MX2016015362A - Endoproteasa especifica para prolina y usos de la misma. - Google Patents
Endoproteasa especifica para prolina y usos de la misma.Info
- Publication number
- MX2016015362A MX2016015362A MX2016015362A MX2016015362A MX2016015362A MX 2016015362 A MX2016015362 A MX 2016015362A MX 2016015362 A MX2016015362 A MX 2016015362A MX 2016015362 A MX2016015362 A MX 2016015362A MX 2016015362 A MX2016015362 A MX 2016015362A
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptide
- proline
- specific endoprotease
- endoprotease activity
- activity
- Prior art date
Links
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 title abstract 6
- 101710118538 Protease Proteins 0.000 title abstract 5
- 229920001184 polypeptide Polymers 0.000 abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 8
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 4
- 150000001413 amino acids Chemical group 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 235000013305 food Nutrition 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C11/00—Fermentation processes for beer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21026—Prolyl oligopeptidase (3.4.21.26), i.e. proline-specific endopeptidase
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se relaciona con un polipéptido que tiene actividad de endoproteasa específica para prolina, en donde el polipéptido tiene menos de 70% de actividad residual cuando el polipéptido se ha mantenido a una temperatura de 65°C durante 15 minutos. La invención se relaciona además con un polipéptido que tiene actividad de endoproteasa específica para prolina que comprende una secuencia de aminoácidos de acuerdo con SEQ ID NO: 1, en donde SEQ ID NO: 1 comprende al menos una sustitución de aminoácidos seleccionada del grupo que consiste de una combinación seleccionada del grupo que consiste de P469A, P469C, P469D, P469E, P469F, P469G, P469H, P469I, P469K, P469L, P469M, P469N, P469Q, P469R, P469S, P469T, P469V, P469W, P469Y, un ácido nucleico que codifica un polipéptido que tiene actividad de endoproteasa específica para prolina, un método para fabricar un polipéptido variante que tiene actividad de endoproteasa específica para prolina, una célula hospedera recombinante y un método para producir el polipéptido y un proceso para la preparación de un producto alimenticio o de pienso en donde se utiliza el polipéptido.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14170879 | 2014-06-03 | ||
| EP14172644 | 2014-06-17 | ||
| EP14172645 | 2014-06-17 | ||
| PCT/EP2015/062328 WO2015185593A1 (en) | 2014-06-03 | 2015-06-03 | Proline-specific endoprotease and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016015362A true MX2016015362A (es) | 2017-04-13 |
| MX376332B MX376332B (es) | 2025-03-07 |
Family
ID=53276885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016015362A MX376332B (es) | 2014-06-03 | 2015-06-03 | Endoproteasa especifica para prolina y usos de la misma. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10294467B2 (es) |
| EP (1) | EP3152305B1 (es) |
| CN (1) | CN106414733B (es) |
| BR (1) | BR112016027526B1 (es) |
| DK (1) | DK3152305T3 (es) |
| EA (1) | EA035178B1 (es) |
| ES (1) | ES2718071T3 (es) |
| MX (1) | MX376332B (es) |
| PL (1) | PL3152305T3 (es) |
| WO (2) | WO2015185593A1 (es) |
| ZA (1) | ZA201607700B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3152304B1 (en) * | 2014-06-03 | 2019-07-24 | DSM IP Assets B.V. | Proline-specific endoprotease and use thereof |
| WO2016120764A1 (en) * | 2015-01-26 | 2016-08-04 | Centre Hospitalier Universitaire Vaudois (Chuv) | Aspergillus oryzae prolyl endopeptidases and use thereof in degradation of polypeptides |
| GB201705750D0 (en) * | 2017-04-10 | 2017-05-24 | Univ Oxford Innovation Ltd | Peptide ligase and use therof |
| EP3830258A1 (en) * | 2018-07-31 | 2021-06-09 | DuPont Nutrition Biosciences ApS | Proline specific endopeptidases |
| EA202190550A1 (ru) * | 2018-08-17 | 2021-04-23 | Ридженерон Фармасьютикалз, Инк. | Способы секвенирования белков de novo |
| EP4299730A4 (en) * | 2021-02-26 | 2025-09-03 | Amano Enzyme Inc | METHOD FOR PRODUCING FERMENTED FOOD OR BEVERAGE, AND ANAEROBIC FERMENTATION METHOD |
| WO2024200535A1 (en) * | 2023-03-27 | 2024-10-03 | Dsm Ip Assets B.V. | Endoprotease composition |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200401589T4 (tr) * | 2000-12-07 | 2004-08-23 | Dsm Ip Assets B.V. | İçeceklerde bulanıklığın engellenmesi ya da azaltılması için yöntem. |
| ATE386110T1 (de) * | 2000-12-07 | 2008-03-15 | Dsm Ip Assets Bv | Prolylendoprotease aus aspergillus niger |
| US8257760B2 (en) * | 2002-06-07 | 2012-09-04 | Dsm Ip Assets B.V. | Method for the prevention or reduction of haze in beverages |
| US8063267B2 (en) * | 2006-03-30 | 2011-11-22 | Novozymes, Inc. | Polypeptides having endoglucanase activity and polynucleotides encoding same |
| US20140205587A1 (en) * | 2011-06-17 | 2014-07-24 | Alvine Pharmaceuticals, Inc. | Proteases for Degrading Gluten |
| RU2014150072A (ru) * | 2012-05-11 | 2016-07-10 | Новозимс А/С | Способ пивоварения |
-
2015
- 2015-06-03 PL PL15727383T patent/PL3152305T3/pl unknown
- 2015-06-03 DK DK15727383.0T patent/DK3152305T3/da active
- 2015-06-03 WO PCT/EP2015/062328 patent/WO2015185593A1/en not_active Ceased
- 2015-06-03 EP EP15727383.0A patent/EP3152305B1/en active Active
- 2015-06-03 US US15/314,825 patent/US10294467B2/en active Active
- 2015-06-03 CN CN201580028642.5A patent/CN106414733B/zh active Active
- 2015-06-03 WO PCT/EP2015/062327 patent/WO2015185592A2/en not_active Ceased
- 2015-06-03 MX MX2016015362A patent/MX376332B/es active IP Right Grant
- 2015-06-03 EA EA201692439A patent/EA035178B1/ru not_active IP Right Cessation
- 2015-06-03 BR BR112016027526-8A patent/BR112016027526B1/pt active IP Right Grant
- 2015-06-03 ES ES15727383T patent/ES2718071T3/es active Active
-
2016
- 2016-11-08 ZA ZA2016/07700A patent/ZA201607700B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015185592A2 (en) | 2015-12-10 |
| DK3152305T3 (da) | 2019-05-20 |
| CN106414733A (zh) | 2017-02-15 |
| US10294467B2 (en) | 2019-05-21 |
| EA201692439A1 (ru) | 2017-04-28 |
| ZA201607700B (en) | 2018-04-25 |
| US20170198272A1 (en) | 2017-07-13 |
| EA035178B1 (ru) | 2020-05-12 |
| BR112016027526A2 (pt) | 2017-10-17 |
| EP3152305A1 (en) | 2017-04-12 |
| MX376332B (es) | 2025-03-07 |
| PL3152305T3 (pl) | 2019-07-31 |
| WO2015185592A3 (en) | 2016-02-11 |
| WO2015185593A1 (en) | 2015-12-10 |
| EP3152305B1 (en) | 2019-02-27 |
| CN106414733B (zh) | 2021-04-23 |
| ES2718071T3 (es) | 2019-06-27 |
| BR112016027526B1 (pt) | 2024-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |