EP3245604A1 (en) 2017-11-22
JP2018508228A (ja) 2018-03-29
EA036566B1 (ru) 2020-11-24
SG10202010694PA (en) 2020-12-30

Similar Documents

Publication Publication Date Title
MX2017009351A (es) Metodo y sistema para determinar el estado de cancer.
GB2601923B (en) Systems and methods for generating, visualizing and classifying molecular functional profiles
ZA201903517B (en) Methods and systems for identity creation, verification and management
EP4582556A3 (en) Methods and compositions for whole transcriptome amplification
EP3732824A4 (en) METHODS AND SYSTEMS FOR NETWORK MICROSEGMENTATION BASED ON CRYPTOGRAPHIC IDENTITY
EP3892316A3 (en) Cell separation devices, systems, and methods
EP3243295A4 (en) Quantum key distribution system, method and apparatus based on trusted relay
EP3350961A4 (en) Computer-implemented cryptographic method for improving a computer network, and terminal, system and computer-readable medium for the same
TW201714434A (en) Network initiated packet data network connection
EP3248310A4 (en) Method, apparatus, and system for quantum key distribution
EP3139331A4 (en) Advertisement template configuration method, server and system
EP3116177A4 (en) Service implementation method for nfv system, and communications unit
EP3349129A4 (en) Region division method in distributed database, region node and system
EP3101971A4 (en) Beam selection method, apparatus and communication system
EP3291161A4 (en) Payment method, apparatus and system
EP3306870A4 (en) Network configuration method, network system and device
SG11201708717RA (en) Service scenario matching method and system
PL3378213T3 (pl) Systemy i sposoby uwierzytelniania komunikatów sieciowych
EP3422760A4 (en) Channel information reporting method, apparatus and system
EP3370366A4 (en) Method, apparatus, and system for providing temporary account information
EP3244667A4 (en) Call supplementary service configuration synchronization method, apparatus and system
EP3142450A4 (en) Communication system, base station, communication method, and nontemporary computer readable medium on which program has been stored
AU2016361427A8 (en) Platinum anticancer agents
EP3285433A4 (en) Network protection method, network node and system
EP3131054A4 (en) Concept-associated online study service method, and service system therefor