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MX2016012690A - Piridin-2-carboxamidas 5,6-disustituidas como agonistas del receptor cannabinoide. - Google Patents

Piridin-2-carboxamidas 5,6-disustituidas como agonistas del receptor cannabinoide.

Info

Publication number
MX2016012690A
MX2016012690A MX2016012690A MX2016012690A MX2016012690A MX 2016012690 A MX2016012690 A MX 2016012690A MX 2016012690 A MX2016012690 A MX 2016012690A MX 2016012690 A MX2016012690 A MX 2016012690A MX 2016012690 A MX2016012690 A MX 2016012690A
Authority
MX
Mexico
Prior art keywords
carboxamides
cannabinoid receptor
receptor agonists
disubstituted pyridine
compound
Prior art date
Application number
MX2016012690A
Other languages
English (en)
Inventor
Nettekoven Matthias
Gobbi Luca
Grether Uwe
Roever Stephan
Rogers - Evans Mark
Slavik Roger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2016012690A publication Critical patent/MX2016012690A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se relaciona con un compuesto de la fórmula (I), en donde R1 a R4 se definen como en la descripción y en las reivindicaciones. El compuesto de la fórmula (I) son agonistas del Receptor Cannabinoide 2 y, por lo tanto, son útiles en el tratamiento de varias enfermedades, tal como dolor, aterosclerosis, inflamación, etcétera.
MX2016012690A 2014-04-04 2015-04-01 Piridin-2-carboxamidas 5,6-disustituidas como agonistas del receptor cannabinoide. MX2016012690A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14163554 2014-04-04
PCT/EP2015/057144 WO2015150438A1 (en) 2014-04-04 2015-04-01 5,6-disubstituted pyridine-2-carboxamides as cannabinoid receptor agonists

Publications (1)

Publication Number Publication Date
MX2016012690A true MX2016012690A (es) 2017-04-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012690A MX2016012690A (es) 2014-04-04 2015-04-01 Piridin-2-carboxamidas 5,6-disustituidas como agonistas del receptor cannabinoide.

Country Status (18)

Country Link
US (2) US20160376237A1 (es)
EP (1) EP3126349B1 (es)
JP (1) JP6353072B2 (es)
KR (2) KR20160132495A (es)
CN (2) CN106458984A (es)
AR (1) AR099932A1 (es)
AU (1) AU2015239537B2 (es)
CA (1) CA2944256A1 (es)
CL (1) CL2016002389A1 (es)
CR (1) CR20160459A (es)
EA (1) EA030032B1 (es)
IL (1) IL247773A0 (es)
MX (1) MX2016012690A (es)
PE (1) PE20161407A1 (es)
PH (1) PH12016501849A1 (es)
SG (1) SG11201608246VA (es)
TW (1) TW201625538A (es)
WO (1) WO2015150438A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6500010B2 (ja) 2013-03-26 2019-04-10 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規ピリジン誘導体
PL3126354T3 (pl) 2014-04-04 2020-06-15 H. Lundbeck A/S Fluorowcowane chinazolino-THF-aminy jako inhibitory PDE1
CR20180298A (es) * 2015-12-09 2018-07-18 Hoffmann La Roche Nuevos derivados de fenilo
GB201703282D0 (en) * 2017-03-01 2017-04-12 Glaxosmithkline Intellectual Property (No 2) Ltd Compounds
JP7300398B2 (ja) 2017-06-20 2023-06-29 エフ． ホフマン－ラ ロシュ アーゲー ピリジン誘導体
EP3813888B1 (en) * 2018-06-27 2025-11-26 F. Hoffmann-La Roche AG Radiolabeled cannabinoid receptor 2 ligand
EP3814328A1 (en) * 2018-06-27 2021-05-05 F. Hoffmann-La Roche AG Novel azetidine-substituted pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2
EP3814337B1 (en) * 2018-06-27 2025-05-14 F. Hoffmann-La Roche AG Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
BR112020025013A2 (pt) * 2018-06-27 2021-03-23 F. Hoffmann-La Roche Ag novos compostos de piridina e pirazina como inibidores do receptor 2 de canabinoide
US20250109093A1 (en) * 2022-01-28 2025-04-03 Nippon Soda Co., Ltd. Method for producing amide compound
CN115160306B (zh) * 2022-08-04 2024-03-26 上海皓鸿生物医药科技有限公司 一种特力利汀中间体的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
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US7691863B2 (en) * 2006-10-04 2010-04-06 Hoffman-La Roche Inc. Pyrazine-2-carboxamide derivatives as CB2 receptor modulators
WO2012031817A1 (en) * 2010-09-09 2012-03-15 F. Hoffmann-La Roche Ag Determination of abca1 protein levels in cells
US9321727B2 (en) * 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
US9403808B2 (en) * 2011-10-28 2016-08-02 Hoffmann-La Roche Inc. Pyrazine derivatives
DK2928868T3 (en) * 2012-12-07 2017-10-23 Hoffmann La Roche Pyridine-2-amides which can be used as CB2 agonists
HUE036911T2 (hu) * 2012-12-07 2018-08-28 Hoffmann La Roche Új piridin származékok

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EP3126349A1 (en) 2017-02-08
KR20160132495A (ko) 2016-11-18
AU2015239537A1 (en) 2016-11-17
EA030032B1 (ru) 2018-06-29
EA201691982A1 (ru) 2017-01-30
US20160376237A1 (en) 2016-12-29
IL247773A0 (en) 2016-11-30
SG11201608246VA (en) 2016-10-28
AR099932A1 (es) 2016-08-31
CR20160459A (es) 2016-12-02
CA2944256A1 (en) 2015-10-08
CL2016002389A1 (es) 2017-03-17
CN111170938A (zh) 2020-05-19
US20180327360A1 (en) 2018-11-15
AU2015239537B2 (en) 2019-04-04
EP3126349B1 (en) 2019-06-26
CN106458984A (zh) 2017-02-22
PE20161407A1 (es) 2016-12-28
TW201625538A (zh) 2016-07-16
JP2017509688A (ja) 2017-04-06
WO2015150438A1 (en) 2015-10-08
PH12016501849A1 (en) 2016-12-19
KR20180072827A (ko) 2018-06-29
JP6353072B2 (ja) 2018-07-04

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