MX2017008520A - Compuestos de pirimidina fusionada para el tratamiento del virus de inmunodeficiencia humana (vih). - Google Patents
Compuestos de pirimidina fusionada para el tratamiento del virus de inmunodeficiencia humana (vih).Info
- Publication number
- MX2017008520A MX2017008520A MX2017008520A MX2017008520A MX2017008520A MX 2017008520 A MX2017008520 A MX 2017008520A MX 2017008520 A MX2017008520 A MX 2017008520A MX 2017008520 A MX2017008520 A MX 2017008520A MX 2017008520 A MX2017008520 A MX 2017008520A
- Authority
- MX
- Mexico
- Prior art keywords
- hiv
- treatment
- pyrimidine compounds
- fused pyrimidine
- compounds
- Prior art date
Links
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En este documento se describen compuestos de la Fórmula (I) y tautómeros y sales farmacéuticas de los mismos, composiciones y formulaciones que contienen estos compuestos, y métodos de uso y elaboración de estos compuestos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462096820P | 2014-12-24 | 2014-12-24 | |
| PCT/US2015/000308 WO2016105532A1 (en) | 2014-12-24 | 2015-12-23 | Fused pyrimidine compounds for the treatment of hiv |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017008520A true MX2017008520A (es) | 2018-03-01 |
Family
ID=55135505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017008520A MX2017008520A (es) | 2014-12-24 | 2015-12-23 | Compuestos de pirimidina fusionada para el tratamiento del virus de inmunodeficiencia humana (vih). |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9701677B2 (es) |
| EP (1) | EP3237414B1 (es) |
| JP (1) | JP6385584B2 (es) |
| KR (1) | KR101985122B1 (es) |
| CN (1) | CN107207498B (es) |
| AU (1) | AU2015371255B2 (es) |
| BR (1) | BR112017013491A2 (es) |
| CA (1) | CA2972014C (es) |
| EA (1) | EA032430B1 (es) |
| ES (1) | ES2735087T3 (es) |
| HK (1) | HK1244270B (es) |
| IL (1) | IL253060A0 (es) |
| MX (1) | MX2017008520A (es) |
| NZ (1) | NZ733135A (es) |
| SG (1) | SG11201705192PA (es) |
| WO (1) | WO2016105532A1 (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015371257B2 (en) | 2014-12-24 | 2018-09-06 | Gilead Sciences, Inc. | Isoquinoline compounds for the treatment of HIV |
| MX2017008520A (es) | 2014-12-24 | 2018-03-01 | Gilead Sciences Inc | Compuestos de pirimidina fusionada para el tratamiento del virus de inmunodeficiencia humana (vih). |
| TW202237569A (zh) | 2014-12-24 | 2022-10-01 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
| EP3939985B1 (en) | 2014-12-26 | 2024-05-08 | Emory University | Pharmaceutical compositions comprising n4-hydroxycytidine derivatives for the treatment or prevention of influenza or coronavirus infections |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| PE20211427A1 (es) | 2016-08-19 | 2021-08-03 | Gilead Sciences Inc | Compuestos terapeuticos utiles para el tratamiento profilatico o terapeutico de una infeccion por el virus del vih |
| AR112412A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas de sal de colina de un inhibidor de la cápside del vih |
| AR112413A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas sólidas de un inhibidor de la cápside del vih |
| ES2995458T3 (en) | 2017-12-07 | 2025-02-10 | Univ Emory | N4-hydroxycytidine derivative and anti-viral uses related thereto |
| EP3752495B1 (en) | 2018-02-15 | 2023-07-19 | Gilead Sciences, Inc. | Pyridine derivatives and their use for treating hiv infection |
| TWI823164B (zh) | 2018-02-16 | 2023-11-21 | 美商基利科學股份有限公司 | 用於製備有療效化合物之方法及中間物 |
| JP7349456B2 (ja) | 2018-07-03 | 2023-09-22 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | ピリドピリミジン誘導体、その調製方法およびその医学的使用 |
| CA3103522C (en) | 2018-07-16 | 2023-11-21 | Gilead Sciences, Inc. | Capsid inhibitors for the treatment of hiv |
| CN119462659A (zh) | 2019-03-22 | 2025-02-18 | 吉利德科学公司 | 桥连三环氨基甲酰基吡啶酮化合物及其药学用途 |
| KR20220106165A (ko) | 2019-11-26 | 2022-07-28 | 길리애드 사이언시즈, 인코포레이티드 | Hiv의 예방을 위한 캡시드 억제제 |
| EP4121437A1 (en) | 2020-03-20 | 2023-01-25 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
| WO2022093552A2 (en) * | 2020-10-16 | 2022-05-05 | Saint Louis Univeristy | Rev-erb agonists |
| KR20230107288A (ko) | 2020-11-11 | 2023-07-14 | 길리애드 사이언시즈, 인코포레이티드 | gp120 CD4 결합 부위-지향 항체를 이용한 요법에 감수성인 HIV 환자를 식별하는 방법 |
| FI4445900T3 (fi) | 2021-12-03 | 2025-08-05 | Gilead Sciences Inc | Terapeuttisia yhdisteitä hiv-virusinfektiota varten |
