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MX2017002704A - Sondas para la proyección de imagen de la proteína huntingtina. - Google Patents

Sondas para la proyección de imagen de la proteína huntingtina.

Info

Publication number
MX2017002704A
MX2017002704A MX2017002704A MX2017002704A MX2017002704A MX 2017002704 A MX2017002704 A MX 2017002704A MX 2017002704 A MX2017002704 A MX 2017002704A MX 2017002704 A MX2017002704 A MX 2017002704A MX 2017002704 A MX2017002704 A MX 2017002704A
Authority
MX
Mexico
Prior art keywords
probes
huntingtin protein
imaging
imaging huntingtin
protein
Prior art date
Application number
MX2017002704A
Other languages
English (en)
Other versions
MX383202B (es
Inventor
Dominguez Celia
John Brown Christopher
Wityak John
Bard Jonathan
CLARK-FREW Daniel
Martin KRÜLLE Thomas
HAYES Sarah
Original Assignee
Chdi Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chdi Foundation Inc filed Critical Chdi Foundation Inc
Publication of MX2017002704A publication Critical patent/MX2017002704A/es
Publication of MX383202B publication Critical patent/MX383202B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Se proporcionan agentes de formación de imágenes que comprenden un compuesto de la Formula I, o su sal farmacéuticamente aceptable, y métodos de su uso.
MX2017002704A 2014-08-29 2015-08-28 Sondas para la proyección de imagen de la proteína huntingtina. MX383202B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462043644P 2014-08-29 2014-08-29
PCT/US2015/047396 WO2016033436A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (2)

Publication Number Publication Date
MX2017002704A true MX2017002704A (es) 2017-10-23
MX383202B MX383202B (es) 2025-03-13

Family

ID=55400644

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017002704A MX383202B (es) 2014-08-29 2015-08-28 Sondas para la proyección de imagen de la proteína huntingtina.
MX2021005891A MX2021005891A (es) 2014-08-29 2017-02-28 Sondas para la proyeccion de imagen de la proteina huntingtina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021005891A MX2021005891A (es) 2014-08-29 2017-02-28 Sondas para la proyeccion de imagen de la proteina huntingtina.

Country Status (20)

Country Link
US (2) US11071793B2 (es)
EP (1) EP3186241B1 (es)
JP (3) JP2017527559A (es)
KR (1) KR102410760B1 (es)
CN (2) CN118005611A (es)
AU (1) AU2015308765B2 (es)
BR (1) BR112017004136B1 (es)
CA (1) CA2959531C (es)
DK (1) DK3186241T3 (es)
EA (1) EA037275B1 (es)
ES (1) ES2841746T3 (es)
HR (1) HRP20202032T1 (es)
HU (1) HUE052892T2 (es)
IL (1) IL250805B (es)
MX (2) MX383202B (es)
PL (1) PL3186241T3 (es)
PT (1) PT3186241T (es)
SG (1) SG11201701578YA (es)
SI (1) SI3186241T1 (es)
WO (1) WO2016033436A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2959505A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
BR112017004140B1 (pt) 2014-08-29 2023-01-10 Chdi Foundation, Inc. Agente de imagemamento, seu uso e compostos
MX383202B (es) 2014-08-29 2025-03-13 Chdi Foundation Inc Sondas para la proyección de imagen de la proteína huntingtina.
CN107108534B (zh) 2014-08-29 2023-05-09 Chdi基金会股份有限公司 用于成像亨廷顿蛋白的探针
AU2016315648B2 (en) 2015-08-28 2021-04-01 Chdi Foundation, Inc. Probes for imaging huntingtin protein
EP3509588B1 (en) * 2016-09-12 2023-06-07 Integral Health,Inc. Bicyclic compounds useful as gpr120 modulators
KR102537985B1 (ko) 2016-09-12 2023-05-30 인테그랄 헬스 인코퍼레이티드 Gpr120 조정제로서 유용한 단환형 화합물
EP3931186A1 (en) 2019-02-25 2022-01-05 CHDI Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof
JP7720847B2 (ja) * 2019-12-18 2025-08-08 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチンチンタンパク質をイメージングするための化合物及びプローブ
US11918662B2 (en) * 2020-06-11 2024-03-05 Chdi Foundation, Inc. Heterocyclic compounds and imaging agents for imaging huntingtin protein
KR20240024045A (ko) * 2021-04-08 2024-02-23 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴 단백질 영상화를 위한 아이소인돌리논 화합물 및 영상화제

