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MX2017008063A - Formas amorfas y polimorficas de (r)-2-hidroxi-2-metil-4-(2,4,5-tr imetil-3,6-dioxociclohexa-1,4-dienil)butanamida. - Google Patents

Formas amorfas y polimorficas de (r)-2-hidroxi-2-metil-4-(2,4,5-tr imetil-3,6-dioxociclohexa-1,4-dienil)butanamida.

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Publication number
MX2017008063A
MX2017008063A MX2017008063A MX2017008063A MX2017008063A MX 2017008063 A MX2017008063 A MX 2017008063A MX 2017008063 A MX2017008063 A MX 2017008063A MX 2017008063 A MX2017008063 A MX 2017008063A MX 2017008063 A MX2017008063 A MX 2017008063A
Authority
MX
Mexico
Prior art keywords
butanamide
methyl
forms
imetil
dioxociclohexa
Prior art date
Application number
MX2017008063A
Other languages
English (en)
Other versions
MX385049B (es
Inventor
Mollard Paul
R Cornell Christopher
E Wesson Kieron
Giannousis Peter
SUCHIT Shazad
Mirmehrabi Mahmoud
Original Assignee
Bioelectron Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioelectron Tech Corp filed Critical Bioelectron Tech Corp
Publication of MX2017008063A publication Critical patent/MX2017008063A/es
Publication of MX385049B publication Critical patent/MX385049B/es

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    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
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Abstract

La presente invención se refiere a formas polimórficas y amorfas de anhidrato, hidrato, y solvatos de (R)-2-hidroxi-2-metil-4-(2,4, 5-trimetil-3,6-dioxociclohexa-1,4-dienil)butanamida y métodos para usar tales composiciones para tratar o suprimir trastornos por estrés oxidativo, que incluyen trastornos mitocondriales, trastornos de procesamiento de energía alterada, enfermedades neurodegenerativas y enfermedades del envejecimiento. Además, se describen métodos para elaborar tales formas polimórficas y amorfas.
MX2017008063A 2014-12-16 2015-12-16 Formas amorfas y polimorficas de (r)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociclohexa-1,4-dienil)butanamida. MX385049B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462092743P 2014-12-16 2014-12-16
US201562133276P 2015-03-13 2015-03-13
PCT/US2015/066211 WO2016100579A1 (en) 2014-12-16 2015-12-16 Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide

Publications (2)

Publication Number Publication Date
MX2017008063A true MX2017008063A (es) 2017-09-28
MX385049B MX385049B (es) 2025-03-14

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MX2017008063A MX385049B (es) 2014-12-16 2015-12-16 Formas amorfas y polimorficas de (r)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociclohexa-1,4-dienil)butanamida.
MX2021009340A MX2021009340A (es) 2014-12-16 2017-06-16 Formas amorfas y polimorficas de (r)-2-hidroxi-2-metil-4-(2,4,5- trimetil-3,6-dioxociclohexa-1,4-dienil)butanamida.

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US (5) US10251847B2 (es)
EP (2) EP3233786B1 (es)
JP (4) JP6810692B2 (es)
KR (1) KR102626895B1 (es)
CN (2) CN114702406B (es)
AU (3) AU2015364640B2 (es)
BR (1) BR112017012988B1 (es)
CA (1) CA2971252C (es)
DK (1) DK3233786T3 (es)
ES (1) ES2912585T3 (es)
HU (1) HUE058877T2 (es)
IL (1) IL252953A0 (es)
MX (2) MX385049B (es)
NZ (1) NZ733528A (es)
PL (1) PL3233786T3 (es)
PT (1) PT3233786T (es)
RU (1) RU2770091C2 (es)
SG (2) SG10202003299PA (es)
SI (1) SI3233786T1 (es)
WO (1) WO2016100579A1 (es)
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