| JP7736929B2 (ja) | 2021-12-03 | 2025-09-09 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖウイルス感染症のための治療化合物 |
| TW202342448A (zh) | 2021-12-03 | 2023-11-01 | 美商基利科學股份有限公司 | 用於ｈｉｖ病毒感染之治療性化合物 |
| TWI856796B (zh) | 2022-04-06 | 2024-09-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
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| EP4577242A1 (en) | 2022-08-26 | 2025-07-02 | Gilead Sciences, Inc. | Dosing and scheduling regimen for broadly neutralizing antibodies |
| US20240226130A1 (en) | 2022-10-04 | 2024-07-11 | Gilead Sciences, Inc. | 4'-thionucleoside analogues and their pharmaceutical use |
| AU2024259111A1 (en) | 2023-04-19 | 2025-10-16 | Gilead Sciences, Inc. | Dosing regimen of capsid inhibitor |
| US20250042926A1 (en) | 2023-05-31 | 2025-02-06 | Gilead Sciences, Inc. | Therapeutic compounds for hiv |
| US20250011352A1 (en) | 2023-05-31 | 2025-01-09 | Gilead Sciences, Inc. | Solid forms |
| WO2025029247A1 (en) | 2023-07-28 | 2025-02-06 | Gilead Sciences, Inc. | Weekly regimen of lenacapavir for the treatment and prevention of hiv |
| WO2025042394A1 (en) | 2023-08-23 | 2025-02-27 | Gilead Sciences, Inc. | Dosing regimen of hiv capsid inhibitor |
| WO2025080863A1 (en) | 2023-10-11 | 2025-04-17 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| TW202515549A (zh) | 2023-10-11 | 2025-04-16 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| WO2025080850A1 (en) | 2023-10-11 | 2025-04-17 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| WO2025137245A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Solid forms of hiv integrase inhibitors |
| WO2025184609A1 (en) | 2024-03-01 | 2025-09-04 | Gilead Sciences, Inc. | Antiviral compounds |
| US20250296932A1 (en) | 2024-03-01 | 2025-09-25 | Gilead Sciences, Inc. | Pharmaceutical compositions comprising hiv integrase inhibitors |
| WO2025184452A1 (en) | 2024-03-01 | 2025-09-04 | Gilead Sciences, Inc. | Solid forms of hiv integrase inhibitors |
| US20260007683A1 (en) | 2024-06-14 | 2026-01-08 | Gilead Sciences, Inc. | Pharmaceutical compositions comprising hiv integrase inhibitors |
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| TW202237569A (zh) | 2014-12-24 | 2022-10-01 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
-
2015
- 2015-12-23 MX MX2017008520A patent/MX2017008520A/es unknown
- 2015-12-23 EP EP15823843.6A patent/EP3237414B1/en active Active
- 2015-12-23 EA EA201791305A patent/EA032430B1/ru not_active IP Right Cessation
- 2015-12-23 SG SG11201705192PA patent/SG11201705192PA/en unknown
- 2015-12-23 NZ NZ733135A patent/NZ733135A/en not_active IP Right Cessation
- 2015-12-23 WO PCT/US2015/000308 patent/WO2016105532A1/en not_active Ceased
- 2015-12-23 AU AU2015371255A patent/AU2015371255B2/en active Active
- 2015-12-23 KR KR1020177020464A patent/KR101985122B1/ko active Active
- 2015-12-23 CN CN201580075810.6A patent/CN107207498B/zh active Active
- 2015-12-23 ES ES15823843T patent/ES2735087T3/es active Active
- 2015-12-23 BR BR112017013491-8A patent/BR112017013491A2/pt not_active Application Discontinuation
- 2015-12-23 JP JP2017534253A patent/JP6385584B2/ja active Active
- 2015-12-23 US US14/998,074 patent/US9701677B2/en active Active
- 2015-12-23 HK HK18103629.3A patent/HK1244270B/en unknown
- 2015-12-23 CA CA2972014A patent/CA2972014C/en active Active
-
2017
- 2017-06-21 IL IL253060A patent/IL253060A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9701677B2 (en) | 2017-07-11 |
| EP3237414B1 (en) | 2019-05-08 |
| SG11201705192PA (en) | 2017-07-28 |
| IL253060A0 (en) | 2017-08-31 |
| HK1244270B (en) | 2020-05-22 |
| JP2018500357A (ja) | 2018-01-11 |
| AU2015371255B2 (en) | 2018-09-27 |
| EA201791305A1 (ru) | 2017-12-29 |
| CA2972014C (en) | 2019-09-24 |
| CA2972014A1 (en) | 2016-06-30 |
| JP6385584B2 (ja) | 2018-09-05 |
| CN107207498B (zh) | 2020-03-24 |
| KR20170131352A (ko) | 2017-11-29 |
| WO2016105532A1 (en) | 2016-06-30 |
| CN107207498A (zh) | 2017-09-26 |
| US20160251347A1 (en) | 2016-09-01 |
| EP3237414A1 (en) | 2017-11-01 |
| HK1244276A1 (zh) | 2018-08-03 |
| EA032430B1 (ru) | 2019-05-31 |
| NZ733135A (en) | 2018-06-29 |
| ES2735087T3 (es) | 2019-12-16 |
| KR101985122B1 (ko) | 2019-05-31 |
| AU2015371255A1 (en) | 2017-07-13 |
| BR112017013491A2 (pt) | 2018-01-09 |
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