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US5726197A (en) * 1992-11-02 1998-03-10 Syntex (U.S.A.) Inc. Isoindolinyl derivatives
WO2000076969A1 (en) * 1999-06-10 2000-12-21 Warner-Lambert Company Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using isoindoline derivatives
PL371366A1 (en) * 2002-03-01 2005-06-13 Takeda Pharmaceutical Company Limited Antidepressant
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
AU2008304231A1 (en) * 2007-09-27 2009-04-02 Albany Molecular Research, Inc. Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
JP5632612B2 (ja) * 2007-12-05 2014-11-26 あすか製薬株式会社 ラクタム化合物又はその塩及びｐｐａｒ活性化剤
WO2010104324A2 (ko) * 2009-03-10 2010-09-16 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
EP2841435B1 (en) * 2012-04-25 2017-09-06 RaQualia Pharma Inc. Pyrrolopyridinone derivatives as ttx-s blockers
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CN107108534B (zh) 2014-08-29 2023-05-09 Chdi基金会股份有限公司 用于成像亨廷顿蛋白的探针
MX383202B (es) 2014-08-29 2025-03-13 Chdi Foundation Inc Sondas para la proyección de imagen de la proteína huntingtina.
BR112017004140B1 (pt) 2014-08-29 2023-01-10 Chdi Foundation, Inc. Agente de imagemamento, seu uso e compostos
CA2959505A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
AU2016315648B2 (en) 2015-08-28 2021-04-01 Chdi Foundation, Inc. Probes for imaging huntingtin protein

Also Published As

Publication number Publication date
JP7042940B2 (ja) 2022-03-28
JP2021088584A (ja) 2021-06-10
KR102410760B1 (ko) 2022-06-20
US12036291B2 (en) 2024-07-16
US11071793B2 (en) 2021-07-27
KR20170047348A (ko) 2017-05-04
IL250805B (en) 2020-08-31
BR112017004136A2 (pt) 2017-12-12
US20210379211A1 (en) 2021-12-09
EA037275B1 (ru) 2021-03-03
EP3186241A4 (en) 2018-04-18
US20170281804A1 (en) 2017-10-05
WO2016033436A1 (en) 2016-03-03
DK3186241T3 (da) 2021-01-11
PL3186241T3 (pl) 2021-05-17
JP2017527559A (ja) 2017-09-21
HRP20202032T1 (hr) 2021-02-19
HUE052892T2 (hu) 2021-05-28
ES2841746T3 (es) 2021-07-09
CA2959531A1 (en) 2016-03-03
SI3186241T1 (sl) 2021-03-31
MX383202B (es) 2025-03-13
PT3186241T (pt) 2021-01-08
CN107074817A (zh) 2017-08-18
CN118005611A (zh) 2024-05-10
EP3186241A1 (en) 2017-07-05
IL250805A0 (en) 2017-04-30
CA2959531C (en) 2023-01-10
BR112017004136B1 (pt) 2022-05-03
AU2015308765A1 (en) 2017-03-23
JP2020079272A (ja) 2020-05-28
JP6843282B2 (ja) 2021-03-17
SG11201701578YA (en) 2017-03-30
CN107074817B (zh) 2023-12-15
EP3186241B1 (en) 2020-10-07
MX2021005891A (es) 2021-06-23
AU2015308765B2 (en) 2020-06-04
EA201790432A1 (ru) 2017-09-29

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