MX2016014000A - Anticuerpo igf-1r y su uso como un vehiculo con especificidad de objetivo para el tratamiento contra el cancer. - Google Patents
Anticuerpo igf-1r y su uso como un vehiculo con especificidad de objetivo para el tratamiento contra el cancer.Info
- Publication number
- MX2016014000A MX2016014000A MX2016014000A MX2016014000A MX2016014000A MX 2016014000 A MX2016014000 A MX 2016014000A MX 2016014000 A MX2016014000 A MX 2016014000A MX 2016014000 A MX2016014000 A MX 2016014000A MX 2016014000 A MX2016014000 A MX 2016014000A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody
- igf
- treatment
- cancer
- binding
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
Abstract
La presente invención se relaciona con un anticuerpo, particularmente con un anticuerpo monoclonal, capaz de unirse a IGF-1R, así como a las secuencias de aminoácidos y ácidos nucleicos que codifican para el mencionado anticuerpo. En uno de sus aspectos, la invención se relaciona con un anticuerpo o con un fragmento de unión al antígeno del mismo, capaz unirse a IGF-1R y, al inducir la incorporación de IGF-1R, de interiorizarse en la célula. La invención también comprende el uso de dicho anticuerpo a manera de un producto o vehículo con especificidad de objetivo en conjugación con otros compuestos anticancerígenos como toxinas, radioelementos o fármacos, y el uso del mismo para el tratamiento contra ciertos tipos cánceres.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461984160P | 2014-04-25 | 2014-04-25 | |
| PCT/EP2015/059050 WO2015162292A1 (en) | 2014-04-25 | 2015-04-27 | Igf-1r antibody and its use as addressing vehicle for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016014000A true MX2016014000A (es) | 2017-05-30 |
| MX380358B MX380358B (es) | 2025-03-12 |
Family
ID=53373391
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016014000A MX380358B (es) | 2014-04-25 | 2015-04-27 | Anticuerpo igf-1r y su uso como un vehiculo con especificidad de objetivo para el tratamiento contra el cancer. |
| MX2021002144A MX2021002144A (es) | 2014-04-25 | 2016-10-25 | Anticuerpo igf-1r y su uso como un vehiculo con especificidad de objetivo para el tratamiento contra el cancer. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021002144A MX2021002144A (es) | 2014-04-25 | 2016-10-25 | Anticuerpo igf-1r y su uso como un vehiculo con especificidad de objetivo para el tratamiento contra el cancer. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US10202458B2 (es) |
| EP (2) | EP3134438B1 (es) |
| JP (2) | JP6835591B2 (es) |
| KR (3) | KR102357032B1 (es) |
| CN (2) | CN106459204B (es) |
| AU (1) | AU2015250760C1 (es) |
| BR (1) | BR112016024575B1 (es) |
| CA (1) | CA2946795C (es) |
| CY (1) | CY1123743T1 (es) |
| DK (1) | DK3134438T3 (es) |
| ES (1) | ES2841249T3 (es) |
| HR (1) | HRP20202047T1 (es) |
| HU (1) | HUE052223T2 (es) |
| IL (2) | IL248357B (es) |
| LT (1) | LT3134438T (es) |
| MA (2) | MA53069B1 (es) |
| MX (2) | MX380358B (es) |
| MY (1) | MY182444A (es) |
| NZ (1) | NZ725423A (es) |
| PL (1) | PL3134438T3 (es) |
| PT (1) | PT3134438T (es) |
| RS (1) | RS61379B1 (es) |
| RU (1) | RU2698977C2 (es) |
| SA (1) | SA516380131B1 (es) |
| SI (1) | SI3134438T1 (es) |
| TN (1) | TN2016000445A1 (es) |
| UA (1) | UA122390C2 (es) |
| WO (1) | WO2015162292A1 (es) |
| ZA (1) | ZA201607095B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3134124T (lt) * | 2014-04-25 | 2019-05-27 | Pierre Fabre Médicament | Igf-1r antikūno ir vaisto konjugatas, ir jo panaudojimas vėžio gydymui |
| US10858423B2 (en) | 2015-10-26 | 2020-12-08 | Pierre Fabre Medicament | Composition for the treatment of IGF-1R expressing cancer |
| JP7183163B2 (ja) | 2017-01-06 | 2022-12-05 | クレシェンド・バイオロジックス・リミテッド | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
| AU2018363292A1 (en) | 2017-11-13 | 2020-05-21 | Crescendo Biologics Limited | Molecules that bind to CD137 and PSMA |
| GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
| US20230243836A1 (en) | 2018-07-20 | 2023-08-03 | Pierre Fabre Medicament | Receptor for vista |
| EP3856258B1 (en) | 2018-09-27 | 2024-07-31 | Pierre Fabre Medicament | Sulfomaleimide-based linkers and corresponding conjugates |
| EP3866856A1 (en) * | 2018-10-19 | 2021-08-25 | MedImmune Limited | Pyrrolobenzodiazepine conjugates |
| BR112022003635A2 (pt) | 2019-09-04 | 2022-05-24 | Pf Medicament | Anticorpo anti-vsig4 ou fragmento de ligação ao antígeno e seu uso |
| EP4353220A1 (en) | 2022-10-12 | 2024-04-17 | Pierre Fabre Medicament | Use of a liquid aqueous composition for solubilization and stabilization of an antibody-drug conjugate |
