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MX2017001211A - Receptores de antigenos quimericos ror1 (ntrkr1) especificos para inmunoterapia del cancer. - Google Patents

Receptores de antigenos quimericos ror1 (ntrkr1) especificos para inmunoterapia del cancer.

Info

Publication number
MX2017001211A
MX2017001211A MX2017001211A MX2017001211A MX2017001211A MX 2017001211 A MX2017001211 A MX 2017001211A MX 2017001211 A MX2017001211 A MX 2017001211A MX 2017001211 A MX2017001211 A MX 2017001211A MX 2017001211 A MX2017001211 A MX 2017001211A
Authority
MX
Mexico
Prior art keywords
ror1
ntrkr1
specifics
receivers
cancer immunotherapy
Prior art date
Application number
MX2017001211A
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English (en)
Other versions
MX367787B (es
Inventor
SCHIFFER-MANNIOUI Cècile
Original Assignee
Cellectis
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Filing date
Publication date
Application filed by Cellectis filed Critical Cellectis
Publication of MX2017001211A publication Critical patent/MX2017001211A/es
Publication of MX367787B publication Critical patent/MX367787B/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A61K40/4251—Kinases, e.g. Raf or Src
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2740/00—Reverse transcribing RNA viruses
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    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

La presente invención se relaciona con receptores de antígenos quiméricos (CAR) que son proteínas quiméricas recombinantes capaces de redirigir la especificidad y reactividad de células inmunes hacia antígenos de membrana seleccionada, y más particularmente en los cuales la unión de ligandos extracelulares es un scFV derivado de un anticuerpo monoclonal ROR1, que confiere inmunidad específica contra las células positivas ROR1. Las células inmunes diseñadas por diseñada por ingeniería, dotadas con estos CAR son particularmente adecuadas para tratar linfomas y leucemia, y para tumores sólidos tales como tumores de mama, colon, pulmón, y riñón.
MX2017001211A 2014-07-29 2015-07-29 Receptores de antígenos quimericos ror1 (ntrkr1) específicos para inmunoterapia del cáncer. MX367787B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201470465 2014-07-29
PCT/EP2015/067444 WO2016016344A1 (en) 2014-07-29 2015-07-29 Ror1(ntrkr1)specific chimeric antigen receptors for cancer immunotherapy

Publications (2)

Publication Number Publication Date
MX2017001211A true MX2017001211A (es) 2017-04-27
MX367787B MX367787B (es) 2019-09-06

Family

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Family Applications (1)

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MX2017001211A MX367787B (es) 2014-07-29 2015-07-29 Receptores de antígenos quimericos ror1 (ntrkr1) específicos para inmunoterapia del cáncer.

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Country Link
US (1) US10752684B2 (es)
EP (2) EP3174557B1 (es)
JP (1) JP6721568B2 (es)
KR (1) KR102048855B1 (es)
CN (1) CN106922148B (es)
AU (1) AU2015295349B2 (es)
BR (1) BR112017001821A2 (es)
CA (1) CA2950381C (es)
DK (2) DK3453406T3 (es)
EA (1) EA034081B1 (es)
ES (2) ES2715413T3 (es)
IL (1) IL250161B (es)
MX (1) MX367787B (es)
WO (1) WO2016016344A1 (es)

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