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MX2016014248A - Compuestos polifluorados que actuan como inhibidores de la tirosina cinasa de bruton. - Google Patents

Compuestos polifluorados que actuan como inhibidores de la tirosina cinasa de bruton.

Info

Publication number
MX2016014248A
MX2016014248A MX2016014248A MX2016014248A MX2016014248A MX 2016014248 A MX2016014248 A MX 2016014248A MX 2016014248 A MX2016014248 A MX 2016014248A MX 2016014248 A MX2016014248 A MX 2016014248A MX 2016014248 A MX2016014248 A MX 2016014248A
Authority
MX
Mexico
Prior art keywords
bruton
tyrosine kinase
kinase inhibitors
compounds acting
polyfluorinated compounds
Prior art date
Application number
MX2016014248A
Other languages
English (en)
Other versions
MX387487B (es
Inventor
Wei He
Original Assignee
Zhejiang Dtrm Biopharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Dtrm Biopharma Co Ltd filed Critical Zhejiang Dtrm Biopharma Co Ltd
Publication of MX2016014248A publication Critical patent/MX2016014248A/es
Publication of MX387487B publication Critical patent/MX387487B/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
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    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proveen aquí compuestos novedosos de pirazolopirimidina multi-sustituida con flúor o sales de los mismos, métodos para preparar los mismos y métodos terapéuticos por administración de los compuestos y sus formulaciones para tratar e inhibir enfermedades o trastornos autoinmunes, enfermedades o trastornos heteroinmunes, enfermedades inflamatorias y cánceres o trastornos.
MX2016014248A 2014-04-29 2015-04-27 Compuestos polifluorados que actúan como inhibidores de la tirosina cinasa de bruton. MX387487B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410175783.7A CN105017256A (zh) 2014-04-29 2014-04-29 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
PCT/CN2015/000290 WO2015165279A1 (zh) 2014-04-29 2015-04-27 多氟化合物作为布鲁顿酪氨酸激酶抑制剂

Publications (2)

Publication Number Publication Date
MX2016014248A true MX2016014248A (es) 2017-05-30
MX387487B MX387487B (es) 2025-03-18

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Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016014248A MX387487B (es) 2014-04-29 2015-04-27 Compuestos polifluorados que actúan como inhibidores de la tirosina cinasa de bruton.
MX2021013118A MX2021013118A (es) 2014-04-29 2015-04-27 Compuestos polifluorados que actuan como inhibidores de la tirosina cinasa de bruton.

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MX2021013118A MX2021013118A (es) 2014-04-29 2015-04-27 Compuestos polifluorados que actuan como inhibidores de la tirosina cinasa de bruton.

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US (3) US9532990B2 (es)
EP (1) EP3138842B1 (es)
JP (2) JP6670756B2 (es)
KR (2) KR20160144378A (es)
CN (3) CN105017256A (es)
AU (1) AU2015252654C1 (es)
BR (1) BR112016025132A2 (es)
CA (1) CA2947338C (es)
EA (2) EA032100B1 (es)
ES (1) ES2857251T3 (es)
IL (1) IL248546B (es)
MX (2) MX387487B (es)
WO (1) WO2015165279A1 (es)

Families Citing this family (51)

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Publication number Priority date Publication date Assignee Title
JP6084292B2 (ja) 2013-07-18 2017-02-22 大鵬薬品工業株式会社 Ｆｇｆｒ阻害剤耐性癌の治療薬
KR101974254B1 (ko) 2013-07-18 2019-04-30 다이호야쿠힌고교 가부시키가이샤 Fgfr 저해제의 간헐 투여용 항종양제
CN105017256A (zh) * 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
WO2016079693A1 (en) * 2014-11-19 2016-05-26 Sun Pharmaceutical Industries Limited A process for the preparation of ibrutinib
US10214532B2 (en) 2015-02-12 2019-02-26 Shanghai Dude Medical Science and Technology Co., Ltd. Process for preparing ibrutinib
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