MX2017000209A - Composicion de lhrh inmunogenica y uso de la misma en cerdos. - Google Patents
Composicion de lhrh inmunogenica y uso de la misma en cerdos.Info
- Publication number
- MX2017000209A MX2017000209A MX2017000209A MX2017000209A MX2017000209A MX 2017000209 A MX2017000209 A MX 2017000209A MX 2017000209 A MX2017000209 A MX 2017000209A MX 2017000209 A MX2017000209 A MX 2017000209A MX 2017000209 A MX2017000209 A MX 2017000209A
- Authority
- MX
- Mexico
- Prior art keywords
- peptide
- pigs
- seq
- vaccine composition
- cell epitope
- Prior art date
Links
- 241000282887 Suidae Species 0.000 title abstract 3
- 230000002163 immunogen Effects 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 abstract 2
- 102100024028 Progonadoliberin-1 Human genes 0.000 abstract 2
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 abstract 2
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 abstract 2
- 230000003308 immunostimulating effect Effects 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 1
- 230000035938 sexual maturation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una composición vacunal para castrar cerdos, que comprende un inmunógeno peptídico y un vehículo de suministro o adyuvante aceptables desde el punto de vista veterinario, en donde el inmunógeno peptídico comprende (a) un péptido de LHRH de la SEQ ID NO: 1, y (b) por lo menos un epítopo de célula T cooperadora seleccionado del grupo que consiste en las SEQ ID NOs: 2, 3, 4 y 5 y, opcionalmente, un péptido inmunoestimulador de la SEQ ID NO: 6, en donde el péptido de LHRH se enlaza en forma covalente a través de su residuo de extremo N terminal al epítopo de célula T cooperadora o péptido inmunoestimulador. También se da a conocer un método para castrar o inhibir las características, incluyendo olor a verraco, inducidas por la maduración sexual de los cerdos al utilizar la composición vacunal.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2014/048164 WO2016014071A1 (en) | 2014-07-25 | 2014-07-25 | Immunogenic lhrh composition and use thereof in pigs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017000209A true MX2017000209A (es) | 2017-05-01 |
| MX395464B MX395464B (es) | 2025-03-25 |
Family
ID=55163454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017000209A MX395464B (es) | 2014-07-25 | 2014-07-25 | Composicion de lhrh inmunogenica y uso de la misma en cerdos. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20170216418A1 (es) |
| EP (2) | EP3191119A4 (es) |
| CN (1) | CN107073086B (es) |
| AU (2) | AU2014401765A1 (es) |
| CA (1) | CA2956065C (es) |
| CO (1) | CO2017001320A2 (es) |
| MX (1) | MX395464B (es) |
| PE (1) | PE20211787A1 (es) |
| RU (1) | RU2745720C2 (es) |
| TW (1) | TWI595884B (es) |
| UA (1) | UA125607C2 (es) |
| WO (1) | WO2016014071A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107703294B (zh) * | 2017-10-12 | 2019-06-04 | 华派生物工程集团有限公司 | 一种用于检测鸡血清中cLHRH抗体效价的ELISA方法 |
| CN107449924B (zh) * | 2017-10-12 | 2019-03-19 | 华派生物工程集团有限公司 | 一种鸡免疫去势效果的判定方法 |
| CN107880135A (zh) * | 2017-11-17 | 2018-04-06 | 华派生物工程集团有限公司 | 一种鸡促黄体素释放激素重组抗原去势疫苗及其制备方法 |
| AU2019200941B2 (en) * | 2018-02-12 | 2021-02-25 | Zoetis Services Llc | Anti-GnRH vaccine |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8900726A (nl) * | 1989-03-23 | 1990-10-16 | Stichting Centr Diergeneeskund | Peptide, immunogene samenstelling en vaccin- of geneesmiddelpreparaat; werkwijze voor het immuniseren van een zoogdier tegen lhrh, en werkwijze voor het verbeteren van de vleeskwaliteit van varkens. |
| US5759551A (en) | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
| JP3795914B2 (ja) * | 1993-04-27 | 2006-07-12 | ユナイテッド・バイオメディカル・インコーポレイテッド | ワクチン用免疫原性ｌｈｒｈペプチド構築体および合成普遍免疫刺激器 |
| WO1995011998A1 (en) | 1993-10-26 | 1995-05-04 | United Biomedical, Inc. | Structured synthetic antigen libraries as diagnostics, vaccines and therapeutics |
| CN1179181A (zh) * | 1995-02-10 | 1998-04-15 | 萨斯喀彻温大学 | GnRH－白细胞毒素嵌合体 |
| BRPI9609411B8 (pt) * | 1995-06-07 | 2020-05-12 | Pepscan Systems Bv | peptídeo, composição, vacina, e, processos para imunocastrar um porco |
| CA2327262A1 (en) * | 1998-05-05 | 1999-11-11 | Biostar Inc. | Methods of raising animals for meat production |
| TWI227241B (en) * | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
| US6025468A (en) * | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
| TWI229679B (en) * | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
| US6780969B2 (en) * | 2000-12-22 | 2004-08-24 | United Biomedical, Inc. | Synthetic peptide composition as immunogens for prevention of urinary tract infection |
| US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| AU2011384799A1 (en) * | 2011-12-30 | 2014-07-03 | United Biomedical, Inc. | Synthetic peptide-based marker vaccine and diagnostic system for effective control of porcine reproductive and respiratory syndrome (PRRS) |
-
2014
- 2014-07-25 RU RU2017105451A patent/RU2745720C2/ru active
- 2014-07-25 CA CA2956065A patent/CA2956065C/en active Active
- 2014-07-25 MX MX2017000209A patent/MX395464B/es unknown
- 2014-07-25 AU AU2014401765A patent/AU2014401765A1/en not_active Abandoned
- 2014-07-25 EP EP14898255.6A patent/EP3191119A4/en not_active Withdrawn
- 2014-07-25 US US15/329,154 patent/US20170216418A1/en not_active Abandoned
- 2014-07-25 PE PE2021000789A patent/PE20211787A1/es unknown
- 2014-07-25 UA UAA201701754A patent/UA125607C2/uk unknown
- 2014-07-25 CN CN201480080234.XA patent/CN107073086B/zh active Active
- 2014-07-25 EP EP20214150.3A patent/EP3842067A1/en active Pending
- 2014-07-25 WO PCT/US2014/048164 patent/WO2016014071A1/en not_active Ceased
-
2015
- 2015-07-24 TW TW104124013A patent/TWI595884B/zh active
-
2017
- 2017-02-10 CO CONC2017/0001320A patent/CO2017001320A2/es unknown
-
2019
- 2019-11-18 US US16/686,672 patent/US20200069781A1/en not_active Abandoned
-
2021
- 2021-03-29 AU AU2021201950A patent/AU2021201950B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX395464B (es) | 2025-03-25 |
| EP3191119A4 (en) | 2018-01-24 |
| EP3191119A1 (en) | 2017-07-19 |
| PE20211787A1 (es) | 2021-09-09 |
| CA2956065C (en) | 2021-05-18 |
| US20200069781A1 (en) | 2020-03-05 |
| UA125607C2 (uk) | 2022-05-04 |
| RU2745720C2 (ru) | 2021-03-31 |
| BR112017000354A2 (pt) | 2017-11-07 |
| EP3842067A1 (en) | 2021-06-30 |
| WO2016014071A1 (en) | 2016-01-28 |
| TW201603821A (zh) | 2016-02-01 |
| CO2017001320A2 (es) | 2017-07-11 |
| CN107073086B (zh) | 2021-07-27 |
| CN107073086A (zh) | 2017-08-18 |
| RU2017105451A (ru) | 2018-08-27 |
| TWI595884B (zh) | 2017-08-21 |
| CA2956065A1 (en) | 2016-01-28 |
| RU2017105451A3 (es) | 2018-08-27 |
| AU2021201950B2 (en) | 2024-06-27 |
| US20170216418A1 (en) | 2017-08-03 |
| AU2014401765A1 (en) | 2017-01-12 |
| AU2021201950A1 (en) | 2021-04-29 |
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