| CR20250458A (es) | 2023-03-30 | 2025-11-21 | Revolution Medicines Inc | Composiciones para inducir la hidrólisis de ras gtp y sus usos |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970198A (en) | 1985-10-17 | 1990-11-13 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
| US5079233A (en) | 1987-01-30 | 1992-01-07 | American Cyanamid Company | N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| FR2661000B1 (fr) | 1990-04-12 | 1992-08-07 | Aerospatiale | Machine d'essais d'eprouvettes en cisaillement. |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| US5561427A (en) | 1994-12-30 | 1996-10-01 | Psc Inc. | Analog to digital converter with continuous conversion cycles and large input signal range |
| FR2873699B1 (fr) * | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
| US7521541B2 (en) | 2004-09-23 | 2009-04-21 | Genetech Inc. | Cysteine engineered antibodies and conjugates |
| FR2888850B1 (fr) * | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| MX2008012146A (es) * | 2006-03-28 | 2008-10-03 | Biogen Idec Inc | Anticuerpos anti-receptor 1 de factor de crecimiento tipo insulina (igf-1r) y uso de los mismos. |
| WO2008079849A2 (en) | 2006-12-22 | 2008-07-03 | Genentech, Inc. | Antibodies to insulin-like growth factor receptor |
| AR066476A1 (es) | 2007-05-08 | 2009-08-19 | Genentech Inc | Anticuerpos anti-muc16 disenados con cisteina y conjugaods de anticuerpos y farmacos |
| MY188455A (en) | 2007-10-19 | 2021-12-09 | Genentech Inc | Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates |
| TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
| WO2011130598A1 (en) | 2010-04-15 | 2011-10-20 | Spirogen Limited | Pyrrolobenzodiazepines and conjugates thereof |
| KR101517320B1 (ko) * | 2011-04-19 | 2015-05-28 | 메리맥 파마슈티컬즈, 인크. | 단일특이적 및 이중특이적 항-igf-1r 및 항 erbb3 항체 |
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2015
- 2015-04-27 KR KR1020207031883A patent/KR102357032B1/ko active Active
- 2015-04-27 KR KR1020227002688A patent/KR20220018620A/ko not_active Ceased
- 2015-04-27 PL PL15727884T patent/PL3134438T3/pl unknown
- 2015-04-27 ES ES15727884T patent/ES2841249T3/es active Active
- 2015-04-27 LT LTEP15727884.7T patent/LT3134438T/lt unknown
- 2015-04-27 HR HRP20202047TT patent/HRP20202047T1/hr unknown
- 2015-04-27 TN TN2016000445A patent/TN2016000445A1/en unknown
- 2015-04-27 NZ NZ725423A patent/NZ725423A/en unknown
- 2015-04-27 MA MA53069A patent/MA53069B1/fr unknown
- 2015-04-27 US US15/305,157 patent/US10202458B2/en active Active
- 2015-04-27 RU RU2016145277A patent/RU2698977C2/ru active
- 2015-04-27 AU AU2015250760A patent/AU2015250760C1/en active Active
- 2015-04-27 MX MX2016014000A patent/MX380358B/es unknown
- 2015-04-27 SI SI201531465T patent/SI3134438T1/sl unknown
- 2015-04-27 EP EP15727884.7A patent/EP3134438B1/en active Active
- 2015-04-27 CA CA2946795A patent/CA2946795C/en active Active
- 2015-04-27 CN CN201580030711.6A patent/CN106459204B/zh active Active
- 2015-04-27 DK DK15727884.7T patent/DK3134438T3/da active
- 2015-04-27 PT PT157278847T patent/PT3134438T/pt unknown
- 2015-04-27 RS RS20201589A patent/RS61379B1/sr unknown
- 2015-04-27 HU HUE15727884A patent/HUE052223T2/hu unknown
- 2015-04-27 UA UAA201611832A patent/UA122390C2/uk unknown
- 2015-04-27 WO PCT/EP2015/059050 patent/WO2015162292A1/en not_active Ceased
- 2015-04-27 CN CN202110050772.6A patent/CN112851808B/zh active Active
- 2015-04-27 KR KR1020167031552A patent/KR102177436B1/ko active Active
- 2015-04-27 MA MA39378A patent/MA39378B2/fr unknown
- 2015-04-27 BR BR112016024575-0A patent/BR112016024575B1/pt active IP Right Grant
- 2015-04-27 JP JP2016564127A patent/JP6835591B2/ja active Active
- 2015-04-27 EP EP20199068.6A patent/EP3783033A1/en active Pending
- 2015-04-27 MY MYPI2016703873A patent/MY182444A/en unknown
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2016
- 2016-10-13 IL IL248357A patent/IL248357B/en active IP Right Grant
- 2016-10-14 ZA ZA2016/07095A patent/ZA201607095B/en unknown
- 2016-10-24 SA SA516380131A patent/SA516380131B1/ar unknown
- 2016-10-25 MX MX2021002144A patent/MX2021002144A/es unknown
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2018
- 2018-12-18 US US16/223,363 patent/US11365259B2/en active Active
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2020
- 2020-04-26 IL IL274226A patent/IL274226A/en unknown
- 2020-12-18 CY CY20201101196T patent/CY1123743T1/el unknown
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2021
- 2021-02-03 JP JP2021015955A patent/JP7191134B2/ja active Active
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